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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— [4-[6-Acetyl-2-(4-fluorophenyl)-5-methyl-3-oxopyridazin-4-yl]sulfanylphenyl]-trimethylazanium;iodide —— C22H23FIN3O2S
    [4-[6-Acetyl-2-(4-fluorophenyl)-5-methyl-3-oxopyridazin-4-yl]sulfanylphenyl]-trimethylazanium;iodide
    —— [4-[6-Acetyl-2-(4-fluorophenyl)-5-methyl-3-oxopyridazin-4-yl]sulfanylphenyl]-trimethylazanium —— C22H23FN3O2S+
    [4-[6-Acetyl-2-(4-fluorophenyl)-5-methyl-3-oxopyridazin-4-yl]sulfanylphenyl]-trimethylazanium
    —— 3-chloro-N-(3,5-dichloro-4-naphthalen-2-ylsulfanylphenyl)-5-(trifluoromethyl)benzenesulfonamide —— C23H13Cl3F3NO2S2
    3-chloro-N-(3,5-dichloro-4-naphthalen-2-ylsulfanylphenyl)-5-(trifluoromethyl)benzenesulfonamide
    —— 3-(2-methyl-2-aminopropanethio)-2-pyridylmethyl 3-(2,2-difluoro-2-(2-pyridyl-N-oxide)ethylamino)-6-chloropyrazin-2-one-1-acetamide 342815-90-1 C23H26ClF2N7O3S
    3-(2-methyl-2-aminopropanethio)-2-pyridylmethyl 3-(2,2-difluoro-2-(2-pyridyl-N-oxide)ethylamino)-6-chloropyrazin-2-one-1-acetamide
    —— N-[1-benzyl-3-[[4-[2-(dimethylamino)ethylsulfanyl]anilino]methyl]cyclopent-2-en-1-yl]-3,3,3-trichloropropanamide —— C26H32Cl3N3OS
    N-[1-benzyl-3-[[4-[2-(dimethylamino)ethylsulfanyl]anilino]methyl]cyclopent-2-en-1-yl]-3,3,3-trichloropropanamide
    —— N-(2-methylquinolin-6-yl)-2-[[3-[(E)-2-phenylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide —— C32H24N4OS
    N-(2-methylquinolin-6-yl)-2-[[3-[(E)-2-phenylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide
    —— 3-(2-Carboxyethylsulfanyl)-2-hydroxy-3-[3-(7-phenylheptylsulfanyl)pyridin-2-yl]propanoic acid —— C24H31NO5S2
    3-(2-Carboxyethylsulfanyl)-2-hydroxy-3-[3-(7-phenylheptylsulfanyl)pyridin-2-yl]propanoic acid
    —— (Z,Z)-2-bromo-3-phenyl-N-(3-thiophen-2-yl-5-thiophen-2-ylsulfanyl-1,2,4-triazol-4-yl)prop-2-en-1-imine —— C19H13BrN4S3
    (Z,Z)-2-bromo-3-phenyl-N-(3-thiophen-2-yl-5-thiophen-2-ylsulfanyl-1,2,4-triazol-4-yl)prop-2-en-1-imine
    —— (E,1R)-1-(4-methylsulfanylphenyl)-4-tributylstannylbut-3-en-1-ol —— C23H40OSSn
    (E,1R)-1-(4-methylsulfanylphenyl)-4-tributylstannylbut-3-en-1-ol
    —— N-[3-(dimethylamino)propyl]-2-[2-(phenylsulfamoyl)phenyl]sulfanylbenzamide —— C24H27N3O3S2
    N-[3-(dimethylamino)propyl]-2-[2-(phenylsulfamoyl)phenyl]sulfanylbenzamide
    —— N-[3,5-dimethyl-4-(2-pyrrolidin-1-ylethoxy)phenyl]-4-(3-methoxyphenyl)sulfanylpyrimidin-2-amine —— C25H30N4O2S
