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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 3-(4-chlorophenyl)sulfanylpropyl-[(2S)-2-hydroxypropyl]azanium —— C12H19ClNOS+
    3-(4-chlorophenyl)sulfanylpropyl-[(2S)-2-hydroxypropyl]azanium
    —— methyl 2,4-dimethyl-5-[(2S)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate —— C18H23N3O4S
    methyl 2,4-dimethyl-5-[(2S)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate
    —— 1-[2,5-dimethyl-1-[[(2S)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C19H21N3O4S
    1-[2,5-dimethyl-1-[[(2S)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— 3-(4-Chlorophenyl)sulfanylpropyl-(2-morpholin-4-ium-4-ylethyl)azanium —— C15H25ClN2OS+2
    3-(4-Chlorophenyl)sulfanylpropyl-(2-morpholin-4-ium-4-ylethyl)azanium
    —— N-[(2R)-butan-2-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C12H15N3O3S
    N-[(2R)-butan-2-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— N-benzyl-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propan-2-ylacetamide —— C18H19N3O3S
    N-benzyl-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-propan-2-ylacetamide
    —— N-(1-cyanocyclohexyl)-2-[(4-hydroxy-6-propylpyrimidin-2-yl)sulfanyl]acetamide —— C16H22N4O2S
    N-(1-cyanocyclohexyl)-2-[(4-hydroxy-6-propylpyrimidin-2-yl)sulfanyl]acetamide
    —— (2S)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanenitrile —— C10H13N3OS
    (2S)-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanenitrile
    —— (2R)-N-(cyclohexylmethyl)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C16H21N3O3S
    (2R)-N-(cyclohexylmethyl)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C15H23N3O4S2
    N-[(3S)-1,1-dioxothiolan-3-yl]-N-ethyl-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— N-[(2R)-butan-2-yl]-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide —— C17H27N3O4S2
    N-[(2R)-butan-2-yl]-N-[(3R)-1,1-dioxothiolan-3-yl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]acetamide
    —— 1-(2-methylsulfanylpyrimidin-4-yl)-N-[(3S)-thiolan-3-yl]piperidin-4-amine —— C14H22N4S2
    1-(2-methylsulfanylpyrimidin-4-yl)-N-[(3S)-thiolan-3-yl]piperidin-4-amine
    —— N-[2-(4-fluorophenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C16H14FN3O3S
    N-[2-(4-fluorophenyl)ethyl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— (2S)-N-(cyclohexylcarbamoyl)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide —— C16H20N4O4S
    (2S)-N-(cyclohexylcarbamoyl)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanamide
    —— methyl 5-[(2S)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C17H17N3O5S
    methyl 5-[(2S)-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— N-[(2S)-butan-2-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C12H15N3O3S
    N-[(2S)-butan-2-yl]-2-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[(4-Bromo-2-fluorophenyl)methylsulfanyl]-5-(furan-2-yl)-1,3,4-oxadiazole —— C13H8BrFN2O2S
    2-[(4-Bromo-2-fluorophenyl)methylsulfanyl]-5-(furan-2-yl)-1,3,4-oxadiazole
    —— (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanamide —— C18H22FN3O2S
    (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(6-oxo-4-propyl-1H-pyrimidin-2-yl)sulfanyl]propanamide
    —— 1-[2,5-dimethyl-1-[[(2R)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylethanone —— C18H22N2O3S
    1-[2,5-dimethyl-1-[[(2R)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-(1-oxidopyridin-1-ium-2-yl)sulfanylethanone
    —— N-[(E)-1-(2,5-dimethylfuran-3-yl)ethylideneamino]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide —— C16H20N4O2S
    N-[(E)-1-(2,5-dimethylfuran-3-yl)ethylideneamino]-2-(4,6-dimethylpyrimidin-2-yl)sulfanylacetamide
    —— 3-(4-fluorophenyl)sulfanyl-N-[(Z)-(1-methyl-6,7-dihydro-5H-indazol-4-ylidene)amino]propanamide —— C17H19FN4OS
    3-(4-fluorophenyl)sulfanyl-N-[(Z)-(1-methyl-6,7-dihydro-5H-indazol-4-ylidene)amino]propanamide
    —— (2R)-N-[(1R)-1-phenylethyl]-2-[(6-phenyl-1,2,4-triazin-3-yl)sulfanyl]butanamide —— C21H22N4OS
    (2R)-N-[(1R)-1-phenylethyl]-2-[(6-phenyl-1,2,4-triazin-3-yl)sulfanyl]butanamide
    —— 2-Amino-6-[(2-fluorophenyl)methylsulfanyl]pyridin-1-ium-3,5-dicarbonitrile —— C14H10FN4S+
    2-Amino-6-[(2-fluorophenyl)methylsulfanyl]pyridin-1-ium-3,5-dicarbonitrile
    —— (2R)-2-thiophen-2-ylsulfanylbutanedioic acid —— C8H8O4S2
    (2R)-2-thiophen-2-ylsulfanylbutanedioic acid
    —— (2R)-2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one —— C18H21N3OS
    (2R)-2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one
    —— (2S)-2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one —— C18H21N3OS
    (2S)-2-[(5-benzyl-4-prop-2-enyl-1,2,4-triazol-3-yl)sulfanyl]cyclohexan-1-one
