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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-(2,5-difluorophenyl)sulfanyl-N-piperidin-1-ylacetamide —— C13H16F2N2OS
    2-(2,5-difluorophenyl)sulfanyl-N-piperidin-1-ylacetamide
    —— 2-(3,4-dimethylphenyl)sulfanyl-N-piperidin-1-ylacetamide —— C15H22N2OS
    2-(3,4-dimethylphenyl)sulfanyl-N-piperidin-1-ylacetamide
    —— 2-(4-chlorophenyl)sulfanyl-5-nitro-N-piperidin-1-ylbenzamide —— C18H18ClN3O3S
    2-(4-chlorophenyl)sulfanyl-5-nitro-N-piperidin-1-ylbenzamide
    —— 2-(2-methylphenyl)sulfanyl-N-piperidin-1-ylacetamide —— C14H20N2OS
    2-(2-methylphenyl)sulfanyl-N-piperidin-1-ylacetamide
    —— 4-amino-2-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-pyrimidin-6-one —— C12H11N5O2S2
    4-amino-2-[(1R)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-pyrimidin-6-one
    —— 4-amino-2-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-pyrimidin-6-one —— C12H11N5O2S2
    4-amino-2-[(1S)-1-(5-thiophen-2-yl-1,3,4-oxadiazol-2-yl)ethyl]sulfanyl-1H-pyrimidin-6-one
    —— 5-[(4-Cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-methyl-1,2-oxazole —— C14H14N4OS2
    5-[(4-Cyclopropyl-5-thiophen-2-yl-1,2,4-triazol-3-yl)sulfanylmethyl]-3-methyl-1,2-oxazole
    —— 7-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one —— C14H16N6OS2
    7-[(1-Cyclopentyltetrazol-5-yl)sulfanylmethyl]-3-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one
    —— 3-Cyclopropyl-5-[[2-(4-fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,2,4-triazol-4-amine —— C15H14FN5S2
    3-Cyclopropyl-5-[[2-(4-fluorophenyl)-1,3-thiazol-4-yl]methylsulfanyl]-1,2,4-triazol-4-amine
    —— 2-[(4-amino-5-cyclopropyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-phenyl-1,3-thiazol-2-yl)-N-prop-2-enylacetamide —— C19H20N6OS2
    2-[(4-amino-5-cyclopropyl-1,2,4-triazol-3-yl)sulfanyl]-N-(4-phenyl-1,3-thiazol-2-yl)-N-prop-2-enylacetamide
    —— 2-[2-(6-Amino-1-cyclopropyl-2,4-dioxopyrimidin-5-yl)-2-oxoethyl]sulfanyl-4,5,6-trimethylpyridine-3-carbonitrile —— C18H19N5O3S
    2-[2-(6-Amino-1-cyclopropyl-2,4-dioxopyrimidin-5-yl)-2-oxoethyl]sulfanyl-4,5,6-trimethylpyridine-3-carbonitrile
    —— 6-Amino-5-[2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-1-cyclopropylpyrimidine-2,4-dione —— C19H20N6O3S
    6-Amino-5-[2-[(5-benzyl-4-methyl-1,2,4-triazol-3-yl)sulfanyl]acetyl]-1-cyclopropylpyrimidine-2,4-dione
    —— (2S)-N-[(2S)-4-phenylbutan-2-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C19H22N4OS2
    (2S)-N-[(2S)-4-phenylbutan-2-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[5-chloro-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]-3-thiophen-3-ylpropanamide —— C16H15ClN4OS2
    N-[5-chloro-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]phenyl]-3-thiophen-3-ylpropanamide
    —— 4,5,6-trimethyl-2-[2-oxo-2-[(2S)-2-thiophen-2-ylpyrrolidin-1-yl]ethyl]sulfanylpyridine-3-carbonitrile —— C19H21N3OS2
    4,5,6-trimethyl-2-[2-oxo-2-[(2S)-2-thiophen-2-ylpyrrolidin-1-yl]ethyl]sulfanylpyridine-3-carbonitrile
    —— N-[(3R)-1,1-dioxothiolan-3-yl]-N-methyl-2-(1-propan-2-yltetrazol-5-yl)sulfanylacetamide —— C11H19N5O3S2
    N-[(3R)-1,1-dioxothiolan-3-yl]-N-methyl-2-(1-propan-2-yltetrazol-5-yl)sulfanylacetamide
    —— 6-Amino-1-cyclopropyl-5-[2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione —— C19H19N5O4S
