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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2S)-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]-2-phenylsulfanylbutanamide —— C15H18N2O3S2
    (2S)-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]-2-phenylsulfanylbutanamide
    —— (2R)-N-ethyl-N-[[(3R)-oxolan-3-yl]methyl]-2-phenylsulfanylbutanamide —— C17H25NO2S
    (2R)-N-ethyl-N-[[(3R)-oxolan-3-yl]methyl]-2-phenylsulfanylbutanamide
    —— N-[2-(4-chlorophenyl)sulfanylphenyl]-2-(4-cyanophenoxy)acetamide —— C21H15ClN2O2S
    N-[2-(4-chlorophenyl)sulfanylphenyl]-2-(4-cyanophenoxy)acetamide
    —— (2S)-N-[2-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)ethyl]-2-phenylsulfanylbutanamide —— C17H22N4OS
    (2S)-N-[2-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)ethyl]-2-phenylsulfanylbutanamide
    —— (2R)-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]-2-phenylsulfanylbutanamide —— C15H18N2O3S2
    (2R)-N-[2-(2,4-dioxo-1,3-thiazolidin-3-yl)ethyl]-2-phenylsulfanylbutanamide
    —— 2-(4-chlorophenyl)sulfanyl-1-[(3R)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]ethanone —— C22H19ClN2O2S
    2-(4-chlorophenyl)sulfanyl-1-[(3R)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]ethanone
    —— (2S)-2-(4-chlorophenyl)sulfanyl-N-[(2R)-4-phenylbutan-2-yl]propanamide —— C19H22ClNOS
    (2S)-2-(4-chlorophenyl)sulfanyl-N-[(2R)-4-phenylbutan-2-yl]propanamide
    —— (2S)-N-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-ylmethyl)-N-methyl-2-phenylsulfanylbutanamide —— C17H22N4OS
    (2S)-N-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-ylmethyl)-N-methyl-2-phenylsulfanylbutanamide
    —— (2S)-N-[2-(4-methylpiperazin-1-yl)ethyl]-2-phenylsulfanylbutanamide —— C17H27N3OS
    (2S)-N-[2-(4-methylpiperazin-1-yl)ethyl]-2-phenylsulfanylbutanamide
    —— 2-(4-chlorophenyl)sulfanyl-N-(2-phenylsulfanylphenyl)acetamide —— C20H16ClNOS2
    2-(4-chlorophenyl)sulfanyl-N-(2-phenylsulfanylphenyl)acetamide
    —— methyl 5-[(2S)-2-(4-chlorophenyl)sulfanylpropanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C17H18ClNO3S
    methyl 5-[(2S)-2-(4-chlorophenyl)sulfanylpropanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— 3-(2-fluorophenyl)sulfanyl-N-[(2R)-2-(3-methylphenyl)-2-morpholin-4-ylethyl]propanamide —— C22H27FN2O2S
    3-(2-fluorophenyl)sulfanyl-N-[(2R)-2-(3-methylphenyl)-2-morpholin-4-ylethyl]propanamide
    —— (2R)-N-[2-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)ethyl]-2-phenylsulfanylbutanamide —— C17H22N4OS
    (2R)-N-[2-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-yl)ethyl]-2-phenylsulfanylbutanamide
    —— 2-(4-chlorophenyl)sulfanyl-1-[(3S)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]ethanone —— C22H19ClN2O2S
    2-(4-chlorophenyl)sulfanyl-1-[(3S)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]ethanone
    —— N-[(2-chlorophenyl)methyl]-2-(4-chlorophenyl)sulfanylacetamide —— C15H13Cl2NOS
    N-[(2-chlorophenyl)methyl]-2-(4-chlorophenyl)sulfanylacetamide
    —— N-[(1S)-1-(2-chlorophenyl)ethyl]-2-(4-chlorophenyl)sulfanylacetamide —— C16H15Cl2NOS
    N-[(1S)-1-(2-chlorophenyl)ethyl]-2-(4-chlorophenyl)sulfanylacetamide
