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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— methyl 2,2-dicyano-N-(2-hydroxyethyl)ethanimidothioate —— C7H9N3OS
    methyl 2,2-dicyano-N-(2-hydroxyethyl)ethanimidothioate
    —— 4-[(2R)-2-methylbutyl]-3-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-1,2,4-triazol-5-one —— C10H13N5O3S2
    4-[(2R)-2-methylbutyl]-3-[(5-nitro-1,3-thiazol-2-yl)sulfanyl]-1H-1,2,4-triazol-5-one
    —— 3-((2-Chloro-6-fluorobenzyl)thio)-6-(pyridin-4-yl)pyridazine —— C16H11ClFN3S
    3-((2-Chloro-6-fluorobenzyl)thio)-6-(pyridin-4-yl)pyridazine
    —— N-[(4-methylphenyl)methyl]-2-(6-pyridin-4-ylpyridazin-3-yl)sulfanylacetamide —— C19H18N4OS
    N-[(4-methylphenyl)methyl]-2-(6-pyridin-4-ylpyridazin-3-yl)sulfanylacetamide
    —— 3-((4-Chlorobenzyl)thio)-6-(pyridin-4-yl)pyridazine —— C16H12ClN3S
    3-((4-Chlorobenzyl)thio)-6-(pyridin-4-yl)pyridazine
    —— N-[(4-chlorophenyl)methyl]-2-(6-pyridin-4-ylpyridazin-3-yl)sulfanylacetamide —— C18H15ClN4OS
    N-[(4-chlorophenyl)methyl]-2-(6-pyridin-4-ylpyridazin-3-yl)sulfanylacetamide
    —— 3-Methylsulfanyl-6-pyridin-4-ylpyridazine —— C10H9N3S
    3-Methylsulfanyl-6-pyridin-4-ylpyridazine
    —— N-(4-fluorobenzyl)-2-((6-(pyridin-4-yl)pyridazin-3-yl)thio)acetamide —— C18H15FN4OS
    N-(4-fluorobenzyl)-2-((6-(pyridin-4-yl)pyridazin-3-yl)thio)acetamide
    —— N-(2-chlorobenzyl)-2-((6-(pyridin-4-yl)pyridazin-3-yl)thio)acetamide —— C18H15ClN4OS
    N-(2-chlorobenzyl)-2-((6-(pyridin-4-yl)pyridazin-3-yl)thio)acetamide
    —— (7S)-7-phenyl-1-[2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetyl]-1,4-diazepan-5-one —— C19H18F3N3O2S
    (7S)-7-phenyl-1-[2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetyl]-1,4-diazepan-5-one
    —— methyl (4R)-2-methyl-5-oxo-4-(5-phenylsulfanylfuran-2-yl)-3,4-dihydroindeno[1,2-b]pyridine-3-carboxylate —— C25H19NO4S
    methyl (4R)-2-methyl-5-oxo-4-(5-phenylsulfanylfuran-2-yl)-3,4-dihydroindeno[1,2-b]pyridine-3-carboxylate
    —— (7R)-7-phenyl-1-[2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetyl]-1,4-diazepan-5-one —— C19H18F3N3O2S
    (7R)-7-phenyl-1-[2-[5-(trifluoromethyl)pyridin-2-yl]sulfanylacetyl]-1,4-diazepan-5-one
    —— methyl 2,2-dicyano-N-(2-methylpropyl)ethanimidothioate —— C9H13N3S
    methyl 2,2-dicyano-N-(2-methylpropyl)ethanimidothioate
    —— (2R)-N-cyclopentyl-2-[[4-methyl-5-(piperidin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]butanamide —— C18H31N5OS
    (2R)-N-cyclopentyl-2-[[4-methyl-5-(piperidin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]butanamide
    —— (2S)-N-cyclopentyl-2-[[4-methyl-5-(piperidin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]butanamide —— C18H31N5OS
    (2S)-N-cyclopentyl-2-[[4-methyl-5-(piperidin-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]butanamide
    —— N-[(1S)-1-phenylethyl]-3-pyridin-2-ylsulfanylpropanamide —— C16H18N2OS
    N-[(1S)-1-phenylethyl]-3-pyridin-2-ylsulfanylpropanamide
    —— 1-[2-methyl-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]phenyl]-3-[(1S)-2-(2-oxopyrrolidin-1-yl)-1-phenylethyl]urea —— C23H25N5O2S2
    1-[2-methyl-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]phenyl]-3-[(1S)-2-(2-oxopyrrolidin-1-yl)-1-phenylethyl]urea
