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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-[(1R)-1-[4-[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]triazol-1-yl]ethyl]-1,3,4-thiadiazol-2-amine —— C13H13N9OS2
    5-[(1R)-1-[4-[5-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]furan-2-yl]triazol-1-yl]ethyl]-1,3,4-thiadiazol-2-amine
    —— (2S)-N-[2-(1-methyltetrazol-5-yl)sulfanylethyl]-2-pyrazol-1-ylbutanamide —— C11H17N7OS
    (2S)-N-[2-(1-methyltetrazol-5-yl)sulfanylethyl]-2-pyrazol-1-ylbutanamide
    —— 3-Fluoro-4-(pentafluoroethylthio)bromobenzene —— C8H3BrF6S
    3-Fluoro-4-(pentafluoroethylthio)bromobenzene
    —— 1-[(E)-2-bromoethenyl]sulfanyl-1,1,2,2,2-pentafluoroethane —— C4H2BrF5S
    1-[(E)-2-bromoethenyl]sulfanyl-1,1,2,2,2-pentafluoroethane
    —— 1-[(2R)-2-(5-ethylfuran-2-yl)azepan-1-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone —— C16H23N5O2S
    1-[(2R)-2-(5-ethylfuran-2-yl)azepan-1-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone
    —— (5R)-3-(3-methylsulfanylphenyl)-5-phenyl-1,3-thiazolidine-2,4-dione —— C16H13NO2S2
    (5R)-3-(3-methylsulfanylphenyl)-5-phenyl-1,3-thiazolidine-2,4-dione
    —— (5S)-3-hydroxy-5-phenyl-2-phenylsulfanylcyclohex-2-en-1-one —— C18H16O2S
    (5S)-3-hydroxy-5-phenyl-2-phenylsulfanylcyclohex-2-en-1-one
    —— (1S)-1-[4-(difluoromethylsulfanyl)phenyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]ethanamine —— C13H16F2N4S
    (1S)-1-[4-(difluoromethylsulfanyl)phenyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]ethanamine
    —— (1R)-1-[4-(difluoromethylsulfanyl)phenyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]ethanamine —— C13H16F2N4S
    (1R)-1-[4-(difluoromethylsulfanyl)phenyl]-N-[(1-methyl-1,2,4-triazol-3-yl)methyl]ethanamine
    —— 1-[(2S)-2-(5-ethylfuran-2-yl)azepan-1-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone —— C16H23N5O2S
    1-[(2S)-2-(5-ethylfuran-2-yl)azepan-1-yl]-2-(1-methyltetrazol-5-yl)sulfanylethanone
    —— (2R)-1-(2-aminophenyl)sulfanyl-3-[3-(trifluoromethyl)pyrazol-1-yl]propan-2-ol —— C13H14F3N3OS
    (2R)-1-(2-aminophenyl)sulfanyl-3-[3-(trifluoromethyl)pyrazol-1-yl]propan-2-ol
    —— (1S)-2,2-dimethyl-N-[(2R)-2-[(S)-methylsulfinyl]propyl]cyclopentan-1-amine —— C11H23NOS
    (1S)-2,2-dimethyl-N-[(2R)-2-[(S)-methylsulfinyl]propyl]cyclopentan-1-amine
    —— (2S)-1-(2-aminophenyl)sulfanyl-3-[3-(trifluoromethyl)pyrazol-1-yl]propan-2-ol —— C13H14F3N3OS
    (2S)-1-(2-aminophenyl)sulfanyl-3-[3-(trifluoromethyl)pyrazol-1-yl]propan-2-ol
    —— 3-[2-oxo-2-(3-phenyl-1,2-oxazol-5-yl)ethyl]sulfanyl-4-[(1R)-1-phenylethyl]-1H-1,2,4-triazol-5-one —— C21H18N4O3S
