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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C14H14ClN3O2S
    N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— 2-[2-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-oxoethyl]sulfanyl-1H-pyrimidin-6-one —— C19H15ClN4O3S
    2-[2-[(3R)-5-(4-chlorophenyl)-3-(furan-2-yl)-3,4-dihydropyrazol-2-yl]-2-oxoethyl]sulfanyl-1H-pyrimidin-6-one
    —— 2-(2-methylphenyl)sulfanyl-N-[5-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)pentyl]acetamide —— C20H23N3O2S2
    2-(2-methylphenyl)sulfanyl-N-[5-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)pentyl]acetamide
    —— N-[(2R)-butan-2-yl]-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C14H21N3O4S2
    N-[(2R)-butan-2-yl]-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-N-(2-methylpropyl)-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C14H21N3O4S2
    N-[(3S)-1,1-dioxothiolan-3-yl]-N-(2-methylpropyl)-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— 2-phenylsulfanyl-N-[5-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)pentyl]acetamide —— C19H21N3O2S2
    2-phenylsulfanyl-N-[5-(3-thiophen-2-yl-1,2,4-oxadiazol-5-yl)pentyl]acetamide
    —— N-[(1R)-1-(2-chlorophenyl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C14H14ClN3O2S
    N-[(1R)-1-(2-chlorophenyl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C14H14ClN3O2S
    N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— 2-[[2-(Hexahydro-1H-azepin-1-yl)-2-oxoethyl]thio]-4(3H)-pyrimidinone 948291-82-5 C12H17N3O2S
    2-[[2-(Hexahydro-1H-azepin-1-yl)-2-oxoethyl]thio]-4(3H)-pyrimidinone
    —— [(3S)-3-cyano-4-imino-2-oxopentyl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate —— C14H16N4O3S
    [(3S)-3-cyano-4-imino-2-oxopentyl] 2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetate
    —— (2S)-N-cyclopentyl-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide —— C12H17N3O2S
    (2S)-N-cyclopentyl-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide
    —— (2R)-N-(1-cyanocyclohexyl)-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide —— C14H18N4O2S
    (2R)-N-(1-cyanocyclohexyl)-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide
    —— (2R)-3-methyl-1-morpholin-4-yl-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylbutan-1-one —— C14H18F3N3O2S
    (2R)-3-methyl-1-morpholin-4-yl-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylbutan-1-one
    —— 2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(thiophen-2-ylmethyl)acetamide —— C11H11N3O2S2
    2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(thiophen-2-ylmethyl)acetamide
    —— (2R)-N-cyclopentyl-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide —— C12H17N3O2S
    (2R)-N-cyclopentyl-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide
    —— (2S)-N-[2-(cyclohexen-1-yl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide —— C15H21N3O2S
    (2S)-N-[2-(cyclohexen-1-yl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]propanamide
    —— ethyl 2,4-dimethyl-5-[2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]-1H-pyrrole-3-carboxylate —— C15H17N3O4S
    ethyl 2,4-dimethyl-5-[2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetyl]-1H-pyrrole-3-carboxylate
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C12H17N3O4S2
    N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C11H15N3O4S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-methyl-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(4-fluorophenyl)methyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C13H12FN3O2S
    N-[(4-fluorophenyl)methyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— 2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide —— C8H8F3N3O2S
    2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-(2,2,2-trifluoroethyl)acetamide
    —— 2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-propylacetamide —— C9H13N3O2S
    2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-propylacetamide
    —— 2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-[(2R)-pentan-2-yl]acetamide —— C11H17N3O2S
    2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-[(2R)-pentan-2-yl]acetamide
    —— N-[(2R)-3-methylbutan-2-yl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C11H17N3O2S
    N-[(2R)-3-methylbutan-2-yl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-butyl-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C10H15N3O2S
    N-butyl-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C12H16N4O2S
    N-[(2R)-2-cyano-3-methylbutan-2-yl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— (2S)-3-methyl-1-morpholin-4-yl-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylbutan-1-one —— C14H18F3N3O2S