    N-[3,5-dimethyl-4-(2-pyrrolidin-1-ylethoxy)phenyl]-4-(3-methoxyphenyl)sulfanylpyrimidin-2-amine
    —— XR5118 —— C20H21N3O2S2
    XR5118
    —— 4-Ethenylpyridine;2-(2-oxidophenyl)sulfanylphenolate;palladium(2+) —— C19H15NO2PdS
    4-Ethenylpyridine;2-(2-oxidophenyl)sulfanylphenolate;palladium(2+)
    —— 5-[(2,3-difluorophenyl)methylsulfanyl]-7-[1-(2-hydroxyethylamino)propan-2-ylamino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C17H19F2N5O2S2
    5-[(2,3-difluorophenyl)methylsulfanyl]-7-[1-(2-hydroxyethylamino)propan-2-ylamino]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— 4-[(6-chloro-1H-benzimidazol-2-yl)sulfanyl]-6-(piperazine-1-carbonyl)-1,3-dihydrobenzimidazol-2-one —— C19H17ClN6O2S
    4-[(6-chloro-1H-benzimidazol-2-yl)sulfanyl]-6-(piperazine-1-carbonyl)-1,3-dihydrobenzimidazol-2-one
    —— 6-(3,5-Dichlorophenyl)sulfanyl-5-propan-2-yl-1-(pyridin-4-ylmethyl)pyrimidine-2,4-dione —— C19H17Cl2N3O2S
    6-(3,5-Dichlorophenyl)sulfanyl-5-propan-2-yl-1-(pyridin-4-ylmethyl)pyrimidine-2,4-dione
    —— 2-methoxyethyl 5-chloro-2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)thio]-3H-benzimidazole-4-carboxylate —— C19H16ClN3O4S
    2-methoxyethyl 5-chloro-2-[(2-oxo-2,3-dihydro-1H-indol-5-yl)thio]-3H-benzimidazole-4-carboxylate
    —— 3-(1-hydroxy-3-methylbutyl)-4,11-dimethoxy-9-methyl-7H-dibenzo[c,f][1,5]oxathiocin-5-one 143096-54-2 C22H26O5S
    3-(1-hydroxy-3-methylbutyl)-4,11-dimethoxy-9-methyl-7H-dibenzo[c,f][1,5]oxathiocin-5-one
    —— 2-(6-acetyl-2-(4-fluorophenyl)-5-methyl-3-oxo-2-hydropyridazin-4-ylthio)ethyl methylsulfonate 259194-07-5 C16H17FN2O5S2
    2-(6-acetyl-2-(4-fluorophenyl)-5-methyl-3-oxo-2-hydropyridazin-4-ylthio)ethyl methylsulfonate
    —— (Z,E)-3-phenyl-N-(3-thiophen-2-yl-5-thiophen-2-ylsulfanyl-1,2,4-triazol-4-yl)prop-2-en-1-imine —— C19H14N4S3
    (Z,E)-3-phenyl-N-(3-thiophen-2-yl-5-thiophen-2-ylsulfanyl-1,2,4-triazol-4-yl)prop-2-en-1-imine
    —— N-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-α-methylbenzyl}-O-methylhydroxylamine —— C21H26FNO3S
    N-{4-[5-fluoro-3-(4-methoxytetrahydropyran-4-yl)phenylthio]-α-methylbenzyl}-O-methylhydroxylamine
    —— 6-methoxy-3-(2-nitro-phenylsulfanyl)-1-pyrimidin-5-ylmethyl-1H-indole 691400-49-4 C20H16N4O3S
    6-methoxy-3-(2-nitro-phenylsulfanyl)-1-pyrimidin-5-ylmethyl-1H-indole
    —— 5-(5-chlorothiadiazol-4-yl)sulfanyl-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C10H9ClN6O2S3
