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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— {3-[4-(3-benzyl-1-butylureido)phenylsulphanyl]phenyl}acetic acid 735273-98-0 C26H28N2O3S
    {3-[4-(3-benzyl-1-butylureido)phenylsulphanyl]phenyl}acetic acid
    —— 2-[4-[3-[1-Phenylethyl(prop-2-enylcarbamoyl)amino]phenyl]sulfanylphenyl]acetic acid —— C26H26N2O3S
    2-[4-[3-[1-Phenylethyl(prop-2-enylcarbamoyl)amino]phenyl]sulfanylphenyl]acetic acid
    —— 3-(4-methoxy-phenylsulfanyl)-6-(4H-[1,2,4]triazole-3-ylsulfanyl)-N-(pyrimidine-4-yl)-2-pyridine carboxamide —— C19H15N7O2S2
    3-(4-methoxy-phenylsulfanyl)-6-(4H-[1,2,4]triazole-3-ylsulfanyl)-N-(pyrimidine-4-yl)-2-pyridine carboxamide
    —— 1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-[2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-ylsulfanyl)-benzyl]-urea 745827-37-6 C22H25N7OS
    1-(2,5-dimethyl-2H-pyrazol-3-yl)-3-[2-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-ylsulfanyl)-benzyl]-urea
    —— 3-(2-nitro-phenylsulfanyl)-1-pyridin-2-ylmethyl-1H-indole-6-carbonitrile monohydrochloride 691400-73-4 C21H14N4O2S*ClH
    3-(2-nitro-phenylsulfanyl)-1-pyridin-2-ylmethyl-1H-indole-6-carbonitrile monohydrochloride
    —— 2-(4-methoxyphenyl)-N-(5-quinolin-4-ylsulfanyl-1,3,4-thiadiazol-2-yl)acetamide 664324-90-7 C20H16N4O2S2
    2-(4-methoxyphenyl)-N-(5-quinolin-4-ylsulfanyl-1,3,4-thiadiazol-2-yl)acetamide
    —— (2S,9S,11S,18S)-1-ethylsulfonyl-10-(trifluoromethyl)-19-oxatetracyclo[8.8.1.02,9.011,18]nonadecane —— C21H33F3O3S
    (2S,9S,11S,18S)-1-ethylsulfonyl-10-(trifluoromethyl)-19-oxatetracyclo[8.8.1.02,9.011,18]nonadecane
    —— 5-(2-hydroxy-1-methylethoxy)-N-(4-methylthiazol-2-yl)-3-([1,3,4]thiadiazol-2-ylsulfanyl)benzamide —— C16H16N4O3S3
    5-(2-hydroxy-1-methylethoxy)-N-(4-methylthiazol-2-yl)-3-([1,3,4]thiadiazol-2-ylsulfanyl)benzamide
    —— 2,4-Bis[(4-chlorophenyl)sulfanyl]-1-isocyanatobenzene —— C19H11Cl2NOS2
    2,4-Bis[(4-chlorophenyl)sulfanyl]-1-isocyanatobenzene
    —— [(1S,2R)-1-(methoxymethoxy)-3-nitro-1-phenyl-3-phenylsulfanylpropan-2-yl]oxy-trimethylsilane —— C20H27NO5SSi
    [(1S,2R)-1-(methoxymethoxy)-3-nitro-1-phenyl-3-phenylsulfanylpropan-2-yl]oxy-trimethylsilane
    —— {3-[4-(3-phenylpropylamino)phenylsulphanyl]phenyl}acetic acid 735273-61-7 C23H23NO2S
    {3-[4-(3-phenylpropylamino)phenylsulphanyl]phenyl}acetic acid
    —— 1-(Benzenesulfonyl)-5-phenylsulfanylindol-4-ol —— C20H15NO3S2
    1-(Benzenesulfonyl)-5-phenylsulfanylindol-4-ol
    —— [(1'R,3'aS,6'S,9'aS)-4'-oxo-6'-prop-1-en-2-ylspiro[1,3-dithiolane-2,8'-2,3,3a,5,6,7,9,9a-octahydro-1H-cyclopenta[8]annulene]-1'-yl] 2,2-dimethylpropanoate —— C21H32O3S2
    [(1'R,3'aS,6'S,9'aS)-4'-oxo-6'-prop-1-en-2-ylspiro[1,3-dithiolane-2,8'-2,3,3a,5,6,7,9,9a-octahydro-1H-cyclopenta[8]annulene]-1'-yl] 2,2-dimethylpropanoate
    —— 3-phenylmethyl-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(thiazole-2-yl)-2-pyridine carboxamide —— C18H14N6OS2
    3-phenylmethyl-6-(4H-[1,2,4]triazole-3-yl-sulfanyl)-N-(thiazole-2-yl)-2-pyridine carboxamide
