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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[[2-[(2,6-Dichlorophenyl)thio]phenyl]methyl]-1-pyrrolidineethanamine 415718-61-5 C19H22Cl2N2S
    N-[[2-[(2,6-Dichlorophenyl)thio]phenyl]methyl]-1-pyrrolidineethanamine
    —— ethoxycarbonyl-thiocarbonimidic acid dimethyl ester 51291-78-2 C6H11NO3S
    ethoxycarbonyl-thiocarbonimidic acid dimethyl ester
    —— 3-(2-Iodoethanesulfonyl)propanamide 185564-46-9 C5H10INO3S
    3-(2-Iodoethanesulfonyl)propanamide
    —— 4-(methylthio)trifluoroacetophenone oxime 253585-96-5 C9H8F3NOS
    4-(methylthio)trifluoroacetophenone oxime
    —— 1-Propanol, 3-[(4-methyl-2-pyrimidinyl)thio]-2-(propylamino)- 1339928-26-5 C11H19N3OS
    1-Propanol, 3-[(4-methyl-2-pyrimidinyl)thio]-2-(propylamino)-
    —— tert-butyl N-[(2S)-1-(4-fluorophenyl)sulfanylpentan-2-yl]carbamate 377083-59-5 C16H24FNO2S
    tert-butyl N-[(2S)-1-(4-fluorophenyl)sulfanylpentan-2-yl]carbamate
    —— 1-Amino-2-methyl-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]pentan-2-ol 1343209-78-8 C9H17N3OS2
    1-Amino-2-methyl-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]pentan-2-ol
    —— 2-Phenylmercapto-2-amino-2-methyl-propanol, 2-Phenylmercaptomethyl-2-amino-propanol 2015-12-5 C10H15NOS
    2-Phenylmercapto-2-amino-2-methyl-propanol, 2-Phenylmercaptomethyl-2-amino-propanol
    —— 1-Benzenesulfonyl-5-phenylsulfanyl-3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine 923583-59-9 C22H16N4O2S2
    1-Benzenesulfonyl-5-phenylsulfanyl-3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine
    —— [6-fluoro-3-(2-fluoro-4-methanesulfonyl-phenylsulfanyl)-2-methyl-indolizin-1-yl]acetic acid 1034653-59-2 C18H15F2NO4S2
    [6-fluoro-3-(2-fluoro-4-methanesulfonyl-phenylsulfanyl)-2-methyl-indolizin-1-yl]acetic acid
    —— N-(2-[(2,3-difluorobenzyl)thio]-6-{[(1S,2S)-2,3-dihydroxy-1-methylpropyl]amino}pyrimidin-4-yl)azetidine-1-sulfonamide 1204707-74-3 C18H23F2N5O4S2
    N-(2-[(2,3-difluorobenzyl)thio]-6-{[(1S,2S)-2,3-dihydroxy-1-methylpropyl]amino}pyrimidin-4-yl)azetidine-1-sulfonamide
    —— N-(2-[(2,3-difluorobenzyl)thio]-6-{[(1R,2S)-2,3-dihydroxy-1-methylpropyl]amino}pyrimidin-4-yl)azetidine-1-sulfonamide 1204707-72-1 C18H23F2N5O4S2
    N-(2-[(2,3-difluorobenzyl)thio]-6-{[(1R,2S)-2,3-dihydroxy-1-methylpropyl]amino}pyrimidin-4-yl)azetidine-1-sulfonamide
    —— 6-(methylsulfonyl)-hex-1-yne 79797-12-9 C7H12O2S
    6-(methylsulfonyl)-hex-1-yne
    —— 3-fluoro-4-(2-(thieno[3,2-c]pyridin-4-ylamino)thiazol-5-ylthio)picolinic acid 1034922-57-0 C16H9FN4O2S3
    3-fluoro-4-(2-(thieno[3,2-c]pyridin-4-ylamino)thiazol-5-ylthio)picolinic acid