    —— 2-[[3-(5-Oxo-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-6-yl)-1,2,4-oxadiazol-5-yl]methylsulfanyl]acetate —— C11H9N4O4S2-
    2-[[3-(5-Oxo-2,3-dihydro-[1,3]thiazolo[3,2-a]pyrimidin-6-yl)-1,2,4-oxadiazol-5-yl]methylsulfanyl]acetate
    —— S-thiophen-2-yl (1S,2R,4R)-bicyclo[2.2.2]oct-5-ene-2-carbothioate —— C13H14OS2
    S-thiophen-2-yl (1S,2R,4R)-bicyclo[2.2.2]oct-5-ene-2-carbothioate
    —— 1-[2-methyl-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]phenyl]-3-[(1R)-2-(2-oxopyrrolidin-1-yl)-1-phenylethyl]urea —— C23H25N5O2S2
    1-[2-methyl-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]phenyl]-3-[(1R)-2-(2-oxopyrrolidin-1-yl)-1-phenylethyl]urea
    —— 2-[(5S,6S)-5-(4-methylsulfanylphenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,10,12-tetraen-4-yl]ethanol —— C21H24N2OS
    2-[(5S,6S)-5-(4-methylsulfanylphenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,10,12-tetraen-4-yl]ethanol
    —— (5R,6S)-4-methyl-5-(4-methylsulfanylphenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,10,12-tetraene —— C20H22N2S
    (5R,6S)-4-methyl-5-(4-methylsulfanylphenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,10,12-tetraene
    —— S-thiophen-2-yl (1S,2S,4R)-bicyclo[2.2.2]oct-5-ene-2-carbothioate —— C13H14OS2
    S-thiophen-2-yl (1S,2S,4R)-bicyclo[2.2.2]oct-5-ene-2-carbothioate
    —— N-[(1R)-1-phenylethyl]-3-pyridin-2-ylsulfanylpropanamide —— C16H18N2OS
    N-[(1R)-1-phenylethyl]-3-pyridin-2-ylsulfanylpropanamide
    —— 2-[(5S,6R)-5-(4-methylsulfanylphenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,10,12-tetraen-4-yl]ethanol —— C21H24N2OS
    2-[(5S,6R)-5-(4-methylsulfanylphenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,10,12-tetraen-4-yl]ethanol
    —— 3,5-Bis(methylsulfanyl)-4-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)-1,2-thiazole —— C6H6N5S3-
    3,5-Bis(methylsulfanyl)-4-(1,2,3-triaza-4-azanidacyclopenta-2,5-dien-5-yl)-1,2-thiazole
    —— 2-[(5R,6S)-5-(4-methylsulfanylphenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,10,12-tetraen-4-yl]ethanol —— C21H24N2OS
    2-[(5R,6S)-5-(4-methylsulfanylphenyl)-3,4-diazatricyclo[8.4.0.02,6]tetradeca-1(14),2,10,12-tetraen-4-yl]ethanol
    —— ethyl (2R)-4-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-ethanimidoyl-3-oxobutanoate —— C16H16ClN3O4S
    ethyl (2R)-4-[[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-2-ethanimidoyl-3-oxobutanoate
    —— 3-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanoate —— C8H9N2O3S-
    3-[(4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanoate
    —— (3R)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(thiophen-2-ylmethyl)piperidine —— C20H24N4S2
    (3R)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(thiophen-2-ylmethyl)piperidine
    —— N-[(R)-phenyl(1,3-thiazol-2-yl)methyl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide —— C14H12N4OS3
    N-[(R)-phenyl(1,3-thiazol-2-yl)methyl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide
    —— (3R)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(furan-2-ylmethyl)piperidine —— C20H24N4OS
    (3R)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(furan-2-ylmethyl)piperidine
    —— (3R)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(furan-2-ylmethyl)piperidin-1-ium —— C20H25N4OS+
    (3R)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(furan-2-ylmethyl)piperidin-1-ium
