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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— (2R)-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate —— C10H9N2O4S-
    (2R)-2-[[5-(2-methylfuran-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]propanoate
    —— (2R)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoic acid —— C6H8N2O3S
    (2R)-2-[(5-methyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanoic acid
    —— 2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-(thiophen-3-ylmethyl)acetamide —— C18H20N4OS3
    2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methyl-N-(thiophen-3-ylmethyl)acetamide
    —— 2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-pentylacetamide —— C17H24N4OS2
    2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-pentylacetamide
    —— N-[(1S)-1-cyclopropylethyl]-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H22N4OS2
    N-[(1S)-1-cyclopropylethyl]-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-benzyl-2-[[5-(5-methyl-1,2-oxazol-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide —— C15H14N4O3S
    N-benzyl-2-[[5-(5-methyl-1,2-oxazol-3-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methylbutan-2-yl)acetamide —— C17H24N4OS2
    2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methylbutan-2-yl)acetamide
    —— [2-[[4-(Dimethylamino)phenyl]methylamino]-2-oxoethyl] 3-(4-methylphenyl)sulfanylpropanoate —— C21H26N2O3S
    [2-[[4-(Dimethylamino)phenyl]methylamino]-2-oxoethyl] 3-(4-methylphenyl)sulfanylpropanoate
    —— 2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2R)-5-methylhexan-2-yl]acetamide —— C18H26N4OS2
    2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2R)-5-methylhexan-2-yl]acetamide
    —— 2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-pentylacetamide —— C16H22N4OS2
    2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-pentylacetamide
    —— N-[(1R)-1-cyclopropylethyl]-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H20N4OS2
    N-[(1R)-1-cyclopropylethyl]-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-[(1R)-1-cyclopropylethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H20N4OS2
    N-[(1R)-1-cyclopropylethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-butyl-2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide —— C17H24N4OS2
    N-butyl-2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— N-hexyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C17H24N4OS2
    N-hexyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-butyl-N-methyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H22N4OS2
    N-butyl-N-methyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dipropylacetamide —— C17H24N4OS2
    2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N,N-dipropylacetamide
    —— N-(4-methylphenyl)-5-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C19H17N5OS2
    N-(4-methylphenyl)-5-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— N-(2-cyanopropan-2-yl)-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide —— C17H21N5OS2
    N-(2-cyanopropan-2-yl)-2-[[5-(2,3-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— N-[(2-fluorophenyl)methyl]-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C18H17FN4OS2
    N-[(2-fluorophenyl)methyl]-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-[(2-fluorophenyl)methyl]-N-methyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C19H19FN4OS2
    N-[(2-fluorophenyl)methyl]-N-methyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 5-[[5-(furan-2-yl)-1,2-oxazol-3-yl]methylsulfanyl]-N-(4-methylphenyl)-1,3,4-thiadiazol-2-amine —— C17H14N4O2S2
    5-[[5-(furan-2-yl)-1,2-oxazol-3-yl]methylsulfanyl]-N-(4-methylphenyl)-1,3,4-thiadiazol-2-amine
    —— N-[[4-(dimethylamino)phenyl]methyl]-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C20H23N5OS2
    N-[[4-(dimethylamino)phenyl]methyl]-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-(3,4-dimethylphenyl)-5-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C20H19N5OS2
    N-(3,4-dimethylphenyl)-5-[[5-(3-methylphenyl)-1,3,4-oxadiazol-2-yl]methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-5-methylhexan-2-yl]acetamide —— C18H26N4OS2
    2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(2S)-5-methylhexan-2-yl]acetamide
    —— N-(3,4-dimethylphenyl)-5-[(1-propyltetrazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine —— C15H19N7S2
