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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[5-(3-ethyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanyl-N-[(1R)-1-(4-fluorophenyl)ethyl]acetamide —— C19H19FN4O2S
    2-[5-(3-ethyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanyl-N-[(1R)-1-(4-fluorophenyl)ethyl]acetamide
    —— 2-[5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanyl-N-[(1R)-1-phenylethyl]acetamide —— C18H18N4O2S
    2-[5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanyl-N-[(1R)-1-phenylethyl]acetamide
    —— N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanylacetamide —— C18H17FN4O2S
    N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanylacetamide
    —— 2-[5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide —— C15H18N4O3S
    2-[5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]acetamide
    —— 2-[5-(3-ethyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C16H20N4O3S
    2-[5-(3-ethyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanylacetamide —— C18H17FN4O2S
    N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanylacetamide
    —— 1-[(3S)-3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C19H19N5OS2
    1-[(3S)-3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— 2-[5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C15H18N4O3S
    2-[5-(3-methyl-1,2,4-oxadiazol-5-yl)pyridin-2-yl]sulfanyl-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— (2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-2-phenylacetonitrile —— C14H13N3S
    (2S)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-2-phenylacetonitrile
    —— 1-[(3S)-3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C18H16FN5OS2
    1-[(3S)-3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— (2R)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-2-phenylacetonitrile —— C14H13N3S
    (2R)-2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-2-phenylacetonitrile
    —— 1-[(3S)-3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-pyrimidin-2-ylsulfanylethanone —— C19H15FN4OS2
    1-[(3S)-3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-pyrimidin-2-ylsulfanylethanone
    —— 1-[(3R)-3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-pyrimidin-2-ylsulfanylethanone —— C19H15FN4OS2
    1-[(3R)-3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-pyrimidin-2-ylsulfanylethanone
    —— 1-[(3R)-3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-pyrimidin-2-ylsulfanylethanone —— C20H18N4OS2
    1-[(3R)-3-(4-methylphenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-pyrimidin-2-ylsulfanylethanone
    —— 1-[(3R)-3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-(4-methylphenyl)sulfanylethanone —— C22H19FN2OS2
    1-[(3R)-3-(4-fluorophenyl)-5-thiophen-2-yl-3,4-dihydropyrazol-2-yl]-2-(4-methylphenyl)sulfanylethanone
    —— ethyl (1R,2R)-2-isothiocyanatocyclopentane-1-carboxylate —— C9H13NO2S
    ethyl (1R,2R)-2-isothiocyanatocyclopentane-1-carboxylate
    —— [(1R)-2,2-dichlorocyclopropyl]sulfanylbenzene —— C9H8Cl2S
    [(1R)-2,2-dichlorocyclopropyl]sulfanylbenzene
    —— 2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N,N-dimethylacetamide —— C15H21N3O2S
    2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N,N-dimethylacetamide
    —— 2-[(3R)-1-ethyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(furan-2-ylmethyl)-N-methylacetamide —— C17H19N3O3S
    2-[(3R)-1-ethyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(furan-2-ylmethyl)-N-methylacetamide
    —— 2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-cyclopropylacetamide —— C16H21N3O2S
    2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-cyclopropylacetamide
    —— 2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-cyclopropylacetamide —— C16H21N3O2S
    2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-cyclopropylacetamide
    —— (3S)-1-butyl-3-(2-morpholin-4-yl-2-oxoethyl)pyrido[2,3-b][1,4]thiazin-2-one —— C17H23N3O3S
    (3S)-1-butyl-3-(2-morpholin-4-yl-2-oxoethyl)pyrido[2,3-b][1,4]thiazin-2-one
    —— 2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-cyclopentylacetamide —— C18H25N3O2S
    2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-cyclopentylacetamide
    —— 2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(2-methylbutan-2-yl)acetamide —— C18H27N3O2S
    2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(2-methylbutan-2-yl)acetamide
    —— N-[(2S)-butan-2-yl]-2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]acetamide —— C17H25N3O2S
    N-[(2S)-butan-2-yl]-2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]acetamide
    —— 2-[(3R)-1-ethyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(thiophen-2-ylmethyl)acetamide —— C16H17N3O2S2
    2-[(3R)-1-ethyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(thiophen-2-ylmethyl)acetamide
