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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (4R)-4-(2-butylsulfanylpyrimidin-5-yl)-3-methyl-1-propan-2-yl-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one —— C18H25N5OS
    (4R)-4-(2-butylsulfanylpyrimidin-5-yl)-3-methyl-1-propan-2-yl-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one
    —— 1-Thiophen-2-yl-2-(6-thiophen-2-ylpyridazin-3-yl)sulfanylethanone 897618-79-0 C14H10N2OS3
    1-Thiophen-2-yl-2-(6-thiophen-2-ylpyridazin-3-yl)sulfanylethanone
    —— 3-((4-Fluorobenzyl)thio)-6-(furan-2-yl)pyridazine —— C15H11FN2OS
    3-((4-Fluorobenzyl)thio)-6-(furan-2-yl)pyridazine
    —— Ethyl 2-(1-methyl-6-oxo-4-propan-2-ylpyrimidin-2-yl)sulfanylacetate —— C12H18N2O3S
    Ethyl 2-(1-methyl-6-oxo-4-propan-2-ylpyrimidin-2-yl)sulfanylacetate
    —— 3,6-Dimethyl-2-[(3-methylphenyl)methylsulfanyl]pyrimidin-4-one —— C14H16N2OS
    3,6-Dimethyl-2-[(3-methylphenyl)methylsulfanyl]pyrimidin-4-one
    —— 1-(Azepan-1-yl)-2-[6-(furan-2-yl)pyridazin-3-yl]sulfanylethanone 872704-12-6 C16H19N3O2S
    1-(Azepan-1-yl)-2-[6-(furan-2-yl)pyridazin-3-yl]sulfanylethanone
    —— (4S)-4-(2-butylsulfanylpyrimidin-5-yl)-3-methyl-1-propan-2-yl-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one —— C18H25N5OS
    (4S)-4-(2-butylsulfanylpyrimidin-5-yl)-3-methyl-1-propan-2-yl-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one
    —— 3-(Ethylthio)-6-(pyridin-4-yl)pyridazine —— C11H11N3S
    3-(Ethylthio)-6-(pyridin-4-yl)pyridazine
    —— 3-((3-Chlorobenzyl)thio)-6-(furan-2-yl)pyridazine —— C15H11ClN2OS
    3-((3-Chlorobenzyl)thio)-6-(furan-2-yl)pyridazine
    —— Methyl 2-(4-tert-butyl-1-methyl-6-oxopyrimidin-2-yl)sulfanylacetate —— C12H18N2O3S
    Methyl 2-(4-tert-butyl-1-methyl-6-oxopyrimidin-2-yl)sulfanylacetate
    —— 2-[6-(Furan-2-yl)pyridazin-3-yl]sulfanyl-1-morpholin-4-ylethanone —— C14H15N3O3S
    2-[6-(Furan-2-yl)pyridazin-3-yl]sulfanyl-1-morpholin-4-ylethanone
    —— N-benzyl-2-[6-(furan-2-yl)pyridazin-3-yl]sulfanylacetamide —— C17H15N3O2S
    N-benzyl-2-[6-(furan-2-yl)pyridazin-3-yl]sulfanylacetamide
    —— 3-((4-Fluorobenzyl)thio)-6-(pyridin-4-yl)pyridazine —— C16H12FN3S
    3-((4-Fluorobenzyl)thio)-6-(pyridin-4-yl)pyridazine
    —— 2-[6-(furan-2-yl)pyridazin-3-yl]sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C15H17N3O3S
    2-[6-(furan-2-yl)pyridazin-3-yl]sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— 2-[6-(furan-2-yl)pyridazin-3-yl]sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C15H17N3O3S
    2-[6-(furan-2-yl)pyridazin-3-yl]sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— Ethyl 2-(4-tert-butyl-1-methyl-6-oxopyrimidin-2-yl)sulfanylacetate —— C13H20N2O3S
    Ethyl 2-(4-tert-butyl-1-methyl-6-oxopyrimidin-2-yl)sulfanylacetate
    —— 6-Tert-butyl-3-methyl-2-prop-2-enylsulfanylpyrimidin-4-one —— C12H18N2OS
    6-Tert-butyl-3-methyl-2-prop-2-enylsulfanylpyrimidin-4-one
    —— ethyl (2S)-2-(1-methyl-6-oxo-4-propan-2-ylpyrimidin-2-yl)sulfanylpropanoate —— C13H20N2O3S
    ethyl (2S)-2-(1-methyl-6-oxo-4-propan-2-ylpyrimidin-2-yl)sulfanylpropanoate
    —— 3-(Furan-2-yl)-6-((4-methylbenzyl)thio)pyridazine —— C16H14N2OS
    3-(Furan-2-yl)-6-((4-methylbenzyl)thio)pyridazine