    N-(3,4-dimethylphenyl)-5-[(1-propyltetrazol-5-yl)methylsulfanyl]-1,3,4-thiadiazol-2-amine
    —— 2-[(3S)-1,1-dioxothiolan-3-yl]sulfanyl-N-(2-phenylsulfanylethyl)acetamide —— C14H19NO3S3
    2-[(3S)-1,1-dioxothiolan-3-yl]sulfanyl-N-(2-phenylsulfanylethyl)acetamide
    —— N-[[4-(dimethylamino)phenyl]methyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C20H23N5OS2
    N-[[4-(dimethylamino)phenyl]methyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-(2-cyanopropan-2-yl)-2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide —— C17H21N5OS2
    N-(2-cyanopropan-2-yl)-2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylacetamide
    —— 2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(furan-2-yl)ethyl]acetamide —— C18H20N4O2S2
    2-[[5-(3,4-dimethylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-[(1S)-1-(furan-2-yl)ethyl]acetamide
    —— N-[(1S)-1-cyclopropylethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H20N4OS2
    N-[(1S)-1-cyclopropylethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-[(3-chlorophenyl)methyl]-N-methyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C19H19ClN4OS2
    N-[(3-chlorophenyl)methyl]-N-methyl-2-[[5-(4-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-(2-phenylsulfanylethyl)propanamide —— C18H23N3OS2
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-(2-phenylsulfanylethyl)propanamide
    —— N-butyl-N-methyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C16H22N4OS2
    N-butyl-N-methyl-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methylbutan-2-yl)acetamide —— C16H22N4OS2
    2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]-N-(2-methylbutan-2-yl)acetamide
    —— N-[2-(2-fluorophenyl)ethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C19H19FN4OS2
    N-[2-(2-fluorophenyl)ethyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— N-[(2-fluorophenyl)methyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide —— C18H17FN4OS2
    N-[(2-fluorophenyl)methyl]-2-[[5-(2-methylanilino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetamide
    —— 3-(2,5-dioxopyrrolidin-1-yl)-N-(2-phenylsulfanylethyl)propanamide —— C15H18N2O3S
    3-(2,5-dioxopyrrolidin-1-yl)-N-(2-phenylsulfanylethyl)propanamide
    —— 3-(2-chlorophenyl)-5-methyl-N-(2-phenylsulfanylethyl)-1,2-oxazole-4-carboxamide —— C19H17ClN2O2S
    3-(2-chlorophenyl)-5-methyl-N-(2-phenylsulfanylethyl)-1,2-oxazole-4-carboxamide
    —— 1-benzyl-N-(2-phenylsulfanylethyl)pyrazole-4-carboxamide —— C19H19N3OS
    1-benzyl-N-(2-phenylsulfanylethyl)pyrazole-4-carboxamide
    —— (E)-3-(5-methylthiophen-2-yl)-N-(2-phenylsulfanylethyl)prop-2-enamide —— C16H17NOS2
    (E)-3-(5-methylthiophen-2-yl)-N-(2-phenylsulfanylethyl)prop-2-enamide
    —— 2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-phenylsulfanylethyl)acetamide —— C18H16ClN3O2S2
    2-[[5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-phenylsulfanylethyl)acetamide
    —— 1-benzyl-3,5-dimethyl-N-(2-phenylsulfanylethyl)pyrazole-4-carboxamide —— C21H23N3OS
    1-benzyl-3,5-dimethyl-N-(2-phenylsulfanylethyl)pyrazole-4-carboxamide
    —— (E)-3-(3-methylthiophen-2-yl)-N-(2-phenylsulfanylethyl)prop-2-enamide —— C16H17NOS2
    (E)-3-(3-methylthiophen-2-yl)-N-(2-phenylsulfanylethyl)prop-2-enamide
    —— 2-(4-bromophenyl)sulfanyl-N-(2-phenylsulfanylethyl)acetamide —— C16H16BrNOS2
    2-(4-bromophenyl)sulfanyl-N-(2-phenylsulfanylethyl)acetamide
    —— 2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-phenylsulfanylethyl)acetamide —— C18H16FN3O2S2
    2-[[5-(4-fluorophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-phenylsulfanylethyl)acetamide
    —— (E)-3-(5-bromothiophen-2-yl)-N-(2-phenylsulfanylethyl)prop-2-enamide —— C15H14BrNOS2
    (E)-3-(5-bromothiophen-2-yl)-N-(2-phenylsulfanylethyl)prop-2-enamide
    —— 2-(2-methylphenyl)sulfanyl-N-(2-phenylsulfanylethyl)acetamide —— C17H19NOS2
    2-(2-methylphenyl)sulfanyl-N-(2-phenylsulfanylethyl)acetamide
    —— 3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1S)-1-(furan-2-yl)ethyl]propanamide —— C16H21N3O2S
    3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)-N-[(1S)-1-(furan-2-yl)ethyl]propanamide
    —— 3-(4-fluorophenyl)sulfanyl-N-[(1S)-1-(furan-2-yl)ethyl]propanamide —— C15H16FNO2S
    3-(4-fluorophenyl)sulfanyl-N-[(1S)-1-(furan-2-yl)ethyl]propanamide
    —— 3-(4-chlorophenyl)sulfanyl-N-[(1S)-1-(furan-2-yl)ethyl]propanamide —— C15H16ClNO2S
    3-(4-chlorophenyl)sulfanyl-N-[(1S)-1-(furan-2-yl)ethyl]propanamide