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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (1S)-1-cyclopentyl-N-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)methyl]-1-phenylmethanamine —— C16H21N3S2
    (1S)-1-cyclopentyl-N-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)methyl]-1-phenylmethanamine
    —— methyl (2S)-2-(4-oxo-1-propan-2-ylpyrimidin-2-yl)sulfanylpropanoate —— C11H16N2O3S
    methyl (2S)-2-(4-oxo-1-propan-2-ylpyrimidin-2-yl)sulfanylpropanoate
    —— methyl (2R)-2-(4-oxo-1-propan-2-ylpyrimidin-2-yl)sulfanylpropanoate —— C11H16N2O3S
    methyl (2R)-2-(4-oxo-1-propan-2-ylpyrimidin-2-yl)sulfanylpropanoate
    —— methyl (3S)-3-(4-methylsulfanylphenyl)-3-(pyridin-4-ylcarbamoylamino)propanoate —— C17H19N3O3S
    methyl (3S)-3-(4-methylsulfanylphenyl)-3-(pyridin-4-ylcarbamoylamino)propanoate
    —— methyl (3R)-3-(4-methylsulfanylphenyl)-3-(pyridin-4-ylcarbamoylamino)propanoate —— C17H19N3O3S
    methyl (3R)-3-(4-methylsulfanylphenyl)-3-(pyridin-4-ylcarbamoylamino)propanoate
    —— 2-[4-(furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-N-(2-morpholin-4-ium-4-ylethyl)acetamide —— C17H20F3N4O3S+
    2-[4-(furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl-N-(2-morpholin-4-ium-4-ylethyl)acetamide
    —— 1-(4-Ethylpiperazin-4-ium-1-yl)-2-[4-thiophen-2-yl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanylethanone —— C17H20F3N4OS2+
    1-(4-Ethylpiperazin-4-ium-1-yl)-2-[4-thiophen-2-yl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanylethanone
    —— (2S)-N'-[2-(4-chlorophenyl)sulfanylacetyl]-2-methylpentanehydrazide —— C14H19ClN2O2S
    (2S)-N'-[2-(4-chlorophenyl)sulfanylacetyl]-2-methylpentanehydrazide
    —— 3-(4-fluorophenyl)sulfanyl-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]propanamide —— C17H26FN3OS
    3-(4-fluorophenyl)sulfanyl-N-[(2S)-1-(4-methylpiperazin-1-yl)propan-2-yl]propanamide
    —— (2R)-N'-[2-(4-chlorophenyl)sulfanylacetyl]-2-methylpentanehydrazide —— C14H19ClN2O2S
    (2R)-N'-[2-(4-chlorophenyl)sulfanylacetyl]-2-methylpentanehydrazide
    —— 2,4-dimethyl-6-[[(3R)-1-methylpiperidin-3-yl]methylsulfanyl]pyrimidine-5-carbonitrile —— C14H20N4S
    2,4-dimethyl-6-[[(3R)-1-methylpiperidin-3-yl]methylsulfanyl]pyrimidine-5-carbonitrile
    —— 2,4-dimethyl-6-[[(3S)-1-methylpiperidin-3-yl]methylsulfanyl]pyrimidine-5-carbonitrile —— C14H20N4S
    2,4-dimethyl-6-[[(3S)-1-methylpiperidin-3-yl]methylsulfanyl]pyrimidine-5-carbonitrile
    —— [(1S,2R)-1-[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-oxadiazol-2-yl]-2-methylbutyl]azanium —— C9H17N4O2S+
    [(1S,2R)-1-[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-oxadiazol-2-yl]-2-methylbutyl]azanium
    —— 3-(4-fluorophenyl)sulfanyl-N-[(2R)-1-(4-methylpiperazin-1-yl)propan-2-yl]propanamide —— C17H26FN3OS
    3-(4-fluorophenyl)sulfanyl-N-[(2R)-1-(4-methylpiperazin-1-yl)propan-2-yl]propanamide
    —— 2-[[(4S)-1,3-dioxan-4-yl]methylsulfanyl]-5-methylsulfanyl-1,3,4-thiadiazole —— C8H12N2O2S3
    2-[[(4S)-1,3-dioxan-4-yl]methylsulfanyl]-5-methylsulfanyl-1,3,4-thiadiazole
    —— [(1S)-2-methyl-1-[5-[(3-methylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]propyl]azanium —— C14H20N3OS+
    [(1S)-2-methyl-1-[5-[(3-methylphenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]propyl]azanium
    —— [(1S)-1-[5-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylpropyl]azanium —— C13H16ClFN3OS+
    [(1S)-1-[5-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylpropyl]azanium
    —— 2-[[(4R)-1,3-dioxan-4-yl]methylsulfanyl]-5-methylsulfanyl-1,3,4-thiadiazole —— C8H12N2O2S3
    2-[[(4R)-1,3-dioxan-4-yl]methylsulfanyl]-5-methylsulfanyl-1,3,4-thiadiazole
    —— [(1S)-1-[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-3-methylbutyl]azanium —— C14H19ClN3OS+
    [(1S)-1-[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-3-methylbutyl]azanium
    —— [(1S)-1-[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-oxadiazol-2-yl]-2-methylpropyl]azanium —— C8H15N4O2S+
    [(1S)-1-[5-(2-amino-2-oxoethyl)sulfanyl-1,3,4-oxadiazol-2-yl]-2-methylpropyl]azanium
    —— [(1S,2R)-1-[5-[2-(dimethylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]-2-methylbutyl]azanium —— C11H21N4O2S+
    [(1S,2R)-1-[5-[2-(dimethylamino)-2-oxoethyl]sulfanyl-1,3,4-oxadiazol-2-yl]-2-methylbutyl]azanium
    —— N-[(2S)-2-(2-chloro-6-fluorophenyl)-2-[(2R)-2-methylmorpholin-4-yl]ethyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide —— C23H30ClFN4O2S
    N-[(2S)-2-(2-chloro-6-fluorophenyl)-2-[(2R)-2-methylmorpholin-4-yl]ethyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide
    —— N-[(2R)-2-(2-chloro-6-fluorophenyl)-2-[(2R)-2-methylmorpholin-4-yl]ethyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide —— C23H30ClFN4O2S
