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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2S)-3-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]propane-1,2-diol —— C10H17N3O3S2
    (2S)-3-[[5-[[(2R)-oxolan-2-yl]methylamino]-1,3,4-thiadiazol-2-yl]sulfanyl]propane-1,2-diol
    —— (2S)-N-[[1-(4-fluorophenyl)cyclobutyl]methyl]-2-pyrimidin-2-ylsulfanylpropanamide —— C18H20FN3OS
    (2S)-N-[[1-(4-fluorophenyl)cyclobutyl]methyl]-2-pyrimidin-2-ylsulfanylpropanamide
    —— 2-(3,4-dimethylphenyl)sulfanyl-N-[(2S)-1-methoxypropan-2-yl]acetamide —— C14H21NO2S
    2-(3,4-dimethylphenyl)sulfanyl-N-[(2S)-1-methoxypropan-2-yl]acetamide
    —— 3-methyl-5-[(1R)-1-(4-methylphenyl)sulfanylethyl]-1,2,4-oxadiazole —— C12H14N2OS
    3-methyl-5-[(1R)-1-(4-methylphenyl)sulfanylethyl]-1,2,4-oxadiazole
    —— 3-methyl-5-[(1S)-1-(4-methylphenyl)sulfanylethyl]-1,2,4-oxadiazole —— C12H14N2OS
    3-methyl-5-[(1S)-1-(4-methylphenyl)sulfanylethyl]-1,2,4-oxadiazole
    —— 6-Tert-butyl-3-methyl-2-[(2-methylphenyl)methylsulfanyl]pyrimidin-4-one —— C17H22N2OS
    6-Tert-butyl-3-methyl-2-[(2-methylphenyl)methylsulfanyl]pyrimidin-4-one
    —— (2R)-N-[[1-(4-fluorophenyl)cyclobutyl]methyl]-2-pyrimidin-2-ylsulfanylpropanamide —— C18H20FN3OS
    (2R)-N-[[1-(4-fluorophenyl)cyclobutyl]methyl]-2-pyrimidin-2-ylsulfanylpropanamide
    —— 2-(3,4-dimethylphenyl)sulfanyl-N-[(2R)-1-methoxypropan-2-yl]acetamide —— C14H21NO2S
    2-(3,4-dimethylphenyl)sulfanyl-N-[(2R)-1-methoxypropan-2-yl]acetamide
    —— 2-(1-Methyltetrazol-5-yl)sulfanylethyl-[(5-phenylfuran-2-yl)methyl]azanium —— C15H18N5OS+
    2-(1-Methyltetrazol-5-yl)sulfanylethyl-[(5-phenylfuran-2-yl)methyl]azanium
    —— 5-[(6-Methyl-2-piperidin-1-ylpyrimidin-4-yl)sulfanylmethyl]-3-(morpholin-4-ium-4-ylmethyl)-1,3,4-oxadiazole-2-thione —— C18H27N6O2S2+
    5-[(6-Methyl-2-piperidin-1-ylpyrimidin-4-yl)sulfanylmethyl]-3-(morpholin-4-ium-4-ylmethyl)-1,3,4-oxadiazole-2-thione
    —— N-[[(2S)-oxolan-2-yl]methyl]-2-[[5-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C14H18N4O2S2
    N-[[(2S)-oxolan-2-yl]methyl]-2-[[5-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— [5-(4-Chlorophenyl)furan-2-yl]methyl-[2-(1-methyltetrazol-5-yl)sulfanylethyl]azanium —— C15H17ClN5OS+
    [5-(4-Chlorophenyl)furan-2-yl]methyl-[2-(1-methyltetrazol-5-yl)sulfanylethyl]azanium
    —— [5-(3-Chlorophenyl)furan-2-yl]methyl-[2-(1-methyltetrazol-5-yl)sulfanylethyl]azanium —— C15H17ClN5OS+
    [5-(3-Chlorophenyl)furan-2-yl]methyl-[2-(1-methyltetrazol-5-yl)sulfanylethyl]azanium
    —— methyl (2R)-2-[(6-phenyl-1,2,4-triazin-3-yl)sulfanyl]propanoate —— C13H13N3O2S
    methyl (2R)-2-[(6-phenyl-1,2,4-triazin-3-yl)sulfanyl]propanoate
    —— [5-(4-Fluorophenyl)furan-2-yl]methyl-[2-(1-methyltetrazol-5-yl)sulfanylethyl]azanium —— C15H17FN5OS+
    [5-(4-Fluorophenyl)furan-2-yl]methyl-[2-(1-methyltetrazol-5-yl)sulfanylethyl]azanium
    —— 6-Phenyl-3-(2-piperidin-1-ium-1-ylethylsulfanyl)-1,2,4-triazine —— C16H21N4S+
    6-Phenyl-3-(2-piperidin-1-ium-1-ylethylsulfanyl)-1,2,4-triazine
    —— methyl (2S)-2-[(6-phenyl-1,2,4-triazin-3-yl)sulfanyl]propanoate —— C13H13N3O2S
    methyl (2S)-2-[(6-phenyl-1,2,4-triazin-3-yl)sulfanyl]propanoate