    3-[2-oxo-2-(3-phenyl-1,2-oxazol-5-yl)ethyl]sulfanyl-4-[(1R)-1-phenylethyl]-1H-1,2,4-triazol-5-one
    —— (1R)-2,2-dimethyl-N-[(2R)-2-[(S)-methylsulfinyl]propyl]cyclopentan-1-amine —— C11H23NOS
    (1R)-2,2-dimethyl-N-[(2R)-2-[(S)-methylsulfinyl]propyl]cyclopentan-1-amine
    —— (1R)-1-(3-fluoro-4-methylsulfanylphenyl)-N-[[(3S)-1-methylsulfonylpyrrolidin-3-yl]methyl]ethanamine —— C15H23FN2O2S2
    (1R)-1-(3-fluoro-4-methylsulfanylphenyl)-N-[[(3S)-1-methylsulfonylpyrrolidin-3-yl]methyl]ethanamine
    —— 1-methylsulfonyl-N-[(2S)-1-phenylsulfanylbutan-2-yl]piperidin-4-amine —— C16H26N2O2S2
    1-methylsulfonyl-N-[(2S)-1-phenylsulfanylbutan-2-yl]piperidin-4-amine
    —— (1R)-1-(3-fluoro-4-methylsulfanylphenyl)-N-[[(3R)-1-methylsulfonylpyrrolidin-3-yl]methyl]ethanamine —— C15H23FN2O2S2
    (1R)-1-(3-fluoro-4-methylsulfanylphenyl)-N-[[(3R)-1-methylsulfonylpyrrolidin-3-yl]methyl]ethanamine
    —— (1S)-1-(3-fluoro-4-methylsulfanylphenyl)-N-[[(3S)-1-methylsulfonylpyrrolidin-3-yl]methyl]ethanamine —— C15H23FN2O2S2
    (1S)-1-(3-fluoro-4-methylsulfanylphenyl)-N-[[(3S)-1-methylsulfonylpyrrolidin-3-yl]methyl]ethanamine
    —— 2-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanyl]-3-hydroxy-5,5-dimethylcyclohex-2-en-1-one —— C23H21N3O2S
    2-[(5,6-Diphenyl-1,2,4-triazin-3-yl)sulfanyl]-3-hydroxy-5,5-dimethylcyclohex-2-en-1-one
    —— (4S,6S)-6-methyl-N-[[(2R)-1-methylsulfonylpyrrolidin-2-yl]methyl]-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-amine —— C14H22N2O2S3
    (4S,6S)-6-methyl-N-[[(2R)-1-methylsulfonylpyrrolidin-2-yl]methyl]-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-amine
    —— N-[(2S)-1-phenylsulfanylbutan-2-yl]oxan-4-amine —— C15H23NOS
    N-[(2S)-1-phenylsulfanylbutan-2-yl]oxan-4-amine
    —— 2,4-dimethyl-N-[[5-(2-morpholin-4-ium-4-ylethylsulfanyl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]methyl]aniline —— C22H34N5O2S+
    2,4-dimethyl-N-[[5-(2-morpholin-4-ium-4-ylethylsulfanyl)-4-[[(2S)-oxolan-2-yl]methyl]-1,2,4-triazol-3-yl]methyl]aniline
    —— Ethyl 2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]acetate —— C18H24N3O3S+
    Ethyl 2-[(4-cyano-1-morpholin-4-yl-5,6,7,8-tetrahydroisoquinolin-2-ium-3-yl)sulfanyl]acetate
    —— N-[(2R)-1-phenylsulfanylbutan-2-yl]oxan-4-amine —— C15H23NOS
    N-[(2R)-1-phenylsulfanylbutan-2-yl]oxan-4-amine
    —— (1S)-1-(3-fluoro-4-methylsulfanylphenyl)-N-[[(3R)-1-methylsulfonylpyrrolidin-3-yl]methyl]ethanamine —— C15H23FN2O2S2
    (1S)-1-(3-fluoro-4-methylsulfanylphenyl)-N-[[(3R)-1-methylsulfonylpyrrolidin-3-yl]methyl]ethanamine
