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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]ethanone —— C17H21N3O3S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]ethanone
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1S)-1-(4-chlorophenyl)ethyl]acetamide —— C19H18ClN3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1S)-1-(4-chlorophenyl)ethyl]acetamide
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1R)-1-(2-chlorophenyl)ethyl]acetamide —— C19H18ClN3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1R)-1-(2-chlorophenyl)ethyl]acetamide
    —— methyl 5-[(2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C20H21N3O4S
    methyl 5-[(2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— 2-Benzyl-5-{[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]sulfanyl}-1,3,4-oxadiazole —— C18H14N4O2S
    2-Benzyl-5-{[(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]sulfanyl}-1,3,4-oxadiazole
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]ethanone —— C17H21N3O3S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]ethanone
    —— (2S)-N-(cyclohexylmethyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C18H23N3OS3
    (2S)-N-(cyclohexylmethyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-cyclopentyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C16H19N3OS3
    (2S)-N-cyclopentyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1S)-1-(2-chlorophenyl)ethyl]acetamide —— C19H18ClN3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1S)-1-(2-chlorophenyl)ethyl]acetamide
    —— (2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C12H13N3O2S
    (2S)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— methyl 5-[(2R)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C20H21N3O4S
    methyl 5-[(2R)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-methyl-N-[(4-methylphenyl)methyl]acetamide —— C20H21N3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-methyl-N-[(4-methylphenyl)methyl]acetamide
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(4-chlorophenyl)methyl]acetamide —— C18H16ClN3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(4-chlorophenyl)methyl]acetamide
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1R)-1-(4-chlorophenyl)ethyl]acetamide —— C19H18ClN3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(1R)-1-(4-chlorophenyl)ethyl]acetamide
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-propylacetamide —— C14H17N3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-propylacetamide
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(thiophen-2-ylmethyl)acetamide —— C16H15N3O2S2
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-(thiophen-2-ylmethyl)acetamide
    —— 1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C19H19N3O3S
    1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— (2R)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C12H13N3O2S
    (2R)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— ethyl (2S)-2-phenyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetate —— C18H16N2O2S3
    ethyl (2S)-2-phenyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetate
    —— N-(1-adamantylmethyl)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C22H27N3O2S
    N-(1-adamantylmethyl)-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(1,2,5-trimethylpyrrol-3-yl)ethanone —— C18H19N3O2S
    2-[(5-Benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-1-(1,2,5-trimethylpyrrol-3-yl)ethanone
    —— N-benzyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C17H15N3OS3
    N-benzyl-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 1-(5-Phenyl-3,4-dihydropyrazol-2-yl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C19H16N4OS3
    1-(5-Phenyl-3,4-dihydropyrazol-2-yl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— N-(1-adamantyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C20H23N3OS3
    N-(1-adamantyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (2S)-N-benzyl-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C19H19N3O2S
    (2S)-N-benzyl-2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— 1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C16H19N3O2S3
    1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— (2S)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C11H11N3OS3
    (2S)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— 2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(3-chlorophenyl)methyl]acetamide —— C18H16ClN3O2S
