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    首页 分子通 按分子结构分类 有机化合物 苯丙烷和聚酮 黄酮类化合物

    黄酮类化合物

    黄酮类化合物 定义与结构特征

    黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。

    生物来源

    黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。

    化学性质 亲水性与溶解度

    由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。

    稳定性与光敏性

    大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。

    生理活性与药用价值

    黄酮类化合物因其丰富的生理活性而备受关注，主要包括：

    • 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
    • 抗炎效应：有助于减轻炎症反应，缓解症状。
    • 心血管保护：可能通过多种机制改善心脑血管健康。
    • 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
    应用领域 食品工业

    作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。

    化妆品行业

    利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。

    药物开发

    由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-Hydroxy-6-methoxy-2-phenyl-7-(3-pyrrolidin-1-ylpropoxy)chromen-4-one 1263323-11-0 C23H25NO5
    5-Hydroxy-6-methoxy-2-phenyl-7-(3-pyrrolidin-1-ylpropoxy)chromen-4-one
    —— N-dodecyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide 1217342-43-2 C29H37NO5
    N-dodecyl 2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetamide
    —— (Z)-3-[(dodecylamino)methylene]-2-phenylchroman-4-one 1262884-80-9 C28H37NO2
    (Z)-3-[(dodecylamino)methylene]-2-phenylchroman-4-one
    —— rutin 1340-08-5 C27H30O16
    rutin
    —— myricetin 7-O-α-L-rhamnopyranoside 184533-14-0 C21H20O12
    myricetin 7-O-α-L-rhamnopyranoside
    —— 3,3',4',5,5',7-hexahydroxy-2',6,6',8-tetranitroflavone 256486-45-0 C15H6N4O16
    3,3',4',5,5',7-hexahydroxy-2',6,6',8-tetranitroflavone
    —— 6-amino-2-(3,4-dimethoxy-phenyl)-chroman-4-one 109471-64-9 C17H17NO4
    6-amino-2-(3,4-dimethoxy-phenyl)-chroman-4-one
    —— myricetin 3-O-galactoside —— C21H20O13
    myricetin 3-O-galactoside
    —— isomyricitrin —— C21H20O13
    isomyricitrin
    —— 2',6,6',8-tetrabromo-3,3',4',5,5',7-hexahydroxyflavone 256486-48-3 C15H6Br4O8
    2',6,6',8-tetrabromo-3,3',4',5,5',7-hexahydroxyflavone
    —— 6-amino-2-(4-methoxy-phenyl)-chroman-4-one 113454-68-5 C16H15NO3
    6-amino-2-(4-methoxy-phenyl)-chroman-4-one
    —— 2,4,4-trimethyl-7,2’,4’-trihydroxy flavan 26505-28-2 C18H20O4
    2,4,4-trimethyl-7,2’,4’-trihydroxy flavan
    —— 2-(3,4-dibenzyloxyphenyl)-3-hydroxy-6-[(1-iminoethyl)amino]-4H-1-benzopyran-4-one 1187016-47-2 C31H26N2O5
    2-(3,4-dibenzyloxyphenyl)-3-hydroxy-6-[(1-iminoethyl)amino]-4H-1-benzopyran-4-one
    —— 2-(3,4-dibenzyloxyphenyl)-3-hydroxy-6-amino-4H-1-benzopyran-4-one 1187016-46-1 C29H23NO5
    2-(3,4-dibenzyloxyphenyl)-3-hydroxy-6-amino-4H-1-benzopyran-4-one
    —— 2-(4-fluorophenyl)-6-[(1-iminoethyl)amino]-4H-1-benzopyran-4-one 1187016-11-0 C17H13FN2O2
    2-(4-fluorophenyl)-6-[(1-iminoethyl)amino]-4H-1-benzopyran-4-one
    —— 2-[(4-imidazol-1-yl)-phenyl]-3-benzyloxy-6-amino-4H-1-benzopyran-4-one 1187016-34-7 C25H19N3O3
    2-[(4-imidazol-1-yl)-phenyl]-3-benzyloxy-6-amino-4H-1-benzopyran-4-one
    —— 2-[(4-imidazol-1-yl)-phenyl]-3-benzyloxy-6-[(1-iminoethyl)amino]-4H-1-benzopyran-4-one 1187016-33-6 C27H22N4O3
    2-[(4-imidazol-1-yl)-phenyl]-3-benzyloxy-6-[(1-iminoethyl)amino]-4H-1-benzopyran-4-one
    —— 2-methyl-2-phenylchroman-4-one 62756-35-8 C16H14O2
    2-methyl-2-phenylchroman-4-one
    —— 2,3-trans-3,4-trans-3-amino-4-hydroxyflavane —— C15H15NO2
    2,3-trans-3,4-trans-3-amino-4-hydroxyflavane
    —— 1429422-60-5 C43H38O6
    —— 3'-O-methyl (-)-epicatechin 5-O-β-glucuronide 603133-94-4 C22H24O12
    3'-O-methyl (-)-epicatechin 5-O-β-glucuronide
    —— 4'-O-methylepicatechin-7-O-β-D-glucuronide 603133-93-3 C22H24O12
    4'-O-methylepicatechin-7-O-β-D-glucuronide
    —— 3′-O-methylepicatechin-4′-O-β-D-glucuronide 1421313-25-8 C22H24O12
    3′-O-methylepicatechin-4′-O-β-D-glucuronide
