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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 1-[(1,3-Dimethyl-4,5,6,7-tetrahydrobenzimidazol-3-ium-2-yl)sulfanyl]propan-2-one —— C12H19N2OS+
    1-[(1,3-Dimethyl-4,5,6,7-tetrahydrobenzimidazol-3-ium-2-yl)sulfanyl]propan-2-one
    —— 5-Ethylsulfanyl-1,3-thiazole-2-sulfonamide —— C5H8N2O2S3
    5-Ethylsulfanyl-1,3-thiazole-2-sulfonamide
    —— 5-Phenylsulfanyl-1,3-dihydroindol-2-one —— C14H11NOS
    5-Phenylsulfanyl-1,3-dihydroindol-2-one
    —— N-(4-methylphenyl)-3-prop-2-enylsulfanyl-1H-1,2,4-triazol-5-amine —— C12H14N4S
    N-(4-methylphenyl)-3-prop-2-enylsulfanyl-1H-1,2,4-triazol-5-amine
    —— 1-Hydroxy-6-phenylsulfanylpyridin-2-one —— C11H9NO2S
    1-Hydroxy-6-phenylsulfanylpyridin-2-one
    —— [4-amino-5-(3-methyl-thiophen-2-ylmethyl)-pyrimidin-2-ylsulfanyl]-acetic acid ethyl ester 476302-16-6 C14H17N3O2S2
    [4-amino-5-(3-methyl-thiophen-2-ylmethyl)-pyrimidin-2-ylsulfanyl]-acetic acid ethyl ester
    —— 4-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-methylpyridine-3-carbonitrile —— C17H19N3OS
    4-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-methylpyridine-3-carbonitrile
    —— 4-(5-ethyl-3-methylsulfanyl-1,2-oxazol-4-yl)-N-phenylpyridin-2-amine —— C17H17N3OS
    4-(5-ethyl-3-methylsulfanyl-1,2-oxazol-4-yl)-N-phenylpyridin-2-amine
    —— (Z)-N-[[5-(2-methylpropylsulfanyl)thiadiazol-4-yl]methoxy]-1-azabicyclo[2.2.1]heptan-3-imine —— C13H20N4OS2
    (Z)-N-[[5-(2-methylpropylsulfanyl)thiadiazol-4-yl]methoxy]-1-azabicyclo[2.2.1]heptan-3-imine
    —— 2-[1-(Methylamino)pentan-3-ylsulfanyl]-6-(trifluoromethyl)pyridine-3-carbonitrile —— C13H16F3N3S
    2-[1-(Methylamino)pentan-3-ylsulfanyl]-6-(trifluoromethyl)pyridine-3-carbonitrile
    —— 3-phenylethynyl-4H-5-thia-2,6,9b-triaza-cyclopenta[a]naphthalene —— C17H11N3S
    3-phenylethynyl-4H-5-thia-2,6,9b-triaza-cyclopenta[a]naphthalene
    —— 3-(cyclohexylmethylsulfanyl)-5-[(2-methylphenyl)methyl]-1H-1,2,4-triazole —— C17H23N3S
    3-(cyclohexylmethylsulfanyl)-5-[(2-methylphenyl)methyl]-1H-1,2,4-triazole
    —— 2-[(4,4,3-trifluoro-3-butenyl)thio]thiazolo[4,5-b]-pyridine —— C10H7F3N2S2
    2-[(4,4,3-trifluoro-3-butenyl)thio]thiazolo[4,5-b]-pyridine
    —— 2-[(6,6-Dioxo-1,6-oxathiecan-4-yl)sulfanyl]ethanol —— C10H20O4S2
    2-[(6,6-Dioxo-1,6-oxathiecan-4-yl)sulfanyl]ethanol
    —— 2-[[3-(furan-2-ylmethylsulfanyl)-1H-1,2,4-triazol-5-yl]methyl]pyridine —— C13H12N4OS
    2-[[3-(furan-2-ylmethylsulfanyl)-1H-1,2,4-triazol-5-yl]methyl]pyridine
    —— 4-Benzyl-1-isopropyl-3-methyl-5-methylsulfanyl-1,3-dihydro-imidazol-2-one —— C15H20N2OS
    4-Benzyl-1-isopropyl-3-methyl-5-methylsulfanyl-1,3-dihydro-imidazol-2-one
    —— 2-[2-(2-Butoxyethylsulfonyl)ethylsulfanyl]ethanol —— C10H22O4S2
    2-[2-(2-Butoxyethylsulfonyl)ethylsulfanyl]ethanol
    —— 5-(5-ethylsulfanylpyridin-3-yl)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole —— C13H19N3S
    5-(5-ethylsulfanylpyridin-3-yl)-2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole
    —— 5-[(3,5-dimethylbenzyl)sulfanyl]-1H-1,2,4-triazol-3-amine —— C11H14N4S
    5-[(3,5-dimethylbenzyl)sulfanyl]-1H-1,2,4-triazol-3-amine
    —— 3-[(3-methylbutyl)thio]-1H-1,2,4-triazol-5-amine —— C7H14N4S
    3-[(3-methylbutyl)thio]-1H-1,2,4-triazol-5-amine
    —— 4-(1H-1,2,4-triazol-5-ylsulfanyl)butane-1-thiol —— C6H11N3S2
    4-(1H-1,2,4-triazol-5-ylsulfanyl)butane-1-thiol
    —— 1-(2-Hydroxy-ethyl)-3-(2-methyl-cyclopent-2-enyl)-thiourea —— C9H16N2OS
    1-(2-Hydroxy-ethyl)-3-(2-methyl-cyclopent-2-enyl)-thiourea
    —— 3-chloro-N-(3,5-dichloro-4-quinolin-3-ylsulfanylphenyl)-5-(trifluoromethyl)benzenesulfonamide —— C22H12Cl3F3N2O2S2
    3-chloro-N-(3,5-dichloro-4-quinolin-3-ylsulfanylphenyl)-5-(trifluoromethyl)benzenesulfonamide
    —— {3-[4-(3-cyclohexyl-1-phenethylureido)phenylsulphanyl]phenyl}acetic acid 735273-77-5 C29H32N2O3S
    {3-[4-(3-cyclohexyl-1-phenethylureido)phenylsulphanyl]phenyl}acetic acid
    —— 3,5-Dichloro-4-[6-(4-fluoro-phenylsulfanyl)-2-oxo-3,4-dihydro-2H-pyrido[3,2-d]pyrimidin-1-yl]-benzoic acid methyl ester —— C21H14Cl2FN3O3S
    3,5-Dichloro-4-[6-(4-fluoro-phenylsulfanyl)-2-oxo-3,4-dihydro-2H-pyrido[3,2-d]pyrimidin-1-yl]-benzoic acid methyl ester
    —— N-[5-(6,7-dimethoxyquinazolin-4-yl)sulfanyl-1,3,4-thiadiazol-2-yl]thiophene-2-carboxamide 664325-13-7 C17H13N5O3S3
    N-[5-(6,7-dimethoxyquinazolin-4-yl)sulfanyl-1,3,4-thiadiazol-2-yl]thiophene-2-carboxamide
    —— 1-(4-chlorophenylamino)-4-[5-(4-pyridyl)-1H-1,2,4-triazolyl-3-ylthio]phthalazine 325781-32-6 C21H14ClN7S
    1-(4-chlorophenylamino)-4-[5-(4-pyridyl)-1H-1,2,4-triazolyl-3-ylthio]phthalazine
    —— 1-(1-Adamantyl)-3-[4-(4-nitrophenyl)sulfanylphenyl]urea —— C23H25N3O3S
    1-(1-Adamantyl)-3-[4-(4-nitrophenyl)sulfanylphenyl]urea
    —— 1-[4-[5-(4-Hydroxyphenyl)sulfanylpentyl]-1,3-thiazolidin-3-yl]-3,3-dimethyl-1-sulfanylidenepentan-2-one —— C21H31NO2S3
    1-[4-[5-(4-Hydroxyphenyl)sulfanylpentyl]-1,3-thiazolidin-3-yl]-3,3-dimethyl-1-sulfanylidenepentan-2-one
    —— Benzyl 4-[[5-[(dimethylamino)methyl]-1,3-thiazol-2-yl]sulfanyl]piperidine-1-carbodithioate —— C19H25N3S4
    Benzyl 4-[[5-[(dimethylamino)methyl]-1,3-thiazol-2-yl]sulfanyl]piperidine-1-carbodithioate
    —— N-(5-tert-butyl-2-methoxyphenyl)-N'-(4-(4-pyridinylthio)phenyl)urea —— C23H25N3O2S
    N-(5-tert-butyl-2-methoxyphenyl)-N'-(4-(4-pyridinylthio)phenyl)urea
    —— 7-(1-aminopropan-2-ylamino)-5-[(3-chloro-2-fluorophenyl)methylsulfanyl]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C15H15ClFN5OS2
    7-(1-aminopropan-2-ylamino)-5-[(3-chloro-2-fluorophenyl)methylsulfanyl]-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— (3S,3aR,4S,9bR)-4-hydroxy-9-(hydroxymethyl)-6-methyl-3-(phenylsulfanylmethyl)-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione —— C21H22O5S
    (3S,3aR,4S,9bR)-4-hydroxy-9-(hydroxymethyl)-6-methyl-3-(phenylsulfanylmethyl)-3,3a,4,5,9a,9b-hexahydroazuleno[4,5-b]furan-2,7-dione
    —— 2-[2-[2-Methyl-3-[(2-methylsulfanylimidazol-1-yl)methyl]phenyl]sulfanylethylsulfanyl]pyrimidine —— C18H20N4S3
