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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (-)-(7aS)-2,3,7,7a-Tetrahydro-7a-phenylthio-1H-indene-1,5(6H)-dione 127053-28-5 C15H14O2S
    (-)-(7aS)-2,3,7,7a-Tetrahydro-7a-phenylthio-1H-indene-1,5(6H)-dione
    —— (+/-)-2,3,7,7a-Tetrahydro-7a-phenylthio-1H-indene-1,5(6H)-dione 127053-28-5 C15H14O2S
    (+/-)-2,3,7,7a-Tetrahydro-7a-phenylthio-1H-indene-1,5(6H)-dione
    —— (2aS,3R,5aR,6R,8aR,8bR)-3,6-dimethyl-6-phenylsulfanylmethyl-2a-[2-(tetrahydropyran-2-yloxy)ethyl]decahydronaphtho[1,8-bc]furan-2-one 535932-79-7 C27H38O4S
    (2aS,3R,5aR,6R,8aR,8bR)-3,6-dimethyl-6-phenylsulfanylmethyl-2a-[2-(tetrahydropyran-2-yloxy)ethyl]decahydronaphtho[1,8-bc]furan-2-one
    —— (+)-(8aS)-3,4,8,8a-Tetrahydro-8a-phenylthio-1,6(2H,7H)-naphthalenedione 127053-29-6 C16H16O2S
    (+)-(8aS)-3,4,8,8a-Tetrahydro-8a-phenylthio-1,6(2H,7H)-naphthalenedione
    —— 2-(phenylthio)-1,3-cyclopentanedione 90036-83-2 C11H10O2S
    2-(phenylthio)-1,3-cyclopentanedione
    —— (2aS,3S,5aR,6R,8aR,8bR)-3,6-dimethyl-6-phenylsulfanylmethyl-2a-[2-(tetrahydropyran-2-yloxy)ethyl]decahydronaphtho[1,8-bc]furan-2-one 535932-73-1 C27H38O4S
    (2aS,3S,5aR,6R,8aR,8bR)-3,6-dimethyl-6-phenylsulfanylmethyl-2a-[2-(tetrahydropyran-2-yloxy)ethyl]decahydronaphtho[1,8-bc]furan-2-one
    —— dimethyl 2-pent-4-enyl-2-phenylsulfanylpropanedioate 196494-61-8 C16H20O4S
    dimethyl 2-pent-4-enyl-2-phenylsulfanylpropanedioate
    —— 2-isopropyl-2-phenyltio-1,3-cyclopentanedione 90036-76-3 C14H16O2S
    2-isopropyl-2-phenyltio-1,3-cyclopentanedione
    —— 5-bromo-1-(methyl-diphenyl-silyl)-2-phenyl-sulfenyl-1-hexanone 282733-21-5 C25H27BrOSSi
    5-bromo-1-(methyl-diphenyl-silyl)-2-phenyl-sulfenyl-1-hexanone
    —— 2-Phenylsulfanyl-1-trimethylsilylhexan-1-one 66132-86-3 C15H24OSSi
    2-Phenylsulfanyl-1-trimethylsilylhexan-1-one
    —— 5-bromo-4-methyl-1-(methyl-diphenyl-silyl)-2-phenyl-sulfenyl-1-pentanone 395664-13-8 C25H27BrOSSi
    5-bromo-4-methyl-1-(methyl-diphenyl-silyl)-2-phenyl-sulfenyl-1-pentanone
    —— 2-(2-phenylthio-1-naphthyl)pyridine 1609120-86-6 C21H15NS
    2-(2-phenylthio-1-naphthyl)pyridine
    —— 5-methyl-2-phenyl-5-phenylthiomethyl-4,5-dihydro-1,3-oxazole 113261-11-3 C17H17NOS
    5-methyl-2-phenyl-5-phenylthiomethyl-4,5-dihydro-1,3-oxazole
    —— ethyl 2-(ethylsulfonemethyl)acrylate 1156548-30-9 C8H14O4S
    ethyl 2-(ethylsulfonemethyl)acrylate
    —— 2-[3-(3,4,5-trimethoxyphenyl)sulfanyl-1H-indol-2-yl]-1,3-oxazole 1337932-91-8 C20H18N2O4S
    2-[3-(3,4,5-trimethoxyphenyl)sulfanyl-1H-indol-2-yl]-1,3-oxazole
