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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[2-(4-methylphenyl)sulfanylethyl]acetamide —— C19H18FN3O2S2
    2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[2-(4-methylphenyl)sulfanylethyl]acetamide
    —— 3-phenyl-5-[(1S)-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazole-2-thione —— C18H14N4OS3
    3-phenyl-5-[(1S)-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1,3,4-thiadiazole-2-thione
    —— 2-[5-[2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetyl]thiophen-2-yl]-1-morpholin-4-ylethanone —— C14H16N4O3S3
    2-[5-[2-[(5-Amino-1,3,4-thiadiazol-2-yl)sulfanyl]acetyl]thiophen-2-yl]-1-morpholin-4-ylethanone
    —— N-[2-(4-methylphenyl)sulfanylethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C17H18N4OS3
    N-[2-(4-methylphenyl)sulfanylethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 2-phenyl-5-[(1S)-1-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,3,4-oxadiazole —— C16H13N5OS2
    2-phenyl-5-[(1S)-1-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethyl]-1,3,4-oxadiazole
    —— 2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(2-phenylsulfanylethyl)acetamide —— C18H17N3O2S2
    2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(2-phenylsulfanylethyl)acetamide
    —— 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(cyclohexen-1-yl)-N-(furan-2-ylmethyl)acetamide —— C15H18N4O2S2
    2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(cyclohexen-1-yl)-N-(furan-2-ylmethyl)acetamide
    —— N-[2-(4-chlorophenyl)sulfanylethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H15ClN4OS3
    N-[2-(4-chlorophenyl)sulfanylethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 1-(2,5-Dimethylthiophen-3-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C16H14N2O2S2
    1-(2,5-Dimethylthiophen-3-yl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— N-[(2,4-dimethylphenyl)methyl]-N-methyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C20H21N3O2S
    N-[(2,4-dimethylphenyl)methyl]-N-methyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-(2-benzylsulfanylethyl)acetamide —— C13H17N5OS2
    2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]-N-(2-benzylsulfanylethyl)acetamide
    —— 2-[5-[2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]acetyl]thiophen-2-yl]-1-morpholin-4-ylethanone —— C14H17N5O3S2
    2-[5-[2-[(5-amino-1H-1,2,4-triazol-3-yl)sulfanyl]acetyl]thiophen-2-yl]-1-morpholin-4-ylethanone
    —— [2-[2-(4-methylphenyl)sulfanylethylamino]-2-oxoethyl] 6-oxo-4,5-dihydro-1H-pyridazine-3-carboxylate —— C16H19N3O4S
    [2-[2-(4-methylphenyl)sulfanylethylamino]-2-oxoethyl] 6-oxo-4,5-dihydro-1H-pyridazine-3-carboxylate
    —— 2-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-phenylsulfanylethyl)acetamide —— C14H18N4OS2
    2-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-phenylsulfanylethyl)acetamide
    —— 2-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-thiophen-2-ylethyl)acetamide —— C12H16N4OS2
    2-[(4,5-dimethyl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-thiophen-2-ylethyl)acetamide
    —— [2-oxo-2-(2-phenylsulfanylethylamino)ethyl] 4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylate —— C19H22N2O4S
    [2-oxo-2-(2-phenylsulfanylethylamino)ethyl] 4-acetyl-3,5-dimethyl-1H-pyrrole-2-carboxylate
    —— 2-[(1S)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-5-phenyl-1,3,4-oxadiazole —— C18H17N5OS2
    2-[(1S)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-5-phenyl-1,3,4-oxadiazole
    —— [2-Oxo-2-(2-thiophen-2-ylethylamino)ethyl] 3-(4-chlorophenyl)sulfanylpropanoate —— C17H18ClNO3S2
    [2-Oxo-2-(2-thiophen-2-ylethylamino)ethyl] 3-(4-chlorophenyl)sulfanylpropanoate
    —— 1-(2,5-Dimethylthiophen-3-yl)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C16H17N3OS3
    1-(2,5-Dimethylthiophen-3-yl)-2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— 4-O-ethyl 2-O-[2-[2-(4-methylphenyl)sulfanylethylamino]-2-oxoethyl] 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate —— C21H26N2O5S
    4-O-ethyl 2-O-[2-[2-(4-methylphenyl)sulfanylethylamino]-2-oxoethyl] 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
    —— 2-[3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1-yl]-N-(2-phenylsulfanylethyl)acetamide —— C16H14ClF3N2O2S
    2-[3-chloro-2-oxo-5-(trifluoromethyl)pyridin-1-yl]-N-(2-phenylsulfanylethyl)acetamide
    —— 2-[(1R)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-5-phenyl-1,3,4-oxadiazole —— C18H17N5OS2
    2-[(1R)-1-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]ethyl]-5-phenyl-1,3,4-oxadiazole
    —— 4-O-ethyl 2-O-[2-oxo-2-(2-phenylsulfanylethylamino)ethyl] 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate —— C20H24N2O5S
