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黄酮类化合物

黄酮类化合物 定义与结构特征

黄酮类化合物是一大类天然存在的有机化合物,属于酚类衍生物。它们的分子结构通常包含两个苯环(A和B环)和一个三碳环(C环),形成一个基本骨架。该骨架由多个亚结构组成,包括黄烷醇、黄酮、黄酮醇等。

生物来源

黄酮类化合物广泛存在于植物界中,常见于许多蔬菜、水果及中药中。例如,在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。

化学性质 亲水性与溶解度

由于其分子结构中含有多个酚羟基,因此具有一定的亲水性和良好的溶解性,这使得黄酮类化合物在药物设计中扮演重要角色。

稳定性与光敏性

大多数黄酮类化合物相对稳定,在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感,容易被氧化,导致颜色变化。

生理活性与药用价值

黄酮类化合物因其丰富的生理活性而备受关注,主要包括:

  • 抗氧化作用:可有效清除体内自由基,保护细胞免受损伤。
  • 抗炎效应:有助于减轻炎症反应,缓解症状。
  • 心血管保护:可能通过多种机制改善心脑血管健康。
  • 抗癌潜力:研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
应用领域 食品工业

作为一种天然色素和抗氧化剂,被广泛应用于食品加工中以提高其保质期及营养价值。

化妆品行业

利用其良好的生物相容性和抗衰老特性,在化妆品配方中应用广泛。

药物开发

由于黄酮类化合物展现出广泛的药理活性,已成为新药研发的重要候选目标之一。

中文名称 英文名称 CAS号 化学式 结构式图片
—— 2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-(4-methoxyphenyl)acetamide —— C29H29NO5
2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-(4-methoxyphenyl)acetamide
—— ethyl (2S)-2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxypropanoate —— C25H28O5
ethyl (2S)-2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxypropanoate
—— 2-(2-Chlorophenyl)-7-methyl-3-[(4-methylphenyl)methoxy]chromen-4-one —— C24H19ClO3
2-(2-Chlorophenyl)-7-methyl-3-[(4-methylphenyl)methoxy]chromen-4-one
—— 2-[2-(4-Tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxyacetic acid —— C22H22O5
2-[2-(4-Tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxyacetic acid
—— [2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 4-bromobenzoate —— C23H14BrClO4
[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 4-bromobenzoate
—— (2R)-2-[2-(4-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxybutanoate —— C20H16ClO5-
(2R)-2-[2-(4-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxybutanoate
—— Methyl 4-[[2-(4-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxymethyl]benzoate —— C25H19ClO5
Methyl 4-[[2-(4-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxymethyl]benzoate
—— [2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 3,4,5-trimethoxybenzoate —— C26H21ClO7
[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 3,4,5-trimethoxybenzoate
—— 2-[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-(1,3-thiazol-2-yl)acetamide —— C21H15ClN2O4S
2-[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-(1,3-thiazol-2-yl)acetamide
—— (2R)-2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxypropanoic acid —— C23H24O5
(2R)-2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxypropanoic acid
—— 2-(4-Tert-butylphenyl)-7-methyl-3-[2-(4-methylphenoxy)ethoxy]chromen-4-one —— C29H30O4
2-(4-Tert-butylphenyl)-7-methyl-3-[2-(4-methylphenoxy)ethoxy]chromen-4-one
—— 2-(4-Tert-butylphenyl)-3-[2-(2,4-dichlorophenyl)-2-oxoethoxy]-7-methylchromen-4-one —— C28H24Cl2O4
2-(4-Tert-butylphenyl)-3-[2-(2,4-dichlorophenyl)-2-oxoethoxy]-7-methylchromen-4-one
—— [2-(4-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 2-phenylacetate —— C24H17ClO4
[2-(4-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 2-phenylacetate
—— 2-[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-(3,4-dimethoxyphenyl)acetamide —— C26H22ClNO6
2-[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-(3,4-dimethoxyphenyl)acetamide
—— [2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 4-fluorobenzoate —— C23H14ClFO4
[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 4-fluorobenzoate
—— [2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] furan-2-carboxylate —— C21H13ClO5
[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] furan-2-carboxylate
—— 2-[7-methyl-2-(4-methylphenyl)-4-oxochromen-3-yl]oxy-N-(4-phenoxyphenyl)acetamide —— C31H25NO5
2-[7-methyl-2-(4-methylphenyl)-4-oxochromen-3-yl]oxy-N-(4-phenoxyphenyl)acetamide
—— 2-[2-(4-Tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxyacetonitrile —— C22H21NO3
2-[2-(4-Tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxyacetonitrile
—— N-(3-chloro-4-methoxyphenyl)-2-[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxyacetamide —— C25H19Cl2NO5
N-(3-chloro-4-methoxyphenyl)-2-[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxyacetamide
—— 2-(4-Tert-butylphenyl)-7-methyl-3-[(4-nitrophenyl)methoxy]chromen-4-one —— C27H25NO5
2-(4-Tert-butylphenyl)-7-methyl-3-[(4-nitrophenyl)methoxy]chromen-4-one
—— 2-(4-Tert-butylphenyl)-3-[(3,4-dichlorophenyl)methoxy]-7-methylchromen-4-one —— C27H24Cl2O3
2-(4-Tert-butylphenyl)-3-[(3,4-dichlorophenyl)methoxy]-7-methylchromen-4-one
—— Ethyl 4-[[2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxyacetyl]amino]benzoate —— C31H31NO6
Ethyl 4-[[2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxyacetyl]amino]benzoate
—— 2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-(3,4-dimethoxyphenyl)acetamide —— C30H31NO6