    —— (3S)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(thiophen-2-ylmethyl)piperidine —— C20H24N4S2
    (3S)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(thiophen-2-ylmethyl)piperidine
    —— (3R)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(thiophen-2-ylmethyl)piperidin-1-ium —— C20H25N4S2+
    (3R)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(thiophen-2-ylmethyl)piperidin-1-ium
    —— N-[(S)-phenyl(1,3-thiazol-2-yl)methyl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide —— C14H12N4OS3
    N-[(S)-phenyl(1,3-thiazol-2-yl)methyl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide
    —— (2S)-2-(4-methylpyrimidin-2-yl)sulfanylpropanoate —— C8H9N2O2S-
    (2S)-2-(4-methylpyrimidin-2-yl)sulfanylpropanoate
    —— (2R)-2-[(5-benzyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoic acid —— C16H18N2O3S
    (2R)-2-[(5-benzyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoic acid
    —— 2-(5-Chloro-1-methyl-6-oxopyridazin-4-yl)sulfanylacetate —— C7H6ClN2O3S-
    2-(5-Chloro-1-methyl-6-oxopyridazin-4-yl)sulfanylacetate
    —— (2R)-2-(4-methylpyrimidin-2-yl)sulfanylpropanoic acid —— C8H10N2O2S
    (2R)-2-(4-methylpyrimidin-2-yl)sulfanylpropanoic acid
    —— (2R)-2-[(5-benzyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate —— C16H17N2O3S-
    (2R)-2-[(5-benzyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate
    —— 2-[(5-benzyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetate —— C14H13N2O3S-
    2-[(5-benzyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetate
    —— Ethyl 4-[1,4-dimethyl-5-[(2-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylbutanoate —— C20H26N2O3S
    Ethyl 4-[1,4-dimethyl-5-[(2-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylbutanoate
    —— 3-Methyl-2-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-6-propylpyrimidin-4-one —— C14H21N3O3S
    3-Methyl-2-(2-morpholin-4-yl-2-oxoethyl)sulfanyl-6-propylpyrimidin-4-one
    —— 2-[(2S)-1-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]pyrrolidin-2-yl]pyridine —— C17H19N5OS
    2-[(2S)-1-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]pyrrolidin-2-yl]pyridine
    —— 2-[(2R)-1-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]pyrrolidin-2-yl]pyridine —— C17H19N5OS
    2-[(2R)-1-[[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]methyl]pyrrolidin-2-yl]pyridine
    —— (6S)-2,2,6-trimethyl-N-[4-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]phenyl]morpholine-4-carboxamide —— C18H23N3O2S2
    (6S)-2,2,6-trimethyl-N-[4-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]phenyl]morpholine-4-carboxamide
    —— [6-[(4,6-Dimethylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 2-(4-chlorophenyl)acetate —— C20H17ClN2O4S
    [6-[(4,6-Dimethylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 2-(4-chlorophenyl)acetate
    —— [6-[(4,6-Dimethylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 2-(4-fluorophenyl)acetate —— C20H17FN2O4S
    [6-[(4,6-Dimethylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 2-(4-fluorophenyl)acetate
    —— 6-(((4,6-dimethylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 2-(m-tolyl)acetate —— C21H20N2O4S
    6-(((4,6-dimethylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 2-(m-tolyl)acetate