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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-[(5Z)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2,3,4-trifluorophenyl)acetamide —— C24H13ClF3N3O5S2
    2-[(5Z)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-(2,3,4-trifluorophenyl)acetamide
    —— 2-((4-Chlorophenyl)sulfanyl)nicotinaldehyde O-methyloxime —— C13H11ClN2OS
    2-((4-Chlorophenyl)sulfanyl)nicotinaldehyde O-methyloxime
    —— (E)-2-(4-chlorophenylthio)nicotinaldehyde O-4-fluorobenzyl oxime —— C19H14ClFN2OS
    (E)-2-(4-chlorophenylthio)nicotinaldehyde O-4-fluorobenzyl oxime
    —— 2-({5-[(2-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(Z)-(4-methylphenyl)methylidene]acetohydrazide —— C19H17ClN4OS3
    2-({5-[(2-chlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}sulfanyl)-N'-[(Z)-(4-methylphenyl)methylidene]acetohydrazide
    —— (E)-3-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]-2-cyano-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)prop-2-enamide —— C24H17N5O2S2
    (E)-3-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]-2-cyano-N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)prop-2-enamide
    —— (5Z)-5-(3H-1-benzothiophen-2-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one —— C11H7NOS3
    (5Z)-5-(3H-1-benzothiophen-2-ylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
    —— (5E)-3-benzyl-5-{2-[(4-chlorophenyl)sulfanyl]benzylidene}-2-thioxo-1,3-thiazolidin-4-one —— C23H16ClNOS3
    (5E)-3-benzyl-5-{2-[(4-chlorophenyl)sulfanyl]benzylidene}-2-thioxo-1,3-thiazolidin-4-one
    —— 2-[[4-ethyl-5-[(4-fluoroanilino)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-(4-fluorophenyl)methylideneamino]acetamide —— C20H20F2N6OS
    2-[[4-ethyl-5-[(4-fluoroanilino)methyl]-1,2,4-triazol-3-yl]sulfanyl]-N-[(Z)-(4-fluorophenyl)methylideneamino]acetamide
    —— (5Z)-3-[(2,4-dichlorophenyl)methyl]-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-1,3-thiazolidine-2,4-dione —— C24H16Cl2N2O4S2
    (5Z)-3-[(2,4-dichlorophenyl)methyl]-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-1,3-thiazolidine-2,4-dione
    —— 2,4-dichloro-N-[(Z)-[5-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]furan-2-yl]methylideneamino]benzamide —— C19H10Cl2N4O4S2
    2,4-dichloro-N-[(Z)-[5-[(6-nitro-1,3-benzothiazol-2-yl)sulfanyl]furan-2-yl]methylideneamino]benzamide
    —— (14E)-14-[[5-(1,3-benzothiazol-2-ylsulfanyl)furan-2-yl]methylidene]-11-thiophen-2-yl-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-13-one —— C30H19N3O2S4
    (14E)-14-[[5-(1,3-benzothiazol-2-ylsulfanyl)furan-2-yl]methylidene]-11-thiophen-2-yl-15-thia-12,17-diazatetracyclo[8.7.0.02,7.012,16]heptadeca-1(10),2,4,6,16-pentaen-13-one
    —— (5Z)-3-[(2-chloro-6-fluorophenyl)methyl]-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-1,3-thiazolidine-2,4-dione —— C24H16ClFN2O4S2
    (5Z)-3-[(2-chloro-6-fluorophenyl)methyl]-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-1,3-thiazolidine-2,4-dione
    —— 2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[(Z)-(5-methylfuran-2-yl)methylideneamino]acetamide —— C14H16N4O2S
    2-(4,6-dimethylpyrimidin-2-yl)sulfanyl-N-[(Z)-(5-methylfuran-2-yl)methylideneamino]acetamide
    —— N-[(Z)-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylideneamino]pentanamide —— C17H18N4O2S
    N-[(Z)-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]methylideneamino]pentanamide
    —— 1-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]-3-phenylthiourea —— C21H18N4O2S2
    1-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]-3-phenylthiourea
    —— N-[(Z)-(4-butylphenyl)methylideneamino]-2-(2-ethylsulfanyl-6-methylpyrimidin-4-yl)oxyacetamide —— C20H26N4O2S
    N-[(Z)-(4-butylphenyl)methylideneamino]-2-(2-ethylsulfanyl-6-methylpyrimidin-4-yl)oxyacetamide
    —— (2E)-2-(1H-benzimidazol-2-yl)-3-{5-[(4-methylphenyl)sulfanyl]furan-2-yl}prop-2-enenitrile —— C21H15N3OS
