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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 6-Amino-1-cyclopropyl-5-[2-[[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione —— C19H19N5O4S
    6-Amino-1-cyclopropyl-5-[2-[[5-(3,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione
    —— 4-(1-Cyclopropyltetrazol-5-yl)sulfanyl-6-(4-fluorophenyl)thieno[3,2-d]pyrimidine —— C16H11FN6S2
    4-(1-Cyclopropyltetrazol-5-yl)sulfanyl-6-(4-fluorophenyl)thieno[3,2-d]pyrimidine
    —— 1-[2,5-dimethyl-1-[[(2S)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-[[5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C20H29N4O3S+
    1-[2,5-dimethyl-1-[[(2S)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-[[5-(pyrrolidin-1-ium-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— 1-[2,5-dimethyl-1-[[(2R)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-[[5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C20H28N4O3S
    1-[2,5-dimethyl-1-[[(2R)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-[[5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— 7-[(4-Ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C16H15N5OS3
    7-[(4-Ethyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 1-[2,5-dimethyl-1-[[(2S)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-[[5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone —— C20H28N4O3S
    1-[2,5-dimethyl-1-[[(2S)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-[[5-(pyrrolidin-1-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethanone
    —— N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C19H18ClN3O2S
    N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[[5-(2-methylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— (2R)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylcyclopentan-1-one —— C11H12N4OS2
    (2R)-2-[1-(thiophen-2-ylmethyl)tetrazol-5-yl]sulfanylcyclopentan-1-one
    —— (2S)-2-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-(4-methylphenyl)propanenitrile —— C15H18N4OS
    (2S)-2-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-(4-methylphenyl)propanenitrile
    —— 2-[(7S)-3-ethyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C14H13N4O2S-
    2-[(7S)-3-ethyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— 2-[(7R)-3-[(4-fluorophenyl)methyl]-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C17H13FN4O2S2
    2-[(7R)-3-[(4-fluorophenyl)methyl]-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7S)-3-[(4-fluorophenyl)methyl]-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C17H12FN4O2S2-
    2-[(7S)-3-[(4-fluorophenyl)methyl]-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— (2R)-2-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-(4-methylphenyl)propanenitrile —— C15H18N4OS
    (2R)-2-[[4-(2-methoxyethyl)-1,2,4-triazol-3-yl]sulfanyl]-3-(4-methylphenyl)propanenitrile
    —— 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-[(1S)-1-phenylbutyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C17H18N6S3
    3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-[(1S)-1-phenylbutyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 3-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-pyridin-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C12H9N7S3
    3-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-pyridin-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(3,4-Dimethylphenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C15H14N6S3
    6-(3,4-Dimethylphenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(Furan-2-yl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C11H8N6OS3
    6-(Furan-2-yl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 3-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C13H10N6S3
    3-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-phenyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 3-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-thiophen-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C11H8N6S4
    3-[(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-thiophen-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-[(1R)-1-phenylbutyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C17H18N6S3
    3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-6-[(1R)-1-phenylbutyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-[(E)-2-(furan-2-yl)ethenyl]-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C13H10N6OS3
    6-[(E)-2-(furan-2-yl)ethenyl]-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-[(1S)-1-phenylbutyl]-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C20H20N4S2
    6-[(1S)-1-phenylbutyl]-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(3-Phenylpropyl)-3-[(phenylsulfanyl)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C19H18N4S2
    6-(3-Phenylpropyl)-3-[(phenylsulfanyl)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(3,4-Dimethylbenzyl)-3-[(phenylsulfanyl)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C19H18N4S2