    2-[(5-benzyl-1,3,4-oxadiazol-2-yl)sulfanyl]-N-[(3-chlorophenyl)methyl]acetamide
    —— (2R)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]-1-pyrrolidin-1-ylpropan-1-one —— C15H17N3OS3
    (2R)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]-1-pyrrolidin-1-ylpropan-1-one
    —— N-(1-cyanocyclopentyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C16H16N4OS3
    N-(1-cyanocyclopentyl)-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 2‐benzyl‐5‐[(4‐bromo‐2‐fluorobenzyl)thio]‐1,3,4‐oxadiazole —— C16H12BrFN2OS
    2‐benzyl‐5‐[(4‐bromo‐2‐fluorobenzyl)thio]‐1,3,4‐oxadiazole
    —— 3-[[4-ethyl-5-[(3S)-1-methylsulfonylpiperidin-3-yl]-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine —— C16H23N5O2S2
    3-[[4-ethyl-5-[(3S)-1-methylsulfonylpiperidin-3-yl]-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine
    —— 1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone —— C16H19N3O2S3
    1-[(2R,6S)-2,6-dimethylmorpholin-4-yl]-2-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]ethanone
    —— 2-[(3,4-Difluorophenyl)methylsulfanyl]-6-ethyl-3-methyl-5-[(3-methylphenyl)methyl]pyrimidin-4-one —— C22H22F2N2OS
    2-[(3,4-Difluorophenyl)methylsulfanyl]-6-ethyl-3-methyl-5-[(3-methylphenyl)methyl]pyrimidin-4-one
    —— 3-[[4-ethyl-5-[(3R)-1-methylsulfonylpiperidin-3-yl]-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine —— C16H23N5O2S2
    3-[[4-ethyl-5-[(3R)-1-methylsulfonylpiperidin-3-yl]-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine
    —— 3-[[5-[(3R)-1-methylsulfonylpiperidin-3-yl]-4-propan-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine —— C17H25N5O2S2
    3-[[5-[(3R)-1-methylsulfonylpiperidin-3-yl]-4-propan-2-yl-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine
    —— 2-[4-chloro-6-(diethylamino)pyrimidin-2-yl]sulfanyl-N-(2-pyrrolidin-1-ium-1-ylethyl)acetamide —— C16H27ClN5OS+
    2-[4-chloro-6-(diethylamino)pyrimidin-2-yl]sulfanyl-N-(2-pyrrolidin-1-ium-1-ylethyl)acetamide
    —— 2-[(3,5-Difluorophenyl)methylsulfanyl]-3,6-dimethyl-5-[(2-methylphenyl)methyl]pyrimidin-4-one —— C21H20F2N2OS
    2-[(3,5-Difluorophenyl)methylsulfanyl]-3,6-dimethyl-5-[(2-methylphenyl)methyl]pyrimidin-4-one
    —— 3-(imidazo[2,1-b][1,3]thiazol-6-ylmethylsulfanyl)-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one —— C13H15N5O2S2
    3-(imidazo[2,1-b][1,3]thiazol-6-ylmethylsulfanyl)-4-[[(2R)-oxolan-2-yl]methyl]-1H-1,2,4-triazol-5-one
    —— (2R)-N-[[1-(4-fluorophenyl)cyclobutyl]methyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C17H21FN4OS
    (2R)-N-[[1-(4-fluorophenyl)cyclobutyl]methyl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— 2-[(3-Fluorophenyl)methylsulfanyl]-3,6-dimethyl-5-[(2-methylphenyl)methyl]pyrimidin-4-one —— C21H21FN2OS
    2-[(3-Fluorophenyl)methylsulfanyl]-3,6-dimethyl-5-[(2-methylphenyl)methyl]pyrimidin-4-one
    —— (2R)-2-(5-benzyl-1,4-dimethyl-6-oxopyrimidin-2-yl)sulfanyl-N-butylpentanamide —— C22H31N3O2S
    (2R)-2-(5-benzyl-1,4-dimethyl-6-oxopyrimidin-2-yl)sulfanyl-N-butylpentanamide
    —— N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H18ClN3O2S
    N-[(1S)-1-(4-chlorophenyl)ethyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 1-[(3R)-1,1-dioxothiolan-3-yl]-3-[(1-phenylsulfanylcyclopropyl)methyl]urea —— C15H20N2O3S2
    1-[(3R)-1,1-dioxothiolan-3-yl]-3-[(1-phenylsulfanylcyclopropyl)methyl]urea
    —— 1-[2,5-Dimethyl-1-(5-methyl-1,2-oxazol-3-yl)pyrrol-3-yl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C21H20N4O3S
    1-[2,5-Dimethyl-1-(5-methyl-1,2-oxazol-3-yl)pyrrol-3-yl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— N-[(2-chlorophenyl)methyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H16ClN3O2S
    N-[(2-chlorophenyl)methyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-cycloheptyl-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H23N3O2S
    N-cycloheptyl-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H18ClN3O2S
    N-[(1S)-1-(2-chlorophenyl)ethyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C17H21N3O3S
    1-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— 2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[2-(4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)ethyl]acetamide —— C16H16N4O3S3
    2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[2-(4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl)ethyl]acetamide