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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylthio)-2-thiophene carboxylic acid —— C19H22O2S2
    5-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylthio)-2-thiophene carboxylic acid
    —— 1-Hydroxy-1-[3-[3-(4-methoxyphenyl)sulfanylphenyl]cyclobutyl]urea —— C18H20N2O3S
    1-Hydroxy-1-[3-[3-(4-methoxyphenyl)sulfanylphenyl]cyclobutyl]urea
    —— 5-[2-[2-(4-hydroxyphenyl)sulfanylethoxy]ethylsulfanyl]-3H-1,3,4-thiadiazole-2-thione —— C12H14N2O2S4
    5-[2-[2-(4-hydroxyphenyl)sulfanylethoxy]ethylsulfanyl]-3H-1,3,4-thiadiazole-2-thione
    —— (Z)-hydroxy-propan-2-yl-[[5-[4-(trifluoromethoxy)phenyl]sulfanylfuran-2-yl]methylidene]azanium —— C15H15F3NO3S+
    (Z)-hydroxy-propan-2-yl-[[5-[4-(trifluoromethoxy)phenyl]sulfanylfuran-2-yl]methylidene]azanium
    —— 2-Benzylsulfanyl-4-chloro-6-cyclohexylpyrimidine-5-carbonitrile —— C18H18ClN3S
    2-Benzylsulfanyl-4-chloro-6-cyclohexylpyrimidine-5-carbonitrile
    —— 3-(4-chloro-anilino)-5-(2-methyl-benzylthio)-1,2,4-triazole 334539-38-7 C16H15ClN4S
    3-(4-chloro-anilino)-5-(2-methyl-benzylthio)-1,2,4-triazole
    —— 3-Chloro-4-(2,4-dichlorophenyl)sulfanylaniline;hydrochloride —— C12H9Cl4NS
    3-Chloro-4-(2,4-dichlorophenyl)sulfanylaniline;hydrochloride
    —— (Z)-cyclohexyl-hydroxy-[[5-(4-methoxyphenyl)sulfanylfuran-2-yl]methylidene]azanium —— C18H22NO3S+
    (Z)-cyclohexyl-hydroxy-[[5-(4-methoxyphenyl)sulfanylfuran-2-yl]methylidene]azanium
    —— 8-(2-Methylpropylsulfanyl)-12-(trifluoromethyl)-3-thia-1,7,10,11-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene —— C12H11F3N4S2
    8-(2-Methylpropylsulfanyl)-12-(trifluoromethyl)-3-thia-1,7,10,11-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),4,7,9,11-pentaene
    —— 5-(furan-2-ylmethylsulfanyl)-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one —— C13H14N4O3S2
    5-(furan-2-ylmethylsulfanyl)-7-(1-hydroxypropan-2-ylamino)-3H-[1,3]thiazolo[4,5-d]pyrimidin-2-one
    —— (Z)-tert-butyl-hydroxy-[[5-(4-methylsulfanylphenyl)sulfanylfuran-2-yl]methylidene]azanium —— C16H20NO2S2+
    (Z)-tert-butyl-hydroxy-[[5-(4-methylsulfanylphenyl)sulfanylfuran-2-yl]methylidene]azanium
    —— 3-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-5-methylthiophene-2-carbonitrile —— C16H18N2OS2
    3-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-5-methylthiophene-2-carbonitrile
    —— 5-Methyl-8-phenylsulfanyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine —— C13H9F3N4S
    5-Methyl-8-phenylsulfanyl-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine
    —— (Z)-butyl-hydroxy-[[5-(4-methoxyphenyl)sulfanylfuran-2-yl]methylidene]azanium —— C16H20NO3S+
    (Z)-butyl-hydroxy-[[5-(4-methoxyphenyl)sulfanylfuran-2-yl]methylidene]azanium
    —— 3-(4-chloro-anilino)-5-(cyclohexylmethylthio)-1,2,4-triazole 334539-33-2 C15H19ClN4S
    3-(4-chloro-anilino)-5-(cyclohexylmethylthio)-1,2,4-triazole
    —— 3-[2-Methyl-3-[(2-methylsulfanylimidazol-1-yl)methyl]phenyl]sulfanylpropan-1-ol —— C15H20N2OS2