    (2S)-3-methyl-1-morpholin-4-yl-2-[4-(trifluoromethyl)pyrimidin-2-yl]sulfanylbutan-1-one
    —— N-[(1S)-1-(2-bromophenyl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C14H14BrN3O2S
    N-[(1S)-1-(2-bromophenyl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C11H15N3O4S2
    N-[(3S)-3-methyl-1,1-dioxothiolan-3-yl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-(1-adamantylmethyl)-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C17H23N3O2S
    N-(1-adamantylmethyl)-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— (3S)-1-methyl-3-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]pyrrolidin-2-one —— C9H12N2OS2
    (3S)-1-methyl-3-[(4-methyl-1,3-thiazol-2-yl)sulfanyl]pyrrolidin-2-one
    —— (3S)-1-methyl-3-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]pyrrolidin-2-one —— C13H13N3OS3
    (3S)-1-methyl-3-[(4-phenyl-5-sulfanylidene-1,3,4-thiadiazol-2-yl)sulfanyl]pyrrolidin-2-one
    —— N-[2-(4-chlorophenyl)sulfanylphenyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C18H14ClN3O2S2
    N-[2-(4-chlorophenyl)sulfanylphenyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— (3S)-1-methyl-3-[(5-methyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]pyrrolidin-2-one —— C11H16N4OS
    (3S)-1-methyl-3-[(5-methyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]pyrrolidin-2-one
    —— (3R)-1-methyl-3-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]pyrrolidin-2-one —— C12H13N3O3S
    (3R)-1-methyl-3-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]pyrrolidin-2-one
    —— 2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-pentan-3-ylacetamide —— C11H17N3O2S
    2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-pentan-3-ylacetamide
    —— (3R)-3-[(5-cyclopropyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-1-methylpyrrolidin-2-one —— C13H18N4OS
    (3R)-3-[(5-cyclopropyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-1-methylpyrrolidin-2-one
    —— (3S)-1-methyl-3-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]pyrrolidin-2-one —— C13H16N4O2S
    (3S)-1-methyl-3-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]pyrrolidin-2-one
    —— (3S)-1-methyl-3-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]pyrrolidin-2-one —— C16H19N3O2S
    (3S)-1-methyl-3-[[5-[(2R)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]pyrrolidin-2-one
    —— (3S)-1-methyl-3-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]pyrrolidin-2-one —— C12H13N3O3S
    (3S)-1-methyl-3-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]pyrrolidin-2-one
    —— (3S)-1-methyl-3-(1-methyltetrazol-5-yl)sulfanylpyrrolidin-2-one —— C7H11N5OS
    (3S)-1-methyl-3-(1-methyltetrazol-5-yl)sulfanylpyrrolidin-2-one
    —— (3S)-3-[(5-cyclopropyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-1-methylpyrrolidin-2-one —— C13H18N4OS
    (3S)-3-[(5-cyclopropyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]-1-methylpyrrolidin-2-one
    —— (3S)-3-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-methylpyrrolidin-2-one —— C13H20N4OS2
    (3S)-3-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-methylpyrrolidin-2-one
    —— (3S)-1-methyl-3-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]pyrrolidin-2-one —— C16H19N3O2S
    (3S)-1-methyl-3-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]pyrrolidin-2-one
    —— N-[(1S)-1-(4-ethylphenyl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C16H19N3O2S
    N-[(1S)-1-(4-ethylphenyl)ethyl]-2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— (3R)-3-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-methylpyrrolidin-2-one —— C13H20N4OS2
    (3R)-3-[[5-(cyclohexylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-methylpyrrolidin-2-one
    —— (3R)-1-methyl-3-[[5-(2-methylfuran-3-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]pyrrolidin-2-one —— C15H18N4O2S
    (3R)-1-methyl-3-[[5-(2-methylfuran-3-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]pyrrolidin-2-one
    —— (3R)-1-methyl-3-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]pyrrolidin-2-one —— C16H19N3O2S
    (3R)-1-methyl-3-[[5-[(2S)-2-phenylpropyl]-1,3,4-oxadiazol-2-yl]sulfanyl]pyrrolidin-2-one
    —— (3R)-3-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-methylpyrrolidin-2-one —— C15H18N4OS2
    (3R)-3-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-1-methylpyrrolidin-2-one
    —— (3R)-3-[[4-amino-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-methylpyrrolidin-2-one —— C12H15N5O2S
    (3R)-3-[[4-amino-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-1-methylpyrrolidin-2-one