    —— 2-[(Z)-2-hydroxy-4-oxopent-2-enyl]sulfanyl-4-methoxy-6-methylpyridine-3-carbonitrile —— C13H14N2O3S
    2-[(Z)-2-hydroxy-4-oxopent-2-enyl]sulfanyl-4-methoxy-6-methylpyridine-3-carbonitrile
    —— 2-(1-methyltetrazol-5-yl)sulfanyl-N-[(1R)-1-phenylethyl]acetamide —— C12H15N5OS
    2-(1-methyltetrazol-5-yl)sulfanyl-N-[(1R)-1-phenylethyl]acetamide
    —— ethyl 2,4-dimethyl-5-[(2S)-2-(1-methyltetrazol-5-yl)sulfanylpropanoyl]-1H-pyrrole-3-carboxylate —— C14H19N5O3S
    ethyl 2,4-dimethyl-5-[(2S)-2-(1-methyltetrazol-5-yl)sulfanylpropanoyl]-1H-pyrrole-3-carboxylate
    —— 1-[(3R)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone —— C18H18N6O2S
    1-[(3R)-3-(furan-2-yl)-5-(4-methylphenyl)-3,4-dihydropyrazol-2-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone
    —— (3S)-3-[[5-(4-methylpiperidin-1-yl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one —— C17H26N4O3S
    (3S)-3-[[5-(4-methylpiperidin-1-yl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one
    —— (3S)-3-[[5-(4-methylpiperidin-1-yl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one —— C17H26N4O3S
    (3S)-3-[[5-(4-methylpiperidin-1-yl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one
    —— (3R)-3-[[5-(4-methylpiperidin-1-yl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one —— C17H26N4O3S
    (3R)-3-[[5-(4-methylpiperidin-1-yl)-4-[[(2R)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one
    —— (3R)-3-[[5-(4-methylpiperidin-1-yl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one —— C17H26N4O3S
    (3R)-3-[[5-(4-methylpiperidin-1-yl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]sulfanyl]oxolan-2-one
    —— 2-(Benzyliminomethyl)-1-benzothiophen-3-one —— C16H13NOS
    2-(Benzyliminomethyl)-1-benzothiophen-3-one
    —— 1-[2,5-dimethyl-1-[[(2R)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-(1-methylimidazol-2-yl)sulfanylethanone —— C17H23N3O2S
    1-[2,5-dimethyl-1-[[(2R)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-(1-methylimidazol-2-yl)sulfanylethanone
    —— 2-(1-Methylimidazol-2-yl)sulfanyl-1-(5-phenyl-3,4-dihydropyrazol-2-yl)ethanone —— C15H16N4OS
    2-(1-Methylimidazol-2-yl)sulfanyl-1-(5-phenyl-3,4-dihydropyrazol-2-yl)ethanone
    —— N-[(4-fluorophenyl)methyl]-2-(1-methylimidazol-2-yl)sulfanylacetamide —— C13H14FN3OS
    N-[(4-fluorophenyl)methyl]-2-(1-methylimidazol-2-yl)sulfanylacetamide
    —— (2R)-3-methylbutane-2-thiol —— C5H12S
    (2R)-3-methylbutane-2-thiol
    —— 2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-(2,5-dimethyl-1-prop-2-enylpyrrol-3-yl)ethanone —— C21H24N4OS
    2-[(5-Benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-1-(2,5-dimethyl-1-prop-2-enylpyrrol-3-yl)ethanone
    —— 1-(1-Adamantyl)-2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C22H27N3OS
    1-(1-Adamantyl)-2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— (2S)-2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C13H16N4OS
    (2S)-2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(1R)-1-(1-adamantyl)ethyl]-2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C24H32N4OS
    N-[(1R)-1-(1-adamantyl)ethyl]-2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— 2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(1-cyanocyclopentyl)acetamide —— C18H21N5OS
    2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]-N-(1-cyanocyclopentyl)acetamide
    —— 2-[1,4-dimethyl-5-[(2-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanyl-N,N-diethylacetamide —— C20H27N3O2S
    2-[1,4-dimethyl-5-[(2-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanyl-N,N-diethylacetamide
    —— 2-[[4-Methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-5-phenyl-1,3,4-oxadiazole —— C17H15N5OS2
    2-[[4-Methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanylmethyl]-5-phenyl-1,3,4-oxadiazole
    —— 1-methyl-N-[2-[[4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]pyrrole-2-carboxamide —— C16H17N5O2S2
    1-methyl-N-[2-[[4-methyl-5-(thiophen-2-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetyl]pyrrole-2-carboxamide
    —— 1-[(4S)-5,5-dimethyl-3-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-2-sulfanylidene-1,3-thiazolidin-4-yl]-1-hydroxy-3-methylurea —— C15H20N4O2S3
    1-[(4S)-5,5-dimethyl-3-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-2-sulfanylidene-1,3-thiazolidin-4-yl]-1-hydroxy-3-methylurea
    —— 5-[(4-Fluorophenyl)methyl]-3,6-dimethyl-2-prop-2-enylsulfanylpyrimidin-4-one —— C16H17FN2OS
    5-[(4-Fluorophenyl)methyl]-3,6-dimethyl-2-prop-2-enylsulfanylpyrimidin-4-one
    —— (2-Oxo-2-pyrrolidin-1-ylethyl) 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate —— C16H20N4O4S
    (2-Oxo-2-pyrrolidin-1-ylethyl) 2-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]acetate