    —— tert-butyl (6-(5-(3-fluoro-2-(2-hydroxy-2-phenylpentylcarbamoyl)pyridin-4-ylthio)thiazol-2-ylamino)pyridin-3-yl)methyl(methyl)carbamate 1034922-54-7 C32H37FN6O4S2
    tert-butyl (6-(5-(3-fluoro-2-(2-hydroxy-2-phenylpentylcarbamoyl)pyridin-4-ylthio)thiazol-2-ylamino)pyridin-3-yl)methyl(methyl)carbamate
    —— 4-(2-(5-((tert-butoxycarbonylamino)methyl)pyridin-2-ylamino)thiazol-5-ylthio)-3-fluoropicolinic acid 1034922-20-7 C20H20FN5O4S2
    4-(2-(5-((tert-butoxycarbonylamino)methyl)pyridin-2-ylamino)thiazol-5-ylthio)-3-fluoropicolinic acid
    —— (S)-3-fluoro-N-(2-hydroxy-2-phenylpentyl)-4-(2-(thieno[3,2-c]pyridin-4-ylamino)thiazol-5-ylthio)picolinamide 1034922-55-8 C27H24FN5O2S3
    (S)-3-fluoro-N-(2-hydroxy-2-phenylpentyl)-4-(2-(thieno[3,2-c]pyridin-4-ylamino)thiazol-5-ylthio)picolinamide
    —— 4-(2-(5-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)pyridin-2-ylamino)thiazol-5-ylthio)-3-fluoropicolinic acid 1034922-48-9 C24H27FN6O4S2
    4-(2-(5-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)pyridin-2-ylamino)thiazol-5-ylthio)-3-fluoropicolinic acid
    —— methyl 4-(2-(5-aminopyridin-2-ylamino)thiazol-5-ylthio)-3-fluoropicolinate 1034922-46-7 C15H12FN5O2S2
    methyl 4-(2-(5-aminopyridin-2-ylamino)thiazol-5-ylthio)-3-fluoropicolinate
    —— methyl 4-(2-(5-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)pyridin-2-ylamino)thiazol-5-ylthio)-3-fluoropicolinate 1034922-47-8 C25H29FN6O4S2
    methyl 4-(2-(5-(1-(tert-butoxycarbonyl)piperidin-4-ylamino)pyridin-2-ylamino)thiazol-5-ylthio)-3-fluoropicolinate
    —— 3-fluoro-4-(2-(5-(methoxymethyl)pyridin-2-ylamino)thiazol-5-ylthio)picolinic acid 1034922-30-9 C16H13FN4O3S2
    3-fluoro-4-(2-(5-(methoxymethyl)pyridin-2-ylamino)thiazol-5-ylthio)picolinic acid
    —— 4-(2-(4-(hydroxymethyl)pyridin-2-ylamino)thiazol-5-ylthio)-N-(2-phenylcyclopropyl)picolinamide 1034922-04-7 C24H21N5O2S2
    4-(2-(4-(hydroxymethyl)pyridin-2-ylamino)thiazol-5-ylthio)-N-(2-phenylcyclopropyl)picolinamide
    —— 4-(2-(4-(hydroxymethyl)pyridin-2-ylamino)thiazol-5-ylthio)picolinic acid 1034922-06-9 C15H12N4O3S2
    4-(2-(4-(hydroxymethyl)pyridin-2-ylamino)thiazol-5-ylthio)picolinic acid
    —— 4-[(2,3-Dicyanophenyl)sulfanyl]-N,N-bis(2-ethoxyethyl)benzamide 879098-02-9 C23H25N3O3S
    4-[(2,3-Dicyanophenyl)sulfanyl]-N,N-bis(2-ethoxyethyl)benzamide
    —— tert-butyl 4-(6-(5-(3-fluoro-2-(2-hydroxy-2-phenylpentylcarbamoyl)pyridin-4-ylthio)thiazol-2-ylamino)pyridin-3-ylamino)piperidine-1-carboxylate 1034922-49-0 C35H42FN7O4S2
    tert-butyl 4-(6-(5-(3-fluoro-2-(2-hydroxy-2-phenylpentylcarbamoyl)pyridin-4-ylthio)thiazol-2-ylamino)pyridin-3-ylamino)piperidine-1-carboxylate