    4-O-ethyl 2-O-[2-oxo-2-(2-phenylsulfanylethylamino)ethyl] 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate
    —— [(1S)-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl] 3-(4-chlorophenyl)sulfanylpropanoate —— C19H17ClN2O3S
    [(1S)-1-(5-phenyl-1,3,4-oxadiazol-2-yl)ethyl] 3-(4-chlorophenyl)sulfanylpropanoate
    —— 2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-phenylsulfanylethyl)acetamide —— C18H20N4OS3
    2-[(4-ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanyl]-N-(2-phenylsulfanylethyl)acetamide
    —— 2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[2-(4-methylphenyl)sulfanylethyl]acetamide —— C15H19N5O2S2
    2-[(4-amino-6-methyl-5-oxo-1,2,4-triazin-3-yl)sulfanyl]-N-[2-(4-methylphenyl)sulfanylethyl]acetamide
    —— (1S)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]ethanamine —— C13H21NS
    (1S)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]ethanamine
    —— 2-Ethanimidoyl-4-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-3-oxobutanenitrile —— C13H13N5O2S
    2-Ethanimidoyl-4-[[5-(furan-2-yl)-4-methyl-1,2,4-triazol-3-yl]sulfanyl]-3-oxobutanenitrile
    —— (1R)-1-(5-methyl-2-propylsulfanylphenyl)ethanamine —— C12H19NS
    (1R)-1-(5-methyl-2-propylsulfanylphenyl)ethanamine
    —— (1S)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)-3-piperazin-1-ylpropan-1-ol —— C17H28N2OS
    (1S)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)-3-piperazin-1-ylpropan-1-ol
    —— (1S)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]-2-piperazin-1-ylethanol —— C17H28N2OS
    (1S)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]-2-piperazin-1-ylethanol
    —— (1R)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]-3-piperazin-1-ylpropan-1-ol —— C18H30N2OS
    (1R)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]-3-piperazin-1-ylpropan-1-ol
    —— (1S)-1-(5-methyl-2-propylsulfanylphenyl)ethanamine —— C12H19NS
    (1S)-1-(5-methyl-2-propylsulfanylphenyl)ethanamine
    —— (1R)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]ethanol —— C13H20OS
    (1R)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]ethanol
    —— (1S)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)ethanamine —— C12H19NS
    (1S)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)ethanamine
    —— (1S)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]ethanol —— C13H20OS
    (1S)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]ethanol
    —— (1R)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)-3-piperazin-1-ylpropan-1-ol —— C17H28N2OS
    (1R)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)-3-piperazin-1-ylpropan-1-ol
    —— (1R)-1-(5-methyl-2-propylsulfanylphenyl)ethanol —— C12H18OS
    (1R)-1-(5-methyl-2-propylsulfanylphenyl)ethanol
    —— (1S)-1-(5-methyl-2-propylsulfanylphenyl)-3-piperazin-1-ylpropan-1-ol —— C17H28N2OS
    (1S)-1-(5-methyl-2-propylsulfanylphenyl)-3-piperazin-1-ylpropan-1-ol
    —— (1R)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)ethanamine —— C12H19NS
    (1R)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)ethanamine
    —— (1S)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]-3-piperazin-1-ylpropan-1-ol —— C18H30N2OS
    (1S)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]-3-piperazin-1-ylpropan-1-ol
    —— (1R)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]ethanamine —— C13H21NS
    (1R)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]ethanamine
    —— (1S)-1-(5-methyl-2-propylsulfanylphenyl)-2-piperazin-1-ylethanol —— C16H26N2OS
    (1S)-1-(5-methyl-2-propylsulfanylphenyl)-2-piperazin-1-ylethanol
    —— (1R)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]-2-piperazin-1-ylethanol —— C17H28N2OS
    (1R)-1-[5-methyl-2-(2-methylpropylsulfanyl)phenyl]-2-piperazin-1-ylethanol
    —— (1S)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)ethanol —— C12H18OS
    (1S)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)ethanol
    —— (1R)-1-(2-ethylsulfanyl-5-methylphenyl)ethanol —— C11H16OS
    (1R)-1-(2-ethylsulfanyl-5-methylphenyl)ethanol
    —— (1R)-1-(5-methyl-2-methylsulfanylphenyl)-3-piperazin-1-ylpropan-1-ol —— C15H24N2OS
    (1R)-1-(5-methyl-2-methylsulfanylphenyl)-3-piperazin-1-ylpropan-1-ol
    —— (1R)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)ethanol —— C12H18OS
    (1R)-1-(5-methyl-2-propan-2-ylsulfanylphenyl)ethanol
    —— (1S)-1-(5-chloro-2-methylsulfanylphenyl)ethanol —— C9H11ClOS
    (1S)-1-(5-chloro-2-methylsulfanylphenyl)ethanol
    —— (1R)-1-(5-chloro-2-methylsulfanylphenyl)-3-piperazin-1-ylpropan-1-ol —— C14H21ClN2OS
    (1R)-1-(5-chloro-2-methylsulfanylphenyl)-3-piperazin-1-ylpropan-1-ol