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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-[2-(2-benzyloxy-ethyl)-5-trifluoromethyl-3H-imidazol-4-ylsulfanyl]-3-chloro-benzonitrile 897626-26-5 C20H15ClF3N3OS
    5-[2-(2-benzyloxy-ethyl)-5-trifluoromethyl-3H-imidazol-4-ylsulfanyl]-3-chloro-benzonitrile
    —— 5-(2-benzyloxymethyl-3-ethyl-5-isopropyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile 868525-48-8 C24H24N4OS
    5-(2-benzyloxymethyl-3-ethyl-5-isopropyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile
    —— 5-(2-benzyloxymethyl-5-trifluoromethyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile 868525-20-6 C20H13F3N4OS
    5-(2-benzyloxymethyl-5-trifluoromethyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile
    —— 2-(6-Chlorobenzo[d][1,3]dioxol-5-ylthio)-1-(4-methoxybenzyl)-1H-imidazo[4,5-c]pyridin-4-amine 1012059-51-6 C21H17ClN4O3S
    2-(6-Chlorobenzo[d][1,3]dioxol-5-ylthio)-1-(4-methoxybenzyl)-1H-imidazo[4,5-c]pyridin-4-amine
    —— 1-(2-hexylsulfanyl-6-methyl-pyrimidin-4-yl)-ethanone 863673-02-3 C13H20N2OS
    1-(2-hexylsulfanyl-6-methyl-pyrimidin-4-yl)-ethanone
    —— {(S)-3-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-1-hydroxymethyl-propyl}-carbamic acid ter-butyl ester 848644-03-1 C18H27ClN2O3S
    {(S)-3-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-1-hydroxymethyl-propyl}-carbamic acid ter-butyl ester
    —— ethyl 2-methyl-6-(4-methylphenyl)sulfanylnicotinate 888022-72-8 C16H17NO2S
    ethyl 2-methyl-6-(4-methylphenyl)sulfanylnicotinate
    —— 4-methyl 2-[2-(phenylthio)ethyl]-2H-1,2,3-triazole-4,5-dicarboxylate 478626-23-2 C13H13N3O4S
    4-methyl 2-[2-(phenylthio)ethyl]-2H-1,2,3-triazole-4,5-dicarboxylate
    —— {(S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-propyl}-carbamic acid ter-butyl ester 848644-02-0 C34H45ClN2O3SSi
    {(S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-propyl}-carbamic acid ter-butyl ester
    —— tert-butyl 2-methyl-6-(4-methylphenyl)sulfanylnicotinate 888022-73-9 C18H21NO2S
    tert-butyl 2-methyl-6-(4-methylphenyl)sulfanylnicotinate
    —— tert-butyl [4-(5,6-diphenylpyrazin-2-ylsulfanyl)butoxy]acetate 475085-44-0 C26H30N2O3S
    tert-butyl [4-(5,6-diphenylpyrazin-2-ylsulfanyl)butoxy]acetate
    —— (S)-2-amino-4-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-butan-1-ol 928761-52-8 C13H19ClN2OS
    (S)-2-amino-4-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-butan-1-ol
    —— 3-(2-Methoxyethoxy)-5-{[(3-methylphenyl)methyl]sulfanyl}-1,2,4-thiadiazole 922505-60-0 C13H16N2O2S2
    3-(2-Methoxyethoxy)-5-{[(3-methylphenyl)methyl]sulfanyl}-1,2,4-thiadiazole
    —— (5-bromo-2-methyl-phenylsulfanyl)-acetic acid 845746-14-7 C9H9BrO2S
    (5-bromo-2-methyl-phenylsulfanyl)-acetic acid
    —— (5-bromo-2-methyl-phenylsulfanyl)-acetic acid tert-butyl ester 845746-13-6 C13H17BrO2S
    (5-bromo-2-methyl-phenylsulfanyl)-acetic acid tert-butyl ester