    —— N-cyclohexyl-2-[(3R)-2-oxo-1-propylpyrido[2,3-b][1,4]thiazin-3-yl]acetamide —— C18H25N3O2S
    N-cyclohexyl-2-[(3R)-2-oxo-1-propylpyrido[2,3-b][1,4]thiazin-3-yl]acetamide
    —— (3R)-1-butyl-3-[2-(4-methyl-1,4-diazepan-1-yl)-2-oxoethyl]pyrido[2,3-b][1,4]thiazin-2-one —— C19H28N4O2S
    (3R)-1-butyl-3-[2-(4-methyl-1,4-diazepan-1-yl)-2-oxoethyl]pyrido[2,3-b][1,4]thiazin-2-one
    —— 2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(cyclopropylmethyl)acetamide —— C17H23N3O2S
    2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(cyclopropylmethyl)acetamide
    —— N-(2-methylpropyl)-2-[(3R)-2-oxo-1-propylpyrido[2,3-b][1,4]thiazin-3-yl]acetamide —— C16H23N3O2S
    N-(2-methylpropyl)-2-[(3R)-2-oxo-1-propylpyrido[2,3-b][1,4]thiazin-3-yl]acetamide
    —— 2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-methyl-N-propylacetamide —— C17H25N3O2S
    2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-methyl-N-propylacetamide
    —— (3R)-3-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1-propylpyrido[2,3-b][1,4]thiazin-2-one —— C17H24N4O2S
    (3R)-3-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1-propylpyrido[2,3-b][1,4]thiazin-2-one
    —— N-(2-methylbutan-2-yl)-2-[(3S)-1-(2-methylpropyl)-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]acetamide —— C18H27N3O2S
    N-(2-methylbutan-2-yl)-2-[(3S)-1-(2-methylpropyl)-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]acetamide
    —— 2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-propan-2-ylacetamide —— C16H23N3O2S
    2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-propan-2-ylacetamide
    —— (3S)-1-butyl-3-[2-(4-methyl-1,4-diazepan-1-yl)-2-oxoethyl]pyrido[2,3-b][1,4]thiazin-2-one —— C19H28N4O2S
    (3S)-1-butyl-3-[2-(4-methyl-1,4-diazepan-1-yl)-2-oxoethyl]pyrido[2,3-b][1,4]thiazin-2-one
    —— 2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(2-methylpropyl)acetamide —— C17H25N3O2S
    2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(2-methylpropyl)acetamide
    —— 2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-propan-2-ylacetamide —— C16H23N3O2S
    2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-propan-2-ylacetamide
    —— 2-[(3S)-1-ethyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-methyl-N-propylacetamide —— C15H21N3O2S
    2-[(3S)-1-ethyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-methyl-N-propylacetamide
    —— (3S)-3-[2-(4-butylpiperazin-1-yl)-2-oxoethyl]-1-(2-methylpropyl)pyrido[2,3-b][1,4]thiazin-2-one —— C21H32N4O2S
    (3S)-3-[2-(4-butylpiperazin-1-yl)-2-oxoethyl]-1-(2-methylpropyl)pyrido[2,3-b][1,4]thiazin-2-one
    —— N-(cyclopropylmethyl)-2-[(3R)-2-oxo-1-propylpyrido[2,3-b][1,4]thiazin-3-yl]acetamide —— C16H21N3O2S
    N-(cyclopropylmethyl)-2-[(3R)-2-oxo-1-propylpyrido[2,3-b][1,4]thiazin-3-yl]acetamide
    —— N-[(2S)-butan-2-yl]-2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]acetamide —— C17H25N3O2S
    N-[(2S)-butan-2-yl]-2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]acetamide
    —— N-(2-methoxyethyl)-2-[(3R)-1-(2-methylpropyl)-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]acetamide —— C16H23N3O3S
    N-(2-methoxyethyl)-2-[(3R)-1-(2-methylpropyl)-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]acetamide
    —— 2-[(3R)-2-oxo-1-propylpyrido[2,3-b][1,4]thiazin-3-yl]-N-propan-2-ylacetamide —— C15H21N3O2S
    2-[(3R)-2-oxo-1-propylpyrido[2,3-b][1,4]thiazin-3-yl]-N-propan-2-ylacetamide
    —— 2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-cyclopentylacetamide —— C18H25N3O2S
    2-[(3R)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-cyclopentylacetamide
    —— (3S)-1-ethyl-3-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-b][1,4]thiazin-2-one —— C15H19N3O2S
    (3S)-1-ethyl-3-(2-oxo-2-pyrrolidin-1-ylethyl)pyrido[2,3-b][1,4]thiazin-2-one
    —— 2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(cyclopropylmethyl)acetamide —— C17H23N3O2S
    2-[(3S)-1-butyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(cyclopropylmethyl)acetamide
    —— 2-[(3R)-1-ethyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-methyl-N-propylacetamide —— C15H21N3O2S
    2-[(3R)-1-ethyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-methyl-N-propylacetamide
    —— 2-[(3S)-1-methyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(thiophen-2-ylmethyl)acetamide —— C15H15N3O2S2
    2-[(3S)-1-methyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-(thiophen-2-ylmethyl)acetamide
    —— N-[(2S)-butan-2-yl]-2-[(3S)-1-(2-methylpropyl)-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]acetamide —— C17H25N3O2S
    N-[(2S)-butan-2-yl]-2-[(3S)-1-(2-methylpropyl)-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]acetamide
    —— 2-[(3R)-1-methyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-propan-2-ylacetamide —— C13H17N3O2S
    2-[(3R)-1-methyl-2-oxopyrido[2,3-b][1,4]thiazin-3-yl]-N-propan-2-ylacetamide