黄酮类化合物是一大类天然存在的有机化合物,属于酚类衍生物。它们的分子结构通常包含两个苯环(A和B环)和一个三碳环(C环),形成一个基本骨架。该骨架由多个亚结构组成,包括黄烷醇、黄酮、黄酮醇等。
生物来源黄酮类化合物广泛存在于植物界中,常见于许多蔬菜、水果及中药中。例如,在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。
化学性质 亲水性与溶解度由于其分子结构中含有多个酚羟基,因此具有一定的亲水性和良好的溶解性,这使得黄酮类化合物在药物设计中扮演重要角色。
稳定性与光敏性大多数黄酮类化合物相对稳定,在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感,容易被氧化,导致颜色变化。
生理活性与药用价值黄酮类化合物因其丰富的生理活性而备受关注,主要包括:
作为一种天然色素和抗氧化剂,被广泛应用于食品加工中以提高其保质期及营养价值。
化妆品行业利用其良好的生物相容性和抗衰老特性,在化妆品配方中应用广泛。
药物开发由于黄酮类化合物展现出广泛的药理活性,已成为新药研发的重要候选目标之一。
中文名称 | 英文名称 | CAS号 | 化学式 | 结构式图片 |
---|---|---|---|---|
—— | N-[4-[5-benzhydryl-4-(2,4-dimethoxyphenyl)-4-(4-methoxyphenyl)-9-oxo-3,10-dioxatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),5,8(13),11,15,17-heptaen-16-yl]-3-(trifluoromethyl)phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide | —— | C75H66F3NO7 |
|
—— | Methyl 6-anilino-8-[4-[[4-(4-pentylcyclohexyl)benzoyl]amino]phenyl]-2,2-diphenylbenzo[h]chromene-5-carboxylate | —— | C57H54N2O4 |
|
—— | Methyl 9-(dimethylamino)-2-(4-methoxyphenyl)-8-[4-[[4-(4-pentylcyclohexyl)benzoyl]amino]phenyl]-2-phenylbenzo[h]chromene-5-carboxylate | —— | C54H56N2O5 |
|
—— | Methyl 9-(dimethylamino)-2-(4-morpholin-4-ylphenyl)-8-[2-[4-[4-(4-pentylcyclohexyl)cyclohexanecarbonyl]oxyphenyl]benzoyl]oxy-2-phenylbenzo[h]chromene-5-carboxylate | —— | C64H70N2O8 |
|
—— | N-[4-[6-oxo-11,11-diphenyl-4-(1-phenylethyl)-3,5,12-trioxatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),8(13),9,15,17-hexaen-17-yl]phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide | —— | C65H59NO5 |
|
—— | N-[4-[19-bromo-9,11-dichloro-5,5-bis(4-hydroxyphenyl)-18-methoxy-21,21-dimethyl-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15(20),16,18-nonaen-17-yl]phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide | —— | C65H58BrCl2NO5 |
|
—— | 8-(4-Benzylpiperazin-4-ium-1-carbonyl)-3-methyl-2-phenylchromen-4-one | —— | C28H27N2O3+ |
|
—— | 2-[4,6-Dioxo-17-[4-[4-[4-(4-pentylcyclohexyl)phenyl]benzoyl]piperazin-1-yl]-11,11-diphenyl-3,12-dioxa-5-azatetracyclo[12.4.0.02,7.08,13]octadeca-1(14),2(7),8(13),9,15,17-hexaen-5-yl]ethyl 2-methylprop-2-enoate | —— | C61H61N3O7 |
|
—— | Methyl 2-(4-methoxyphenyl)-6-methyl-8-[4-[4-[4-(4-pentylcyclohexyl)phenyl]benzoyl]piperazin-1-yl]-2-phenylnaphtho[2,1-h]chromene-5-carboxylate | —— | C61H62N2O5 |
|
—— | N-[4-[11-(4-methoxyphenyl)-11-(4-morpholin-4-ylphenyl)-21-oxo-12,22-dioxapentacyclo[12.8.0.02,7.08,13.015,20]docosa-1,3,5,7,9,13,15,17,19-nonaen-3-yl]-3-(trifluoromethyl)phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide | —— | C68H61F3N2O6 |
|
—— | N-[4-[10-methoxy-5-(4-methoxyphenyl)-21,21-dimethyl-5-[4-[(2S)-2-methylbutoxy]phenyl]-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15,17,19-nonaen-3-yl]phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide | —— | C71H73NO5 |