    (2E)-2-(1H-benzimidazol-2-yl)-3-{5-[(4-methylphenyl)sulfanyl]furan-2-yl}prop-2-enenitrile
    —— N-(2-methoxyphenyl)-2-[(5Z)-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide —— C26H21N3O6S2
    N-(2-methoxyphenyl)-2-[(5Z)-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]acetamide
    —— (5E)-3-(3-chlorophenyl)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one —— C22H12Cl2N2O3S3
    (5E)-3-(3-chlorophenyl)-5-[[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one
    —— (NE)-N-[4-(4-chlorophenyl)sulfanyl-3-nitro-1,1-dioxo-2H-thiophen-5-ylidene]hydroxylamine —— C10H7ClN2O5S2
    (NE)-N-[4-(4-chlorophenyl)sulfanyl-3-nitro-1,1-dioxo-2H-thiophen-5-ylidene]hydroxylamine
    —— N-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]benzamide —— C21H17N3O3S
    N-[(Z)-[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylideneamino]benzamide
    —— 2-[(5Z)-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-naphthalen-1-ylacetamide —— C29H21N3O5S2
    2-[(5Z)-5-[[4-(4-methylphenyl)sulfanyl-3-nitrophenyl]methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]-N-naphthalen-1-ylacetamide
    —— N-[(Z)-[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylideneamino]furan-2-carboxamide —— C18H12ClN3O4S
    N-[(Z)-[4-(4-chlorophenyl)sulfanyl-3-nitrophenyl]methylideneamino]furan-2-carboxamide
    —— 6-[5-bromo-2-[[(E)-(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]amino]phenyl]-3-ethylsulfanyl-2H-1,2,4-triazin-5-one —— C22H19BrN6O2S
    6-[5-bromo-2-[[(E)-(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]amino]phenyl]-3-ethylsulfanyl-2H-1,2,4-triazin-5-one
    —— (E)-3-[5-[4-(difluoromethylsulfanyl)phenyl]furan-2-yl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)prop-2-enenitrile —— C21H18F2N4OS
    (E)-3-[5-[4-(difluoromethylsulfanyl)phenyl]furan-2-yl]-2-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)prop-2-enenitrile
    —— 3-[2-(4-Fluorophenyl)vinyl]-2-quinoxalinyl phenyl sulfide —— C22H15FN2S
    3-[2-(4-Fluorophenyl)vinyl]-2-quinoxalinyl phenyl sulfide
    —— ethyl (Z)-3-(4-methylsulfanylanilino)but-2-enoate —— C13H17NO2S
    ethyl (Z)-3-(4-methylsulfanylanilino)but-2-enoate
    —— (3E)-5-(4-methylphenyl)-3-(4-{[4-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-3-nitrobenzylidene)furan-2(3H)-one —— C26H19N5O4S
    (3E)-5-(4-methylphenyl)-3-(4-{[4-methyl-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}-3-nitrobenzylidene)furan-2(3H)-one
    —— (E)-3-amino-2-[2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]but-2-enenitrile —— C15H15N5OS2
    (E)-3-amino-2-[2-[[5-(benzylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]but-2-enenitrile
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(1E)-1-(4-methylphenyl)ethylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C21H19ClN8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-chlorophenyl)sulfanyl]methyl}-N'-[(1E)-1-(4-methylphenyl)ethylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— 2-[(E)-2-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]ethenyl]-1H-benzimidazole —— C18H14N6O2S
    2-[(E)-2-[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]ethenyl]-1H-benzimidazole
    —— N'-{(Z)-[4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylidene}benzohydrazide —— C21H14N4O3S2
    N'-{(Z)-[4-(1,3-benzothiazol-2-ylsulfanyl)-3-nitrophenyl]methylidene}benzohydrazide
    —— (6E)-4-bromo-6-[[2-[4-[methyl-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]amino]-6-phenylsulfanyl-1,3,5-triazin-2-yl]hydrazinyl]methylidene]cyclohexa-2,4-dien-1-one —— C21H19BrN8O2S
    (6E)-4-bromo-6-[[2-[4-[methyl-[(4-methyl-1,2,5-oxadiazol-3-yl)methyl]amino]-6-phenylsulfanyl-1,3,5-triazin-2-yl]hydrazinyl]methylidene]cyclohexa-2,4-dien-1-one
    —— (5E)-5-({4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene)-1,3-thiazolidine-2,4-dione —— C14H7BrClNO3S2
    (5E)-5-({4-bromo-5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene)-1,3-thiazolidine-2,4-dione