    3-[2-Methyl-3-[(2-methylsulfanylimidazol-1-yl)methyl]phenyl]sulfanylpropan-1-ol
    —— (Z)-tert-butyl-hydroxy-[[5-(4-methoxyphenyl)sulfanylfuran-2-yl]methylidene]azanium —— C16H20NO3S+
    (Z)-tert-butyl-hydroxy-[[5-(4-methoxyphenyl)sulfanylfuran-2-yl]methylidene]azanium
    —— 8-methylthio-6-(thiazol-2-yl)-4,5-dihydrothieno[3,4-g]-1,2-benzisoxazole —— C13H10N2OS3
    8-methylthio-6-(thiazol-2-yl)-4,5-dihydrothieno[3,4-g]-1,2-benzisoxazole
    —— 3-anilino-5-(2-methyl-benzylthio)-1,2,4-triazole 334538-73-7 C16H16N4S
    3-anilino-5-(2-methyl-benzylthio)-1,2,4-triazole
    —— 4-(2-Amino-4-chlorophenyl)sulfanyl-3-chloroaniline —— C12H10Cl2N2S
    4-(2-Amino-4-chlorophenyl)sulfanyl-3-chloroaniline
    —— (2S)-1-(6-phenylsulfanylindazol-1-yl)propan-2-amine —— C16H17N3S
    (2S)-1-(6-phenylsulfanylindazol-1-yl)propan-2-amine
    —— 5,8-dimethyl-3,4-dihydro-2H-pyridazino[4,5-b][1,4]thiazepin-9-one —— C9H13N3OS
    5,8-dimethyl-3,4-dihydro-2H-pyridazino[4,5-b][1,4]thiazepin-9-one
    —— 4-[(1R)-3-(2-hydroxyethylamino)-1-(1,2-oxazol-5-yl)propyl]sulfanyl-6-methoxypyridine-3-carbonitrile —— C15H18N4O3S
    4-[(1R)-3-(2-hydroxyethylamino)-1-(1,2-oxazol-5-yl)propyl]sulfanyl-6-methoxypyridine-3-carbonitrile
    —— 2,2-Dichloroethyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate —— C11H10Cl2N4O2S
    2,2-Dichloroethyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate
    —— N-(3,5-dimethylphenyl)-4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)pyrimidin-2-amine —— C17H18N4OS
    N-(3,5-dimethylphenyl)-4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)pyrimidin-2-amine
    —— 8-Fluoro-3-methyl-6-(4-methylpiperazin-1-yl)pyrrolo[2,1-b][1,3]benzothiazepine —— C18H20FN3S
    8-Fluoro-3-methyl-6-(4-methylpiperazin-1-yl)pyrrolo[2,1-b][1,3]benzothiazepine
    —— 4-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-methoxypyridine-3-carbonitrile —— C17H19N3O2S
    4-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-methoxypyridine-3-carbonitrile
    —— (+/-) 3-(6-Pyrid-2-ylthio-3-pyridyl)-9-methyl-3,9-diazabicyclo-[4.2.1]-nonane 387870-20-4 C18H22N4S
    (+/-) 3-(6-Pyrid-2-ylthio-3-pyridyl)-9-methyl-3,9-diazabicyclo-[4.2.1]-nonane
    —— 5-[(2-methylphenyl)methyl]-3-[(3-methylthiophen-2-yl)methylsulfanyl]-1H-1,2,4-triazole —— C16H17N3S2
    5-[(2-methylphenyl)methyl]-3-[(3-methylthiophen-2-yl)methylsulfanyl]-1H-1,2,4-triazole
    —— Methyl 2-[4-[4-(furan-2-yl)pyrazol-1-yl]pyrimidin-2-yl]sulfanylacetate —— C14H12N4O3S
    Methyl 2-[4-[4-(furan-2-yl)pyrazol-1-yl]pyrimidin-2-yl]sulfanylacetate
    —— 2-[[5-[(3-methylphenyl)methyl]-1H-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine —— C16H16N4S
    2-[[5-[(3-methylphenyl)methyl]-1H-1,2,4-triazol-3-yl]sulfanylmethyl]pyridine
    —— 2-[1-(Methylamino)hexan-3-ylsulfanyl]-6-(trifluoromethyl)pyridine-3-carbonitrile —— C14H18F3N3S
    2-[1-(Methylamino)hexan-3-ylsulfanyl]-6-(trifluoromethyl)pyridine-3-carbonitrile
    —— 4-[[3-(furan-2-ylmethylsulfanyl)-1H-1,2,4-triazol-5-yl]methyl]-N,N-dimethylaniline —— C16H18N4OS
    4-[[3-(furan-2-ylmethylsulfanyl)-1H-1,2,4-triazol-5-yl]methyl]-N,N-dimethylaniline