    —— 2-(furan-3-yl)-3-[(3,4,5-trimethoxyphenyl)thio]-1H-indole 1337932-86-1 C21H19NO4S
    2-(furan-3-yl)-3-[(3,4,5-trimethoxyphenyl)thio]-1H-indole
    —— 4-(2-nitro-1-phenylsulfanylethyl)phenol 110113-57-0 C14H13NO3S
    4-(2-nitro-1-phenylsulfanylethyl)phenol
    —— isopropyl S-3,6-diisopropylpyrazin-2-ylthiolcarbonate 104272-89-1 C14H22N2O2S
    isopropyl S-3,6-diisopropylpyrazin-2-ylthiolcarbonate
    —— 1H-Purin-6-amine, 2-((3-nitro-2-pyridiyl)thio)- 75477-68-8 C10H7N7O2S
    1H-Purin-6-amine, 2-((3-nitro-2-pyridiyl)thio)-
    —— N-(5-Bromo-4-methylsulphanylpyrimidin-2-yl)-N'-pyrimidin-2-yl-benzene-1,4-diamine 1034358-66-1 C15H13BrN6S
    N-(5-Bromo-4-methylsulphanylpyrimidin-2-yl)-N'-pyrimidin-2-yl-benzene-1,4-diamine
    —— methyl-thiocarbamic acid <i>S</i>-propyl ester 39076-37-4 C5H11NOS
    methyl-thiocarbamic acid <i>S</i>-propyl ester
    —— 4-(2-Amino-1-phenylsulfanylethyl)phenol 1027955-71-0 C14H15NOS
    4-(2-Amino-1-phenylsulfanylethyl)phenol
    —— ethyl-thiocarbamic acid <i>S</i>-butyl ester 39078-40-5 C7H15NOS
    ethyl-thiocarbamic acid <i>S</i>-butyl ester
    —— 2,4(1H,3H)-Pyrimidinedione, 1-((2-hydroxyethoxy)methyl)-5-iodo-6-(phenylthio)- 125056-92-0 C13H13IN2O4S
    2,4(1H,3H)-Pyrimidinedione, 1-((2-hydroxyethoxy)methyl)-5-iodo-6-(phenylthio)-
    —— 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-5-(2-(Z)-phenylvinyl)uracil 131194-26-8 C21H20N2O4S
    1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)-5-(2-(Z)-phenylvinyl)uracil
    —— S-[3,6-di(propan-2-yl)pyrazin-2-yl] chloromethanethioate 107292-22-8 C11H15ClN2OS
    S-[3,6-di(propan-2-yl)pyrazin-2-yl] chloromethanethioate
    —— 1-<(2-hydroxyethoxy)methyl>-5-(methoxycarbonyl)-6-(phenylthio)uracil 137897-81-5 C15H16N2O6S
    1-<(2-hydroxyethoxy)methyl>-5-(methoxycarbonyl)-6-(phenylthio)uracil
    —— 1-[(2-hydroxyethoxy)methyl]-5-(2-phenylethynyl)-6-phenylthiouracil 125056-93-1 C21H18N2O4S
    1-[(2-hydroxyethoxy)methyl]-5-(2-phenylethynyl)-6-phenylthiouracil
    —— 1-[(2-hydroxyethoxy)methyl]-5,6-diphenylthiouracil 125057-00-3 C19H18N2O4S2
    1-[(2-hydroxyethoxy)methyl]-5,6-diphenylthiouracil
    —— 2-benzylthio-3,6-diisopropylpyrazine 120061-24-7 C17H22N2S
    2-benzylthio-3,6-diisopropylpyrazine
    —— 1-[(2-hydroxyethoxy)methyl]-5-ethynyl-6-phenylthiouracil 125056-95-3 C15H14N2O4S
    1-[(2-hydroxyethoxy)methyl]-5-ethynyl-6-phenylthiouracil
    —— 1-[(2-hydroxyethoxy)methyl]-5-isobutyroyl-6-phenylthiouracil 125057-02-5 C17H20N2O5S
    1-[(2-hydroxyethoxy)methyl]-5-isobutyroyl-6-phenylthiouracil
    —— propyl-thiocarbamic acid <i>S</i>-propyl ester 39078-46-1 C7H15NOS
