硫甲磺酸钠 - CAS号 1950-85-2

物化性质

熔点：

265 °C (dec.)
溶解度：

DMSO（少许）、甲醇（少许）、水（少许）
稳定性/保质期：

Moisture Sensitive: Desiccate

计算性质

辛醇/水分配系数(LogP)：

-3.5
重原子数：

6
可旋转键数：

0
环数：

0.0
sp3杂化的碳原子比例：

1.0
拓扑面积：

43.5
氢给体数：

0
氢受体数：

3

安全信息

危险品标志：

Xi
安全说明：

S26
危险类别码：

R36/37/38
WGK Germany：

3
海关编码：

2930909090
危险标志：

GHS07
危险性描述：

H315,H319,H335
危险性防范说明：

P261,P305 + P351 + P338
储存条件：

Refrigerator

SDS

SDS：a08500238930cf81ecc6d95f23a63fcf

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Section 1. IDENTIFICATION OF THE SUBSTANCE/MIXTURE
Product identifiers
Product name : Sodium methanethiosulfonate
CAS-No. : 1950-85-2

Section 2. HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Skin irritation (Category 2)
Eye irritation (Category 2)
Specific target organ toxicity - single exposure (Category 3)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
Irritating to eyes, respiratory system and skin.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word Warning
Hazard statement(s)
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary statement(s)
Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove
contact lenses, if present and easy to do. Continue rinsing.
Supplemental Hazard none
Statements
Safety data sheet available on request.
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R36/37/38 Irritating to eyes, respiratory system and skin.
S-phrase(s)
S26 In case of contact with eyes, rinse immediately with plenty of water and
seek medical advice.
Other hazards - none

Section 3. COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Synonyms : Sodium methylthiosulfonate
Methanesulfonothioic acid sodium salt
Formula : CH3O2S2Na
Molecular Weight : 134,15 g/mol
Component Concentration
Sodium methanethiosulfonate
CAS-No. 1950-85-2 -
EC-No. 217-770-0

Section 4. FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Indication of any immediate medical attention and special treatment needed
no data available

Section 5. FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, Sulphur oxides, Sodium oxides
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available

Section 6. ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure
adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.

Section 7. HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
hygroscopic Store under nitrogen.
Specific end uses
no data available

Section 8. EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and
at the end of workday.
Personal protective equipment
Eye/face protection
Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested
and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
impervious clothing, The type of protective equipment must be selected according to the
concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher
level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges.
Use respirators and components tested and approved under appropriate government standards
such as NIOSH (US) or CEN (EU).

Section 9. PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a) Appearance Form: crystalline
Colour: white
b) Odour no data available
c) Odour Threshold no data available
d) pH no data available
e) Melting point/freezing Melting point/range: 265 °C - dec.
point
f) Initial boiling point and no data available
boiling range
g) Flash point no data available
h) Evaporation rate no data available
i) Flammability (solid, gas) no data available
j) Upper/lower no data available
flammability or
explosive limits
k) Vapour pressure no data available
l) Vapour density no data available
m) Relative density no data available
n) Water solubility no data available
o) Partition coefficient: n- no data available
octanol/water
p) Autoignition no data available
temperature
q) Decomposition no data available
temperature
r) Viscosity no data available
s) Explosive properties no data available
t) Oxidizing properties no data available
Other safety information
no data available

Section 10. STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available

Section 11. TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
no data available
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
no data available
Germ cell mutagenicity
no data available
Carcinogenicity
IARC: No component of this product present at levels greater than or equal to 0.1% is identified as
probable, possible or confirmed human carcinogen by IARC.
Reproductive toxicity
no data available
Specific target organ toxicity - single exposure
Inhalation - May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation May be harmful if inhaled. Causes respiratory tract irritation.
Ingestion May be harmful if swallowed.
Skin May be harmful if absorbed through skin. Causes skin irritation.
Eyes Causes serious eye irritation.
Signs and Symptoms of Exposure
To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: Not available

Section 12. ECOLOGICAL INFORMATION
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available

Section 13. DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.

