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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(E)-1-(4-cyclohexylphenyl)ethylideneamino]acetamide —— C24H29BrN2OS
    2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(E)-1-(4-cyclohexylphenyl)ethylideneamino]acetamide
    —— N'-[(E)-(4-bromophenyl)methylidene]-2-[(5-{[(4-chlorophenyl)amino]methyl}-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide —— C20H20BrClN6OS
    N'-[(E)-(4-bromophenyl)methylidene]-2-[(5-{[(4-chlorophenyl)amino]methyl}-4-ethyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide
    —— 2-(3,5-dimethyl-4-nitropyrazol-1-yl)-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]acetamide —— C15H17N5O3S
    2-(3,5-dimethyl-4-nitropyrazol-1-yl)-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]acetamide
    —— 3-methyl-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]butanamide —— C13H18N2OS
    3-methyl-N-[(E)-(4-methylsulfanylphenyl)methylideneamino]butanamide
    —— N'-{(E)-[3-bromo-4-(dimethylamino)phenyl]methylidene}-2-[(4-chlorophenyl)sulfanyl]propanehydrazide —— C18H19BrClN3OS
    N'-{(E)-[3-bromo-4-(dimethylamino)phenyl]methylidene}-2-[(4-chlorophenyl)sulfanyl]propanehydrazide
    —— 2-(2-butylsulfanyl-6-methylpyrimidin-4-yl)sulfanyl-N-[(E)-(2-fluorophenyl)methylideneamino]acetamide —— C18H21FN4OS2
    2-(2-butylsulfanyl-6-methylpyrimidin-4-yl)sulfanyl-N-[(E)-(2-fluorophenyl)methylideneamino]acetamide
    —— 2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetic acid (4-CL-benzylidene)-hydrazide —— C15H15ClN4OS
    2-(4,6-Dimethyl-pyrimidin-2-ylsulfanyl)-acetic acid (4-CL-benzylidene)-hydrazide
    —— 1-[(E)-(3-nitro-4-pyrimidin-2-ylsulfanylphenyl)methylideneamino]-3-(oxolan-2-ylmethyl)thiourea —— C17H18N6O3S2
    1-[(E)-(3-nitro-4-pyrimidin-2-ylsulfanylphenyl)methylideneamino]-3-(oxolan-2-ylmethyl)thiourea
    —— 2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-N'-{(E)-[5-(morpholin-4-yl)furan-2-yl]methylidene}acetohydrazide —— C17H21N5O3S
    2-[(4,6-dimethylpyrimidin-2-yl)sulfanyl]-N'-{(E)-[5-(morpholin-4-yl)furan-2-yl]methylidene}acetohydrazide
    —— 2-((4-Methylphenyl)sulfanyl)nicotinaldehyde o-(4-methylbenzyl)oxime —— C21H20N2OS
    2-((4-Methylphenyl)sulfanyl)nicotinaldehyde o-(4-methylbenzyl)oxime
    —— N'-[(E)-{4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene]-2-(quinolin-8-yloxy)acetohydrazide —— C22H15BrClN3O3S
    N'-[(E)-{4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene]-2-(quinolin-8-yloxy)acetohydrazide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methylphenyl)sulfanyl]methyl}-N'-[(1E)-1-(pyridin-3-yl)ethylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C20H19N9O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methylphenyl)sulfanyl]methyl}-N'-[(1E)-1-(pyridin-3-yl)ethylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(phenylsulfanyl)methyl]-N'-[(1E)-1-(pyridin-3-yl)ethylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C19H17N9O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(phenylsulfanyl)methyl]-N'-[(1E)-1-(pyridin-3-yl)ethylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— 2-methyl-N-[(E)-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylideneamino]imidazo[1,2-a]pyridine-3-carboxamide —— C19H16N8O3S
    2-methyl-N-[(E)-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylideneamino]imidazo[1,2-a]pyridine-3-carboxamide
    —— 2-[5-[(E)-[(4-nitrophenyl)hydrazinylidene]methyl]furan-2-yl]sulfanyl-3-phenylquinazolin-4-one —— C25H17N5O4S
    2-[5-[(E)-[(4-nitrophenyl)hydrazinylidene]methyl]furan-2-yl]sulfanyl-3-phenylquinazolin-4-one
    —— N'-[(E)-(4-fluorophenyl)methylidene]-2-(phenylsulfanyl)propanehydrazide —— C16H15FN2OS
