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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(3-fluorophenyl)methyl]-N-methylacetamide —— C18H16F2N4OS2
    2-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(3-fluorophenyl)methyl]-N-methylacetamide
    —— 2-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(5-methylfuran-2-yl)methyl]acetamide —— C17H17FN4O2S2
    2-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-[(5-methylfuran-2-yl)methyl]acetamide
    —— N-(cyclopenten-1-yl)-2-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propylacetamide —— C18H21FN4OS2
    N-(cyclopenten-1-yl)-2-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-propylacetamide
    —— (2S)-3-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-methylpropanenitrile —— C12H11FN4S2
    (2S)-3-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-methylpropanenitrile
    —— N-(4-fluorophenyl)-5-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C13H11FN4OS2
    N-(4-fluorophenyl)-5-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— [2-(2,5-Dimethyl-1-pyridin-2-ylpyrrol-3-yl)-2-oxoethyl] 2-(2,5-difluorophenyl)sulfanylacetate —— C21H18F2N2O3S
    [2-(2,5-Dimethyl-1-pyridin-2-ylpyrrol-3-yl)-2-oxoethyl] 2-(2,5-difluorophenyl)sulfanylacetate
    —— N-butyl-2-[[5-(3-chloro-4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide —— C16H21ClN4OS2
    N-butyl-2-[[5-(3-chloro-4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— 2-[[5-(3-chloro-4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide —— C17H17ClN4O2S2
    2-[[5-(3-chloro-4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide
    —— N-(4-fluorophenyl)-5-(2-methylsulfanylethylsulfanyl)-1,3,4-thiadiazol-2-amine —— C11H12FN3S3
    N-(4-fluorophenyl)-5-(2-methylsulfanylethylsulfanyl)-1,3,4-thiadiazol-2-amine
    —— N-[(4-ethylphenyl)methyl]-2-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide —— C20H21FN4OS2
    N-[(4-ethylphenyl)methyl]-2-[[5-(4-fluoroanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— Methyl 3-[[5-(3-chloro-4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoate —— C13H14ClN3O2S2
    Methyl 3-[[5-(3-chloro-4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanoate
    —— N-(3-chloro-2-methylphenyl)-5-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C14H13ClN4OS2
    N-(3-chloro-2-methylphenyl)-5-[(3-methyl-1,2-oxazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-(3-chloro-2-methylphenyl)-5-methylsulfanyl-1,3,4-thiadiazol-2-amine —— C10H10ClN3S2
    N-(3-chloro-2-methylphenyl)-5-methylsulfanyl-1,3,4-thiadiazol-2-amine
    —— (2R)-3-[[5-(3-chloro-4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-methylpropanenitrile —— C13H13ClN4S2
    (2R)-3-[[5-(3-chloro-4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-methylpropanenitrile
    —— N-butyl-2-[[5-(3-chloro-2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide —— C16H21ClN4OS2
    N-butyl-2-[[5-(3-chloro-2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— 3-[[5-(3-Chloro-2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanenitrile —— C12H11ClN4S2
    3-[[5-(3-Chloro-2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]propanenitrile
    —— N-(3-chloro-2-methylphenyl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C16H12ClN5O2S2
    N-(3-chloro-2-methylphenyl)-5-[[5-(furan-2-yl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-(3-chloro-2-methylphenyl)-5-(2-methylsulfanylethylsulfanyl)-1,3,4-thiadiazol-2-amine —— C12H14ClN3S3
    N-(3-chloro-2-methylphenyl)-5-(2-methylsulfanylethylsulfanyl)-1,3,4-thiadiazol-2-amine
    —— (2R)-3-[[5-(3-chloro-2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-methylpropanenitrile —— C13H13ClN4S2
    (2R)-3-[[5-(3-chloro-2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-2-methylpropanenitrile
    —— 2-[[5-(3-chloro-2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide —— C17H17ClN4O2S2
    2-[[5-(3-chloro-2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(furan-2-ylmethyl)-N-methylacetamide
    —— 2,3-Dihydroimidazo[2,1-b][1,3]thiazol-5-amine —— C5H7N3S
    2,3-Dihydroimidazo[2,1-b][1,3]thiazol-5-amine
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[2-(2-fluorophenyl)ethyl]propanamide —— C18H22FN3OS
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[2-(2-fluorophenyl)ethyl]propanamide
    —— 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(4-methylphenyl)methyl]acetamide —— C18H16ClN3O2S
    2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-[(4-methylphenyl)methyl]acetamide
    —— N-[(1R)-1-(2-chlorophenyl)-2-oxocyclohexyl]-2-[(4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-methylacetamide —— C19H23ClN4O2S
    N-[(1R)-1-(2-chlorophenyl)-2-oxocyclohexyl]-2-[(4-ethyl-1,2,4-triazol-3-yl)sulfanyl]-N-methylacetamide