Section 14. TRANSPORT INFORMATION
UN number
ADR/RID: - IMDG: - IATA: -
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
Packaging group
ADR/RID: - IMDG: - IATA: -
Environmental hazards
ADR/RID: no IMDG Marine pollutant: no IATA: no
Special precautions for user
no data available

Section 15. REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment

SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

作为反应物：

描述：

硫甲磺酸钠以 N,N-二甲基甲酰胺为溶剂，生成

参考文献：

名称：

A New 1′-Methylenedisulfide Deoxyribose that Forms an Efficient Cross-Link to DNA Cytosine-5 Methyltransferase (DNMT)

摘要：

A newly designed 1'-methylenedisulfide deoxyribose probe can efficiently cross-link to DNA cytosine-5-methyltransferases (DNMTs) through the active Cys residue, which provides a new toot to covalently trap DNMT-DNA complexes.

DOI：

10.1021/ja8064304
作为产物：

描述：

methanesulfonic acid sodium salt 在硫化氢作用下，以甲醇为溶剂，生成硫甲磺酸钠

参考文献：

名称：

Coating Surfaces

摘要：

公开了一种间接地将特定结合对（或sbp）的成员附着到表面的方法，该方法包括以下步骤：（a）将表面与具有侧链的聚合物的溶液接触，该侧链符合以下公式X-Y-Z-R，其中X是一个空间群；Y是硫、硒或碲原子；Z是硫、硒或碲原子，其中任何一个可能与一个或两个氧原子结合；其中R是任何适当的基团，使得-Z-R构成一个脱离基团；使得至少一些-Z-R基团被取代，聚合物通过X-Y基团结合到表面；和（b）将步骤（a）得到的涂有聚合物的表面与包含sbp成员的溶液接触，从而使聚合物与sbp成员发生反应，将sbp成员间接地附着到表面。

公开号：

US20090275721A1
作为试剂：

描述：

2,3,4,6-四乙酰氧基-alpha-D-吡喃糖溴化物在硫甲磺酸钠作用下，以 N,N-二甲基甲酰胺为溶剂，以59%的产率得到1,3,4,6-四-o-乙酰基-alpha-d-吡喃半乳糖

参考文献：

名称：

WO2006/55437

摘要：

公开号：

点击查看最新优质反应信息

文献信息

Palladium- and/or Copper-Catalyzed Cross-Coupling Reactions of Paramagnetic Vinyl Bromides and Iodides

作者：Tamás Kálai、Györgyi Úr、Gergely Fekete、József Jekő、Kálmán Hideg

DOI：10.1055/s-0036-1589034

日期：2017.8

3-substituted-4-iodo-(2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-1-yl)oxidanyl compounds is synthesized to achieve NH2- and SH-specific spin labels. The new vinyl iodides are tested in Sonogashira and Buchwald–Hartwig cross-coupling reactions to produce a paramagnetic β-amino acid ester, pyrroline nitroxide-condensed heterocycles, including a paramagnetic α,α′-dipyridyl ligand and a spin-labeled sulfonamide

献给TamásPatonay教授的纪念抽象的合成了一系列新的3-取代的-4-碘-（2,2,5,5-四甲基-2,5-二氢-1 H-吡咯-1-基）氧烷基化合物，从而获得NH 2-和SH-特定的旋转标签。新的乙烯基碘化物在Sonogashira和Buchwald-Hartwig的交叉偶联反应中进行了测试，以产生顺磁性β-氨基酸酯，吡咯啉一氧化氮缩合的杂环，包括顺磁性α，α'-联吡啶基配体和自旋标记的磺酰胺。合成了一系列新的3-取代的-4-碘-（2,2,5,5-四甲基-2,5-二氢-1 H-吡咯-1-基）氧烷基化合物，从而获得NH 2-和SH-特定的旋转标签。新的乙烯基碘化物在Sonogashira和Buchwald-Hartwig的交叉偶联反应中进行了测试，以产生顺磁性β-氨基酸酯，吡咯啉一氧化氮缩合的杂环，包括顺磁性α，α'-联吡啶基配体和自旋标记的磺酰胺。
Photochemical Nucleophile Mapping: Identification of Tyr311 Within the Catalytic Domain of Rabbit Muscle Glyceraldehyde‐3‐phosphate Dehydrogenase<sup>†</sup>