    —— 3-(Ethylthio)-6-(2-furanyl)pyridazine —— C10H10N2OS
    3-(Ethylthio)-6-(2-furanyl)pyridazine
    —— N-cyclopentyl-2-[6-(furan-2-yl)pyridazin-3-yl]sulfanylacetamide 872723-07-4 C15H17N3O2S
    N-cyclopentyl-2-[6-(furan-2-yl)pyridazin-3-yl]sulfanylacetamide
    —— 2-(2-Adamantan-1-yl-2-oxo-ethylsulfanyl)-4-methoxymethyl-6-methyl-nicotinonitrile —— C21H26N2O2S
    2-(2-Adamantan-1-yl-2-oxo-ethylsulfanyl)-4-methoxymethyl-6-methyl-nicotinonitrile
    —— 3-[(3-Fluorophenyl)methylthio]-6-(2-furanyl)pyridazine —— C15H11FN2OS
    3-[(3-Fluorophenyl)methylthio]-6-(2-furanyl)pyridazine
    —— 3-(Furan-2-yl)-6-((3-methylbenzyl)thio)pyridazine —— C16H14N2OS
    3-(Furan-2-yl)-6-((3-methylbenzyl)thio)pyridazine
    —— N-cyclohexyl-2-[6-(furan-2-yl)pyridazin-3-yl]sulfanylacetamide 894005-55-1 C16H19N3O2S
    N-cyclohexyl-2-[6-(furan-2-yl)pyridazin-3-yl]sulfanylacetamide
    —— 3,6-Dimethyl-2-[(4-methylphenyl)methylsulfanyl]pyrimidin-4-one —— C14H16N2OS
    3,6-Dimethyl-2-[(4-methylphenyl)methylsulfanyl]pyrimidin-4-one
    —— 3-[(4-Chlorophenyl)methylsulfanyl]-5-propan-2-yl-4-prop-2-enyl-1,2,4-triazole —— C15H18ClN3S
    3-[(4-Chlorophenyl)methylsulfanyl]-5-propan-2-yl-4-prop-2-enyl-1,2,4-triazole
    —— Ethyl 2-(1,4,5-trimethyl-6-oxopyrimidin-2-yl)sulfanylacetate —— C11H16N2O3S
    Ethyl 2-(1,4,5-trimethyl-6-oxopyrimidin-2-yl)sulfanylacetate
    —— 5-benzyl-2-[(2,5-dimethylbenzyl)sulfanyl]-3,6-dimethyl-4(3H)-pyrimidinone —— C22H24N2OS
    5-benzyl-2-[(2,5-dimethylbenzyl)sulfanyl]-3,6-dimethyl-4(3H)-pyrimidinone
    —— 3-[5-[[(3S)-3-(3,5-dimethylpyrazol-1-yl)pyrrolidin-1-yl]methyl]furan-2-yl]sulfanyl-4-methyl-1,2,4-triazole —— C17H22N6OS
    3-[5-[[(3S)-3-(3,5-dimethylpyrazol-1-yl)pyrrolidin-1-yl]methyl]furan-2-yl]sulfanyl-4-methyl-1,2,4-triazole
    —— (4S)-4-(2-propylsulfanylpyrimidin-5-yl)-1-(pyridin-3-ylmethyl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one —— C19H20N6OS
    (4S)-4-(2-propylsulfanylpyrimidin-5-yl)-1-(pyridin-3-ylmethyl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one
    —— 3-[5-[[(3R)-3-(3,5-dimethylpyrazol-1-yl)pyrrolidin-1-yl]methyl]furan-2-yl]sulfanyl-4-methyl-1,2,4-triazole —— C17H22N6OS
    3-[5-[[(3R)-3-(3,5-dimethylpyrazol-1-yl)pyrrolidin-1-yl]methyl]furan-2-yl]sulfanyl-4-methyl-1,2,4-triazole
    —— (4R)-4-(2-propylsulfanylpyrimidin-5-yl)-1-(pyridin-3-ylmethyl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one —— C19H20N6OS
    (4R)-4-(2-propylsulfanylpyrimidin-5-yl)-1-(pyridin-3-ylmethyl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one
    —— (2S)-2-(7-butyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N,N-dimethyl-3-oxobutanamide —— C18H25N5O4S
    (2S)-2-(7-butyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N,N-dimethyl-3-oxobutanamide
    —— 2-((2-cyclopentyl-6,8-dimethyl-5,7-dioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl)thio)-N-propylacetamide —— C18H25N5O3S
    2-((2-cyclopentyl-6,8-dimethyl-5,7-dioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidin-4-yl)thio)-N-propylacetamide
    —— (2R)-2-(7-cyclopentyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N,N-dimethyl-3-oxobutanamide —— C19H25N5O4S
    (2R)-2-(7-cyclopentyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N,N-dimethyl-3-oxobutanamide