|
—— | N-[4-[5-(4-methoxyphenyl)-21,21-dimethyl-5-[4-(trifluoromethoxy)phenyl]-10-(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15,17,19-nonaen-3-yl]phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide | —— | C67H59F6NO4 |
|
—— | ethyl (1R,9S,13S)-9-phenyl-11-sulfanylidene-8-oxa-10,12-diazatricyclo[7.3.1.02,7]trideca-2,4,6-triene-13-carboxylate | —— | C19H18N2O3S |
|
—— | [10-Methoxy-21,21-dimethyl-5-(4-morpholin-4-ylphenyl)-5-phenyl-17,19-bis(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8,10,12,15(20),16,18-nonaen-11-yl] 4-[4-[4-(4-phenylcyclohexyl)cyclohexanecarbonyl]oxyphenyl]benzoate | —— | C73H65F6NO7 |
|
—— | [4-(4-Pentylcyclohexyl)cyclohexyl] 4-[5-(4-butoxyphenyl)-5-(4-fluorophenyl)-21,21-dimethyl-10-(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15,17,19-nonaen-3-yl]benzoate | —— | C63H66F4O4 |
|
—— | N-[4-[5-(4-butoxyphenyl)-5-(4-fluorophenyl)-21,21-dimethyl-10-(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15,17,19-nonaen-3-yl]phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide | —— | C69H65F4NO3 |
|
—— | Dimethyl 8-[4-[[4-(4-pentylcyclohexyl)benzoyl]amino]phenyl]-2,2-diphenylbenzo[h]chromene-5,6-dicarboxylate | —— | C53H51NO6 |
|
—— | N-[4-[21,21-dimethyl-5-(4-morpholin-4-ylphenyl)-5-phenyl-10-(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15,17,19-nonaen-3-yl]phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide | —— | C69H65F3N2O3 |
|
—— | N-[4-[5-(4-fluorophenyl)-21,21-dimethyl-5-(4-morpholin-4-ylphenyl)-12-(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15(20),16,18-nonaen-17-yl]phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide | —— | C69H64F4N2O3 |
|
—— | 2-(2-morpholin-4-yl-1,3-thiazol-4-yl)-N'-[(2S)-2-phenyl-2H-chromen-4-yl]acetohydrazide | —— | C24H24N4O3S |
|
—— | 2-(2-morpholin-4-yl-1,3-thiazol-4-yl)-N'-[(2R)-2-phenyl-2H-chromen-4-yl]acetohydrazide | —— | C24H24N4O3S |
|
—— | silver;4-[5,7-dihydroxy-4-oxo-3-[(3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-2-yl]-2,6-dihydroxyphenolate | —— | C21H19AgO12 |
|
—— | propan-2-yl (2S)-2-[[[(2R,3R,4R,5R)-4-fluoro-3-hydroxy-4-methyl-5-(2-methylidene-4-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-(4-oxo-2-phenylchromen-6-yl)oxyphosphoryl]amino]propanoate | —— | C32H35FN3O10P |
|
—— | N'-[(2S)-2-phenyl-2H-chromen-4-yl]-1,3-benzodioxole-5-carbohydrazide | —— | C23H18N2O4 |
|
—— | N'-[(2R)-2-phenyl-2H-chromen-4-yl]-1,3-benzodioxole-5-carbohydrazide | —— | C23H18N2O4 |
|
—— | N-(2-hydroxyethyl)-4-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxamide | —— | C25H31NO4 |
|