作者：Yasumaru Hatanaka、Masaki Kaneda、Takenori Tomohiro

DOI：10.1562/2006-02-28-ra-824

日期：2007.1

Abstract
Photochemical mapping of nucleophiles in close proximity to the active site Cys149 of rabbit glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) was demonstrated based on the nucleophilic aromatic photosubstitution reaction using two regioisomers of alkoxy‐fluoro‐nitro‐substituted benzenes. Two photophores were covalently attached to the active site SH group of GAPDH and the protein was subjected to photolysis then to the cyanogen bromide cleavage reaction. The advantage of this method is the capability to chase labeled products by monitoring absorption at 380 nm because of the chromogenic property of photophore. HPLC separation identified a large labeled peptide fragment that was further digested by V8 protease for Edman sequence analysis. From the recent X‐ray crystallography of rabbit GAPDH, Tyr311, His176, Ser238 and Lys183 are closely located to catalytic Cys149. Among these nucleophiles, Tyr311 was preferentially labeled with 2‐fluoro‐4‐nitrophenoxy photophore and no label was identified with the isomeric 4‐fluoro‐2‐nitrophenoxy photophore. The result clearly reflects the distance between Cys149 and nucleophiles to distinguish the nearest Tyr311. As photophores show great reactivity even with water under neutral conditions, the distance between nucleophiles and photophores is important for photo‐induced nucleophilic aromatic substitution. The method will provide a useful technique to survey nucleophiles within the catalytic domain.

摘要利用烷氧基-氟-硝基取代苯的两个区域异构体进行亲核芳香族光取代反应，证明了靠近兔甘油醛-3-磷酸脱氢酶（GAPDH）活性位点 Cys149 的亲核物的光化学图谱。两个光敏剂共价连接到 GAPDH 的活性位点 SH 基团上，然后对蛋白质进行光解，再进行溴化氰裂解反应。这种方法的优点是，由于光团具有发色性，可以通过监测 380 纳米波长的吸收来追寻标记产物。高效液相色谱分离确定了一个大的标记肽片段，该片段被 V8 蛋白酶进一步消化，用于 Edman 序列分析。根据最近对兔 GAPDH 的 X 射线晶体学研究，Tyr311、His176、Ser238 和 Lys183 与催化 Cys149 的位置非常接近。在这些亲核物中，Tyr311 优先被 2-氟-4-硝基苯氧基光致发光体标记，而同分异构的 4-氟-2-硝基苯氧基光致发光体则没有标记。这一结果清楚地反映了 Cys149 与亲核物之间的距离，以区分最近的 Tyr311。由于在中性条件下，亲光体甚至与水也有很大的反应活性，因此亲核物与亲光体之间的距离对于光诱导的亲核芳香取代非常重要。该方法将为研究催化域内的亲核物提供有用的技术。
Anti-inflammatory agents

申请人：Sulfidris S.r.l.

公开号：EP1832575A1

公开（公告）日：2007-09-12

The present invention relates to novel thiosulfonates derivatives. The present invention also provides methods for preventing, treating and/or reducing inflammation-associated diseases in the cardiovascular, connective tissue, pulmonary, gastrointestinal, respiratory, urogenital, nervous or cutaneous systems as well as infective and tumoral diseases employing said compounds.

本发明涉及新型的硫代硫酸盐衍生物。本发明还提供了使用所述化合物预防、治疗和/或减少心血管、结缔组织、肺、胃肠、呼吸、泌尿生殖、神经或皮肤系统以及感染性和肿瘤性疾病中的炎症相关疾病的方法。
[EN] ANTISENSE OLIGONUCLEOTIDES WITH IMPROVED PHARMACOKINETIC PROPERTIES<br/>[FR] OLIGONUCLÉOTIDES ANTISENS AYANT DES PROPRIÉTÉS PHARMACOCINÉTIQUES AMÉLIORÉES

