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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C20H27N5O3S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S,2R)-2-methylcyclohexyl]acetamide —— C22H31N5O2S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1S,2R)-2-methylcyclohexyl]acetamide
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3R)-5-(4-bromophenyl)-3-[4-(dimethylamino)phenyl]-3,4-dihydropyrazol-2-yl]ethanone —— C21H21BrN6OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3R)-5-(4-bromophenyl)-3-[4-(dimethylamino)phenyl]-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-cyanoethyl)-N-methylacetamide —— C19H24N6O2S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-cyanoethyl)-N-methylacetamide
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(cyclohexylmethyl)acetamide —— C22H31N5O2S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(cyclohexylmethyl)acetamide
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-3-methylbutan-2-yl]acetamide —— C20H29N5O2S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(2R)-3-methylbutan-2-yl]acetamide
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3R)-5-(3-bromophenyl)-3-[4-(dimethylamino)phenyl]-3,4-dihydropyrazol-2-yl]ethanone —— C21H21BrN6OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3R)-5-(3-bromophenyl)-3-[4-(dimethylamino)phenyl]-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-5-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-3,4-dihydropyrazol-2-yl]ethanone —— C21H21ClN6OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-5-(4-chlorophenyl)-3-[4-(dimethylamino)phenyl]-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-5-(4-bromophenyl)-3-[4-(dimethylamino)phenyl]-3,4-dihydropyrazol-2-yl]ethanone —— C21H21BrN6OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-5-(4-bromophenyl)-3-[4-(dimethylamino)phenyl]-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide —— C22H31N5O2S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[(1R,2S)-2-methylcyclohexyl]acetamide
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-3-[4-(dimethylamino)phenyl]-5-phenyl-3,4-dihydropyrazol-2-yl]ethanone —— C21H22N6OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-3-[4-(dimethylamino)phenyl]-5-phenyl-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-5-(3-bromophenyl)-3-[4-(dimethylamino)phenyl]-3,4-dihydropyrazol-2-yl]ethanone —— C21H21BrN6OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-5-(3-bromophenyl)-3-[4-(dimethylamino)phenyl]-3,4-dihydropyrazol-2-yl]ethanone
    —— (3S)-3-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]oxolan-2-one —— C17H20N4O3S
    (3S)-3-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]oxolan-2-one
    —— 1-(Azepan-1-yl)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C21H29N5O2S
    1-(Azepan-1-yl)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3R)-3-[4-(dimethylamino)phenyl]-5-phenyl-3,4-dihydropyrazol-2-yl]ethanone —— C21H22N6OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3R)-3-[4-(dimethylamino)phenyl]-5-phenyl-3,4-dihydropyrazol-2-yl]ethanone
    —— 4-[4-Benzyl-5-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]morpholine —— C20H20ClFN4OS
    4-[4-Benzyl-5-[(2-chloro-6-fluorophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]morpholine
    —— 4-[4-Benzyl-5-[(2-fluorophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]morpholine —— C20H21FN4OS
    4-[4-Benzyl-5-[(2-fluorophenyl)methylsulfanyl]-1,2,4-triazol-3-yl]morpholine
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3R)-3-(4-chlorophenyl)-5-(4-fluorophenyl)-3,4-dihydropyrazol-2-yl]ethanone —— C19H15ClFN5OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3R)-3-(4-chlorophenyl)-5-(4-fluorophenyl)-3,4-dihydropyrazol-2-yl]ethanone
    —— 2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-methylbutyl)acetamide —— C20H29N5O2S
    2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(3-methylbutyl)acetamide
    —— methyl (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanoate —— C17H22N4O3S
    methyl (2S)-2-[(4-benzyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]propanoate
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]cyclopropanecarboxamide —— C15H24N4OS
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]cyclopropanecarboxamide
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-3-(4-chlorophenyl)-5-(4-fluorophenyl)-3,4-dihydropyrazol-2-yl]ethanone —— C19H15ClFN5OS2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-1-[(3S)-3-(4-chlorophenyl)-5-(4-fluorophenyl)-3,4-dihydropyrazol-2-yl]ethanone
    —— (E)-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-3-thiophen-2-ylprop-2-enamide —— C18H24N4OS2
    (E)-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-3-thiophen-2-ylprop-2-enamide
    —— (2R)-N-[(6-morpholin-4-ylpyrimidin-4-yl)methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C18H20N4O2S
    (2R)-N-[(6-morpholin-4-ylpyrimidin-4-yl)methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— (2S)-N-[(6-morpholin-4-ylpyrimidin-4-yl)methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide —— C18H20N4O2S