    —— (1R)-2,2-dimethyl-N-[(2S)-2-[(S)-methylsulfinyl]propyl]cyclopentan-1-amine —— C11H23NOS
    (1R)-2,2-dimethyl-N-[(2S)-2-[(S)-methylsulfinyl]propyl]cyclopentan-1-amine
    —— 1-methylsulfonyl-N-[(2R)-1-phenylsulfanylbutan-2-yl]piperidin-4-amine —— C16H26N2O2S2
    1-methylsulfonyl-N-[(2R)-1-phenylsulfanylbutan-2-yl]piperidin-4-amine
    —— (1S)-2,2-dimethyl-N-[(2S)-2-[(S)-methylsulfinyl]propyl]cyclopentan-1-amine —— C11H23NOS
    (1S)-2,2-dimethyl-N-[(2S)-2-[(S)-methylsulfinyl]propyl]cyclopentan-1-amine
    —— (4R,6S)-6-methyl-N-[[(2R)-1-methylsulfonylpyrrolidin-2-yl]methyl]-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-amine —— C14H22N2O2S3
    (4R,6S)-6-methyl-N-[[(2R)-1-methylsulfonylpyrrolidin-2-yl]methyl]-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-amine
    —— 3-[(5-Phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate —— C11H9N2O3S-
    3-[(5-Phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoate
    —— 1-[(3R)-3-[(dimethylamino)methyl]-1,4-thiazepan-4-yl]-3-phenylsulfanylpropan-1-one —— C17H26N2OS2
    1-[(3R)-3-[(dimethylamino)methyl]-1,4-thiazepan-4-yl]-3-phenylsulfanylpropan-1-one
    —— 1-[(3R)-3-[(dimethylamino)methyl]-1,4-thiazepan-4-yl]-2-(4-fluorophenyl)sulfanylethanone —— C16H23FN2OS2
    1-[(3R)-3-[(dimethylamino)methyl]-1,4-thiazepan-4-yl]-2-(4-fluorophenyl)sulfanylethanone
    —— 2-[(12R)-2-oxo-10-thia-1,8-diazatricyclo[7.3.0.03,7]dodeca-3(7),8-dien-12-yl]-N-[2-(2-pyrazol-1-yl-1,3-thiazol-4-yl)ethyl]acetamide —— C19H20N6O2S2
    2-[(12R)-2-oxo-10-thia-1,8-diazatricyclo[7.3.0.03,7]dodeca-3(7),8-dien-12-yl]-N-[2-(2-pyrazol-1-yl-1,3-thiazol-4-yl)ethyl]acetamide
    —— 1-[(3S)-3-[(dimethylamino)methyl]-1,4-thiazepan-4-yl]-3-phenylsulfanylpropan-1-one —— C17H26N2OS2
    1-[(3S)-3-[(dimethylamino)methyl]-1,4-thiazepan-4-yl]-3-phenylsulfanylpropan-1-one
    —— 1-[(3S)-3-[(dimethylamino)methyl]-1,4-thiazepan-4-yl]-2-(4-fluorophenyl)sulfanylethanone —— C16H23FN2OS2
    1-[(3S)-3-[(dimethylamino)methyl]-1,4-thiazepan-4-yl]-2-(4-fluorophenyl)sulfanylethanone
    —— 2-[(12S)-2-oxo-10-thia-1,8-diazatricyclo[7.3.0.03,7]dodeca-3(7),8-dien-12-yl]-N-[2-(2-pyrazol-1-yl-1,3-thiazol-4-yl)ethyl]acetamide —— C19H20N6O2S2
    2-[(12S)-2-oxo-10-thia-1,8-diazatricyclo[7.3.0.03,7]dodeca-3(7),8-dien-12-yl]-N-[2-(2-pyrazol-1-yl-1,3-thiazol-4-yl)ethyl]acetamide
    —— 2-[[4-methyl-5-(morpholin-4-ium-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylethyl)acetamide —— C18H26N5O2S+
    2-[[4-methyl-5-(morpholin-4-ium-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]-N-(2-phenylethyl)acetamide