    propyl-thiocarbamic acid <i>S</i>-propyl ester
    —— 2-(4-methylbenzylthio)-3,6-diisopropylpyrazine 120061-27-0 C18H24N2S
    2-(4-methylbenzylthio)-3,6-diisopropylpyrazine
    —— isobutyl S-3,6-diisopropylpyrazin-2-ylthiolcarbonate 104272-90-4 C15H24N2O2S
    isobutyl S-3,6-diisopropylpyrazin-2-ylthiolcarbonate
    —— 1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-<2-(trimethylsilyl)ethynyl>uracil 131194-25-7 C24H36N2O4SSi2
    1-<<2-<(tert-butyldimethylsilyl)oxy>ethoxy>methyl>-6-(phenylthio)-5-<2-(trimethylsilyl)ethynyl>uracil
    —— 1-[(2-hydroxyethoxy)methyl]-6-phenylthiocytosine 125057-04-7 C13H15N3O3S
    1-[(2-hydroxyethoxy)methyl]-6-phenylthiocytosine
    —— 2-Methylmercapto-6-methyl-pyrimidin-aldehyd-4 1075-58-7 C7H8N2OS
    2-Methylmercapto-6-methyl-pyrimidin-aldehyd-4
    —— 3-Cyclohexyl-6-methylsulfanyl-1,2,4,5-tetrazine 159801-90-8 C9H14N4S
    3-Cyclohexyl-6-methylsulfanyl-1,2,4,5-tetrazine
    —— Pyrrolo<2,1-e>sym-triazolo<1,2-a><3,1,6>benzothiadiazocine 112798-03-5 C13H10N4S
    Pyrrolo<2,1-e>sym-triazolo<1,2-a><3,1,6>benzothiadiazocine
    —— 3-(4-chloro-phenylsulfanyl)-azetidine 1340259-48-4 C9H10ClNS
    3-(4-chloro-phenylsulfanyl)-azetidine
    —— 3-[(4-chlorophenyl)thio]-1-azetidinecarbonyl chloride 132924-61-9 C10H9Cl2NOS
    3-[(4-chlorophenyl)thio]-1-azetidinecarbonyl chloride
    —— 5,6-Dihydro-6-thioxopyrrolo<1,2-a><3,1,6>benzothiadiazocine 112798-08-0 C12H10N2S2
    5,6-Dihydro-6-thioxopyrrolo<1,2-a><3,1,6>benzothiadiazocine
    —— 3-[(4-{[(3S)-1-methylpyrrolidin-3-yl]methoxy}phenyl)thio]-N-(3-methyl-1,2,4-thiadiazol-5-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)thio]pyridine-2-carboxamide 1018966-17-0 C24H26N8O2S3
    3-[(4-{[(3S)-1-methylpyrrolidin-3-yl]methoxy}phenyl)thio]-N-(3-methyl-1,2,4-thiadiazol-5-yl)-6-[(4-methyl-4H-1,2,4-triazol-3-yl)thio]pyridine-2-carboxamide
    —— 4-{[(2-pyrazinyl)methyl]sulfanyl}aniline 497853-54-0 C11H11N3S
    4-{[(2-pyrazinyl)methyl]sulfanyl}aniline
    —— Diethyl N-<4-(2-Methylthio)thiazolyl>aminomethylenemalonate 94507-75-2 C12H16N2O4S2
    Diethyl N-<4-(2-Methylthio)thiazolyl>aminomethylenemalonate
    —— 2-(4-fluorophenylthio)tetrahydropyran 146328-81-6 C11H13FOS
    2-(4-fluorophenylthio)tetrahydropyran
    —— Methylthioharnstoff —— C2H6N2S*H
    Methylthioharnstoff
    —— <4-Nitro-phenyl>-<m-tolyl>-sulfid 76590-34-6 C13H11NO2S
    <4-Nitro-phenyl>-<m-tolyl>-sulfid
    —— bis(4-methylphenyl) N,N'-dihydroxypentanediimidothioate 1390628-49-5 C19H22N2O2S2
    bis(4-methylphenyl) N,N'-dihydroxypentanediimidothioate