    5-(5-chlorothiadiazol-4-yl)sulfanyl-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— 2-[6-fluoro-2-methyl-4-(4-methylsulfinylphenyl)sulfanyl-3H-inden-1-yl]acetic acid —— C19H17FO3S2
    2-[6-fluoro-2-methyl-4-(4-methylsulfinylphenyl)sulfanyl-3H-inden-1-yl]acetic acid
    —— azanide;dichloroplatinum(2+);thiourea —— CH8Cl2N4PtS
    azanide;dichloroplatinum(2+);thiourea
    —— 1-(4-tert-butylphenyl)-N-methyl-N-[(3-phenylsulfanylphenyl)methyl]methanamine —— C25H29NS
    1-(4-tert-butylphenyl)-N-methyl-N-[(3-phenylsulfanylphenyl)methyl]methanamine
    —— 1-(Cyclohexylmethyl)-6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-pyrimidine-2,4-dione —— C21H28N2O2S
    1-(Cyclohexylmethyl)-6-(3,5-dimethylphenyl)sulfanyl-5-ethyl-pyrimidine-2,4-dione
    —— (Z)-tert-butyl-hydroxy-[[5-[4-(trifluoromethoxy)phenyl]sulfanylfuran-2-yl]methylidene]azanium —— C16H17F3NO3S+
    (Z)-tert-butyl-hydroxy-[[5-[4-(trifluoromethoxy)phenyl]sulfanylfuran-2-yl]methylidene]azanium
    —— 2-[[4-(4-Methylphenyl)sulfanylthieno[2,3-c]pyridin-2-yl]methylamino]oxyacetic acid —— C17H16N2O3S2
    2-[[4-(4-Methylphenyl)sulfanylthieno[2,3-c]pyridin-2-yl]methylamino]oxyacetic acid
    —— N-tert-butyl-N-[[5-(4-methoxyphenyl)sulfanylthiophen-2-yl]methyl]hydroxylamine —— C16H21NO2S2
    N-tert-butyl-N-[[5-(4-methoxyphenyl)sulfanylthiophen-2-yl]methyl]hydroxylamine
    —— 6-chloro-5-(2,4-dichlorophenyl)sulfanyl-1H-benzimidazole —— C13H7Cl3N2S
    6-chloro-5-(2,4-dichlorophenyl)sulfanyl-1H-benzimidazole
    —— 4-Chloro-5-(1,2,3,4-tetrahydroisoquinolin-5-ylsulfanyl)benzene-1,2-diamine —— C15H16ClN3S
    4-Chloro-5-(1,2,3,4-tetrahydroisoquinolin-5-ylsulfanyl)benzene-1,2-diamine
    —— 4,4-dimethyl-6-(1-methylpyrazol-3-yl)-8-methylsulfanyl-5H-thieno[3,4-g][1,2]benzoxazole —— C16H17N3OS2
    4,4-dimethyl-6-(1-methylpyrazol-3-yl)-8-methylsulfanyl-5H-thieno[3,4-g][1,2]benzoxazole
    —— 3-(4-chloro-anilino)-5-(pyridin-4-ylmethylthio)-1,2,4-triazole 334539-34-3 C14H12ClN5S
    3-(4-chloro-anilino)-5-(pyridin-4-ylmethylthio)-1,2,4-triazole
    —— 4-[2-(2-Pyridin-2-ylsulfanylethoxy)ethylsulfanyl]phenol —— C15H17NO2S2
    4-[2-(2-Pyridin-2-ylsulfanylethoxy)ethylsulfanyl]phenol
    —— 8-Cyclopentylsulfanyl-5-methyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine —— C12H13F3N4S
    8-Cyclopentylsulfanyl-5-methyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
    —— 3-(thiazol-2-yl)thio-2,3-dihydro-1,1-dioxidebenzo[b]thiophene 246169-11-9 C11H9NO2S3
    3-(thiazol-2-yl)thio-2,3-dihydro-1,1-dioxidebenzo[b]thiophene
