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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-piperidin-1-ylpyridine-3,5-dicarbonitrile 1030619-36-3 C22H19ClN6S2
    2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-piperidin-1-ylpyridine-3,5-dicarbonitrile
    —— 2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-(methylthio)pyridine-3,5-di-carbonitrile 1030619-76-1 C18H12ClN5S3
    2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-(methylthio)pyridine-3,5-di-carbonitrile
    —— 5-(2'-Methoxy-ethylthio)-1,3,4-thiadiazol-2(3H)-on 37158-71-7 C5H8N2O2S2
    5-(2'-Methoxy-ethylthio)-1,3,4-thiadiazol-2(3H)-on
    —— 5-allylamino-3-methylthio-1,2,4-triazole 88722-67-2 C6H10N4S
    5-allylamino-3-methylthio-1,2,4-triazole
    —— 1-allyl-5-amino-3-methylthio-1,2,4-triazole 84827-80-5 C6H10N4S
    1-allyl-5-amino-3-methylthio-1,2,4-triazole
    —— Diphenyl-[[1-(phenylsulfanylmethyl)triazol-4-yl]methyl]phosphane 1046818-17-0 C22H20N3PS
    Diphenyl-[[1-(phenylsulfanylmethyl)triazol-4-yl]methyl]phosphane
    —— N-[(2-phenylthio)phenyl]-1-piperazinylcarboxamide 837383-82-1 C17H19N3OS
    N-[(2-phenylthio)phenyl]-1-piperazinylcarboxamide
    —— 4-(3-Cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl)-3-oxo-butyric acid isopropyl ester 445390-62-5 C16H18N2O3S
    4-(3-Cyano-6,7-dihydro-5H-[1]pyrindin-2-ylsulfanyl)-3-oxo-butyric acid isopropyl ester
    —— 2-(1-methyl-1H-tetrazol-5-ylthio)-N-benzylacetamide 140406-24-2 C11H13N5OS
    2-(1-methyl-1H-tetrazol-5-ylthio)-N-benzylacetamide
    —— 2-[(3-cyano-4-methyl-6-oxo-1H-pyridin-2-yl)sulfanyl]acetamide 134616-75-4 C9H9N3O2S
    2-[(3-cyano-4-methyl-6-oxo-1H-pyridin-2-yl)sulfanyl]acetamide
    —— (3-cyano-6-methyl-2-pyridylthio)acetic acid 309279-80-9 C9H8N2O2S
    (3-cyano-6-methyl-2-pyridylthio)acetic acid
    —— (E,Z)-methyl 3,3-dimethyl-2-phenylthiocyclopropanecarboxylate 83461-08-9 C13H16O2S
    (E,Z)-methyl 3,3-dimethyl-2-phenylthiocyclopropanecarboxylate
    —— (Z)-methyl 3,3-dimethyl-2-phenylthiocyclopropanecarboxylate 83461-08-9 C13H16O2S
    (Z)-methyl 3,3-dimethyl-2-phenylthiocyclopropanecarboxylate
    —— 3-(2-furyl)-6-phenyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadizine 183536-45-0 C14H10N4OS
    3-(2-furyl)-6-phenyl-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadizine
    —— [3-(2-carbamoyl-phenylsulfanyl)-1-(3,5-difluoro-benzyl)-1H-indol-6-yl]-methyl-carbamic acid tert-butyl ester 868673-31-8 C28H27F2N3O3S
    [3-(2-carbamoyl-phenylsulfanyl)-1-(3,5-difluoro-benzyl)-1H-indol-6-yl]-methyl-carbamic acid tert-butyl ester
    —— bis-[4-(2-chloro-acetylamino)-phenyl]-sulfane 66603-24-5 C16H14Cl2N2O2S