    N-[(2R)-2-(2-chloro-6-fluorophenyl)-2-[(2R)-2-methylmorpholin-4-yl]ethyl]-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide
    —— (2R)-N-[(Z)-butan-2-ylideneamino]-2-(4-chlorophenyl)sulfanylpropanamide —— C13H17ClN2OS
    (2R)-N-[(Z)-butan-2-ylideneamino]-2-(4-chlorophenyl)sulfanylpropanamide
    —— (2R)-2-(3-methyl-2,4-dioxo-7-propan-2-yl-1-propylpyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N-propan-2-ylpropanamide —— C19H29N5O3S
    (2R)-2-(3-methyl-2,4-dioxo-7-propan-2-yl-1-propylpyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N-propan-2-ylpropanamide
    —— (2S)-2-(3-methyl-2,4-dioxo-7-propan-2-yl-1-propylpyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N-propan-2-ylpropanamide —— C19H29N5O3S
    (2S)-2-(3-methyl-2,4-dioxo-7-propan-2-yl-1-propylpyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N-propan-2-ylpropanamide
    —— 2-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-phenylbutyl]acetamide —— C22H26N4O2S
    2-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1S)-1-phenylbutyl]acetamide
    —— 2-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-phenylbutyl]acetamide —— C22H26N4O2S
    2-[[5-cyclopropyl-4-(furan-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[(1R)-1-phenylbutyl]acetamide
    —— 2-[(5-Phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-thiophen-2-ylethanone —— C14H10N2O2S2
    2-[(5-Phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-thiophen-2-ylethanone
    —— 1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C16H19N3O3S
    1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— 2-[(3-Bromophenyl)methylsulfanyl]-5-phenyl-1,3,4-oxadiazole —— C15H11BrN2OS
    2-[(3-Bromophenyl)methylsulfanyl]-5-phenyl-1,3,4-oxadiazole
    —— N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C18H16ClN3O2S
    N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C18H16ClN3O2S
    N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C16H19N3O3S
    1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— N-[(1R)-1-(2-chlorophenyl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C18H16ClN3O2S
    N-[(1R)-1-(2-chlorophenyl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— ethyl 2,5-dimethyl-4-[2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]-1H-pyrrole-3-carboxylate —— C19H19N3O4S
    ethyl 2,5-dimethyl-4-[2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]-1H-pyrrole-3-carboxylate
    —— N-[2-(4-fluorophenyl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C18H16FN3O2S
    N-[2-(4-fluorophenyl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— (2R)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanenitrile —— C11H9N3OS
    (2R)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanenitrile
    —— 1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C20H23N3O3S
    1-[1-[(2S)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— N-[(2S)-3-methylbutan-2-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C15H19N3O2S
    N-[(2S)-3-methylbutan-2-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— (2S)-N-cyclopropyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C14H15N3O2S
    (2S)-N-cyclopropyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— ethyl 2,4-dimethyl-5-[2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]-1H-pyrrole-3-carboxylate —— C19H19N3O4S
    ethyl 2,4-dimethyl-5-[2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetyl]-1H-pyrrole-3-carboxylate
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C14H15N3O4S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— N-(1-cyanocyclopentyl)-2-(2,4-dimethylphenyl)sulfanylacetamide —— C16H20N2OS
    N-(1-cyanocyclopentyl)-2-(2,4-dimethylphenyl)sulfanylacetamide
    —— (4R)-5-acetyl-4-(4-ethylphenyl)-6-methyl-2-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-3-carbonitrile —— C24H24N2OS2
    (4R)-5-acetyl-4-(4-ethylphenyl)-6-methyl-2-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-3-carbonitrile
    —— (2S)-N-benzyl-2-(2,4-dimethylphenyl)sulfanylpropanamide —— C18H21NOS
    (2S)-N-benzyl-2-(2,4-dimethylphenyl)sulfanylpropanamide
    —— (2S)-2-[[(2R)-butan-2-yl]disulfanyl]butane —— C8H18S2
    (2S)-2-[[(2R)-butan-2-yl]disulfanyl]butane
    —— 2-(2,4-dimethylphenyl)sulfanyl-N-(2-phenylethyl)acetamide —— C18H21NOS
    2-(2,4-dimethylphenyl)sulfanyl-N-(2-phenylethyl)acetamide
    —— (2S)-2-(2,4-dimethylphenyl)sulfanyl-N-(furan-2-ylmethyl)propanamide —— C16H19NO2S
    (2S)-2-(2,4-dimethylphenyl)sulfanyl-N-(furan-2-ylmethyl)propanamide
    —— 2-(2,4-dimethylphenyl)sulfanyl-N-[(1R)-1-(4-fluorophenyl)ethyl]acetamide —— C18H20FNOS
    2-(2,4-dimethylphenyl)sulfanyl-N-[(1R)-1-(4-fluorophenyl)ethyl]acetamide