    —— N-[(1R)-1-(2-chlorophenyl)ethyl]-2-(4-chlorophenyl)sulfanylacetamide —— C16H15Cl2NOS
    N-[(1R)-1-(2-chlorophenyl)ethyl]-2-(4-chlorophenyl)sulfanylacetamide
    —— (2R)-N-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-ylmethyl)-N-methyl-2-phenylsulfanylbutanamide —— C17H22N4OS
    (2R)-N-(6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-3-ylmethyl)-N-methyl-2-phenylsulfanylbutanamide
    —— 2-(4-Chlorophenyl)sulfanyl-1-[2,5-dimethyl-1-(5-methyl-1,2-oxazol-3-yl)pyrrol-3-yl]ethanone —— C18H17ClN2O2S
    2-(4-Chlorophenyl)sulfanyl-1-[2,5-dimethyl-1-(5-methyl-1,2-oxazol-3-yl)pyrrol-3-yl]ethanone
    —— 3-(2-fluorophenyl)sulfanyl-N-[(2S)-2-(3-methylphenyl)-2-morpholin-4-ylethyl]propanamide —— C22H27FN2O2S
    3-(2-fluorophenyl)sulfanyl-N-[(2S)-2-(3-methylphenyl)-2-morpholin-4-ylethyl]propanamide
    —— (2R)-N-[2-(4-methylpiperazin-1-yl)ethyl]-2-phenylsulfanylbutanamide —— C17H27N3OS
    (2R)-N-[2-(4-methylpiperazin-1-yl)ethyl]-2-phenylsulfanylbutanamide
    —— 2-(4-chlorophenyl)sulfanyl-N-[(1S)-1-(3,4-dimethylphenyl)ethyl]acetamide —— C18H20ClNOS
    2-(4-chlorophenyl)sulfanyl-N-[(1S)-1-(3,4-dimethylphenyl)ethyl]acetamide
    —— 2-(4-chlorophenyl)sulfanyl-N-[(2S)-2-phenylpropyl]acetamide —— C17H18ClNOS
    2-(4-chlorophenyl)sulfanyl-N-[(2S)-2-phenylpropyl]acetamide
    —— N-[2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)sulfanylacetamide —— C16H15Cl2NOS
    N-[2-(4-chlorophenyl)ethyl]-2-(4-chlorophenyl)sulfanylacetamide
    —— 2-(4-Chlorophenyl)sulfanyl-1-[1-[(4-fluorophenyl)methyl]-2,5-dimethylpyrrol-3-yl]ethanone —— C21H19ClFNOS
    2-(4-Chlorophenyl)sulfanyl-1-[1-[(4-fluorophenyl)methyl]-2,5-dimethylpyrrol-3-yl]ethanone
    —— 4-[4-methyl-5-[(1R)-1-phenylethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C15H20N4OS
    4-[4-methyl-5-[(1R)-1-phenylethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— 2-(4-chlorophenyl)sulfanyl-N-[(2R)-2-phenylpropyl]acetamide —— C17H18ClNOS
    2-(4-chlorophenyl)sulfanyl-N-[(2R)-2-phenylpropyl]acetamide
    —— (2R)-2-[(4-methyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-3-(4-methylphenyl)propanenitrile —— C17H21N5OS
    (2R)-2-[(4-methyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-3-(4-methylphenyl)propanenitrile
    —— (2S)-2-[(4-methyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-3-(4-methylphenyl)propanenitrile —— C17H21N5OS
    (2S)-2-[(4-methyl-5-morpholin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-3-(4-methylphenyl)propanenitrile
    —— 4-[4-methyl-5-[(1S)-1-phenylethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C15H20N4OS
    4-[4-methyl-5-[(1S)-1-phenylethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— 4-[4-methyl-5-[(1R)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C18H22N6O2S
    4-[4-methyl-5-[(1R)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— 2-(1-tert-butylimidazol-2-yl)sulfanyl-N-[[(2R)-1-ethylpyrrolidin-2-yl]methyl]acetamide —— C16H28N4OS
    2-(1-tert-butylimidazol-2-yl)sulfanyl-N-[[(2R)-1-ethylpyrrolidin-2-yl]methyl]acetamide
    —— 2-(1-tert-butylimidazol-2-yl)sulfanyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]acetamide —— C16H28N4OS
    2-(1-tert-butylimidazol-2-yl)sulfanyl-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]acetamide