    bis-[4-(2-chloro-acetylamino)-phenyl]-sulfane
    —— (3,5-Dimethyl-4-pyrazolyl)-4,6-dimethyl-2-pyrimidinyl sulfide 90331-22-9 C11H14N4S
    (3,5-Dimethyl-4-pyrazolyl)-4,6-dimethyl-2-pyrimidinyl sulfide
    —— 5-Methyl-[1,3]dithiolo[4,5-d][1,3]dithiol-2-one 250788-53-5 C5H4OS4
    5-Methyl-[1,3]dithiolo[4,5-d][1,3]dithiol-2-one
    —— 4,5-[(1,3-dithian-2-yl)methylenedithio]-1,3-dithiol-2-one 240129-90-2 C8H8OS6
    4,5-[(1,3-dithian-2-yl)methylenedithio]-1,3-dithiol-2-one
    —— t-butyl 3-(3-allyloxy-3-oxopropyl)-4-methyl-5-({4-methyl-5-oxo-3-[2-(p-tolylthio)ethyl]-1H-pyrrol-2(5H)-ylidene}methyl)-1H-pyrrole-2-carboxylate 242127-03-3 C31H38N2O5S
    t-butyl 3-(3-allyloxy-3-oxopropyl)-4-methyl-5-({4-methyl-5-oxo-3-[2-(p-tolylthio)ethyl]-1H-pyrrol-2(5H)-ylidene}methyl)-1H-pyrrole-2-carboxylate
    —— (3-(benzyloxy)allyl)(phenyl)sulfane 86367-87-5 C16H16OS
    (3-(benzyloxy)allyl)(phenyl)sulfane
    —— 2-(5-Pyridin-3-yl-[1,3,4]oxadiazol-2-ylsulfanyl)-acetamide 332358-16-4 C9H8N4O2S
    2-(5-Pyridin-3-yl-[1,3,4]oxadiazol-2-ylsulfanyl)-acetamide
    —— Hept-5-yne-1-thiol 77213-94-6 C7H12S
    Hept-5-yne-1-thiol
    —— 2,8-dimethyl-2<i>H</i>,8<i>H</i>-[1,4]dithiino[2,3-<i>d</i>;5,6-<i>d</i>']dipyridazine-1,9-dione 25819-01-6 C10H8N4O2S2
    2,8-dimethyl-2<i>H</i>,8<i>H</i>-[1,4]dithiino[2,3-<i>d</i>;5,6-<i>d</i>']dipyridazine-1,9-dione
    —— (4''S,5''R)-methyl N-<2-(2'',2''-dimethyl-5''-vinyl-<1'',3''>dioxolan-4''-ylmethyl)-<1,3>dithian-2-ylmethyl>carbamate 139540-32-2 C15H25NO4S2
    (4''S,5''R)-methyl N-<2-(2'',2''-dimethyl-5''-vinyl-<1'',3''>dioxolan-4''-ylmethyl)-<1,3>dithian-2-ylmethyl>carbamate
    —— 2-[2-(2-isopropoxyethylamino)benzylthio]imidazole 134017-57-5 C15H21N3OS
    2-[2-(2-isopropoxyethylamino)benzylthio]imidazole
    —— N,N-di(butyl)-N'-pivaloylthiourea 446310-85-6 C14H28N2OS
    N,N-di(butyl)-N'-pivaloylthiourea
    —— 2,6-Me2C6H3NHC6H4CH=NPh-2-SPh 1382241-20-4 C27H24N2S
    2,6-Me2C6H3NHC6H4CH=NPh-2-SPh
    —— (R)-1-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-[1,3]dithian-2-yl}-4-hydroxy-5-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-pentan-2-one 169899-65-4 C35H52O5S2Si
    (R)-1-{2-[2-(tert-Butyl-diphenyl-silanyloxy)-1,1-dimethyl-ethyl]-[1,3]dithian-2-yl}-4-hydroxy-5-((4R,5R)-2,2,5-trimethyl-[1,3]dioxolan-4-yl)-pentan-2-one
    —— 2-methylsulfanyl-6-(6-morpholin-4-yl-pyridin-2-yl)-pyrimidin-4-ylamine 1061750-23-9 C14H17N5OS
    2-methylsulfanyl-6-(6-morpholin-4-yl-pyridin-2-yl)-pyrimidin-4-ylamine
    —— 2,6-i-Pr2C6H3NHC6H4CH=NPh-2-SPh 1382241-23-7 C31H32N2S
    2,6-i-Pr2C6H3NHC6H4CH=NPh-2-SPh