    (2S)-N-[(6-morpholin-4-ylpyrimidin-4-yl)methyl]-2,3-dihydro-1-benzothiophene-2-carboxamide
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2-phenylsulfanylacetamide —— C19H26N4OS2
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2-phenylsulfanylacetamide
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2-(4-fluorophenyl)sulfanylacetamide —— C19H25FN4OS2
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2-(4-fluorophenyl)sulfanylacetamide
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2-(4-methylphenyl)sulfanylacetamide —— C20H28N4OS2
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2-(4-methylphenyl)sulfanylacetamide
    —— (E)-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-3-(3-methylthiophen-2-yl)prop-2-enamide —— C19H26N4OS2
    (E)-N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-3-(3-methylthiophen-2-yl)prop-2-enamide
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2,5-dimethyl-1-propan-2-ylpyrrole-3-carboxamide —— C21H33N5OS
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2,5-dimethyl-1-propan-2-ylpyrrole-3-carboxamide
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-3,5-dimethyl-1,2-oxazole-4-carboxamide —— C17H25N5O2S
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-3,5-dimethyl-1,2-oxazole-4-carboxamide
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2-(2-methylphenyl)sulfanylacetamide —— C20H28N4OS2
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2-(2-methylphenyl)sulfanylacetamide
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2-(3,4-dimethylphenyl)sulfanylacetamide —— C21H30N4OS2
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-2-(3,4-dimethylphenyl)sulfanylacetamide
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]cyclohexanecarboxamide —— C18H30N4OS
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]cyclohexanecarboxamide
    —— N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-4-oxo-4-thiophen-2-ylbutanamide —— C19H26N4O2S2
    N-[3-(4-cyclopentyl-5-methylsulfanyl-1,2,4-triazol-3-yl)propyl]-4-oxo-4-thiophen-2-ylbutanamide
    —— [(2R)-2,3-dihydro-1-benzothiophen-2-yl]-[2-[[ethyl(methyl)amino]methyl]-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]methanone —— C19H24N4OS
    [(2R)-2,3-dihydro-1-benzothiophen-2-yl]-[2-[[ethyl(methyl)amino]methyl]-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]methanone
    —— [(2S)-2,3-dihydro-1-benzothiophen-2-yl]-[2-[[ethyl(methyl)amino]methyl]-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]methanone —— C19H24N4OS
    [(2S)-2,3-dihydro-1-benzothiophen-2-yl]-[2-[[ethyl(methyl)amino]methyl]-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-5-yl]methanone
    —— 2-benzylsulfanyl-5-[1-[(3R)-pyrrolidin-3-yl]imidazol-2-yl]pyrimidine —— C18H19N5S
    2-benzylsulfanyl-5-[1-[(3R)-pyrrolidin-3-yl]imidazol-2-yl]pyrimidine
    —— 2-methylsulfanyl-4,6-bis[[(2S)-piperidin-2-yl]oxy]pyrimidine —— C15H24N4O2S
    2-methylsulfanyl-4,6-bis[[(2S)-piperidin-2-yl]oxy]pyrimidine
    —— 2-benzylsulfanyl-5-[1-[(3S)-pyrrolidin-3-yl]imidazol-2-yl]pyrimidine —— C18H19N5S
    2-benzylsulfanyl-5-[1-[(3S)-pyrrolidin-3-yl]imidazol-2-yl]pyrimidine
    —— 2-methylsulfanyl-6-[(2S)-piperidin-2-yl]oxy-4-[(2R)-piperidin-2-yl]oxypyrimidine —— C15H24N4O2S
    2-methylsulfanyl-6-[(2S)-piperidin-2-yl]oxy-4-[(2R)-piperidin-2-yl]oxypyrimidine
    —— 2-methylsulfanyl-4,6-bis[[(2R)-piperidin-2-yl]oxy]pyrimidine —— C15H24N4O2S
    2-methylsulfanyl-4,6-bis[[(2R)-piperidin-2-yl]oxy]pyrimidine
    —— N-[[5-[2-(2,5-difluorophenyl)sulfanylacetyl]thiophen-2-yl]methyl]-2,2-dimethylpropanamide —— C18H19F2NO2S2
    N-[[5-[2-(2,5-difluorophenyl)sulfanylacetyl]thiophen-2-yl]methyl]-2,2-dimethylpropanamide
    —— N-[(3-chlorophenyl)methyl]-2-(2,5-difluorophenyl)sulfanylacetamide —— C15H12ClF2NOS
    N-[(3-chlorophenyl)methyl]-2-(2,5-difluorophenyl)sulfanylacetamide
    —— 2-[(2,5-Difluorophenyl)sulfanylmethyl]-5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazole —— C15H12F2N2O2S
    2-[(2,5-Difluorophenyl)sulfanylmethyl]-5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazole
    —— 2-(2,5-difluorophenyl)sulfanyl-1-[1-[(3S)-1,1-dioxothiolan-3-yl]-2,5-dimethylpyrrol-3-yl]ethanone —— C18H19F2NO3S2
    2-(2,5-difluorophenyl)sulfanyl-1-[1-[(3S)-1,1-dioxothiolan-3-yl]-2,5-dimethylpyrrol-3-yl]ethanone
    —— (2R)-2-(2,5-difluorophenyl)sulfanyl-N-[(2S)-2-phenylpropyl]propanamide —— C18H19F2NOS
    (2R)-2-(2,5-difluorophenyl)sulfanyl-N-[(2S)-2-phenylpropyl]propanamide
    —— N-[[5-[2-(2,5-difluorophenyl)sulfanylacetyl]thiophen-2-yl]methyl]acetamide —— C15H13F2NO2S2
    N-[[5-[2-(2,5-difluorophenyl)sulfanylacetyl]thiophen-2-yl]methyl]acetamide
    —— (2S)-2-(2,5-difluorophenyl)sulfanyl-N-(furan-2-ylmethyl)propanamide —— C14H13F2NO2S
    (2S)-2-(2,5-difluorophenyl)sulfanyl-N-(furan-2-ylmethyl)propanamide
    —— 2-(2,5-difluorophenyl)sulfanyl-N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]acetamide —— C13H15F2NO3S2
    2-(2,5-difluorophenyl)sulfanyl-N-[(3R)-3-methyl-1,1-dioxothiolan-3-yl]acetamide