    6-Amino-1-cyclopropyl-5-[2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione
    —— (2R)-2-[[5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylpropanamide —— C12H20N4O2S3
    (2R)-2-[[5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylpropanamide
    —— 2-(1-benzyltetrazol-5-yl)sulfanyl-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]ethanone —— C16H21N5O2S
    2-(1-benzyltetrazol-5-yl)sulfanyl-1-[(2S,6S)-2,6-dimethylmorpholin-4-yl]ethanone
    —— [(3R,4R)-4-hydroxy-1,1-dioxothiolan-3-yl]-[2-(4-methylphenyl)sulfanylethyl]azanium —— C13H20NO3S2+
    [(3R,4R)-4-hydroxy-1,1-dioxothiolan-3-yl]-[2-(4-methylphenyl)sulfanylethyl]azanium
    —— 2-(1-benzyltetrazol-5-yl)sulfanyl-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]ethanone —— C16H21N5O2S
    2-(1-benzyltetrazol-5-yl)sulfanyl-1-[(2R,6R)-2,6-dimethylmorpholin-4-yl]ethanone
    —— (3S,4S)-4-[2-(4-methylphenyl)sulfanylethylamino]-1,1-dioxothiolan-3-ol —— C13H19NO3S2
    (3S,4S)-4-[2-(4-methylphenyl)sulfanylethylamino]-1,1-dioxothiolan-3-ol
    —— (2S)-2-[[5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylpropanamide —— C12H20N4O2S3
    (2S)-2-[[5-[2-(diethylamino)-2-oxoethyl]sulfanyl-1,3,4-thiadiazol-2-yl]sulfanyl]-N-methylpropanamide
    —— 6-Amino-1-cyclopropyl-5-[2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetyl]pyrimidine-2,4-dione —— C18H16N4O3S2
    6-Amino-1-cyclopropyl-5-[2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]acetyl]pyrimidine-2,4-dione
    —— 5-(4-Methylphenyl)-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]thieno[2,3-d]pyrimidine —— C16H12N4S3
    5-(4-Methylphenyl)-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]thieno[2,3-d]pyrimidine
    —— 5-(4-Chlorophenyl)-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]thieno[2,3-d]pyrimidine —— C15H9ClN4S3
    5-(4-Chlorophenyl)-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]thieno[2,3-d]pyrimidine
    —— 3-[(4-Methylsulfanylphenyl)methylsulfanyl]-5-(trifluoromethyl)-1,2,4-triazol-4-amine —— C11H11F3N4S2
    3-[(4-Methylsulfanylphenyl)methylsulfanyl]-5-(trifluoromethyl)-1,2,4-triazol-4-amine
    —— 2-(4-bromophenyl)sulfanyl-N-(1-propylpiperidin-4-yl)acetamide —— C16H23BrN2OS
    2-(4-bromophenyl)sulfanyl-N-(1-propylpiperidin-4-yl)acetamide
    —— 2-(4-bromo-2-methylphenyl)sulfanyl-N-(1-propylpiperidin-4-yl)acetamide —— C17H25BrN2OS
    2-(4-bromo-2-methylphenyl)sulfanyl-N-(1-propylpiperidin-4-yl)acetamide
    —— 3-[5-[(1S)-1-cyano-2-(4-methylphenyl)ethyl]sulfanyl-4-(2-methylpropyl)-1,2,4-triazol-3-yl]propanamide —— C19H25N5OS
    3-[5-[(1S)-1-cyano-2-(4-methylphenyl)ethyl]sulfanyl-4-(2-methylpropyl)-1,2,4-triazol-3-yl]propanamide
    —— 3-[2-(1-cyclopropyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]sulfanyl-4-propyl-1H-1,2,4-triazol-5-one —— C16H22N4O2S
    3-[2-(1-cyclopropyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]sulfanyl-4-propyl-1H-1,2,4-triazol-5-one
    —— (2S)-N-(cyclooctylmethyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C15H26N4OS
    (2S)-N-(cyclooctylmethyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— (2R)-N-(cyclooctylmethyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C15H26N4OS
    (2R)-N-(cyclooctylmethyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— 5-(carbamoylamino)-N-[2-(4-chlorophenyl)sulfanylethyl]pentanamide —— C14H20ClN3O2S
    5-(carbamoylamino)-N-[2-(4-chlorophenyl)sulfanylethyl]pentanamide