    —— PhNHC6H4CH=NPh-2-SPh 1382241-17-9 C25H20N2S
    PhNHC6H4CH=NPh-2-SPh
    —— 2-(4-Pyridyl)-ethyl-4-fluorphenyl-sulfid 62237-51-8 C13H12FNS
    2-(4-Pyridyl)-ethyl-4-fluorphenyl-sulfid
    —— tert-butyl 4-(2-((4-nitrophenyl)thio)benzoyl)piperazine-1-carboxylate 1391741-37-9 C22H25N3O5S
    tert-butyl 4-(2-((4-nitrophenyl)thio)benzoyl)piperazine-1-carboxylate
    —— 2-(3,4,5-trimethoxyphenylthio)benzoxazole 1569303-96-3 C16H15NO4S
    2-(3,4,5-trimethoxyphenylthio)benzoxazole
    —— [(5-Benzyl-4-ethyl-4h-1,2,4-triazol-3-yl)sulfanyl]acetic acid 305337-14-8 C13H15N3O2S
    [(5-Benzyl-4-ethyl-4h-1,2,4-triazol-3-yl)sulfanyl]acetic acid
    —— methyl 7-oxo-6-phenylthio-octanoate 98711-86-5 C15H20O3S
    methyl 7-oxo-6-phenylthio-octanoate
    —— 3,3-bis(phenylsulfenyl)bicyclo<4.3.0>-1(6)-nonen-2-one 107053-86-1 C21H20OS2
    3,3-bis(phenylsulfenyl)bicyclo<4.3.0>-1(6)-nonen-2-one
    —— 5-(4,6-dichloro-2-methylsulfanylpyrimidin-5-yl)dipyrromethane 1217353-51-9 C14H12Cl2N4S
    5-(4,6-dichloro-2-methylsulfanylpyrimidin-5-yl)dipyrromethane
    —— 1-methylsulfonyl-cyclohexene 59059-68-6 C7H12O2S
    1-methylsulfonyl-cyclohexene
    —— 5-acetyl-4-methylsulfanyl-6-morpholino-2-phenylpyrimidine 339584-48-4 C17H19N3O2S
    5-acetyl-4-methylsulfanyl-6-morpholino-2-phenylpyrimidine
    —— (5-p-Tolyl-[1,3,4]oxadiazol-2-ylsulfanyl)-acetic acid isopropyl ester 5807-40-9 C14H16N2O3S
    (5-p-Tolyl-[1,3,4]oxadiazol-2-ylsulfanyl)-acetic acid isopropyl ester
    —— 6-[2-(1,3-dioxolan-2-yl)ethyl]-2,2-bisphenylthiocyclohexanone 258514-09-9 C23H26O3S2
    6-[2-(1,3-dioxolan-2-yl)ethyl]-2,2-bisphenylthiocyclohexanone
    —— 6-[2-(1,3-dioxolan-2-yl)ethyl]-2-phenylthio-2-cyclohexen-1-one 258514-11-3 C17H20O3S
    6-[2-(1,3-dioxolan-2-yl)ethyl]-2-phenylthio-2-cyclohexen-1-one
    —— ((E)-3-Methyl-buta-1,3-dienylsulfanyl)-benzene 53097-26-0 C11H12S
    ((E)-3-Methyl-buta-1,3-dienylsulfanyl)-benzene
    —— 5-hydroxy-2-methyl-4,4-bisphenylthiohept-1-ene 98793-20-5 C20H24OS2
    5-hydroxy-2-methyl-4,4-bisphenylthiohept-1-ene
    —— (4H-[1,2,4]Triazol-3-ylsulfanyl)-acetic acid ethyl ester 307545-28-4 C6H9N3O2S
    (4H-[1,2,4]Triazol-3-ylsulfanyl)-acetic acid ethyl ester
    —— 3-methyl-3-(phenylsulfenyl)-bicyclo<4.3.0>-1(6)-nonen-2-one 107053-83-8 C16H18OS
    3-methyl-3-(phenylsulfenyl)-bicyclo<4.3.0>-1(6)-nonen-2-one
    —— 3-(phenylsulfenyl)-bicyclo<4.3.0>-1(6)-nonen-2-one 107053-82-7 C15H16OS
    3-(phenylsulfenyl)-bicyclo<4.3.0>-1(6)-nonen-2-one
    —— 7-(phenylsulfenyl)-1-methylbicyclo<4.3.0>-6(7)-nonen-2-one 107053-85-0 C16H18OS
    7-(phenylsulfenyl)-1-methylbicyclo<4.3.0>-6(7)-nonen-2-one