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黄酮类化合物

黄酮类化合物 定义与结构特征

黄酮类化合物是一大类天然存在的有机化合物,属于酚类衍生物。它们的分子结构通常包含两个苯环(A和B环)和一个三碳环(C环),形成一个基本骨架。该骨架由多个亚结构组成,包括黄烷醇、黄酮、黄酮醇等。

生物来源

黄酮类化合物广泛存在于植物界中,常见于许多蔬菜、水果及中药中。例如,在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。

化学性质 亲水性与溶解度

由于其分子结构中含有多个酚羟基,因此具有一定的亲水性和良好的溶解性,这使得黄酮类化合物在药物设计中扮演重要角色。

稳定性与光敏性

大多数黄酮类化合物相对稳定,在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感,容易被氧化,导致颜色变化。

生理活性与药用价值

黄酮类化合物因其丰富的生理活性而备受关注,主要包括:

  • 抗氧化作用:可有效清除体内自由基,保护细胞免受损伤。
  • 抗炎效应:有助于减轻炎症反应,缓解症状。
  • 心血管保护:可能通过多种机制改善心脑血管健康。
  • 抗癌潜力:研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
应用领域 食品工业

作为一种天然色素和抗氧化剂,被广泛应用于食品加工中以提高其保质期及营养价值。

化妆品行业

利用其良好的生物相容性和抗衰老特性,在化妆品配方中应用广泛。

药物开发

由于黄酮类化合物展现出广泛的药理活性,已成为新药研发的重要候选目标之一。

中文名称 英文名称 CAS号 化学式 结构式图片
—— [6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] 2,2-diphenylacetate —— C29H18Cl2O4
[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] 2,2-diphenylacetate
—— [6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] methanesulfonate —— C16H10Cl2O5S
[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] methanesulfonate
—— 2-(4-Tert-butylphenyl)-6-chloro-3-(2-naphthalen-1-yloxyethoxy)chromen-4-one —— C31H27ClO4
2-(4-Tert-butylphenyl)-6-chloro-3-(2-naphthalen-1-yloxyethoxy)chromen-4-one
—— 6-Chloro-2-(2-chlorophenyl)-3-[(2-fluorophenyl)methoxy]chromen-4-one —— C22H13Cl2FO3
6-Chloro-2-(2-chlorophenyl)-3-[(2-fluorophenyl)methoxy]chromen-4-one
—— 2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-naphthalen-1-ylacetamide —— C27H17Cl2NO4
2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-naphthalen-1-ylacetamide
—— 3-[2-(1-Benzofuran-2-yl)-2-oxoethoxy]-2-(4-tert-butylphenyl)-6-chlorochromen-4-one —— C29H23ClO5
3-[2-(1-Benzofuran-2-yl)-2-oxoethoxy]-2-(4-tert-butylphenyl)-6-chlorochromen-4-one
—— (2S)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-(3,5-dichlorophenyl)propanamide —— C24H15Cl4NO4
(2S)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-(3,5-dichlorophenyl)propanamide
—— 6-Chloro-2-(2-chlorophenyl)-3-phenylmethoxychromen-4-one —— C22H14Cl2O3
6-Chloro-2-(2-chlorophenyl)-3-phenylmethoxychromen-4-one
—— 2-[2-(4-tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxy-N-(5-methyl-1,3-benzothiazol-2-yl)acetamide —— C29H25ClN2O4S
2-[2-(4-tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxy-N-(5-methyl-1,3-benzothiazol-2-yl)acetamide
—— 6-Chloro-2-(2-chlorophenyl)-3-[(2-chlorophenyl)methoxy]chromen-4-one —— C22H13Cl3O3
6-Chloro-2-(2-chlorophenyl)-3-[(2-chlorophenyl)methoxy]chromen-4-one
—— 2-Phenoxyethyl 2-[2-(4-tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxyacetate —— C29H27ClO6
2-Phenoxyethyl 2-[2-(4-tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxyacetate
—— 2-(4-Tert-butylphenyl)-6-chloro-3-(3-naphthalen-1-yloxypropoxy)chromen-4-one —— C32H29ClO4
2-(4-Tert-butylphenyl)-6-chloro-3-(3-naphthalen-1-yloxypropoxy)chromen-4-one
—— [6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] 4-fluorobenzoate —— C22H11Cl2FO4
[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] 4-fluorobenzoate
—— 2-[2-(4-tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxy-N-(3-chloro-4-methoxyphenyl)acetamide —— C28H25Cl2NO5
2-[2-(4-tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxy-N-(3-chloro-4-methoxyphenyl)acetamide
—— 3-[[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxymethyl]benzoate —— C23H13Cl2O5-
3-[[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxymethyl]benzoate
—— Ethyl 2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetate —— C19H14Cl2O5
Ethyl 2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetate
—— 5-[[2-(4-Tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxymethyl]furan-2-carboxylic acid —— C25H21ClO6
5-[[2-(4-Tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxymethyl]furan-2-carboxylic acid
—— 2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-phenylacetamide —— C23H15Cl2NO4
2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-phenylacetamide
—— 2-Methylpropyl 2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetate —— C21H18Cl2O5
2-Methylpropyl 2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetate
—— 6-Chloro-3-[(2-chloro-6-fluorophenyl)methoxy]-2-(2-chlorophenyl)chromen-4-one —— C22H12Cl3FO3
6-Chloro-3-[(2-chloro-6-fluorophenyl)methoxy]-2-(2-chlorophenyl)chromen-4-one
—— N-(4-acetamidophenyl)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetamide —— C25H18Cl2N2O5
N-(4-acetamidophenyl)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetamide
—— 3-[[2-(4-Tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxymethyl]benzoate —— C27H22ClO5-
3-[[2-(4-Tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxymethyl]benzoate
—— 6-Chloro-2-(2-chlorophenyl)-3-[2-(4-methoxyphenoxy)ethoxy]chromen-4-one —— C24H18Cl2O5