    —— 3-chloro-N-(5-quinolin-4-ylsulfanyl-1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide 1026818-57-4 C16H9ClN4OS3
    3-chloro-N-(5-quinolin-4-ylsulfanyl-1,3,4-thiadiazol-2-yl)thiophene-2-carboxamide
    —— 3-(4-ethylsulfanylquinolin-3-yl)sulfanyl-1H-quinoline-4-thione —— C20H16N2S3
    3-(4-ethylsulfanylquinolin-3-yl)sulfanyl-1H-quinoline-4-thione
    —— 5-(2-hydroxy-1-methyl-ethoxy)-3-([1,3,4]thiadiazol-2-ylsulfanyl)-N-thiazol-2-yl-benzamide —— C15H14N4O3S3
    5-(2-hydroxy-1-methyl-ethoxy)-3-([1,3,4]thiadiazol-2-ylsulfanyl)-N-thiazol-2-yl-benzamide
    —— 7,7-dimethyl-3-(1-piperidin-1-ylpropan-2-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-b][4,1,2]benzothiadiazin-9-one —— C18H27N5OS
    7,7-dimethyl-3-(1-piperidin-1-ylpropan-2-yl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-b][4,1,2]benzothiadiazin-9-one
    —— N-(5-quinolin-4-ylsulfanyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide 664324-88-3 C16H10N4O2S2
    N-(5-quinolin-4-ylsulfanyl-1,3,4-thiadiazol-2-yl)furan-2-carboxamide
    —— Ethyl 4,4,4-trifluoro-2-phenylsulfanyl-3-(trifluoromethyl)butanoate —— C13H12F6O2S
    Ethyl 4,4,4-trifluoro-2-phenylsulfanyl-3-(trifluoromethyl)butanoate
    —— 1-(2-chlorophenyl)-N-(4-phenylsulfanylphenyl)methanimine oxide —— C19H14ClNOS
    1-(2-chlorophenyl)-N-(4-phenylsulfanylphenyl)methanimine oxide
    —— (2S,3R)-2-[(2S,3S)-3-methoxy-5-methylhex-5-en-2-yl]-3-(4-methylphenyl)sulfanyloxane —— C20H30O2S
    (2S,3R)-2-[(2S,3S)-3-methoxy-5-methylhex-5-en-2-yl]-3-(4-methylphenyl)sulfanyloxane
    —— N-(4-benzyl-5-methylsulfanyl-1,2,4-triazol-3-yl)-1,3-dithiolan-2-imine —— C13H14N4S3
    N-(4-benzyl-5-methylsulfanyl-1,2,4-triazol-3-yl)-1,3-dithiolan-2-imine
    —— ethyl (2S,3S)-3-hydroxy-2-phenylsulfanyldecanoate —— C18H28O3S
    ethyl (2S,3S)-3-hydroxy-2-phenylsulfanyldecanoate
    —— 3-(4',7'a-dimethylspiro[1,3-dithiolane-2,5'-6,7-dihydro-3H-indene]-1'-yl)furan —— C17H20OS2
    3-(4',7'a-dimethylspiro[1,3-dithiolane-2,5'-6,7-dihydro-3H-indene]-1'-yl)furan
    —— (1R,2S,5S,6S,7S)-5-Chloro-2-(p-tolylthio)-3-oxatricyclo<5.2.1.0<sup>2,6</sup>>dec-8-en-4-one —— C16H15ClO2S
    (1R,2S,5S,6S,7S)-5-Chloro-2-(p-tolylthio)-3-oxatricyclo<5.2.1.0<sup>2,6</sup>>dec-8-en-4-one
    —— methyl (1R<sup>*</sup>,6S<sup>*</sup>,8S<sup>*</sup>)-8-methylsulfonyl-2-oxa-7-thiabicyclo<4.2.0>octane-8-acetate 7,7-dioxide 144632-67-7 C10H16O7S2
    methyl (1R<sup>*</sup>,6S<sup>*</sup>,8S<sup>*</sup>)-8-methylsulfonyl-2-oxa-7-thiabicyclo<4.2.0>octane-8-acetate 7,7-dioxide
    —— 5-Chloro-2-(p-tolylthio)-3-oxatricyclo<5.2.1.0<sup>2,6</sup>>dec-8-en-4-one —— C16H15ClO2S
    5-Chloro-2-(p-tolylthio)-3-oxatricyclo<5.2.1.0<sup>2,6</sup>>dec-8-en-4-one
    —— Ethyl-carbamic acid (4aS,9aR)-1,4a-dimethyl-1,2,3,4,4a,9a-hexahydro-benzo[4,5]thieno[2,3-b]pyridin-6-yl ester —— C16H22N2O2S
    Ethyl-carbamic acid (4aS,9aR)-1,4a-dimethyl-1,2,3,4,4a,9a-hexahydro-benzo[4,5]thieno[2,3-b]pyridin-6-yl ester
    —— 2-Methyl-5-[(6-phenyl-1,2,4-triazin-3-yl)methylsulfanyl]-1,3,4-thiadiazole —— C13H11N5S2
    2-Methyl-5-[(6-phenyl-1,2,4-triazin-3-yl)methylsulfanyl]-1,3,4-thiadiazole