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[3-[(2R)-2-methylpiperidin-1-ium-1-yl]propyl]propanamide —— C19H33N4OS+
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[3-[(2R)-2-methylpiperidin-1-ium-1-yl]propyl]propanamide
    —— 2-(4-bromophenyl)sulfanyl-N-[3-[(2R)-2-methylpiperidin-1-ium-1-yl]propyl]acetamide —— C17H26BrN2OS+
    2-(4-bromophenyl)sulfanyl-N-[3-[(2R)-2-methylpiperidin-1-ium-1-yl]propyl]acetamide
    —— 3-(4,6-Dimethyl-2-methylsulfanylpyrimidin-5-yl)-1-[4-(thiophen-2-ylmethyl)piperazin-4-ium-1-yl]propan-1-one —— C19H27N4OS2+
    3-(4,6-Dimethyl-2-methylsulfanylpyrimidin-5-yl)-1-[4-(thiophen-2-ylmethyl)piperazin-4-ium-1-yl]propan-1-one
    —— N-(2-benzylsulfanylethyl)-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide —— C19H25N3OS2
    N-(2-benzylsulfanylethyl)-3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanamide
    —— 1-(4-fluorophenyl)-3-[[(2S)-2-phenylsulfanylpropanoyl]amino]thiourea —— C16H16FN3OS2
    1-(4-fluorophenyl)-3-[[(2S)-2-phenylsulfanylpropanoyl]amino]thiourea
    —— 1-(4-fluorophenyl)-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea —— C16H16FN3OS2
    1-(4-fluorophenyl)-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea
    —— 1-(4-chlorophenyl)-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea —— C16H16ClN3OS2
    1-(4-chlorophenyl)-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea
    —— 1-(4-Fluorophenyl)-3-[(2-phenylsulfanylacetyl)amino]thiourea —— C15H14FN3OS2
    1-(4-Fluorophenyl)-3-[(2-phenylsulfanylacetyl)amino]thiourea
    —— 1-(2-Fluorophenyl)-3-(3-phenylsulfanylpropanoylamino)thiourea —— C16H16FN3OS2
    1-(2-Fluorophenyl)-3-(3-phenylsulfanylpropanoylamino)thiourea
    —— (3R,5R)-5-methyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)oxolan-2-one —— C12H17N3O2S
    (3R,5R)-5-methyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)oxolan-2-one
    —— 1-(2-fluorophenyl)-3-[[(2S)-2-phenylsulfanylpropanoyl]amino]thiourea —— C16H16FN3OS2
    1-(2-fluorophenyl)-3-[[(2S)-2-phenylsulfanylpropanoyl]amino]thiourea
    —— 1-[[2-(2,5-Dimethylphenyl)sulfanylacetyl]amino]-3-(2-fluorophenyl)thiourea —— C17H18FN3OS2
    1-[[2-(2,5-Dimethylphenyl)sulfanylacetyl]amino]-3-(2-fluorophenyl)thiourea
    —— 1-(2-fluorophenyl)-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea —— C16H16FN3OS2
    1-(2-fluorophenyl)-3-[[(2R)-2-phenylsulfanylpropanoyl]amino]thiourea
    —— 2-[(1R)-1-(1-cyclopropyltetrazol-5-yl)sulfanylethyl]-5-(3-methylphenyl)-1,3,4-oxadiazole —— C15H16N6OS
    2-[(1R)-1-(1-cyclopropyltetrazol-5-yl)sulfanylethyl]-5-(3-methylphenyl)-1,3,4-oxadiazole
    —— N-(1,3-benzodioxol-5-ylmethyl)-N-methyl-2-phenylsulfanylpyridine-3-carboxamide —— C21H18N2O3S
    N-(1,3-benzodioxol-5-ylmethyl)-N-methyl-2-phenylsulfanylpyridine-3-carboxamide
    —— 4-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-2-thiophen-2-yl-1,3-thiazole —— C14H15N5S3
    4-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-2-thiophen-2-yl-1,3-thiazole
    —— (2S)-2-(2,4-dimethylphenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]propanamide —— C16H23NO2S
    (2S)-2-(2,4-dimethylphenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]propanamide
    —— 5-Methyl-1-pyrimidin-2-ylsulfanyl-[1,2,4]triazolo[4,3-a]quinoline —— C15H11N5S
    5-Methyl-1-pyrimidin-2-ylsulfanyl-[1,2,4]triazolo[4,3-a]quinoline
    —— 2-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazole —— C15H18N6O2S
    2-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-5-(2,5-dimethylfuran-3-yl)-1,3,4-oxadiazole
    —— (2R)-2-(2,4-dimethylphenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]propanamide —— C16H23NO2S
    (2R)-2-(2,4-dimethylphenyl)sulfanyl-N-[[(2R)-oxolan-2-yl]methyl]propanamide
    —— (3S,5R)-5-methyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)oxolan-2-one —— C12H17N3O2S
    (3S,5R)-5-methyl-3-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-ylsulfanyl)oxolan-2-one
    —— 3-[2-(4-Chlorophenyl)sulfanylethylsulfanyl]-4-ethyl-5-(furan-2-yl)-1,2,4-triazole —— C16H16ClN3OS2
    3-[2-(4-Chlorophenyl)sulfanylethylsulfanyl]-4-ethyl-5-(furan-2-yl)-1,2,4-triazole
    —— N-(cyclohexen-1-yl)-N-cyclopropyl-2-[[5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C18H26N4O2S
    N-(cyclohexen-1-yl)-N-cyclopropyl-2-[[5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-3-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-methylpropanenitrile —— C12H14N4OS
    (2R)-3-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-methylpropanenitrile
    —— (2S)-3-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-methylpropanenitrile —— C12H14N4OS
    (2S)-3-[[4-ethyl-5-(furan-2-yl)-1,2,4-triazol-3-yl]sulfanyl]-2-methylpropanenitrile
    —— N-[(2-bromophenyl)methyl]-2-(1-cyclopropyltetrazol-5-yl)sulfanyl-N-methylacetamide —— C14H16BrN5OS
    N-[(2-bromophenyl)methyl]-2-(1-cyclopropyltetrazol-5-yl)sulfanyl-N-methylacetamide