    —— (2R,3R)-2-(4-methoxy-3-phenylmethoxyphenyl)-3,5-bis(phenylmethoxy)-3,4-dihydro-2H-chromen-7-ol 1365537-17-2 C37H34O6
    (2R,3R)-2-(4-methoxy-3-phenylmethoxyphenyl)-3,5-bis(phenylmethoxy)-3,4-dihydro-2H-chromen-7-ol
    —— epicatechin-7-O-β-D-glucuronide 389136-63-4 C21H22O12
    epicatechin-7-O-β-D-glucuronide
    —— 4'-O-methyl-(-)-epicatechin-3'-O-β-D-glucuronide 603133-92-2 C22H24O12
    4'-O-methyl-(-)-epicatechin-3'-O-β-D-glucuronide
    —— 4′-O-methyl(−)-epicatechin-7β-D-glucuronide 1146696-37-8 C22H24O12
    4′-O-methyl(−)-epicatechin-7β-D-glucuronide
    —— (-)-epicatechin 4'-O-glucuronide 1146696-35-6 C21H22O12
    (-)-epicatechin 4'-O-glucuronide
    —— 3-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one 1621-74-5 C16H12O5
    3-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
    —— 7-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one 76426-28-3 C16H14O5
    7-hydroxy-2-(3-hydroxy-4-methoxyphenyl)chroman-4-one
    —— 3-(benzyloxy)-2-phenyl-4H-chromen-4-one 152459-36-4 C22H16O3
    3-(benzyloxy)-2-phenyl-4H-chromen-4-one
    —— 3-(benzyloxy)-2-(4-methoxyphenyl)-4H-chromen-4-one 88187-01-3 C23H18O4
    3-(benzyloxy)-2-(4-methoxyphenyl)-4H-chromen-4-one
    —— T-Phe 1270004-59-5 C27H23NO10
    T-Phe
    —— 4'-O-CO-(Phe-OtBu)-tricin 1270004-51-7 C31H31NO10
    4'-O-CO-(Phe-OtBu)-tricin
    —— 5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl trifluoromethanesulfonate 109586-45-0 C16H9F3O6S
    5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl trifluoromethanesulfonate
    —— 5-hydroxy-7-(2-hydroxyethoxy)-2-[3-hydroxy-4-(2-hydroxyethoxy)phenyl]-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxychromen-4-one —— C31H38O18
    5-hydroxy-7-(2-hydroxyethoxy)-2-[3-hydroxy-4-(2-hydroxyethoxy)phenyl]-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxychromen-4-one
    —— alvocidib 2044686-42-0 C21H21ClNO8P
    alvocidib
    —— 3-hydroxy-2-p-tolylchroman-4-one 1233689-66-1 C16H14O3
    3-hydroxy-2-p-tolylchroman-4-one
    —— cis-(-)-flavodimethoxol hydrochloride 358739-92-1 C23H24ClNO5*ClH
    cis-(-)-flavodimethoxol hydrochloride
    —— 7-hydroxy-4'-methoxyflavylium chloride 1222-48-6 C16H13O3*Cl
    7-hydroxy-4'-methoxyflavylium chloride
    —— 5,7-diacetoxy-2-(4-acetoxy-phenyl)-chroman 64670-92-4 C21H20O7
    5,7-diacetoxy-2-(4-acetoxy-phenyl)-chroman
    —— (1S)-1,5-anhydro-2-O-(6-deoxy-beta-L-mannopyranosyl)-1-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol —— C27H30O14
    (1S)-1,5-anhydro-2-O-(6-deoxy-beta-L-mannopyranosyl)-1-[5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol
    —— 6-cyano-2,2-diphenyl-[2H]-pyran[5,6-c]dibenzothiophene 444581-37-7 C28H17NOS
    6-cyano-2,2-diphenyl-[2H]-pyran[5,6-c]dibenzothiophene
    —— 6-bromo-2,2-diphenyl-[2H]-pyran[6,5-a]dibenzothiophene 444581-35-5 C27H17BrOS
    6-bromo-2,2-diphenyl-[2H]-pyran[6,5-a]dibenzothiophene
    —— (2S,3S)-2-(1,3-benzodioxol-5-yl)-5,7-dimethoxy-3,4-dihydro-2H-chromen-3-ol 87562-72-9 C18H18O6
    (2S,3S)-2-(1,3-benzodioxol-5-yl)-5,7-dimethoxy-3,4-dihydro-2H-chromen-3-ol
    —— 2-(3-chloro-4-methoxyphenyl)-5,7-dihydroxy-4H-chromen-4-one 1192136-16-5 C16H11ClO5
    2-(3-chloro-4-methoxyphenyl)-5,7-dihydroxy-4H-chromen-4-one
    —— 5,7-dihydroxy-4'-nitroflavone 110865-14-0 C15H9NO6
    5,7-dihydroxy-4'-nitroflavone
    —— methyl 2-(2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetoxy)benzoate 1235837-79-2 C25H18O8
    methyl 2-(2-(5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yloxy)acetoxy)benzoate
    —— epicatechin-(4β<*>8)-epicatechin-(4β<*>2)-phloroglucinol 68178-64-3 C36H30O15
    epicatechin-(4β<*>8)-epicatechin-(4β<*>2)-phloroglucinol
    —— epicatechin-(4β<*>6)-epicatechin-(4β<*>2)-phloroglucinol 82792-70-9 C36H30O15
    epicatechin-(4β<*>6)-epicatechin-(4β<*>2)-phloroglucinol