    —— {3-[3-(2-amino-6-chloropyrimidin-4-ylsulfanyl)propionylamino]propyl} carbamic acid tert-butyl ester 1052647-68-3 C15H24ClN5O3S
    {3-[3-(2-amino-6-chloropyrimidin-4-ylsulfanyl)propionylamino]propyl} carbamic acid tert-butyl ester
    —— 2-Methyl-3-(octane-1-sulfonyl)propanoic acid 141516-28-1 C12H24O4S
    2-Methyl-3-(octane-1-sulfonyl)propanoic acid
    —— 4-(2-bromoethyl)-2-fluoro-1-methylsulfanylbenzene 919360-43-3 C9H10BrFS
    4-(2-bromoethyl)-2-fluoro-1-methylsulfanylbenzene
    —— 1-Butanol, 3-(ethylamino)-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]- 1339077-98-3 C9H17N3OS2
    1-Butanol, 3-(ethylamino)-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-
    —— 2-[4-(1-Ethyl-2,5-dioxopyrrolidin-3-yl)sulfanylphenyl]acetic acid 1336858-35-5 C14H15NO4S
    2-[4-(1-Ethyl-2,5-dioxopyrrolidin-3-yl)sulfanylphenyl]acetic acid
    —— 2-cyclopropylmethanesulfonyl-2-methyl-propionic acid 1218915-27-5 C8H14O4S
    2-cyclopropylmethanesulfonyl-2-methyl-propionic acid
    —— 2-methyl-2-(3,3,3-trifluoro-propane-1-sulfonyl)-propionic acid ethyl ester 1218916-06-3 C9H15F3O4S
    2-methyl-2-(3,3,3-trifluoro-propane-1-sulfonyl)-propionic acid ethyl ester
    —— 2-methyl-2-(3,3,3-trifluoro-propane-1-sulfonyl)-propionic acid 1218916-07-4 C7H11F3O4S
    2-methyl-2-(3,3,3-trifluoro-propane-1-sulfonyl)-propionic acid
    —— 3-amino-1-(3-(cyclohexylmethylthio)phenyl)-1-deuteropropan-1-ol 1215075-51-6 C16H25NOS
    3-amino-1-(3-(cyclohexylmethylthio)phenyl)-1-deuteropropan-1-ol
    —— ethyl (E)-3-[4-(4-chloroanilino)-2-methylsulfanylpyrimidin-5-yl]prop-2-enoate 1222315-85-6 C16H16ClN3O2S
    ethyl (E)-3-[4-(4-chloroanilino)-2-methylsulfanylpyrimidin-5-yl]prop-2-enoate
    —— 3-Pentylsulfanyl-propylamine 53056-88-5 C8H19NS
    3-Pentylsulfanyl-propylamine
    —— N-(5-bromopyridin-2-yl)-5-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-1,3-thiazol-2-amine 874476-83-2 C14H12BrN5S2
    N-(5-bromopyridin-2-yl)-5-(6-methyl-2-methylsulfanylpyrimidin-4-yl)-1,3-thiazol-2-amine
    —— N-(5-cyclopropyl-1H-pyrazol-3-yl)-7-(4-(5-ethyl-1,3,4-oxadiazol-2-yl)phenylthio)imidazo[1,2-f]pyrimidin-5-amine 883736-05-8 C22H20N8OS
    N-(5-cyclopropyl-1H-pyrazol-3-yl)-7-(4-(5-ethyl-1,3,4-oxadiazol-2-yl)phenylthio)imidazo[1,2-f]pyrimidin-5-amine
    —— 3-(4-(trifluoromethyl)phenylthio)phenylmethanol 1011531-74-0 C14H11F3OS
    3-(4-(trifluoromethyl)phenylthio)phenylmethanol
    —— (R)-4-phenylsulfanylmethyl-4,5-dihydrooxazol-2-ylamine 1043494-15-0 C10H12N2OS
    (R)-4-phenylsulfanylmethyl-4,5-dihydrooxazol-2-ylamine
    —— 1-(5-chloro-1,3-thiazol-2-yl)-5-[5-(methylsulfanyl)pyridin-2-yl]-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione 1080061-39-7 C20H23ClN2O3S2