    —— (1S)-1-[4-butyl-5-(pyridin-2-ylmethylsulfanyl)-1,2,4-triazol-3-yl]-N,N-dimethylpropan-1-amine —— C17H27N5S
    (1S)-1-[4-butyl-5-(pyridin-2-ylmethylsulfanyl)-1,2,4-triazol-3-yl]-N,N-dimethylpropan-1-amine
    —— N-benzyl-N-[(2S)-butan-2-yl]-3-(1-methyltetrazol-5-yl)sulfanylpropanamide —— C16H23N5OS
    N-benzyl-N-[(2S)-butan-2-yl]-3-(1-methyltetrazol-5-yl)sulfanylpropanamide
    —— (2S)-N-[1-(2-methylpropyl)piperidin-4-yl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide —— C18H26N2O2S
    (2S)-N-[1-(2-methylpropyl)piperidin-4-yl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide
    —— (2R)-N-[(1S)-1-[(2S)-oxolan-2-yl]ethyl]-2-pyrimidin-2-ylsulfanylpropanamide —— C13H19N3O2S
    (2R)-N-[(1S)-1-[(2S)-oxolan-2-yl]ethyl]-2-pyrimidin-2-ylsulfanylpropanamide
    —— (1R)-1-[4-butyl-5-(pyridin-2-ylmethylsulfanyl)-1,2,4-triazol-3-yl]-N,N-dimethylpropan-1-amine —— C17H27N5S
    (1R)-1-[4-butyl-5-(pyridin-2-ylmethylsulfanyl)-1,2,4-triazol-3-yl]-N,N-dimethylpropan-1-amine
    —— (2R)-N-[1-(2-methylpropyl)piperidin-4-yl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide —— C18H26N2O2S
    (2R)-N-[1-(2-methylpropyl)piperidin-4-yl]-2,3-dihydro-1,4-benzoxathiine-2-carboxamide
    —— N-[[(2R)-oxolan-2-yl]methyl]-2-[[5-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C14H18N4O2S2
    N-[[(2R)-oxolan-2-yl]methyl]-2-[[5-(thiophen-2-ylmethyl)-1H-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— (2R)-N-[(1R)-1-[(2S)-oxolan-2-yl]ethyl]-2-pyrimidin-2-ylsulfanylpropanamide —— C13H19N3O2S
    (2R)-N-[(1R)-1-[(2S)-oxolan-2-yl]ethyl]-2-pyrimidin-2-ylsulfanylpropanamide
    —— (2R)-N-[(1S)-1-[(2R)-oxolan-2-yl]ethyl]-2-pyrimidin-2-ylsulfanylpropanamide —— C13H19N3O2S
    (2R)-N-[(1S)-1-[(2R)-oxolan-2-yl]ethyl]-2-pyrimidin-2-ylsulfanylpropanamide
    —— (2S)-N-[3-chloro-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]-2-methylbutanamide —— C14H17ClN4OS
    (2S)-N-[3-chloro-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]-2-methylbutanamide
    —— 2-pyridin-4-yl-5-[(1S)-1-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-oxadiazole —— C16H12N6O2S
    2-pyridin-4-yl-5-[(1S)-1-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-pyridin-4-yl-5-[(1R)-1-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-oxadiazole —— C16H12N6O2S
    2-pyridin-4-yl-5-[(1R)-1-(3-pyridin-4-yl-1,2,4-oxadiazol-5-yl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— (2R)-N-[(1R)-1-[(2R)-oxolan-2-yl]ethyl]-2-pyrimidin-2-ylsulfanylpropanamide —— C13H19N3O2S
    (2R)-N-[(1R)-1-[(2R)-oxolan-2-yl]ethyl]-2-pyrimidin-2-ylsulfanylpropanamide
    —— (2R)-N-[3-chloro-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]-2-methylbutanamide —— C14H17ClN4OS
    (2R)-N-[3-chloro-4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]-2-methylbutanamide
    —— 4-methyl-1-[4-[[(2R)-oxolan-2-yl]methyl]-5-prop-2-enylsulfanyl-1,2,4-triazol-3-yl]piperidine —— C16H26N4OS
    4-methyl-1-[4-[[(2R)-oxolan-2-yl]methyl]-5-prop-2-enylsulfanyl-1,2,4-triazol-3-yl]piperidine
    —— (3S)-N-[2-methyl-4-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]phenyl]oxolane-3-carboxamide —— C16H18N2O2S2