申请人：UNIV VIENNA

公开号：WO2015032968A1

公开（公告）日：2015-03-12

The invention relates to an antisense or siRNA oligonucleotide or conjugate with improved pharmacokinetic properties, methods of producing the same as well as the use of such compounds and conjugates, e.g. as pharmaceutical composition, a pharmaceutical kit, a medicament or a tool in biomedical research. The conjugates of the invention have the formula I being P - (L - S - S - Y - X)n, wherein P represents a natural, artificial and/or modified oligonucleotide, L represents a linker group attached to one or more nucleosides at any position within the oligonucleotides sequence; S represents sulfur; X represents a ligand; Y represents a spacer and n is an integer ranging from 1 to the oligonucleotide length of P. The oligonucleotides of the invention have the formula II being P- (L - S - R)n, wherein P represents a natural, artificial and /or modified oligonucleotide, L represents a linker group attached to one or more nucleosides at any position within the oligonucleotides sequence, S represents sulfur, R represents either hydrogen or a thiol protecting group, preferably trityl or tertiary butyl, and n is an integer ranging from 1 to the oligonucleotide length of P. In addition, the pharmaceutical composition or pharmaceutical kit or conjugate can be used for the treatment of a disease or disorder that can be at least in part alleviated by therapy, wherein the disease or disorder is selected from the group consisting of bacterial infections, viral infections, cancer, metabolic diseases and immunological disorders and preferably cancer.

该发明涉及具有改进的药代动力学性质的反义物或siRNA寡核苷酸或结合物，以及生产这些物质的方法，以及这些化合物和结合物的用途，例如作为药物组合物、药物工具包、药物或生物医学研究中的工具。该发明的结合物具有公式I，其中P代表天然、人工和/或修饰的寡核苷酸，L代表连接基团，连接到寡核苷酸序列中的一个或多个核苷酸的任何位置；S代表硫；X代表配体；Y代表间隔物，n是一个整数，范围从1到P的寡核苷酸长度。该发明的寡核苷酸具有公式II，其中P代表天然、人工和/或修饰的寡核苷酸，L代表连接基团，连接到寡核苷酸序列中的一个或多个核苷酸的任何位置，S代表硫，R代表氢或硫醇保护基团，优选三苯甲基或叔丁基，n是一个整数，范围从1到P的寡核苷酸长度。此外，药物组合物或药物工具包或结合物可用于治疗至少部分可通过治疗缓解的疾病或紊乱，其中所述疾病或紊乱选自细菌感染、病毒感染、癌症、代谢性疾病和免疫紊乱等组成的一组，优选癌症。
Interactions of aromatic mannosyl disulfide derivatives with Concanavalin A: synthesis, thermodynamic and NMR spectroscopy studies

作者：Bandaru Narasimha Murthy、Sharmistha Sinha、Avadhesha Surolia、Narayanaswamy Jayaraman、László Szilágyi、Ildikó Szabó、Katalin E. Kövér

DOI：10.1016/j.carres.2009.06.008

日期：2009.9

alpha-D-Mannopyranosyl units were attached to an aromatic scaffold through disulfide linkages to obtain mono- to trivalent glycosylated ligands for lectin binding studies. Isothermal titration calorimetric (ITC) measurements indicated that binding affinities of these derivatives to Concanavalin A (Con A) were comparable to or slightly higher than that of methyl alpha-D-mannopyranoside (K(a) values in the range of

通过二硫键将α-D-甘露吡喃糖基单元连接到芳香族骨架上，以获得用于凝集素结合研究的单价至三价糖基化配体。等温滴定热法（ITC）测量表明，这些衍生物与伴刀豆球蛋白A（Con A）的结合亲和力与甲基α-D-甘露吡喃糖苷（K（a）值在10（4）范围内）相当或稍高。 M（-1））。凝集素-配体配合物的化学计量与相应配体的形式价（1-3）一致，表明与二价和三价衍生物相互作用时发生交联。但是，后者无法观察到多价效应。使用饱和转移差异（STD）NMR竞争实验显示，这些配体与Con A的碳水化合物结合位点结合。

硫甲磺酸钠 | 1950-85-2

物质功能分类

分子结构分类

物化性质

计算性质

安全信息

SDS

反应信息

文献信息

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