    2-[2-[2-Methyl-3-[(2-methylsulfanylimidazol-1-yl)methyl]phenyl]sulfanylethylsulfanyl]pyrimidine
    —— 2-[[2-(4-Morpholinyl)ethyl]amino]-5-(pentylthio)thiazolo[4,5-d]pyrimidin-7(4H)-one 259100-56-6 C16H25N5O2S2
    2-[[2-(4-Morpholinyl)ethyl]amino]-5-(pentylthio)thiazolo[4,5-d]pyrimidin-7(4H)-one
    —— 7-[(2-Hydroxy-1,1-dimethylethyl)amino]-5-[[(2-methyl-4-thiazolyl)methyl]thio] thiazolo[4,5-d]pyrimidin-2(3H)-one —— C14H17N5O2S3
    7-[(2-Hydroxy-1,1-dimethylethyl)amino]-5-[[(2-methyl-4-thiazolyl)methyl]thio] thiazolo[4,5-d]pyrimidin-2(3H)-one
    —— 5-[(3-chlorophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C15H15ClN4O2S2
    5-[(3-chlorophenyl)methylsulfanyl]-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— 3-[(6R)-1-azabicyclo[3.2.1]octan-6-yl]-4-butylsulfanyl-1,2,5-thiadiazole —— C13H21N3S2
    3-[(6R)-1-azabicyclo[3.2.1]octan-6-yl]-4-butylsulfanyl-1,2,5-thiadiazole
    —— ethyl 2-[(7-nitro-2,3-dioxo-1,4-dihydroquinoxalin-6-yl)sulfanyl]-1H-imidazole-5-carboxylate —— C14H11N5O6S
    ethyl 2-[(7-nitro-2,3-dioxo-1,4-dihydroquinoxalin-6-yl)sulfanyl]-1H-imidazole-5-carboxylate
    —— 3-[(6R)-1-azabicyclo[3.2.1]octan-6-yl]-4-butylsulfanyl-1,2,5-thiadiazole;oxalic acid —— C15H23N3O4S2
    3-[(6R)-1-azabicyclo[3.2.1]octan-6-yl]-4-butylsulfanyl-1,2,5-thiadiazole;oxalic acid
    —— 4-[[(2S,4S)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol —— C17H19NO2S2
    4-[[(2S,4S)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol
    —— N-(aminoiminomethyl)-4-methylthio-6,7-dihydro-5H-benzocycloheptene-8-carboxamide methanesulfonate —— CH4O3S*C14H17N3OS
    N-(aminoiminomethyl)-4-methylthio-6,7-dihydro-5H-benzocycloheptene-8-carboxamide methanesulfonate
    —— 6-acetyl-2-(3-chlorophenyl)-5-methyl-4-phenylthio-3(2H)-pyridazinone 259192-79-5 C19H15ClN2O2S
    6-acetyl-2-(3-chlorophenyl)-5-methyl-4-phenylthio-3(2H)-pyridazinone
    —— 4-[[(2S,4S)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol;hydrochloride —— C17H20ClNO2S2
    4-[[(2S,4S)-4-(4-hydroxyphenyl)sulfanylpyrrolidin-2-yl]methylsulfanyl]phenol;hydrochloride
    —— 2-Methyl-6-[[6-[(4-methylpyrimidin-2-yl)sulfanylmethyl]pyridin-2-yl]methylsulfanyl]pyrazine —— C17H17N5S2
    2-Methyl-6-[[6-[(4-methylpyrimidin-2-yl)sulfanylmethyl]pyridin-2-yl]methylsulfanyl]pyrazine
    —— (5E,8E,11E,14E)-1-propylsulfanylicosa-5,8,11,14-tetraene —— C23H40S
    (5E,8E,11E,14E)-1-propylsulfanylicosa-5,8,11,14-tetraene
    —— N-(4-methylphenyl)-3-quinolin-8-ylsulfanyl-1H-1,2,4-triazol-5-amine —— C18H15N5S
    N-(4-methylphenyl)-3-quinolin-8-ylsulfanyl-1H-1,2,4-triazol-5-amine
    —— 5-[(6-nitro-1H-benzimidazol-5-yl)sulfanyl]-1,2,3,4-tetrahydroisoquinoline —— C16H14N4O2S
    5-[(6-nitro-1H-benzimidazol-5-yl)sulfanyl]-1,2,3,4-tetrahydroisoquinoline
    —— 3-chloro-4-(2,4-dichlorophenyl)sulfanyl-N-methylaniline —— C13H10Cl3NS
    3-chloro-4-(2,4-dichlorophenyl)sulfanyl-N-methylaniline
    —— 7-methyl-4-[[5-(methylthio)-1,3,4-thiadiazol-2-yl]thio]thieno[3,2-d]pyrimidine —— C10H8N4S4
    7-methyl-4-[[5-(methylthio)-1,3,4-thiadiazol-2-yl]thio]thieno[3,2-d]pyrimidine