    N'-[(E)-(4-fluorophenyl)methylidene]-2-(phenylsulfanyl)propanehydrazide
    —— 2-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-{(E)-[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide —— C21H19ClN4O2S3
    2-({5-[(4-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-{(E)-[2-hydroxy-3-(prop-2-en-1-yl)phenyl]methylidene}acetohydrazide
    —— 6-(Isopropylsulfanyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde oxime —— C9H11N3OS2
    6-(Isopropylsulfanyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde oxime
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(2,4-difluorophenyl)methylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C16H13F2N11O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(2,4-difluorophenyl)methylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— [(Z)-(2-oxo-1-benzothiophen-3-ylidene)amino]thiourea —— C9H7N3OS2
    [(Z)-(2-oxo-1-benzothiophen-3-ylidene)amino]thiourea
    —— 3-[(E)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]-2-sulfanylidene-1,3-thiazolidin-4-one —— C17H13N3O3S3
    3-[(E)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]-2-sulfanylidene-1,3-thiazolidin-4-one
    —— N'-[(E)-(5-methylfuran-2-yl)methylidene]-2-[(4-methyl-5-{[(2-methylphenyl)amino]methyl}-4H-1,2,4-triazol-3-yl)sulfanyl]propanehydrazide —— C20H24N6O2S
    N'-[(E)-(5-methylfuran-2-yl)methylidene]-2-[(4-methyl-5-{[(2-methylphenyl)amino]methyl}-4H-1,2,4-triazol-3-yl)sulfanyl]propanehydrazide
    —— N'-[(E)-(2-bromophenyl)methylidene]-2-[(4-methylphenyl)sulfanyl]acetohydrazide —— C16H15BrN2OS
    N'-[(E)-(2-bromophenyl)methylidene]-2-[(4-methylphenyl)sulfanyl]acetohydrazide
    —— 3,5-dibromo-N'-({4-bromo-5-[(4-chlorophenyl)sulfanyl]-2-furyl}methylene)-4-hydroxybenzohydrazide —— C18H10Br3ClN2O3S
    3,5-dibromo-N'-({4-bromo-5-[(4-chlorophenyl)sulfanyl]-2-furyl}methylene)-4-hydroxybenzohydrazide
    —— 4-[(E)-(5-benzylsulfanyl-1,3,4-thiadiazol-2-yl)iminomethyl]-N,N-dimethylaniline —— C18H18N4S2
    4-[(E)-(5-benzylsulfanyl-1,3,4-thiadiazol-2-yl)iminomethyl]-N,N-dimethylaniline
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-phenylmethylidene]-5-[(phenylsulfanyl)methyl]-1H-1,2,3-triazole-4-carbohydrazide —— C19H16N8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-phenylmethylidene]-5-[(phenylsulfanyl)methyl]-1H-1,2,3-triazole-4-carbohydrazide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-{(E)-[4-(dimethylamino)phenyl]methylidene}-5-{[(4-methylphenyl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C22H23N9O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-{(E)-[4-(dimethylamino)phenyl]methylidene}-5-{[(4-methylphenyl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-2-thiophen-2-ylacetamide —— C17H15N5O3S2
    N-[(E)-[4-(1-methylimidazol-2-yl)sulfanyl-3-nitrophenyl]methylideneamino]-2-thiophen-2-ylacetamide
    —— N-[(E)-[2-(4,6-dimethoxypyrimidin-2-yl)sulfanylphenyl]methylideneamino]-2-methylaniline —— C20H20N4O2S
    N-[(E)-[2-(4,6-dimethoxypyrimidin-2-yl)sulfanylphenyl]methylideneamino]-2-methylaniline
    —— N,N'-bis[(E)-(4-methylsulfanylphenyl)methylideneamino]butanediamide —— C20H22N4O2S2
    N,N'-bis[(E)-(4-methylsulfanylphenyl)methylideneamino]butanediamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(4-ethylphenyl)methylidene]-5-{[(4-methylphenyl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C22H22N8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(4-ethylphenyl)methylidene]-5-{[(4-methylphenyl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— 4-fluoro-N-[(E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide —— C17H12FN3O2S
