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    首页 分子通 按分子结构分类 有机化合物 苯丙烷和聚酮 黄酮类化合物

    黄酮类化合物

    黄酮类化合物 定义与结构特征

    黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。

    生物来源

    黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。

    化学性质 亲水性与溶解度

    由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。

    稳定性与光敏性

    大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。

    生理活性与药用价值

    黄酮类化合物因其丰富的生理活性而备受关注，主要包括：

    • 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
    • 抗炎效应：有助于减轻炎症反应，缓解症状。
    • 心血管保护：可能通过多种机制改善心脑血管健康。
    • 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
    应用领域 食品工业

    作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。

    化妆品行业

    利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。

    药物开发

    由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-(3-fluoro-2-methylphenyl)-3,4-dihydro-2H-chromen-6-ol —— C16H15FO2
    2-(3-fluoro-2-methylphenyl)-3,4-dihydro-2H-chromen-6-ol
    —— 4-[[2-(2-fluoro-3-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid —— C23H25FO5
    4-[[2-(2-fluoro-3-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid
    —— [trans-4-(2-o-Tolyl-chroman-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester —— C27H35NO4
    [trans-4-(2-o-Tolyl-chroman-6-yloxy)-cyclohexyl]-carbamic acid tert-butyl ester
    —— 1-benzyl-4-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxamide —— C29H31NO3
    1-benzyl-4-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxamide
    —— 4-[(5-chloro-2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxylic acid —— C22H23ClO4
    4-[(5-chloro-2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxylic acid
    —— [4-[(3-methyl-2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexanecarbonyl] 4-[[2-(2-fluoro-3-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylate —— C46H49FO8
    [4-[(3-methyl-2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexanecarbonyl] 4-[[2-(2-fluoro-3-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylate
    —— ethyl 4-[[(2S)-2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylate;ethyl 4-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylate —— C75H90O12
    ethyl 4-[[(2S)-2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylate;ethyl 4-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylate
    —— 4-[[2-(2-fluoro-3-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid;4-[(3-methyl-2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxylic acid —— C46H51FO9
    4-[[2-(2-fluoro-3-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid;4-[(3-methyl-2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxylic acid
    —— 6-(1,4-dioxa-spiro[4.5]dec-8-yloxy)-2-phenyl-chroman —— C23H26O4
    6-(1,4-dioxa-spiro[4.5]dec-8-yloxy)-2-phenyl-chroman
    —— 1-benzyl-4-(2-phenyl-chroman-6-yloxy)-cyclohexylamine —— C28H31NO2
    1-benzyl-4-(2-phenyl-chroman-6-yloxy)-cyclohexylamine
    —— trans-4-((S)-2-o-Tolyl-chroman-6-yloxy)-cyclohexanecarboxylic acid —— C23H26O4
    trans-4-((S)-2-o-Tolyl-chroman-6-yloxy)-cyclohexanecarboxylic acid
    —— trans-4-((S)-2-o-tolyl-chroman-6-yloxy)-cyclohexanecarboxylic acid ethyl ester —— C25H30O4
    trans-4-((S)-2-o-tolyl-chroman-6-yloxy)-cyclohexanecarboxylic acid ethyl ester
    —— [4-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexanecarbonyl] 4-[[2-(3-fluoro-2-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylate —— C46H49FO8
    [4-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexanecarbonyl] 4-[[2-(3-fluoro-2-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylate
    —— 6-Hydroxy-7-methyl-2-(2-methylphenyl)-2,3-dihydrochromen-4-one —— C17H16O3
    6-Hydroxy-7-methyl-2-(2-methylphenyl)-2,3-dihydrochromen-4-one
    —— ethyl 4-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylate —— C25H30O4
    ethyl 4-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylate
    —— trans-4-(2-o-Tolyl-chroman-6-yloxy)-cyclohexylamine hydrochloride —— C22H28ClNO2
    trans-4-(2-o-Tolyl-chroman-6-yloxy)-cyclohexylamine hydrochloride
    —— 4-[[2-(2-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexan-1-one —— C21H21FO3
    4-[[2-(2-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexan-1-one
    —— N-[4-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexyl]pyrrolidine-2-carboxamide —— C26H32N2O3
    N-[4-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexyl]pyrrolidine-2-carboxamide
    —— 4-[[2-(3-fluoro-2-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid;4-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid —— C46H51FO9
    4-[[2-(3-fluoro-2-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid;4-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid
    —— 4-[[2-(3-fluoro-2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexan-1-one —— C22H23FO3
    4-[[2-(3-fluoro-2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexan-1-one
    —— [cis-4-(2-o-Tolyl-chroman-6-yloxy)-cyclohexylmethyl]amine hydrochloride —— C23H30ClNO2
    [cis-4-(2-o-Tolyl-chroman-6-yloxy)-cyclohexylmethyl]amine hydrochloride
    —— 8-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,4-dioxaspiro[4.5]decane —— C24H28O4
    8-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,4-dioxaspiro[4.5]decane
    —— 2-amino-N-[4-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexyl]acetamide —— C23H28N2O3
    2-amino-N-[4-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexyl]acetamide
    —— 8-[[2-(2-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,4-dioxaspiro[4.5]decane —— C23H25FO4