    —— (2R)-2-{[5-(benzylthio)-2-chloro[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-3-methylbutan-1-ol 849943-26-6 C17H19ClN4OS2
    (2R)-2-{[5-(benzylthio)-2-chloro[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-3-methylbutan-1-ol
    —— (4-Amino-2-pyrimidinyl)-essigsaeure-ethylester 61445-75-8 C8H11N3O2S
    (4-Amino-2-pyrimidinyl)-essigsaeure-ethylester
    —— 3-(3-{[(5-chloro-thiophen-3-yl)methyl]thio}-5-oxo-2,5-dihydro-1,2,4-triazin-6-yl)-propionic acid ethyl ester 824983-32-6 C13H14ClN3O3S2
    3-(3-{[(5-chloro-thiophen-3-yl)methyl]thio}-5-oxo-2,5-dihydro-1,2,4-triazin-6-yl)-propionic acid ethyl ester
    —— 5-[(4-methyl-1,3-thiazol-2-yl)thio]thiophene-2-sulfonamide 900814-33-7 C8H8N2O2S4
    5-[(4-methyl-1,3-thiazol-2-yl)thio]thiophene-2-sulfonamide
    —— [[2-(phenylthio)-5-(aminooxoacetyl)-6-ethyl-7-(phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]acetic acid methyl ester 253331-89-4 C26H24N4O5S
    [[2-(phenylthio)-5-(aminooxoacetyl)-6-ethyl-7-(phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]acetic acid methyl ester
    —— 3-{[(5-chloro-thiophen-3-yl)methyl]thio}-6-ethyl-1,2,4-triazin-5(2H)-one 824983-29-1 C10H10ClN3OS2
    3-{[(5-chloro-thiophen-3-yl)methyl]thio}-6-ethyl-1,2,4-triazin-5(2H)-one
    —— 1-(6-methyl-pyridin-2-yl)-2-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone 673480-84-7 C13H13N3OS
    1-(6-methyl-pyridin-2-yl)-2-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone
    —— 2-((4-chlorobenzyl)thio)-3-nitropyridine 878404-83-2 C12H9ClN2O2S
    2-((4-chlorobenzyl)thio)-3-nitropyridine
    —— 3-[(4-methyl-1,3-thiazol-2-yl)thio]thiophene-2-sulfonamide 900814-34-8 C8H8N2O2S4
    3-[(4-methyl-1,3-thiazol-2-yl)thio]thiophene-2-sulfonamide
    —— 2-methylthio-4-(3-trifluoromethylpyridin-2-yl)pyrimidine 749257-99-6 C11H8F3N3S
    2-methylthio-4-(3-trifluoromethylpyridin-2-yl)pyrimidine
    —— 5-(3-methylpyridine-2-yl)-3-methylsulfanyl[1,2,4]triazine 749257-69-0 C10H10N4S
    5-(3-methylpyridine-2-yl)-3-methylsulfanyl[1,2,4]triazine
    —— 3-methylthio-5-(3-trifluoromethylpyridin-2-yl)[1,2,4]triazine 749257-80-5 C10H7F3N4S
    3-methylthio-5-(3-trifluoromethylpyridin-2-yl)[1,2,4]triazine
    —— 1-(2-(4-bromophenyl)ethynyl)-2-trifluoromethylsulfanyl-benzene 1214756-25-8 C15H8BrF3S
    1-(2-(4-bromophenyl)ethynyl)-2-trifluoromethylsulfanyl-benzene
    —— 1-(2-(4-methylphenyl)ethynyl)-2-trifluoromethylsulfanyl-benzene 1214756-23-6 C16H11F3S
    1-(2-(4-methylphenyl)ethynyl)-2-trifluoromethylsulfanyl-benzene
    —— 2-fluoro-5-[(3-methoxyphenyl)thio]pyridine 1057004-34-8 C12H10FNOS
    2-fluoro-5-[(3-methoxyphenyl)thio]pyridine
    —— 4-(diethoxymethyl)-2-(methylthio)pyridine 650628-71-0 C11H17NO2S
    4-(diethoxymethyl)-2-(methylthio)pyridine
    —— 6-Chloro-2-(3-methanesulfonyl-4-nitro-1H-indol-7-ylsulfanyl)-1H-benzoimidazole 548457-97-2 C16H11ClN4O4S2