    4-fluoro-N-[(E)-(5-pyridin-2-ylsulfanylfuran-2-yl)methylideneamino]benzamide
    —— 4-(Methylthio)benzaldehyde (2-(4-bromophenyl)-1,3-thiazol-4-YL)hydrazone —— C17H14BrN3S2
    4-(Methylthio)benzaldehyde (2-(4-bromophenyl)-1,3-thiazol-4-YL)hydrazone
    —— 2-[(E)-1-(5-{[(4-Bromophenyl)sulfanyl]methyl}-2,4-dimethylphenyl)methylidene]-1-hydrazinecarboxamide —— C17H18BrN3OS
    2-[(E)-1-(5-{[(4-Bromophenyl)sulfanyl]methyl}-2,4-dimethylphenyl)methylidene]-1-hydrazinecarboxamide
    —— 2-({5-[(2-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(1E)-1-(4-hydroxyphenyl)ethylidene]acetohydrazide —— C19H17ClN4O2S3
    2-({5-[(2-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(1E)-1-(4-hydroxyphenyl)ethylidene]acetohydrazide
    —— (1S)-1-[3-(2-methylpropylsulfanyl)phenyl]ethanol —— C12H18OS
    (1S)-1-[3-(2-methylpropylsulfanyl)phenyl]ethanol
    —— (2R)-1-[(S)-methylsulfinyl]propan-2-amine —— C4H11NOS
    (2R)-1-[(S)-methylsulfinyl]propan-2-amine
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(4-methylphenyl)methylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C17H17N11O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(E)-(4-methylphenyl)methylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— 2-(1,3-benzothiazol-2-ylsulfanyl)-3-[(E)-1,2,4-triazol-4-yliminomethyl]pyrido[1,2-a]pyrimidin-4-one —— C18H11N7OS2
    2-(1,3-benzothiazol-2-ylsulfanyl)-3-[(E)-1,2,4-triazol-4-yliminomethyl]pyrido[1,2-a]pyrimidin-4-one
    —— 2-({5-[(2-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(1E)-1-(2-hydroxyphenyl)ethylidene]acetohydrazide —— C19H17ClN4O2S3
    2-({5-[(2-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(1E)-1-(2-hydroxyphenyl)ethylidene]acetohydrazide
    —— 2-((4-Chlorophenyl)sulfanyl)nicotinaldehyde oxime —— C12H9ClN2OS
    2-((4-Chlorophenyl)sulfanyl)nicotinaldehyde oxime
    —— 2-((4-Chlorophenyl)sulfanyl)nicotinaldehyde O-(4-fluorobenzyl)oxime —— C19H14ClFN2OS
    2-((4-Chlorophenyl)sulfanyl)nicotinaldehyde O-(4-fluorobenzyl)oxime
    —— 2-((4-Chlorophenyl)sulfanyl)nicotinaldehyde O-(2,4-dichlorobenzyl)oxime —— C19H13Cl3N2OS
    2-((4-Chlorophenyl)sulfanyl)nicotinaldehyde O-(2,4-dichlorobenzyl)oxime
    —— 4-(decyloxy)-N'-{(E)-[5-(quinolin-8-ylsulfanyl)furan-2-yl]methylidene}benzohydrazide —— C31H35N3O3S
    4-(decyloxy)-N'-{(E)-[5-(quinolin-8-ylsulfanyl)furan-2-yl]methylidene}benzohydrazide
    —— N-[(E)-[5-(1,3-benzoxazol-2-ylsulfanyl)-2-methylpyrazolo[1,5-a]quinazolin-3-yl]methylideneamino]-3-morpholin-4-ylsulfonylbenzamide —— C30H25N7O5S2
    N-[(E)-[5-(1,3-benzoxazol-2-ylsulfanyl)-2-methylpyrazolo[1,5-a]quinazolin-3-yl]methylideneamino]-3-morpholin-4-ylsulfonylbenzamide
    —— N-[(E)-[5-(1,3-benzothiazol-2-ylsulfanyl)furan-2-yl]methylideneamino]-2-methylbenzamide —— C20H15N3O2S2
    N-[(E)-[5-(1,3-benzothiazol-2-ylsulfanyl)furan-2-yl]methylideneamino]-2-methylbenzamide
    —— 2-[(Z)-(2-oxo-1-benzothiophen-3-ylidene)amino]guanidine —— C9H8N4OS
    2-[(Z)-(2-oxo-1-benzothiophen-3-ylidene)amino]guanidine
    —— N'-[(E)-{4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene]-2,4-dichlorobenzohydrazide —— C18H10BrCl3N2O2S
    N'-[(E)-{4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene]-2,4-dichlorobenzohydrazide
    —— N'-[(E)-(4-hydroxyphenyl)methylidene]-2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide —— C19H18N4O2S3
    N'-[(E)-(4-hydroxyphenyl)methylidene]-2-({5-[(4-methylbenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)acetohydrazide
    —— 6-tert-butyl-4-{[(E)-(3-methylphenyl)methylidene]amino}-3-(methylsulfanyl)-1,2,4-triazin-5(4H)-one —— C16H20N4OS
    6-tert-butyl-4-{[(E)-(3-methylphenyl)methylidene]amino}-3-(methylsulfanyl)-1,2,4-triazin-5(4H)-one