    8-[[2-(2-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,4-dioxaspiro[4.5]decane
    —— N-[4-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexyl]pyrrolidine-2-carboxamide —— C26H32N2O3
    N-[4-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexyl]pyrrolidine-2-carboxamide
    —— 4-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxylic acid —— C22H24O4
    4-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxylic acid
    —— 4-(2-o-tolyl-chroman-6-yloxy)-cyclohexanone —— C22H24O3
    4-(2-o-tolyl-chroman-6-yloxy)-cyclohexanone
    —— 4-[[2-(2,6-dimethylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexan-1-one —— C23H26O3
    4-[[2-(2,6-dimethylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexan-1-one
    —— (Tetrahydrofuran-3-ylmethyl)-[trans-4-(2-o-tolyl-chroman-6-yloxy)-cyclohexyl]-amine —— C27H35NO3
    (Tetrahydrofuran-3-ylmethyl)-[trans-4-(2-o-tolyl-chroman-6-yloxy)-cyclohexyl]-amine
    —— 4-[[(2R)-2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid —— C23H26O4
    4-[[(2R)-2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid
    —— 5,5-dimethyl-2-(2-fluorophenyl)-(4-morpholinophenyl)-9-(4-(4-(4-pentylcyclohexyl)-[1,1'-biphenyl]-4-ylcarboxamido)phenyl)-2,5-dihydro-7-oxofuro[3',4':3,4]naphtho[1,2-b]pyran —— C63H61FN2O5
    5,5-dimethyl-2-(2-fluorophenyl)-(4-morpholinophenyl)-9-(4-(4-(4-pentylcyclohexyl)-[1,1'-biphenyl]-4-ylcarboxamido)phenyl)-2,5-dihydro-7-oxofuro[3',4':3,4]naphtho[1,2-b]pyran
    —— ethyl 2-[5-[(2R)-5,7-dimethoxy-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyphenoxy]acetate —— C21H24O7
    ethyl 2-[5-[(2R)-5,7-dimethoxy-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyphenoxy]acetate
    —— (3R)-3-hydroxy-3-[2-[4-(3-methoxy-4-methylphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid —— C26H26O5
    (3R)-3-hydroxy-3-[2-[4-(3-methoxy-4-methylphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
    —— (3R)-methyl 3-cyclobutyl-3-((R or S)-2-(2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)chroman-7-yl)propanoate —— C30H31FO4
    (3R)-methyl 3-cyclobutyl-3-((R or S)-2-(2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)chroman-7-yl)propanoate
    —— (3S)-3-cyclopropyl-3-[2-[3-[cyclopropyl(methoxy)methyl]-4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid —— C33H35FO5
    (3S)-3-cyclopropyl-3-[2-[3-[cyclopropyl(methoxy)methyl]-4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
    —— 3-[2-[3-(2,6-dimethylphenyl)phenyl]-3,4-dihydro-2H-chromen-6-yl]-5-methylhex-4-enoic acid —— C30H32O3
    3-[2-[3-(2,6-dimethylphenyl)phenyl]-3,4-dihydro-2H-chromen-6-yl]-5-methylhex-4-enoic acid
    —— (3R)-3-[2-[4-(3-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid —— C25H23FO5
    (3R)-3-[2-[4-(3-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid
    —— (3S)-3-cyclopropyl-3-[2-[4-(2-fluoro-5-methoxyphenyl)-3-(2,2,2-trifluoro-1-methoxyethyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid —— C31H30F4O5
    (3S)-3-cyclopropyl-3-[2-[4-(2-fluoro-5-methoxyphenyl)-3-(2,2,2-trifluoro-1-methoxyethyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
    —— methyl (3R)-3-[2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoate —— C26H25FO5
    methyl (3R)-3-[2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoate
    —— 3-[2-[3-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid —— C26H25NO4
    3-[2-[3-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid
    —— (3R)-3-[2-[2-fluoro-4-(3-methylpyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid —— C24H22FNO4
    (3R)-3-[2-[2-fluoro-4-(3-methylpyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid
    —— 3-[2-[3-(4-cyanophenoxy)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid —— C28H23NO4
    3-[2-[3-(4-cyanophenoxy)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid
    —— 3-cyclopropyl-3-[2-[3-(2,6-dimethylphenyl)phenyl]-3,4-dihydro-2H-chromen-6-yl]propanoic acid —— C29H30O3
    3-cyclopropyl-3-[2-[3-(2,6-dimethylphenyl)phenyl]-3,4-dihydro-2H-chromen-6-yl]propanoic acid
    —— (3S)-3-[2-[3-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid —— C26H25NO4
    (3S)-3-[2-[3-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid
    —— (3S)-3-[2-[4-butoxy-3-(2,6-dimethylphenyl)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid —— C33H36O4
    (3S)-3-[2-[4-butoxy-3-(2,6-dimethylphenyl)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid
    —— (3R)-3-[2-(2-fluoro-4-furo[3,2-b]pyridin-5-ylphenyl)-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid —— C25H20FNO5
    (3R)-3-[2-(2-fluoro-4-furo[3,2-b]pyridin-5-ylphenyl)-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid
    —— methyl (3R)-3-[2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxy-2-methylpropanoate —— C27H27FO5
    methyl (3R)-3-[2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxy-2-methylpropanoate
    —— (3R)-3-cyclobutyl-3-[(2R)-2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid —— C29H29FO4
    (3R)-3-cyclobutyl-3-[(2R)-2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
    —— 3-[2-[4-(2-fluoro-5-hydroxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-2-methylbutanoic acid —— C26H25FO4
    3-[2-[4-(2-fluoro-5-hydroxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-2-methylbutanoic acid
    —— methyl (2S,3R)-3-[2-(2-fluoro-4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-yl]-3-hydroxy-2-methylpropanoate —— C20H21FO5
    methyl (2S,3R)-3-[2-(2-fluoro-4-hydroxyphenyl)-3,4-dihydro-2H-chromen-7-yl]-3-hydroxy-2-methylpropanoate