2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-(3,4-dimethoxyphenyl)acetamide
—— Methyl 4-[[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxymethyl]benzoate —— C25H19ClO5
Methyl 4-[[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxymethyl]benzoate
—— Benzyl 2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxyacetate —— C29H28O5
Benzyl 2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxyacetate
—— [2-(4-Tert-butylphenyl)-7-methyl-4-oxochromen-3-yl] pyridine-3-carboxylate —— C26H23NO4
[2-(4-Tert-butylphenyl)-7-methyl-4-oxochromen-3-yl] pyridine-3-carboxylate
—— [2-(4-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] pentanoate —— C21H19ClO4
[2-(4-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] pentanoate
—— 2-(4-Tert-butylphenyl)-3-[(4-fluorophenyl)methoxy]-7-methylchromen-4-one —— C27H25FO3
2-(4-Tert-butylphenyl)-3-[(4-fluorophenyl)methoxy]-7-methylchromen-4-one
—— 2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-cyclohexylacetamide —— C28H33NO4
2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-cyclohexylacetamide
—— [2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 4-(dimethylamino)benzoate —— C25H20ClNO4
[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 4-(dimethylamino)benzoate
—— [2-(4-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 3,5-dimethoxybenzoate —— C25H19ClO6
[2-(4-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 3,5-dimethoxybenzoate
—— methyl (2R)-2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxypropanoate —— C24H26O5
methyl (2R)-2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxypropanoate
—— (2S)-2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxypropanoate —— C23H23O5-
(2S)-2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxypropanoate
—— 2-(4-Chlorophenyl)-7-methyl-3-[(2-methylphenyl)methoxy]chromen-4-one —— C24H19ClO3
2-(4-Chlorophenyl)-7-methyl-3-[(2-methylphenyl)methoxy]chromen-4-one
—— 2-[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-(furan-2-ylmethyl)acetamide —— C23H18ClNO5
2-[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-(furan-2-ylmethyl)acetamide
—— [2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl] (E)-3-(4-chlorophenyl)prop-2-enoate —— C29H25ClO4
[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl] (E)-3-(4-chlorophenyl)prop-2-enoate
—— [2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] thiophene-2-carboxylate —— C21H13ClO4S
[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] thiophene-2-carboxylate
—— 2-(4-Tert-butylphenyl)-3-[(2,4-dichlorophenyl)methoxy]-7-methylchromen-4-one —— C27H24Cl2O3
2-(4-Tert-butylphenyl)-3-[(2,4-dichlorophenyl)methoxy]-7-methylchromen-4-one
—— 2-(2-Chlorophenyl)-3-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxoethoxy]-7-methylchromen-4-one —— C26H19ClO6
2-(2-Chlorophenyl)-3-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxoethoxy]-7-methylchromen-4-one
—— 2-[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide —— C28H26ClNO6
2-[2-(2-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxy-N-[2-(3,4-dimethoxyphenyl)ethyl]acetamide
—— 2-[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxyacetamide —— C18H14ClNO4
2-[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxyacetamide
—— (2S)-2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxypropanoic acid —— C23H24O5
(2S)-2-[2-(4-tert-butylphenyl)-7-methyl-4-oxochromen-3-yl]oxypropanoic acid
—— [2-(4-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] methyl carbonate —— C18H13ClO5
[2-(4-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] methyl carbonate
—— [2-(4-Tert-butylphenyl)-7-methyl-4-oxochromen-3-yl] 4-(dimethylamino)benzoate —— C29H29NO4
[2-(4-Tert-butylphenyl)-7-methyl-4-oxochromen-3-yl] 4-(dimethylamino)benzoate
—— methyl (2S)-2-[2-(4-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxy-3-oxobutanoate —— C21H17ClO6
methyl (2S)-2-[2-(4-chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxy-3-oxobutanoate
—— [2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 4-methoxybenzoate —— C24H17ClO5
[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 4-methoxybenzoate
—— 2-(2-Chlorophenyl)-7-methyl-3-[(4-nitrophenyl)methoxy]chromen-4-one —— C23H16ClNO5
2-(2-Chlorophenyl)-7-methyl-3-[(4-nitrophenyl)methoxy]chromen-4-one
—— 2-[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxyacetic acid —— C18H13ClO5
2-[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl]oxyacetic acid
—— [2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 2,4-dichlorobenzoate —— C23H13Cl3O4
[2-(2-Chlorophenyl)-7-methyl-4-oxochromen-3-yl] 2,4-dichlorobenzoate
—— 2-(2-Chlorophenyl)-7-methyl-3-(2-morpholin-4-yl-2-oxoethoxy)chromen-4-one —— C22H20ClNO5
2-(2-Chlorophenyl)-7-methyl-3-(2-morpholin-4-yl-2-oxoethoxy)chromen-4-one