    —— [(1R,3S)-3-methoxycyclohexyl] (2R)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanoate —— C13H21N3O3S
    [(1R,3S)-3-methoxycyclohexyl] (2R)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanoate
    —— N-[(3-propyl-1,2,4-oxadiazol-5-yl)methyl]-2-(2,2,2-trifluoroethylsulfanyl)aniline —— C14H16F3N3OS
    N-[(3-propyl-1,2,4-oxadiazol-5-yl)methyl]-2-(2,2,2-trifluoroethylsulfanyl)aniline
    —— (2R)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-3-methyl-N-[[(2R)-oxolan-2-yl]methyl]butanamide —— C15H24N4O2S
    (2R)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-3-methyl-N-[[(2R)-oxolan-2-yl]methyl]butanamide
    —— [(1S,3S)-3-methoxycyclohexyl] (2R)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanoate —— C13H21N3O3S
    [(1S,3S)-3-methoxycyclohexyl] (2R)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]propanoate
    —— (2S)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-3-methyl-N-[[(2R)-oxolan-2-yl]methyl]butanamide —— C15H24N4O2S
    (2S)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-3-methyl-N-[[(2R)-oxolan-2-yl]methyl]butanamide
    —— 1-benzyl-N-[2-(4-chlorophenyl)sulfanylethyl]-3,5-dimethylpyrazole-4-carboxamide —— C21H22ClN3OS
    1-benzyl-N-[2-(4-chlorophenyl)sulfanylethyl]-3,5-dimethylpyrazole-4-carboxamide
    —— N-[(2S)-2-(dimethylamino)-2-(4-methylphenyl)ethyl]-2-pyridin-4-ylsulfanylacetamide —— C18H23N3OS
    N-[(2S)-2-(dimethylamino)-2-(4-methylphenyl)ethyl]-2-pyridin-4-ylsulfanylacetamide
    —— (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-thiophen-2-ylethyl)propanamide —— C19H21N3O2S2
    (2R)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-thiophen-2-ylethyl)propanamide
    —— (2S)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-3-methyl-N-[[(2S)-oxolan-2-yl]methyl]butanamide —— C15H24N4O2S
    (2S)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-3-methyl-N-[[(2S)-oxolan-2-yl]methyl]butanamide
    —— (2R)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-3-methyl-N-[[(2S)-oxolan-2-yl]methyl]butanamide —— C15H24N4O2S
    (2R)-2-(4-amino-6-methylpyrimidin-2-yl)sulfanyl-3-methyl-N-[[(2S)-oxolan-2-yl]methyl]butanamide
    —— N-[2-(4-chlorophenyl)sulfanylethyl]-1-methylpyrazole-4-carboxamide —— C13H14ClN3OS
    N-[2-(4-chlorophenyl)sulfanylethyl]-1-methylpyrazole-4-carboxamide
    —— N-[(2R)-2-(dimethylamino)-2-(4-methylphenyl)ethyl]-2-pyridin-4-ylsulfanylacetamide —— C18H23N3OS
    N-[(2R)-2-(dimethylamino)-2-(4-methylphenyl)ethyl]-2-pyridin-4-ylsulfanylacetamide
    —— N-[2-(4-chlorophenyl)sulfanylethyl]-4-oxo-4-thiophen-2-ylbutanamide —— C16H16ClNO2S2
    N-[2-(4-chlorophenyl)sulfanylethyl]-4-oxo-4-thiophen-2-ylbutanamide
    —— N-[2-(4-chlorophenyl)sulfanylethyl]-3-(3,6-dioxo-1H-pyridazin-2-yl)propanamide —— C15H16ClN3O3S
    N-[2-(4-chlorophenyl)sulfanylethyl]-3-(3,6-dioxo-1H-pyridazin-2-yl)propanamide
    —— (2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-thiophen-2-ylethyl)propanamide —— C19H21N3O2S2
    (2S)-2-[[5-(3,5-dimethylphenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(2-thiophen-2-ylethyl)propanamide
    —— 2-[(1S)-1-[[5-(2-methylfuran-3-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethyl]-5-phenyl-1,3,4-oxadiazole —— C20H19N5O2S
    2-[(1S)-1-[[5-(2-methylfuran-3-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethyl]-5-phenyl-1,3,4-oxadiazole