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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 4-Phenylsulfanyl-hept-6-en-2-one 87143-62-2 C13H16OS
    4-Phenylsulfanyl-hept-6-en-2-one
    —— (1,1-dibromo-2,2-dimethylpropyl)-isothiocyanate 71056-01-4 C6H9Br2NS
    (1,1-dibromo-2,2-dimethylpropyl)-isothiocyanate
    —— N'-(3-amino-5-dodecylthio-4H-1,2,4-triazol-4-yl)-3,5-dimethylpyrazol-1-carboxamidine 1303533-20-1 C20H36N8S
    N'-(3-amino-5-dodecylthio-4H-1,2,4-triazol-4-yl)-3,5-dimethylpyrazol-1-carboxamidine
    —— dodecane-1,2-dithiol 26073-84-7 C12H26S2
    dodecane-1,2-dithiol
    —— (2R,6R,7S,9R,14S)-14-<(S)-(tert-Butyldimethylsilyloxy)phenylmethyl>-15-methylene-2,9-bis(phenylthiomethyl)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane 244155-74-6 C40H52O5S2Si
    (2R,6R,7S,9R,14S)-14-<(S)-(tert-Butyldimethylsilyloxy)phenylmethyl>-15-methylene-2,9-bis(phenylthiomethyl)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecane
    —— (2R,6S,7R,9R)-2,9-Bis(phenylthiomethyl)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecan-14-one 244155-56-4 C26H30O5S2
    (2R,6S,7R,9R)-2,9-Bis(phenylthiomethyl)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecan-14-one
    —— (2R,6S,7R,9R,15S)-15-<(S)-(Hydroxy)phenylmethyl>-2,9-bis(phenylthiomethyl)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecan-14-one 244155-60-0 C33H36O6S2
    (2R,6S,7R,9R,15S)-15-<(S)-(Hydroxy)phenylmethyl>-2,9-bis(phenylthiomethyl)-1,8,13,16-tetraoxadispiro<5.0.5.4>hexadecan-14-one
    —— 7-methyl-3-phenylthiooct-6-en-4-olide 102070-50-8 C15H18O2S
    7-methyl-3-phenylthiooct-6-en-4-olide
    —— O-propan-2-yl N-propan-2-ylcarbamothioate 188257-28-5 C7H15NOS
    O-propan-2-yl N-propan-2-ylcarbamothioate
    —— 2-((3-Cyano-6-methylpyridin-2-yl)thio)-2-phenylacetic acid 329903-73-3 C15H12N2O2S
    2-((3-Cyano-6-methylpyridin-2-yl)thio)-2-phenylacetic acid
    —— 2,6-Bis(methylsulfanyl)-3-nitropyridine 225942-01-8 C7H8N2O2S2
    2,6-Bis(methylsulfanyl)-3-nitropyridine
    —— rac-(3,3,3-trifluoro-1-methyl-propylsulfanyl)-benzene 898260-08-7 C10H11F3S
    rac-(3,3,3-trifluoro-1-methyl-propylsulfanyl)-benzene
    —— Tetra(1,4-dithiacyclohexene)porphyrazine 24724-50-3 C24H18N8S8
    Tetra(1,4-dithiacyclohexene)porphyrazine
    —— 4(1H)-Pyrimidinone, 2-((1,3-dioxolan-2-ylmethyl)thio)-5-(1-methylethyl)-6-(phenylmethyl)- 199852-04-5 C18H22N2O3S
    4(1H)-Pyrimidinone, 2-((1,3-dioxolan-2-ylmethyl)thio)-5-(1-methylethyl)-6-(phenylmethyl)-
    —— 4(1H)-Pyrimidinone, 2-((1,3-dioxolan-2-ylmethyl)thio)-5-ethyl-6-(phenylmethyl)- 199851-94-0 C17H20N2O3S
    4(1H)-Pyrimidinone, 2-((1,3-dioxolan-2-ylmethyl)thio)-5-ethyl-6-(phenylmethyl)-
    —— 4(1H)-Pyrimidinone, 6-((3,5-dimethylphenyl)methyl)-2-((1,3-dioxolan-2-ylmethyl)thio)-5-ethyl- 199851-98-4 C19H24N2O3S
    4(1H)-Pyrimidinone, 6-((3,5-dimethylphenyl)methyl)-2-((1,3-dioxolan-2-ylmethyl)thio)-5-ethyl-