    —— N'-{(E)-[4-(dimethylamino)phenyl]methylidene}-3-[(4-methylphenyl)sulfanyl]propanehydrazide —— C19H23N3OS
    N'-{(E)-[4-(dimethylamino)phenyl]methylidene}-3-[(4-methylphenyl)sulfanyl]propanehydrazide
    —— N,N'-dimethyl-N,N'-bis[(Z)-(4-methylsulfanylphenyl)methylideneamino]ethane-1,2-diamine —— C20H26N4S2
    N,N'-dimethyl-N,N'-bis[(Z)-(4-methylsulfanylphenyl)methylideneamino]ethane-1,2-diamine
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-N'-[(2E)-4-phenylbutan-2-ylidene]-1H-1,2,3-triazole-4-carbohydrazide —— C19H21N11O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-N'-[(2E)-4-phenylbutan-2-ylidene]-1H-1,2,3-triazole-4-carbohydrazide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(5-chlorothiophen-2-yl)ethylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide —— C15H14ClN11O2S2
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N'-[(1E)-1-(5-chlorothiophen-2-yl)ethylidene]-5-{[(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl}-1H-1,2,3-triazole-4-carbohydrazide
    —— 4-[(2Z)-2-[[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylidene]hydrazinyl]-3-nitrobenzenesulfonamide —— C16H14N8O6S2
    4-[(2Z)-2-[[4-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]-3-nitrophenyl]methylidene]hydrazinyl]-3-nitrobenzenesulfonamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-5-propyltriazole-4-carboxamide —— C16H18N8O2S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-(4-methylsulfanylphenyl)methylideneamino]-5-propyltriazole-4-carboxamide
    —— 2-[(Z)-1-(1-benzofuran-2-yl)ethylideneamino]oxy-N-[2-(4-chlorophenyl)sulfanylphenyl]acetamide —— C24H19ClN2O3S
    2-[(Z)-1-(1-benzofuran-2-yl)ethylideneamino]oxy-N-[2-(4-chlorophenyl)sulfanylphenyl]acetamide
    —— (6Z)-2-(1-adamantyl)-5-imino-6-[(5-phenylsulfanylfuran-2-yl)methylidene]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one —— C26H24N4O2S2
    (6Z)-2-(1-adamantyl)-5-imino-6-[(5-phenylsulfanylfuran-2-yl)methylidene]-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
    —— (5E)-5-[(2-methoxyphenyl)methylidene]-2-phenyl-3-(6-phenylsulfanyl-1H-benzimidazol-2-yl)imidazol-4-one —— C30H22N4O2S
    (5E)-5-[(2-methoxyphenyl)methylidene]-2-phenyl-3-(6-phenylsulfanyl-1H-benzimidazol-2-yl)imidazol-4-one
    —— (E)-N-(cyclopropylmethyl)-3-phenylsulfanylprop-2-enamide —— C13H15NOS
    (E)-N-(cyclopropylmethyl)-3-phenylsulfanylprop-2-enamide
    —— 1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-(5-methylfuran-2-yl)methylideneamino]-5-(phenylsulfanylmethyl)triazole-4-carboxamide —— C18H16N8O3S
    1-(4-amino-1,2,5-oxadiazol-3-yl)-N-[(Z)-(5-methylfuran-2-yl)methylideneamino]-5-(phenylsulfanylmethyl)triazole-4-carboxamide
    —— (6E)-6-({5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene)-5-imino-2-propyl-5,6-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one —— C19H15ClN4O2S2
    (6E)-6-({5-[(4-chlorophenyl)sulfanyl]furan-2-yl}methylidene)-5-imino-2-propyl-5,6-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
    —— 5-(2-(4-Bromoanilino)vinyl)-3-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)sulfanyl)-4-isothiazolecarbonitrile —— C18H9BrClF3N4S2
    5-(2-(4-Bromoanilino)vinyl)-3-((3-chloro-5-(trifluoromethyl)-2-pyridinyl)sulfanyl)-4-isothiazolecarbonitrile
    —— (2Z)-2-[(4-bromothiophen-2-yl)methylidene]-6-chloro-4-methyl-1-benzothiophen-3-one —— C14H8BrClOS2
    (2Z)-2-[(4-bromothiophen-2-yl)methylidene]-6-chloro-4-methyl-1-benzothiophen-3-one
    —— 3-[(2-Chloro-6-fluorobenzyl)sulfanyl]-5-[2-(dimethylamino)vinyl]-4-isothiazolecarbonitrile —— C15H13ClFN3S2
    3-[(2-Chloro-6-fluorobenzyl)sulfanyl]-5-[2-(dimethylamino)vinyl]-4-isothiazolecarbonitrile
    —— (Z)-1-[5-(4-chlorophenyl)sulfanyl-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]-N-methoxymethanimine —— C13H11ClF3N3OS
    (Z)-1-[5-(4-chlorophenyl)sulfanyl-1-methyl-3-(trifluoromethyl)pyrazol-4-yl]-N-methoxymethanimine