    —— N-cyclohexyl-2-[[4-methyl-5-(morpholin-4-ium-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C16H28N5O2S+
    N-cyclohexyl-2-[[4-methyl-5-(morpholin-4-ium-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— N-[(1S,2R)-2-methylcyclohexyl]-2-[[4-methyl-5-(morpholin-4-ium-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C17H30N5O2S+
    N-[(1S,2R)-2-methylcyclohexyl]-2-[[4-methyl-5-(morpholin-4-ium-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 4-[[5-[(4-Fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]morpholin-4-ium —— C15H20FN4OS+
    4-[[5-[(4-Fluorophenyl)methylsulfanyl]-4-methyl-1,2,4-triazol-3-yl]methyl]morpholin-4-ium
    —— N-[(1R,2R)-2-methylcyclohexyl]-2-[[4-methyl-5-(morpholin-4-ium-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C17H30N5O2S+
    N-[(1R,2R)-2-methylcyclohexyl]-2-[[4-methyl-5-(morpholin-4-ium-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 2-[[4-Methyl-5-(morpholin-4-ium-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide —— C10H18N5O2S+
    2-[[4-Methyl-5-(morpholin-4-ium-4-ylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
    —— 4-[(6R)-2-fluoro-8-methoxy-6H-benzo[b][4,1]benzoxathiepin-6-yl]-1-methylpiperidin-1-ium —— C20H23FNO2S+
    4-[(6R)-2-fluoro-8-methoxy-6H-benzo[b][4,1]benzoxathiepin-6-yl]-1-methylpiperidin-1-ium
    —— N-[(2S)-2-[4-(dimethylamino)phenyl]-2-hydroxyethyl]-2-(4-fluorophenyl)sulfanylacetamide —— C18H21FN2O2S
    N-[(2S)-2-[4-(dimethylamino)phenyl]-2-hydroxyethyl]-2-(4-fluorophenyl)sulfanylacetamide
    —— N-[(2S)-2-[4-(dimethylamino)phenyl]-2-hydroxyethyl]-3-phenylsulfanylpropanamide —— C19H24N2O2S
    N-[(2S)-2-[4-(dimethylamino)phenyl]-2-hydroxyethyl]-3-phenylsulfanylpropanamide
    —— [2-[4-chloro-2-[(1R)-1-hydroxyethyl]phenyl]sulfanylphenyl]-(4-methylpiperazin-4-ium-1-yl)methanone —— C20H24ClN2O2S+
    [2-[4-chloro-2-[(1R)-1-hydroxyethyl]phenyl]sulfanylphenyl]-(4-methylpiperazin-4-ium-1-yl)methanone
    —— ethyl (6R)-2-acetylimino-7-(hydroxyamino)-6-phenylsulfanyl-5,6-dihydro-4H-1-benzothiophene-3-carboxylate —— C19H20N2O4S2
    ethyl (6R)-2-acetylimino-7-(hydroxyamino)-6-phenylsulfanyl-5,6-dihydro-4H-1-benzothiophene-3-carboxylate
    —— N-[(2R)-2-[4-(dimethylamino)phenyl]-2-hydroxyethyl]-3-phenylsulfanylpropanamide —— C19H24N2O2S
    N-[(2R)-2-[4-(dimethylamino)phenyl]-2-hydroxyethyl]-3-phenylsulfanylpropanamide
    —— N-[(2R)-2-[4-(dimethylamino)phenyl]-2-hydroxyethyl]-2-(4-fluorophenyl)sulfanylacetamide —— C18H21FN2O2S
    N-[(2R)-2-[4-(dimethylamino)phenyl]-2-hydroxyethyl]-2-(4-fluorophenyl)sulfanylacetamide