    1-(5-chloro-1,3-thiazol-2-yl)-5-[5-(methylsulfanyl)pyridin-2-yl]-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione
    —— 1-[5-(1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)pyridin-2-yl]-6-cyclopentyl-5-[5-(methylsulfanyl)pyridin-2-yl]hexane-1,4-dione 1080061-44-4 C30H44N2O3SSi
    1-[5-(1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)pyridin-2-yl]-6-cyclopentyl-5-[5-(methylsulfanyl)pyridin-2-yl]hexane-1,4-dione
    —— 1-[5-(1,2-dihydroxy-2-methylpropyl)pyridin-2-yl]-5-[5-(methylsulfanyl)pyridin-2-yl]-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione 1080060-85-0 C26H34N2O5S
    1-[5-(1,2-dihydroxy-2-methylpropyl)pyridin-2-yl]-5-[5-(methylsulfanyl)pyridin-2-yl]-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione
    —— 1-[5-(1,2-bis{[tert-butyl(dimethyl)silyl]oxy}ethyl)pyridin-2-yl]-6-cyclopentyl-5-[5-(methylsulfanyl)pyridin-2-yl]hexane-1,4-dione 1080061-48-8 C36H58N2O4SSi2
    1-[5-(1,2-bis{[tert-butyl(dimethyl)silyl]oxy}ethyl)pyridin-2-yl]-6-cyclopentyl-5-[5-(methylsulfanyl)pyridin-2-yl]hexane-1,4-dione
    —— 1-[5-(1-hydroxy-2-methoxyethyl)-1,3-thiazol-2-yl]-5-[5-(methylsulfanyl)pyridin-2-yl]-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione 1080061-37-5 C23H30N2O5S2
    1-[5-(1-hydroxy-2-methoxyethyl)-1,3-thiazol-2-yl]-5-[5-(methylsulfanyl)pyridin-2-yl]-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione
    —— [3-chloro-4-(methylsulfanyl)phenyl](morpholin-4-yl)acetonitrile 1080060-48-5 C13H15ClN2OS
    [3-chloro-4-(methylsulfanyl)phenyl](morpholin-4-yl)acetonitrile
    —— 1-[5-(1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)pyridin-2-yl]-5-[5-(methylsulfanyl)pyridin-2-yl]-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione 1080061-41-1 C30H44N2O4SSi
    1-[5-(1-{[tert-butyl(dimethyl)silyl]oxy}ethyl)pyridin-2-yl]-5-[5-(methylsulfanyl)pyridin-2-yl]-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione
    —— 5-methyl-5-[5-(methylsulfanyl)pyridin-2-yl]-1-(pyridin-2-yl)-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione 1080061-36-4 C23H28N2O3S
    5-methyl-5-[5-(methylsulfanyl)pyridin-2-yl]-1-(pyridin-2-yl)-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione
    —— 2-(methylsulfanyl)-5-[1-(5-(pyridin-2-yl)-1H-pyrrol-2-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl]pyridine 1080062-83-4 C22H25N3OS
    2-(methylsulfanyl)-5-[1-(5-(pyridin-2-yl)-1H-pyrrol-2-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl]pyridine
    —— 5-[3-fluoro-4-(methylsulfanyl)phenyl]-1-(pyridin-2-yl)-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione 1080061-15-9 C23H26FNO3S
    5-[3-fluoro-4-(methylsulfanyl)phenyl]-1-(pyridin-2-yl)-6-(tetrahydro-2H-pyran-4-yl)hexane-1,4-dione