    —— N-(3-fluorophenyl)-4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)pyridin-2-amine —— C16H14FN3OS
    N-(3-fluorophenyl)-4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)pyridin-2-amine
    —— N-(4-fluorophenyl)-4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)pyridin-2-amine —— C16H14FN3OS
    N-(4-fluorophenyl)-4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)pyridin-2-amine
    —— 4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)-N-phenylpyrimidin-2-amine —— C15H14N4OS
    4-(5-methyl-3-methylsulfanyl-1,2-oxazol-4-yl)-N-phenylpyrimidin-2-amine
    —— (5S,6S)-6-(3-isohexylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane 162183-71-3 C15H25N3S2
    (5S,6S)-6-(3-isohexylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— 5-[(2-methylphenyl)methyl]-3-(thiophen-3-ylmethylsulfanyl)-1H-1,2,4-triazole —— C15H15N3S2
    5-[(2-methylphenyl)methyl]-3-(thiophen-3-ylmethylsulfanyl)-1H-1,2,4-triazole
    —— 2-[(4R)-2-amino-1,7-dihydroxyoctan-4-yl]sulfanyl-6-methylpyridine-3-carbonitrile —— C15H23N3O2S
    2-[(4R)-2-amino-1,7-dihydroxyoctan-4-yl]sulfanyl-6-methylpyridine-3-carbonitrile
    —— 2,2-Difluoroethyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate —— C11H10F2N4O2S
    2,2-Difluoroethyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate
    —— 2-[(1R)-3-amino-1-phenylpropyl]sulfanyl-6-(fluoromethyl)pyridine-3-carbonitrile —— C16H16FN3S
    2-[(1R)-3-amino-1-phenylpropyl]sulfanyl-6-(fluoromethyl)pyridine-3-carbonitrile
    —— 2-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-methylpyridine-3-carbonitrile —— C17H19N3OS
    2-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-methylpyridine-3-carbonitrile
    —— Ethyl 2-[4-(4-cyanopyrazol-1-yl)pyrimidin-2-yl]sulfanylacetate —— C12H11N5O2S
    Ethyl 2-[4-(4-cyanopyrazol-1-yl)pyrimidin-2-yl]sulfanylacetate
    —— 3-[(4-fluorophenyl)methylsulfanyl]-5-[(2-methylphenyl)methyl]-1H-1,2,4-triazole —— C17H16FN3S
    3-[(4-fluorophenyl)methylsulfanyl]-5-[(2-methylphenyl)methyl]-1H-1,2,4-triazole
    —— methyl (E)-4-phenyl-3-phenylsulfanylbut-2-enoate —— C17H16O2S
    methyl (E)-4-phenyl-3-phenylsulfanylbut-2-enoate
    —— 3-(furan-2-ylmethylsulfanyl)-5-[(2-methylphenyl)methyl]-1H-1,2,4-triazole —— C15H15N3OS
    3-(furan-2-ylmethylsulfanyl)-5-[(2-methylphenyl)methyl]-1H-1,2,4-triazole
    —— 2-(5-Benzylsulfanylthiophen-2-yl)pyrazine —— C15H12N2S2
    2-(5-Benzylsulfanylthiophen-2-yl)pyrazine
    —— 5-Methylsulfanyl-10,11,12,13,14,16-hexazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2(7),3,5,9,12,14-heptaen-8-one —— C11H6N6OS
    5-Methylsulfanyl-10,11,12,13,14,16-hexazatetracyclo[7.7.0.02,7.011,15]hexadeca-1(16),2(7),3,5,9,12,14-heptaen-8-one
    —— exo-6-(3-cyclopropylmethylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane —— C13H19N3S2
    exo-6-(3-cyclopropylmethylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
    —— 5-(4-Hydroxyphenyl)sulfanyl-1,3-dihydroindol-2-one —— C14H11NO2S
    5-(4-Hydroxyphenyl)sulfanyl-1,3-dihydroindol-2-one