    —— 4-[4-methyl-5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C15H18N6O2S2
    4-[4-methyl-5-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— 4-[4-methyl-5-[(1S)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine —— C18H22N6O2S
    4-[4-methyl-5-[(1S)-1-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]ethyl]sulfanyl-1,2,4-triazol-3-yl]morpholine
    —— 2-[(1R)-1-(1-cyclopentyltetrazol-5-yl)sulfanylethyl]-5-(2-methylpropyl)-1,3,4-oxadiazole —— C14H22N6OS
    2-[(1R)-1-(1-cyclopentyltetrazol-5-yl)sulfanylethyl]-5-(2-methylpropyl)-1,3,4-oxadiazole
    —— 2-[(1S)-1-(1-benzyltetrazol-5-yl)sulfanylethyl]-5-(2-methylpropyl)-1,3,4-oxadiazole —— C16H20N6OS
    2-[(1S)-1-(1-benzyltetrazol-5-yl)sulfanylethyl]-5-(2-methylpropyl)-1,3,4-oxadiazole
    —— 2-[(1S)-1-(5-ethyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-6-methyl-4-(trifluoromethyl)pyridine-3-carbonitrile —— C14H13F3N4OS
    2-[(1S)-1-(5-ethyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-6-methyl-4-(trifluoromethyl)pyridine-3-carbonitrile
    —— [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 4-tert-butylbenzoate —— C25H25NO3S
    [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 4-tert-butylbenzoate
    —— 3-[(1S)-1-(5-ethyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one —— C16H19N5O2S
    3-[(1S)-1-(5-ethyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-4-(2-phenylethyl)-1H-1,2,4-triazol-5-one
    —— (2S)-N-[[(3S)-1,1-dioxothiolan-3-yl]methyl]-2-phenylsulfanylbutanamide —— C15H21NO3S2
    (2S)-N-[[(3S)-1,1-dioxothiolan-3-yl]methyl]-2-phenylsulfanylbutanamide
    —— N-cyclohexyl-5-[(1S)-1-(5-ethyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine —— C14H21N5OS2
    N-cyclohexyl-5-[(1S)-1-(5-ethyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— (2R)-N-[[(3R)-1,1-dioxothiolan-3-yl]methyl]-2-phenylsulfanylbutanamide —— C15H21NO3S2
    (2R)-N-[[(3R)-1,1-dioxothiolan-3-yl]methyl]-2-phenylsulfanylbutanamide
    —— 2-[2-[3-[[(2R)-oxan-2-yl]methylsulfanyl]-1,2,4-triazol-4-yl]ethyl]pyridine —— C15H20N4OS
    2-[2-[3-[[(2R)-oxan-2-yl]methylsulfanyl]-1,2,4-triazol-4-yl]ethyl]pyridine
    —— N-[(4-chlorophenyl)methyl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C19H19ClN4OS2
    N-[(4-chlorophenyl)methyl]-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(2-methylphenyl)methyl]acetamide —— C21H24N4OS2
    2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(2-methylphenyl)methyl]acetamide
    —— 5-[(2-bromophenyl)methylsulfanyl]-N-(4-ethylphenyl)-1,3,4-thiadiazol-2-amine —— C17H16BrN3S2
    5-[(2-bromophenyl)methylsulfanyl]-N-(4-ethylphenyl)-1,3,4-thiadiazol-2-amine
    —— [2-[4-(2,5-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] furan-2-carboxylate —— C21H19NO4S
    [2-[4-(2,5-Dimethylphenyl)sulfanylanilino]-2-oxoethyl] furan-2-carboxylate
    —— N-(1-cyanocyclohexyl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide —— C20H25N5OS2
    N-(1-cyanocyclohexyl)-2-[[5-(4-ethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— 5-[(3-chlorophenyl)methylsulfanyl]-N-(4-ethylphenyl)-1,3,4-thiadiazol-2-amine —— C17H16ClN3S2
    5-[(3-chlorophenyl)methylsulfanyl]-N-(4-ethylphenyl)-1,3,4-thiadiazol-2-amine