    6-(3,4-Dimethylbenzyl)-3-[(phenylsulfanyl)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-[(E)-2-(furan-2-yl)ethenyl]-3-[(phenylsulfanyl)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C16H12N4OS2
    6-[(E)-2-(furan-2-yl)ethenyl]-3-[(phenylsulfanyl)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(4-Fluorophenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C13H9FN6S3
    6-(4-Fluorophenyl)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(4-Chlorobenzyl)-3-[(phenylsulfanyl)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C17H13ClN4S2
    6-(4-Chlorobenzyl)-3-[(phenylsulfanyl)methyl][1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(2-Chlorophenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C16H11ClN4S2
    6-(2-Chlorophenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— 6-(4-Methylphenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole —— C17H14N4S2
    6-(4-Methylphenyl)-3-(phenylsulfanylmethyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole
    —— (2S)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-pyrimidin-2-ylsulfanylpropan-1-one —— C15H17N3O2S
    (2S)-1-(4-acetyl-3,5-dimethyl-1H-pyrrol-2-yl)-2-pyrimidin-2-ylsulfanylpropan-1-one
    —— 2-(3-chlorophenyl)-5-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole —— C16H12Cl2N2OS
    2-(3-chlorophenyl)-5-[(1S)-1-(2-chlorophenyl)ethyl]sulfanyl-1,3,4-oxadiazole
    —— 2-[(7S)-3-(2-cyclohexylethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C20H23N4O2S-
    2-[(7S)-3-(2-cyclohexylethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— 2-[(7S)-6-(4-chlorophenyl)-3-ethyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C14H12ClN4O2S-
    2-[(7S)-6-(4-chlorophenyl)-3-ethyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— 2-[(7S)-6-(4-chlorophenyl)-3-ethyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C14H13ClN4O2S
    2-[(7S)-6-(4-chlorophenyl)-3-ethyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7R)-3-(2-cyclohexylethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C20H23N4O2S-
    2-[(7R)-3-(2-cyclohexylethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— 2-[(7S)-3-(2-cyclohexylethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C20H24N4O2S
    2-[(7S)-3-(2-cyclohexylethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7S)-6-(4-chlorophenyl)-3-methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C13H10ClN4O2S-
    2-[(7S)-6-(4-chlorophenyl)-3-methyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— [(7s)-6-(4-Chlorophenyl)-3-(Thiophen-2-Yl)-7h-[1,2,4]triazolo[3,4-B][1,3,4]thiadiazin-7-Yl]acetic Acid —— C16H11ClN4O2S2
    [(7s)-6-(4-Chlorophenyl)-3-(Thiophen-2-Yl)-7h-[1,2,4]triazolo[3,4-B][1,3,4]thiadiazin-7-Yl]acetic Acid
    —— 2-[(7S)-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C12H9ClN4O2S
    2-[(7S)-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7R)-3-ethyl-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C15H16N4O2S
    2-[(7R)-3-ethyl-6-(4-methylphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7R)-3-(2-cyclohexylethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C20H24N4O2S
    2-[(7R)-3-(2-cyclohexylethyl)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7S)-3-[(4-fluorophenyl)methyl]-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C19H15FN4O2S
    2-[(7S)-3-[(4-fluorophenyl)methyl]-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7S)-3-ethyl-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C12H11N4O2S2-
    2-[(7S)-3-ethyl-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— 2-[(1S)-1-(1-cyclopropyltetrazol-5-yl)sulfanylethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole —— C15H16N6OS
    2-[(1S)-1-(1-cyclopropyltetrazol-5-yl)sulfanylethyl]-5-(4-methylphenyl)-1,3,4-oxadiazole
    —— 2-[(7S)-3-ethyl-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid —— C12H12N4O2S2
    2-[(7S)-3-ethyl-6-thiophen-2-yl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
    —— 2-[(7R)-3-[(4-fluorophenyl)methyl]-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate —— C19H14FN4O2S-
    2-[(7R)-3-[(4-fluorophenyl)methyl]-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetate
    —— 4-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-2-(4-fluorophenyl)-1,3-thiazole —— C16H16FN5S2
    4-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-2-(4-fluorophenyl)-1,3-thiazole
    —— 2-[(1S)-1-(1-cyclopropyltetrazol-5-yl)sulfanylethyl]-5-phenyl-1,3,4-oxadiazole —— C14H14N6OS
    2-[(1S)-1-(1-cyclopropyltetrazol-5-yl)sulfanylethyl]-5-phenyl-1,3,4-oxadiazole
    —— 1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]ethanone —— C18H22N2O2S2
    1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]-2-[[4-(4-methylphenyl)-1,3-thiazol-2-yl]sulfanyl]ethanone
    —— N,N-dibenzyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C19H19N3OS2
    N,N-dibenzyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide