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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-butyl-3-(4-chlorophenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]propanamide —— C17H24ClNO3S2
    N-butyl-3-(4-chlorophenyl)sulfanyl-N-[(3R)-1,1-dioxothiolan-3-yl]propanamide
    —— 2-[(1R)-1-[[5-(2-methylfuran-3-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethyl]-5-phenyl-1,3,4-oxadiazole —— C20H19N5O2S
    2-[(1R)-1-[[5-(2-methylfuran-3-yl)-4-prop-2-enyl-1,2,4-triazol-3-yl]sulfanyl]ethyl]-5-phenyl-1,3,4-oxadiazole
    —— 4-(4-chlorophenyl)sulfanyl-N-[(2S)-2-hydroxy-3,3-dimethylbutyl]butanamide —— C16H24ClNO2S
    4-(4-chlorophenyl)sulfanyl-N-[(2S)-2-hydroxy-3,3-dimethylbutyl]butanamide
    —— 4-(4-chlorophenyl)sulfanyl-N-[(2R)-2-hydroxy-3,3-dimethylbutyl]butanamide —— C16H24ClNO2S
    4-(4-chlorophenyl)sulfanyl-N-[(2R)-2-hydroxy-3,3-dimethylbutyl]butanamide
    —— 4-bromo-N'-[3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoyl]-1H-pyrrole-2-carbohydrazide —— C15H18BrN5O2S
    4-bromo-N'-[3-(4,6-dimethyl-2-methylsulfanylpyrimidin-5-yl)propanoyl]-1H-pyrrole-2-carbohydrazide
    —— 3-(4-fluorophenyl)sulfanyl-N-[(2R)-2-(2-hydroxyethyl)-4-methylpentyl]propanamide —— C17H26FNO2S
    3-(4-fluorophenyl)sulfanyl-N-[(2R)-2-(2-hydroxyethyl)-4-methylpentyl]propanamide
    —— 3-(4-fluorophenyl)sulfanyl-N-[(2S)-2-(2-hydroxyethyl)-4-methylpentyl]propanamide —— C17H26FNO2S
    3-(4-fluorophenyl)sulfanyl-N-[(2S)-2-(2-hydroxyethyl)-4-methylpentyl]propanamide
    —— 5-[[(3S)-oxan-3-yl]methylsulfanyl]-1-prop-2-enyltetrazole —— C10H16N4OS
    5-[[(3S)-oxan-3-yl]methylsulfanyl]-1-prop-2-enyltetrazole
    —— 4-bromo-N'-[2-(2,5-difluorophenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide —— C13H10BrF2N3O2S
    4-bromo-N'-[2-(2,5-difluorophenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide
    —— 4-bromo-N'-(2-phenylsulfanylacetyl)-1H-pyrrole-2-carbohydrazide —— C13H12BrN3O2S
    4-bromo-N'-(2-phenylsulfanylacetyl)-1H-pyrrole-2-carbohydrazide
    —— 4-bromo-N'-(3-phenylsulfanylpropanoyl)-1H-pyrrole-2-carbohydrazide —— C14H14BrN3O2S
    4-bromo-N'-(3-phenylsulfanylpropanoyl)-1H-pyrrole-2-carbohydrazide
    —— 4-bromo-N'-[2-(2-methylphenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide —— C14H14BrN3O2S
    4-bromo-N'-[2-(2-methylphenyl)sulfanylacetyl]-1H-pyrrole-2-carbohydrazide
    —— 5-[(2R)-4-phenylsulfanylbutan-2-yl]sulfanyl-1-(2,2,2-trifluoroethyl)tetrazole —— C13H15F3N4S2
    5-[(2R)-4-phenylsulfanylbutan-2-yl]sulfanyl-1-(2,2,2-trifluoroethyl)tetrazole
    —— 5-[[(3R)-oxan-3-yl]methylsulfanyl]-1-prop-2-enyltetrazole —— C10H16N4OS
    5-[[(3R)-oxan-3-yl]methylsulfanyl]-1-prop-2-enyltetrazole
    —— 5-[(2S)-4-phenylsulfanylbutan-2-yl]sulfanyl-1-(2,2,2-trifluoroethyl)tetrazole —— C13H15F3N4S2
    5-[(2S)-4-phenylsulfanylbutan-2-yl]sulfanyl-1-(2,2,2-trifluoroethyl)tetrazole
    —— 2-methyl-N-[[(3R)-1-[(2S)-4-phenylsulfanylbutan-2-yl]piperidin-3-yl]methyl]propanamide —— C20H32N2OS
    2-methyl-N-[[(3R)-1-[(2S)-4-phenylsulfanylbutan-2-yl]piperidin-3-yl]methyl]propanamide
    —— 2-methyl-N-[[(3S)-1-[(2S)-4-phenylsulfanylbutan-2-yl]piperidin-3-yl]methyl]propanamide —— C20H32N2OS
    2-methyl-N-[[(3S)-1-[(2S)-4-phenylsulfanylbutan-2-yl]piperidin-3-yl]methyl]propanamide
    —— (2R)-N,N-dibenzyl-2-[(5-oxo-4-prop-2-enyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C22H24N4O2S
    (2R)-N,N-dibenzyl-2-[(5-oxo-4-prop-2-enyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— methyl 2,4-dimethyl-5-[(2S)-2-[(5-oxo-4-prop-2-enyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate —— C16H20N4O4S
    methyl 2,4-dimethyl-5-[(2S)-2-[(5-oxo-4-prop-2-enyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate
    —— (2S)-N,N-dibenzyl-2-[(5-oxo-4-prop-2-enyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C22H24N4O2S
    (2S)-N,N-dibenzyl-2-[(5-oxo-4-prop-2-enyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— methyl 2,4-dimethyl-5-[(2R)-2-[(5-oxo-4-prop-2-enyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate —— C16H20N4O4S
    methyl 2,4-dimethyl-5-[(2R)-2-[(5-oxo-4-prop-2-enyl-1H-1,2,4-triazol-3-yl)sulfanyl]propanoyl]-1H-pyrrole-3-carboxylate
    —— 4-methyl-2-[(1R)-1-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]-1H-pyrimidin-6-one —— C13H17N5O2S2
    4-methyl-2-[(1R)-1-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]-1H-pyrimidin-6-one
    —— 4-methyl-2-[(1S)-1-(1,3,4-thiadiazol-2-ylsulfanyl)ethyl]-1H-pyrimidin-6-one —— C9H10N4OS2
    4-methyl-2-[(1S)-1-(1,3,4-thiadiazol-2-ylsulfanyl)ethyl]-1H-pyrimidin-6-one
    —— 4-methyl-2-[(1S)-1-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]-1H-pyrimidin-6-one —— C13H17N5O2S2
    4-methyl-2-[(1S)-1-[(5-morpholin-4-yl-1,3,4-thiadiazol-2-yl)sulfanyl]ethyl]-1H-pyrimidin-6-one
    —— 4-methyl-2-[(1R)-1-(1,3,4-thiadiazol-2-ylsulfanyl)ethyl]-1H-pyrimidin-6-one —— C9H10N4OS2
    4-methyl-2-[(1R)-1-(1,3,4-thiadiazol-2-ylsulfanyl)ethyl]-1H-pyrimidin-6-one
    —— 6-methyl-2-[(1R)-1-[[5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]-1H-pyrimidin-4-one —— C14H14N4O2S2
    6-methyl-2-[(1R)-1-[[5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]-1H-pyrimidin-4-one
    —— 4-methyl-2-[(1S)-1-[[5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]-1H-pyrimidin-6-one —— C14H15N5O2S2
    4-methyl-2-[(1S)-1-[[5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]-1H-pyrimidin-6-one
    —— 4-methyl-2-[(1R)-1-[[5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]-1H-pyrimidin-6-one —— C14H15N5O2S2
    4-methyl-2-[(1R)-1-[[5-[(2-methyl-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]-1H-pyrimidin-6-one
    —— 6-methyl-2-[(1S)-1-[[5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]-1H-pyrimidin-4-one —— C14H14N4O2S2
    6-methyl-2-[(1S)-1-[[5-(3-methylthiophen-2-yl)-1,3,4-oxadiazol-2-yl]sulfanyl]ethyl]-1H-pyrimidin-4-one
    —— 5-[methyl-[(2R,3R)-3-methylsulfonylbutan-2-yl]amino]pentan-1-ol —— C11H25NO3S
    5-[methyl-[(2R,3R)-3-methylsulfonylbutan-2-yl]amino]pentan-1-ol
    —— 5-[methyl-[(2R,3S)-3-methylsulfonylbutan-2-yl]amino]pentan-1-ol —— C11H25NO3S
    5-[methyl-[(2R,3S)-3-methylsulfonylbutan-2-yl]amino]pentan-1-ol
    —— 5-[methyl-[(2S,3S)-3-methylsulfonylbutan-2-yl]amino]pentan-1-ol —— C11H25NO3S
    5-[methyl-[(2S,3S)-3-methylsulfonylbutan-2-yl]amino]pentan-1-ol
    —— 5-[methyl-[(2S,3R)-3-methylsulfonylbutan-2-yl]amino]pentan-1-ol —— C11H25NO3S
    5-[methyl-[(2S,3R)-3-methylsulfonylbutan-2-yl]amino]pentan-1-ol
    —— 11-Methyl-10-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one —— C19H16N4OS3
    11-Methyl-10-(7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9,11-tetraen-12-ylsulfanyl)-7-thia-9,11-diazatricyclo[6.4.0.02,6]dodeca-1(8),2(6),9-trien-12-one
    —— 3-Butyl-5,6-dimethyl-2-thieno[2,3-d]pyrimidin-4-ylsulfanylthieno[2,3-d]pyrimidin-4-one —— C18H18N4OS3
    3-Butyl-5,6-dimethyl-2-thieno[2,3-d]pyrimidin-4-ylsulfanylthieno[2,3-d]pyrimidin-4-one
    —— 2-(2-Nitrophenyl)sulfanyl-3-phenylthieno[2,3-d]pyrimidin-4-one —— C18H11N3O3S2
    2-(2-Nitrophenyl)sulfanyl-3-phenylthieno[2,3-d]pyrimidin-4-one
    —— 5-Nitro-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]benzonitrile —— C16H9N3O2S2
    5-Nitro-2-[(4-phenyl-1,3-thiazol-2-yl)sulfanyl]benzonitrile
    —— 3-Ethyl-2-thieno[2,3-d]pyrimidin-4-ylsulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one —— C18H16N4OS3
    3-Ethyl-2-thieno[2,3-d]pyrimidin-4-ylsulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
    —— 2-(4-Methylsulfonyl-2-nitrophenyl)sulfanyl-4-phenyl-1,3-thiazole —— C16H12N2O4S3
    2-(4-Methylsulfonyl-2-nitrophenyl)sulfanyl-4-phenyl-1,3-thiazole
    —— 3-(2-Methoxyethyl)-2-(2-nitrophenyl)sulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one —— C19H19N3O4S2
    3-(2-Methoxyethyl)-2-(2-nitrophenyl)sulfanyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-4-one
    —— 4-[(4-Phenyl-1,3-thiazol-2-yl)sulfanyl]thieno[2,3-d]pyrimidine —— C15H9N3S3
    4-[(4-Phenyl-1,3-thiazol-2-yl)sulfanyl]thieno[2,3-d]pyrimidine
    —— N-ethyl-5-[(2S)-1,1,1-trifluoropropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-amine —— C7H10F3N3S2
    N-ethyl-5-[(2S)-1,1,1-trifluoropropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— 3-[(1S,2S,4S)-2,4-dimethylcyclohexyl]-1-ethyl-1-[(2S)-1-ethylsulfonylpropan-2-yl]urea —— C16H32N2O3S
    3-[(1S,2S,4S)-2,4-dimethylcyclohexyl]-1-ethyl-1-[(2S)-1-ethylsulfonylpropan-2-yl]urea
    —— N-ethyl-5-[(2R)-1,1,1-trifluoropropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-amine —— C7H10F3N3S2
    N-ethyl-5-[(2R)-1,1,1-trifluoropropan-2-yl]sulfanyl-1,3,4-thiadiazol-2-amine
    —— 3-[(1R,2S,4S)-2,4-dimethylcyclohexyl]-1-ethyl-1-[(2R)-1-ethylsulfonylpropan-2-yl]urea —— C16H32N2O3S
    3-[(1R,2S,4S)-2,4-dimethylcyclohexyl]-1-ethyl-1-[(2R)-1-ethylsulfonylpropan-2-yl]urea
    —— 1-(2-tert-butylsulfonylethyl)-3-[(1R,2R,4R)-2,4-dimethylcyclohexyl]urea —— C15H30N2O3S
    1-(2-tert-butylsulfonylethyl)-3-[(1R,2R,4R)-2,4-dimethylcyclohexyl]urea
    —— 1-(2-tert-butylsulfonylethyl)-3-[(1S,2R,4S)-2,4-dimethylcyclohexyl]urea —— C15H30N2O3S
    1-(2-tert-butylsulfonylethyl)-3-[(1S,2R,4S)-2,4-dimethylcyclohexyl]urea
    —— 3-[(1S,2S,4S)-2,4-dimethylcyclohexyl]-1-ethyl-1-[(2R)-1-ethylsulfonylpropan-2-yl]urea —— C16H32N2O3S
    3-[(1S,2S,4S)-2,4-dimethylcyclohexyl]-1-ethyl-1-[(2R)-1-ethylsulfonylpropan-2-yl]urea
    —— 1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(2S)-1-(1,2,4-triazol-1-yl)propan-2-yl]urea —— C14H18FN5OS
    1-[2-(2-fluorophenyl)sulfanylethyl]-3-[(2S)-1-(1,2,4-triazol-1-yl)propan-2-yl]urea
    —— 3-[(1R,2S,4S)-2,4-dimethylcyclohexyl]-1-ethyl-1-[(2S)-1-ethylsulfonylpropan-2-yl]urea —— C16H32N2O3S
    3-[(1R,2S,4S)-2,4-dimethylcyclohexyl]-1-ethyl-1-[(2S)-1-ethylsulfonylpropan-2-yl]urea