—— | N'-[(2R)-2-phenyl-2H-chromen-4-yl]-2-[3-(trifluoromethyl)pyrazol-1-yl]acetohydrazide | —— | C21H17F3N4O2 |
|
—— | N'-[(2S)-2-phenyl-2H-chromen-4-yl]-2-[3-(trifluoromethyl)pyrazol-1-yl]acetohydrazide | —— | C21H17F3N4O2 |
|
—— | 5,5-dimethyl-2-(2-fluorophenyl)-(4-morpholinophenyl)-9-(4-(4-(4-pentylcyclohexyl)phenyloxycarbonyl)phenyl)-2,5-dihydro-7-oxofuro[3',4':3,4]naphtho[1,2-b]pyran | —— | C57H57FN2O5 |
|
—— | (2R,3R)-N-benzyl-2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3,4-dihydro-2H-chromen-3-amine | —— | C26H29NO5 |
|
—— | (2R,3R)-2-(4-hydroxy-3-phenylmethoxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol | —— | C22H20O6 |
|
—— | (2S)-2-(3-hydroxy-4-phenylmethoxyphenyl)-3,4-dihydro-2H-chromene-5,7-diol | —— | C22H20O5 |
|
—— | 5-[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-1,3-benzodioxol-2-one | —— | C16H12O7 |
|
—— | (2R,3R)-2-[4-hydroxy-3-(3-methylbut-2-enoxy)phenyl]-3,4-dihydro-2H-chromene-3,5,7-triol | —— | C20H22O6 |
|
—— | 1-[[(2R,3R)-5,7-dibutoxy-2-(3,4-dibutoxyphenyl)-3,4-dihydro-2H-chromen-3-yl]oxy]ethyl 2-methylpropanoate | —— | C37H56O8 |
|
—— | [(2R,3R)-2-[3,4-bis(phenylmethoxy)phenyl]-7-methyl-5-phenylmethoxy-3,4-dihydro-2H-chromen-3-yl] octanoate | —— | C45H48O6 |
|
—— | (2R,3S)-2-[3,4-bis(phenylmethoxy)phenyl]-7-methyl-5-phenylmethoxy-3,4-dihydro-2H-chromen-3-ol | —— | C37H34O5 |
|
—— | tert-butyl ((((2R,3R)-2-(3,4-dihydroxyphenyl)-5,7-dihydroxychroman-3-yl)oxy)methyl)carbonate | —— | C21H24O9 |
|
—— | (2R,3R)-2-[3,4-bis(phenylmethoxy)phenyl]-3-methoxy-7-methyl-5-phenylmethoxy-3,4-dihydro-2H-chromene | —— | C38H36O5 |
|
—— | (2R)-2-[3,4-bis(phenylmethoxy)phenyl]-7-methyl-5-phenylmethoxy-4H-chromen-3-one | —— | C37H32O5 |
|
—— | 1-[[(2R,3R)-2-[3,4-bis(phenylmethoxy)phenyl]-7-methyl-5-phenylmethoxy-3,4-dihydro-2H-chromen-3-yl]oxy]ethyl 2-methylpropanoate | —— | C43H44O7 |
|
—— | 4-hydroxy-N'-[(2R)-2-phenyl-2H-chromen-4-yl]benzohydrazide | —— | C22H18N2O3 |
|
—— | 4-hydroxy-N'-[(2S)-2-phenyl-2H-chromen-4-yl]benzohydrazide | —— | C22H18N2O3 |
|
—— | 5,7-Dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)chromen-4-one;ethoxyethane | —— | C21H24O8 |
|
—— | ethyl 4-[[2-(2-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylate | —— | C24H27FO4 |
|
—— | [4-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexyl]methanamine | —— | C22H27NO2 |
|
—— | N-[cis-4-(2-Phenyl-chroman-6-yloxy)-cyclohexylmethyl]-methanesulfonamide | —— | C23H29NO4S |
|
—— | 2-(3-fluoro-2-methoxyphenyl)-3,4-dihydro-2H-chromen-6-ol | —— | C16H15FO3 |
|
—— | ethyl 4-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxylate | —— | C24H28O4 |
|
—— | tert-butyl N-[4-[[2-(5-fluoro-2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexyl]carbamate | —— | C27H34FNO4 |
|