    (3S)-N-[2-methyl-4-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]phenyl]oxolane-3-carboxamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-2-(3-methylphenyl)sulfanylacetamide —— C13H17NO3S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-2-(3-methylphenyl)sulfanylacetamide
    —— 4-(2-Chlorophenyl)sulfanyl-2-ethanimidoyl-3-oxobutanenitrile —— C12H11ClN2OS
    4-(2-Chlorophenyl)sulfanyl-2-ethanimidoyl-3-oxobutanenitrile
    —— 1-[(2R)-2-(3-fluorophenyl)-2-hydroxyethyl]-3-[(4-methylsulfanylphenyl)methyl]urea —— C17H19FN2O2S
    1-[(2R)-2-(3-fluorophenyl)-2-hydroxyethyl]-3-[(4-methylsulfanylphenyl)methyl]urea
    —— (2S)-2-(4-bromophenyl)sulfanyl-N-(1-butylpiperidin-4-yl)propanamide —— C18H27BrN2OS
    (2S)-2-(4-bromophenyl)sulfanyl-N-(1-butylpiperidin-4-yl)propanamide
    —— (2R)-2-(4-bromophenyl)sulfanyl-N-(1-butylpiperidin-4-yl)propanamide —— C18H27BrN2OS
    (2R)-2-(4-bromophenyl)sulfanyl-N-(1-butylpiperidin-4-yl)propanamide
    —— 1-[4-[[(2R)-oxolan-2-yl]methyl]-5-propan-2-ylsulfanyl-1,2,4-triazol-3-yl]piperidine —— C15H26N4OS
    1-[4-[[(2R)-oxolan-2-yl]methyl]-5-propan-2-ylsulfanyl-1,2,4-triazol-3-yl]piperidine
    —— 4-methyl-N'-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)methoxy]benzenecarboximidamide —— C12H14N4OS2
    4-methyl-N'-[(5-methylsulfanyl-1,3,4-thiadiazol-2-yl)methoxy]benzenecarboximidamide
    —— 1-[4-[[(2S)-oxolan-2-yl]methyl]-5-propan-2-ylsulfanyl-1,2,4-triazol-3-yl]piperidine —— C15H26N4OS
    1-[4-[[(2S)-oxolan-2-yl]methyl]-5-propan-2-ylsulfanyl-1,2,4-triazol-3-yl]piperidine
    —— N-[(2-chlorophenyl)methyl]-2-[4-(3,5-dimethylphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide —— C21H20ClN3O2S
    N-[(2-chlorophenyl)methyl]-2-[4-(3,5-dimethylphenyl)-3-oxopyrazin-2-yl]sulfanylacetamide
    —— ethyl (2S)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-2-phenylacetate —— C13H15N3O2S
    ethyl (2S)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-2-phenylacetate
    —— ethyl (2R)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-2-phenylacetate —— C13H15N3O2S
    ethyl (2R)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-2-phenylacetate
    —— 2-((4-(3,5-dimethylphenyl)-3-oxo-3,4-dihydropyrazin-2-yl)thio)-N-phenethylacetamide —— C22H23N3O2S
    2-((4-(3,5-dimethylphenyl)-3-oxo-3,4-dihydropyrazin-2-yl)thio)-N-phenethylacetamide
    —— (6R)-4-methyl-5-[3-(4-methylphenyl)-2H-1,2,4-oxadiazol-5-ylidene]-6-(4-methylsulfanylphenyl)-1,6-dihydropyrimidine-2-thione —— C21H20N4OS2
    (6R)-4-methyl-5-[3-(4-methylphenyl)-2H-1,2,4-oxadiazol-5-ylidene]-6-(4-methylsulfanylphenyl)-1,6-dihydropyrimidine-2-thione
    —— 3-(4-fluorophenyl)sulfanyl-N-[[(2S)-1-methylpyrrolidin-2-yl]methyl]propanamide —— C15H21FN2OS
    3-(4-fluorophenyl)sulfanyl-N-[[(2S)-1-methylpyrrolidin-2-yl]methyl]propanamide
    —— 3-(4-chlorophenyl)sulfanyl-N-[[(2R)-1-methylpyrrolidin-2-yl]methyl]propanamide —— C15H21ClN2OS
    3-(4-chlorophenyl)sulfanyl-N-[[(2R)-1-methylpyrrolidin-2-yl]methyl]propanamide
    —— 3-(4-fluorophenyl)sulfanyl-N-[[(2R)-1-methylpyrrolidin-2-yl]methyl]propanamide —— C15H21FN2OS
    3-(4-fluorophenyl)sulfanyl-N-[[(2R)-1-methylpyrrolidin-2-yl]methyl]propanamide
    —— 3-(4-chlorophenyl)sulfanyl-N-[[(2S)-1-methylpyrrolidin-2-yl]methyl]propanamide —— C15H21ClN2OS
    3-(4-chlorophenyl)sulfanyl-N-[[(2S)-1-methylpyrrolidin-2-yl]methyl]propanamide