    6-Chloro-2-(3-methanesulfonyl-4-nitro-1H-indol-7-ylsulfanyl)-1H-benzoimidazole
    —— (R)-N-{2-Chloro-4-[4-(pyrrolidin-1-ylsulphonyl)phenylsulphanyl]phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 252017-38-2 C20H20ClF3N2O4S2
    (R)-N-{2-Chloro-4-[4-(pyrrolidin-1-ylsulphonyl)phenylsulphanyl]phenyl}-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
    —— 4-[[4-[2-(benzylamino)ethyl]phenyl]thio]phenol 477256-81-8 C21H21NOS
    4-[[4-[2-(benzylamino)ethyl]phenyl]thio]phenol
    —— 1-[2-(pyridin-2-yl)thioethyl]piperidine 349445-42-7 C12H18N2S
    1-[2-(pyridin-2-yl)thioethyl]piperidine
    —— Acetic acid--(phenylsulfanyl)methanol (1/1) 57440-42-3 C9H12O3S
    Acetic acid--(phenylsulfanyl)methanol (1/1)
    —— 6-methyl-4-(4-methylthio)phenyl-2-oxo-2H-pyran-3-carboxylic acid ethyl ester 387866-28-6 C16H16O4S
    6-methyl-4-(4-methylthio)phenyl-2-oxo-2H-pyran-3-carboxylic acid ethyl ester
    —— 5(6)-(5-isoquinolylsulfanyl)-2-trifluoromethyl-1H-benzo[d]imidazole hydrochloride 203338-41-4 C17H10F3N3S*ClH
    5(6)-(5-isoquinolylsulfanyl)-2-trifluoromethyl-1H-benzo[d]imidazole hydrochloride
    —— 3-Chlor-propionsaeure-<2-phenylmercapto-ethylamid> 91131-29-2 C11H14ClNOS
    3-Chlor-propionsaeure-<2-phenylmercapto-ethylamid>
    —— (Z)-2-tert-butylsulfonyl-3-ethoxyprop-2-enenitrile —— C9H15NO3S
    (Z)-2-tert-butylsulfonyl-3-ethoxyprop-2-enenitrile
    —— 2-((Furan-2-ylmethyl)thio)thiazole 176981-11-6 C8H7NOS2
    2-((Furan-2-ylmethyl)thio)thiazole
    —— (1R)-1-[4-(methylsulfanyl)phenyl]ethan-1-amine —— C9H13NS
    (1R)-1-[4-(methylsulfanyl)phenyl]ethan-1-amine
    —— (S)-2-(Pyridin-2-ylsulfanyl)-propionic acid —— C8H9NO2S
    (S)-2-(Pyridin-2-ylsulfanyl)-propionic acid
    —— 2-[[5-(2-Chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]thio]-N-[2-(phenylthio)phenyl]acetamide 1209646-18-3 C23H19ClN4OS2
    2-[[5-(2-Chlorophenyl)-4-methyl-4H-1,2,4-triazol-3-yl]thio]-N-[2-(phenylthio)phenyl]acetamide
    —— 2-[[4-Benzyl-5-(2-thienyl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine 1012073-55-0 C19H16N4S2
    2-[[4-Benzyl-5-(2-thienyl)-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine
    —— Fenticonazole, (R)- 1268165-29-2 C24H20Cl2N2OS
    Fenticonazole, (R)-
    —— methyl N-[(2-methylsulfanylphenyl)methyl]carbamate 37527-98-3 C10H13NO2S
    methyl N-[(2-methylsulfanylphenyl)methyl]carbamate
    —— 5-({[butyl(1-{[2-methyl-6-({4-[(methylsulfonyl)amino]phenyl}thio)-3-pyridinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2,4-difluorobenzamide 1150617-17-6 C31H38F2N6O4S2
    5-({[butyl(1-{[2-methyl-6-({4-[(methylsulfonyl)amino]phenyl}thio)-3-pyridinyl]methyl}-4-piperidinyl)amino]carbonyl}amino)-2,4-difluorobenzamide
    —— (3S,4S,6R)-2,4,6-trimethyl-7-phenylsulfanylhept-1-en-3-ol 1147093-71-7 C16H24OS
    (3S,4S,6R)-2,4,6-trimethyl-7-phenylsulfanylhept-1-en-3-ol
    —— 2,2';2',2''-ter(1,3-dithiolan-2-yl) 1155851-67-4 C9H14S6
    2,2';2',2''-ter(1,3-dithiolan-2-yl)