    —— N-benzyl-2-[3-cyano-4-(dimethylamino)pyridin-1-ium-2-yl]sulfanylacetamide —— C17H19N4OS+
    N-benzyl-2-[3-cyano-4-(dimethylamino)pyridin-1-ium-2-yl]sulfanylacetamide
    —— N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-5-phenyl-1,2,4-triazin-3-amine —— C17H15N5S
    N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-5-phenyl-1,2,4-triazin-3-amine
    —— (1R)-1-methyl-2-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine —— C16H19N5OS
    (1R)-1-methyl-2-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine
    —— (4S)-1-methyl-4-[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]-3-propan-2-yl-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one —— C17H20N6O2S
    (4S)-1-methyl-4-[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]-3-propan-2-yl-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one
    —— (4R)-1-methyl-4-[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]-3-propan-2-yl-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one —— C17H20N6O2S
    (4R)-1-methyl-4-[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]-3-propan-2-yl-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one
    —— (1S)-1-methyl-2-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine —— C16H19N5OS
    (1S)-1-methyl-2-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]-3,4-dihydro-1H-pyrrolo[1,2-a]pyrazine
    —— (NE)-N-[1-(4-hydroxyimino-6,6-dimethyl-3-methylsulfanyl-5,7-dihydro-2-benzothiophen-1-yl)ethylidene]hydroxylamine —— C13H18N2O2S2
    (NE)-N-[1-(4-hydroxyimino-6,6-dimethyl-3-methylsulfanyl-5,7-dihydro-2-benzothiophen-1-yl)ethylidene]hydroxylamine
    —— 2-[(2R)-butan-2-yl]sulfanyl-4-(4-chlorophenyl)thiophene-3-carbonitrile —— C15H14ClNS2
    2-[(2R)-butan-2-yl]sulfanyl-4-(4-chlorophenyl)thiophene-3-carbonitrile
    —— [2-[4-(2,5-dimethylphenyl)sulfanylanilino]-2-oxoethyl] 6-oxo-4,5-dihydro-1H-pyridazine-3-carboxylate —— C21H21N3O4S
    [2-[4-(2,5-dimethylphenyl)sulfanylanilino]-2-oxoethyl] 6-oxo-4,5-dihydro-1H-pyridazine-3-carboxylate
    —— (4S)-2-methyl-4-[2-(2H-triazol-4-ylsulfanyl)ethylamino]pentan-2-ol —— C10H20N4OS
    (4S)-2-methyl-4-[2-(2H-triazol-4-ylsulfanyl)ethylamino]pentan-2-ol
    —— (4R)-1-(furan-2-ylmethyl)-4-(2-propylsulfanylpyrimidin-5-yl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one —— C18H19N5O2S
    (4R)-1-(furan-2-ylmethyl)-4-(2-propylsulfanylpyrimidin-5-yl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one
    —— (4S)-1-(furan-2-ylmethyl)-4-(2-propylsulfanylpyrimidin-5-yl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one —— C18H19N5O2S
    (4S)-1-(furan-2-ylmethyl)-4-(2-propylsulfanylpyrimidin-5-yl)-4,5-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one
    —— 7-[(2,5-Dimethylphenyl)methylsulfanyl]-3-methyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one —— C14H14N4OS2
    7-[(2,5-Dimethylphenyl)methylsulfanyl]-3-methyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one
    —— 3-Methyl-7-[(3-methylphenyl)methylthio]-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one —— C13H12N4OS2
    3-Methyl-7-[(3-methylphenyl)methylthio]-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one