6-Chloro-2-(2-chlorophenyl)-3-[2-(4-methoxyphenoxy)ethoxy]chromen-4-one
—— (2S)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-(4-ethylphenyl)propanamide —— C26H21Cl2NO4
(2S)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-(4-ethylphenyl)propanamide
—— 6-Chloro-2-(2-chlorophenyl)-3-propan-2-yloxychromen-4-one —— C18H14Cl2O3
6-Chloro-2-(2-chlorophenyl)-3-propan-2-yloxychromen-4-one
—— [6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] furan-2-carboxylate —— C20H10Cl2O5
[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] furan-2-carboxylate
—— 6-Chloro-2-(2-chlorophenyl)-3-(2-oxo-2-piperidin-1-ylethoxy)chromen-4-one —— C22H19Cl2NO4
6-Chloro-2-(2-chlorophenyl)-3-(2-oxo-2-piperidin-1-ylethoxy)chromen-4-one
—— 5-[[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxymethyl]furan-2-carboxylate —— C21H11Cl2O6-
5-[[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxymethyl]furan-2-carboxylate
—— 6-Chloro-2-(2-chlorophenyl)-3-[(3,4-dichlorophenyl)methoxy]chromen-4-one —— C22H12Cl4O3
6-Chloro-2-(2-chlorophenyl)-3-[(3,4-dichlorophenyl)methoxy]chromen-4-one
—— N-(4-bromophenyl)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetamide —— C23H14BrCl2NO4
N-(4-bromophenyl)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetamide
—— 2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-(4-methoxyphenyl)acetamide —— C24H17Cl2NO5
2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-(4-methoxyphenyl)acetamide
—— 3-[2-(Azepan-1-yl)-2-oxoethoxy]-2-(4-tert-butylphenyl)-6-chlorochromen-4-one —— C27H30ClNO4
3-[2-(Azepan-1-yl)-2-oxoethoxy]-2-(4-tert-butylphenyl)-6-chlorochromen-4-one
—— (2R)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-(2,4,6-trimethylphenyl)propanamide —— C27H23Cl2NO4
(2R)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-(2,4,6-trimethylphenyl)propanamide
—— (2S)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-phenylpropanamide —— C24H17Cl2NO4
(2S)-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-phenylpropanamide
—— 6-Chloro-2-(2-chlorophenyl)-3-[2-(3,4-dimethylphenyl)-2-oxoethoxy]chromen-4-one —— C25H18Cl2O4
6-Chloro-2-(2-chlorophenyl)-3-[2-(3,4-dimethylphenyl)-2-oxoethoxy]chromen-4-one
—— 6-Chloro-2-(2-chlorophenyl)-3-[2-(4-methylphenyl)-2-oxoethoxy]chromen-4-one —— C24H16Cl2O4
6-Chloro-2-(2-chlorophenyl)-3-[2-(4-methylphenyl)-2-oxoethoxy]chromen-4-one
—— 6-Chloro-2-(2-chlorophenyl)-3-hydroxychromen-4-one —— C15H8Cl2O3
6-Chloro-2-(2-chlorophenyl)-3-hydroxychromen-4-one
—— Benzyl 2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetate —— C24H16Cl2O5
Benzyl 2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetate
—— [6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] 3,4,5-trimethoxybenzoate —— C25H18Cl2O7
[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] 3,4,5-trimethoxybenzoate
—— N-(4-acetamidophenyl)-2-[2-(4-tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxyacetamide —— C29H27ClN2O5
N-(4-acetamidophenyl)-2-[2-(4-tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxyacetamide
—— 2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-(4-chlorophenyl)acetamide —— C23H14Cl3NO4
2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxy-N-(4-chlorophenyl)acetamide
—— Ethyl 2-[[2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetyl]amino]-1,3-benzothiazole-5-carboxylate —— C27H18Cl2N2O6S
Ethyl 2-[[2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetyl]amino]-1,3-benzothiazole-5-carboxylate
—— N-benzyl-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetamide —— C24H17Cl2NO4
N-benzyl-2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetamide
—— 6-Chloro-2-(2-chlorophenyl)-3-[2-(4-fluorophenyl)-2-oxoethoxy]chromen-4-one —— C23H13Cl2FO4
6-Chloro-2-(2-chlorophenyl)-3-[2-(4-fluorophenyl)-2-oxoethoxy]chromen-4-one
—— N-[4-[2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetyl]phenyl]acetamide —— C25H17Cl2NO5
N-[4-[2-[6-chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetyl]phenyl]acetamide
—— [6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] 2-methylpropanoate —— C19H14Cl2O4
[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl] 2-methylpropanoate
—— 2-(4-Tert-butylphenyl)-6-chloro-3-(2-oxo-2-thiophen-2-ylethoxy)chromen-4-one —— C25H21ClO4S
2-(4-Tert-butylphenyl)-6-chloro-3-(2-oxo-2-thiophen-2-ylethoxy)chromen-4-one
—— 2-[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetate —— C17H9Cl2O5-
2-[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetate
—— 2-[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetamide —— C17H11Cl2NO4
2-[6-Chloro-2-(2-chlorophenyl)-4-oxochromen-3-yl]oxyacetamide
—— 2-[2-(4-tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxy-N-(2-chlorophenyl)acetamide —— C27H23Cl2NO4
2-[2-(4-tert-butylphenyl)-6-chloro-4-oxochromen-3-yl]oxy-N-(2-chlorophenyl)acetamide