    —— 3-anilino-5-(pyridin-4-ylmethylthio)-1,2,4-triazole 334538-67-9 C14H13N5S
    3-anilino-5-(pyridin-4-ylmethylthio)-1,2,4-triazole
    —— N-[(1S,2R,4R)-7-azabicyclo[2.2.1]hept-2-yl]-5-[(4-chlorophenyl)-sulfanyl]-1,3,4-thiadiazole-2-carboxamide 500612-17-9 C15H15ClN4OS2
    N-[(1S,2R,4R)-7-azabicyclo[2.2.1]hept-2-yl]-5-[(4-chlorophenyl)-sulfanyl]-1,3,4-thiadiazole-2-carboxamide
    —— 3-Fluoro-4-(1-isopropyl-3-methyl-5-m-tolylsulfanyl-1H-pyrazol-4-ylmethyl)-pyridine 412326-87-5 C20H22FN3S
    3-Fluoro-4-(1-isopropyl-3-methyl-5-m-tolylsulfanyl-1H-pyrazol-4-ylmethyl)-pyridine
    —— 2-(4-Chlorophenyl)-4-methyl-5-(1-oxidopyridin-1-ium-2-yl)sulfanyl-1,2-thiazol-3-one —— C15H11ClN2O2S2
    2-(4-Chlorophenyl)-4-methyl-5-(1-oxidopyridin-1-ium-2-yl)sulfanyl-1,2-thiazol-3-one
    —— [2-(4-Acetamido-phenyl-sulfanyl)-pyrimidin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine —— C16H16N6OS
    [2-(4-Acetamido-phenyl-sulfanyl)-pyrimidin-4-yl]-(5-methyl-2H-pyrazol-3-yl)-amine
    —— 5-(1,3-benzothiazol-6-ylsulfanyl)-N-(5-methyl-1H-pyrazol-3-yl)-1,2,4-triazin-3-amine —— C14H11N7S2
    5-(1,3-benzothiazol-6-ylsulfanyl)-N-(5-methyl-1H-pyrazol-3-yl)-1,2,4-triazin-3-amine
    —— 5-[(4-chlorophenyl)methyl]-3-[(4-fluorophenyl)methylsulfanyl]-1H-1,2,4-triazole —— C16H13ClFN3S
    5-[(4-chlorophenyl)methyl]-3-[(4-fluorophenyl)methylsulfanyl]-1H-1,2,4-triazole
    —— N-[(1S,2R,4R)-7-azabicyclo[2.2.1]hept-2-yl]-5-(phenylsulfanyl)-1,3,4-thiadiazole-2-carboxamide 500612-15-7 C15H16N4OS2
    N-[(1S,2R,4R)-7-azabicyclo[2.2.1]hept-2-yl]-5-(phenylsulfanyl)-1,3,4-thiadiazole-2-carboxamide
    —— 1-Methyl-2-[(4-methylphenyl)methylsulfanyl]-5-(thiophen-2-ylsulfanylmethyl)pyrrole —— C18H19NS3
    1-Methyl-2-[(4-methylphenyl)methylsulfanyl]-5-(thiophen-2-ylsulfanylmethyl)pyrrole
    —— exo-8-methyl-6-(3-hexylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane —— C16H27N3S2
    exo-8-methyl-6-(3-hexylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— 1-Benzyl-4-(hydroxymethyl)-3-methyl-5-pyridin-4-ylsulfanylimidazol-2-one —— C17H17N3O2S
    1-Benzyl-4-(hydroxymethyl)-3-methyl-5-pyridin-4-ylsulfanylimidazol-2-one
    —— exo-6-(3-benzylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane —— C16H19N3S2
    exo-6-(3-benzylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— 2-[(1R,3R)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-methylpyridine-3-carbonitrile —— C17H19N3OS
    2-[(1R,3R)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-methylpyridine-3-carbonitrile