    —— S-methyl S-tridec-1-en-3-yl carbonodithioate 909025-54-3 C15H28OS2
    S-methyl S-tridec-1-en-3-yl carbonodithioate
    —— (2-bromophenylthiomethyl)-1,3-dioxolane 864684-51-5 C10H11BrO2S
    (2-bromophenylthiomethyl)-1,3-dioxolane
    —— 2-(2,6-dimethylphenyl)thio-5-methyl-1,3,4-oxadiazole 197371-58-7 C11H12N2OS
    2-(2,6-dimethylphenyl)thio-5-methyl-1,3,4-oxadiazole
    —— (E)-S-methyl O-tridec-2-enyl carbonodithioate 909025-53-2 C15H28OS2
    (E)-S-methyl O-tridec-2-enyl carbonodithioate
    —— 2-(2-chloro-4-nitro-phenylsulfanyl)-benzothiazole-6-carbonitrile 315228-91-2 C14H6ClN3O2S2
    2-(2-chloro-4-nitro-phenylsulfanyl)-benzothiazole-6-carbonitrile
    —— α-1-(thiophenyl)-2,3-O-isopropylidene-D-ribofuranose 153984-49-7 C14H18O4S
    α-1-(thiophenyl)-2,3-O-isopropylidene-D-ribofuranose
    —— 2-(2,4-difluorophenyl)-1-(4-(3-((5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl)thio)propyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol 1528792-80-4 C26H28BrF2N7O2S
    2-(2,4-difluorophenyl)-1-(4-(3-((5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl)thio)propyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol
    —— 2-benzylsulfanyl-5-(5-bromo-furan-2-yl)-[1,3,4]oxadiazole 959696-85-6 C13H9BrN2O2S
    2-benzylsulfanyl-5-(5-bromo-furan-2-yl)-[1,3,4]oxadiazole
    —— 4-methylsulfanyl-2-phenyl-6H-1,3-thiazin-6-one 1217055-33-8 C11H9NOS2
    4-methylsulfanyl-2-phenyl-6H-1,3-thiazin-6-one
    —— 1-[(5-Ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]propan-2-one 81555-98-8 C7H10N2O2S
    1-[(5-Ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]propan-2-one
    —— 6-Methyl-uracil-sulfonsaeure-(5)-azid —— C5H5N5O4S
    6-Methyl-uracil-sulfonsaeure-(5)-azid
    —— (Z)-3-{(phenylthio)methylene}tetrahydropyran-2-one 1231177-51-7 C12H12O2S
    (Z)-3-{(phenylthio)methylene}tetrahydropyran-2-one
    —— (E)-5-hydroxy-N-phenyl-2-(phenylthiomethylene)pentanethioamide 1231177-55-1 C18H19NOS2
    (E)-5-hydroxy-N-phenyl-2-(phenylthiomethylene)pentanethioamide
    —— 7-fluoro-9,10-dihydropyrrolo[2,1-b][1,3]benzothiazepin-9-one 256950-28-4 C12H8FNOS
    7-fluoro-9,10-dihydropyrrolo[2,1-b][1,3]benzothiazepin-9-one
    —— (+/-)-7-fluoro-9,10-dihydro-9-hydroxypyrrolo[2,1-b][1,3]benzothiazepine 256950-29-5 C12H10FNOS
    (+/-)-7-fluoro-9,10-dihydro-9-hydroxypyrrolo[2,1-b][1,3]benzothiazepine
    —— (+/-)-9-bromo-9,10-dihydro-7-fluoropyrrolo[2,1-b][1,3]benzothiazepine 256950-30-8 C12H9BrFNS
    (+/-)-9-bromo-9,10-dihydro-7-fluoropyrrolo[2,1-b][1,3]benzothiazepine
    —— Methyl 4-(3-cyano-6-methylpyridin-2-yl)sulfanyl-3-oxobutanoate 625372-26-1 C12H12N2O3S
    Methyl 4-(3-cyano-6-methylpyridin-2-yl)sulfanyl-3-oxobutanoate
    —— (E)-4-hydroxy-N-phenyl-2-(phenylthiomethylene)butanethioamide 1231177-48-2 C17H17NOS2
    (E)-4-hydroxy-N-phenyl-2-(phenylthiomethylene)butanethioamide
    —— (E)-3-(phenylthiomethylene)dihydrofuran-2(3H)-one 69993-32-4 C11H10O2S
    (E)-3-(phenylthiomethylene)dihydrofuran-2(3H)-one
    —— 3-cyano-N-1,2,4-thiadiazol-5-yl-4-{[2-(trifluoromethyl)phenyl]thio}benzenesulfonamide 1354917-34-2 C16H9F3N4O2S3
    3-cyano-N-1,2,4-thiadiazol-5-yl-4-{[2-(trifluoromethyl)phenyl]thio}benzenesulfonamide
    —— N-(6-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclo-propanecarboxamide 1208247-64-6 C16H13N7OS
    N-(6-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclo-propanecarboxamide
    —— 3-cyano-4-[(3-methoxyphenyl)thio]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide 1354917-06-8 C16H12N4O3S3
    3-cyano-4-[(3-methoxyphenyl)thio]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide
    —— 3-cyano-4-[(3,4-difluorophenyl)thio]-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide 1354917-36-4 C15H8F2N4O2S3
    3-cyano-4-[(3,4-difluorophenyl)thio]-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide
    —— 1-benzyl-6-bromomethyl-5-chloro-3-(ethylsulfanyl)-2(1H)-pyrazinone 658071-59-1 C14H14BrClN2OS
    1-benzyl-6-bromomethyl-5-chloro-3-(ethylsulfanyl)-2(1H)-pyrazinone
    —— S<sup>1</sup>-{[1-benzyl-3-chloro-1,6-dihydro-5-(ethylsulfanyl)-6-oxo-2-pyrazinyl]methyl}ethanethioate 658071-60-4 C16H17ClN2O2S2
    S<sup>1</sup>-{[1-benzyl-3-chloro-1,6-dihydro-5-(ethylsulfanyl)-6-oxo-2-pyrazinyl]methyl}ethanethioate
    —— 1-benzyl-5-chloro-3-(ethylsulfanyl)-6-[(2-propynylsulfanyl)methyl]-2(1H)-pyrazinone 658071-62-6 C17H17ClN2OS2
    1-benzyl-5-chloro-3-(ethylsulfanyl)-6-[(2-propynylsulfanyl)methyl]-2(1H)-pyrazinone
    —— N-benzyl-4-(4-(3-(2,4-dichlorophenyl)thioureido)phenylthio)picolinamide 1395063-43-0 C26H20Cl2N4OS2
    N-benzyl-4-(4-(3-(2,4-dichlorophenyl)thioureido)phenylthio)picolinamide
    —— 6-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)pyridazin-3-ylamine 1208249-65-3 C10H8N6S
    6-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)pyridazin-3-ylamine
    —— 4-[4-benzyl-5-methyl-3-oxo-6-(o-tolylthio)-3,4-dihydropyrazin-2-ylamino]benzonitrile 467468-95-7 C26H22N4OS
    4-[4-benzyl-5-methyl-3-oxo-6-(o-tolylthio)-3,4-dihydropyrazin-2-ylamino]benzonitrile
    —— 2-benzylthio-4-(3-bromophenylamino)-6-methylpyrimidine hydrochloride 1162754-39-3 C18H16BrN3S*ClH
    2-benzylthio-4-(3-bromophenylamino)-6-methylpyrimidine hydrochloride
    —— 2-(benzylthio)-4-chloro-6-methylpyrimidine 121180-58-3 C12H11ClN2S
    2-(benzylthio)-4-chloro-6-methylpyrimidine
    —— 2,6-bis-(methylthio)-4-ethyl-3-methylpyridine 128736-18-5 C10H15NS2
    2,6-bis-(methylthio)-4-ethyl-3-methylpyridine
    —— 3,5-Dimethyl-2-[(4-methylphenyl)amino]-6-methylsulfanylthiopyran-4-one 99878-38-3 C15H17NOS2
    3,5-Dimethyl-2-[(4-methylphenyl)amino]-6-methylsulfanylthiopyran-4-one
    —— acetic acid 3-[6-amino-8-(7-chlorobenzothiazol-2-ylsulfanyl)-purin-9-yl]-propyl ester 908355-51-1 C17H15ClN6O2S2
    acetic acid 3-[6-amino-8-(7-chlorobenzothiazol-2-ylsulfanyl)-purin-9-yl]-propyl ester