    —— (1'R,4'S,5'R,6'R)-5'-chloro-6'-phenylsulfanylspiro[1,3-dioxolane-2,2'-7-oxabicyclo[2.2.1]heptane] —— C14H15ClO3S
    (1'R,4'S,5'R,6'R)-5'-chloro-6'-phenylsulfanylspiro[1,3-dioxolane-2,2'-7-oxabicyclo[2.2.1]heptane]
    —— (4-Benzyl-5-methylsulfanyl-1,2,4-triazol-3-yl)carbamodithioic acid —— C11H12N4S3
    (4-Benzyl-5-methylsulfanyl-1,2,4-triazol-3-yl)carbamodithioic acid
    —— 3-[2-[2-(1,3-Dioxolan-2-yl)ethyl]-1,3-dithian-2-yl]pyridine —— C14H19NO2S2
    3-[2-[2-(1,3-Dioxolan-2-yl)ethyl]-1,3-dithian-2-yl]pyridine
    —— 2-[[2-amino-4-([18F]fluoromethyl)phenyl]thio]-N,N-dimethylbenzenemethanamine —— C16H19FN2S
    2-[[2-amino-4-([18F]fluoromethyl)phenyl]thio]-N,N-dimethylbenzenemethanamine
    —— Methyl 2-((4-methyl-1,2,4-triazol-3-yl)thio)acetoacetate (aminocarbonyl)hydrazone —— C9H14N6O3S
    Methyl 2-((4-methyl-1,2,4-triazol-3-yl)thio)acetoacetate (aminocarbonyl)hydrazone
    —— 3-(3-Methyl-imidazo[1,2-b]pyridazin-6-ylsulfanyl)-propane-1-sulfonic acid amide —— C10H14N4O2S2
    3-(3-Methyl-imidazo[1,2-b]pyridazin-6-ylsulfanyl)-propane-1-sulfonic acid amide
    —— (Z,3S,4S)-2-hydroxy-3-methyl-4-phenylsulfanyloct-1-ene-1-diazonium —— C15H21N2OS+
    (Z,3S,4S)-2-hydroxy-3-methyl-4-phenylsulfanyloct-1-ene-1-diazonium
    —— 2-Fluoro-3,3,5,5-tetramethyl-2-phenylsulfanylcyclohexan-1-one —— C16H21FOS
    2-Fluoro-3,3,5,5-tetramethyl-2-phenylsulfanylcyclohexan-1-one
    —— (1S,2R,6R,7R)-2-(p-Tolylthio)-3-oxatricyclo<5.2.1.0<sup>2,6</sup>>dec-8-en-4-one —— C16H16O2S
    (1S,2R,6R,7R)-2-(p-Tolylthio)-3-oxatricyclo<5.2.1.0<sup>2,6</sup>>dec-8-en-4-one
    —— N,N-dimethyl-N-({3-[4-(methylsulfanyl)benzyl]-4-pyridinyl}methyl)amine 662150-41-6 C16H20N2S
    N,N-dimethyl-N-({3-[4-(methylsulfanyl)benzyl]-4-pyridinyl}methyl)amine
    —— 5-ethylthio-2-(1-methyl-4-nitro-2-pyrrolyl)-1,3,4-thiadiazole —— C9H10N4O2S2
    5-ethylthio-2-(1-methyl-4-nitro-2-pyrrolyl)-1,3,4-thiadiazole
    —— 4-Isopropyl-2-methyl-5-(3,4-dimethylphenylthio)-1-[(4-pyridyl)methyl]-1H-pyrrole-3-methanol —— C23H28N2OS
    4-Isopropyl-2-methyl-5-(3,4-dimethylphenylthio)-1-[(4-pyridyl)methyl]-1H-pyrrole-3-methanol
    —— N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-5-(4-chlorophenylsulfanyl)-thiophene-2-carboxamide —— C18H19ClN2OS2
    N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]-5-(4-chlorophenylsulfanyl)-thiophene-2-carboxamide
    —— 4-cyclohexylthio-3-isopropyl-1-methyl-5-{ [ (pyridin-4-ylmethyl)amino]methyl}-1,3-dihydro-2-imidazolone —— C20H30N4OS
    4-cyclohexylthio-3-isopropyl-1-methyl-5-{ [ (pyridin-4-ylmethyl)amino]methyl}-1,3-dihydro-2-imidazolone
    —— N-(3-phenylsulfanylphenyl)-4-(1,3-thiazol-2-yl)pyrimidin-2-amine —— C19H14N4S2
    N-(3-phenylsulfanylphenyl)-4-(1,3-thiazol-2-yl)pyrimidin-2-amine
    —— N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-5-(4-fluorophenyl)sulfanyl-1,3,4-thiadiazole-2-carboxamide —— C16H17FN4OS2
    N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl]-5-(4-fluorophenyl)sulfanyl-1,3,4-thiadiazole-2-carboxamide
    —— (2S,4R)-2-amino-4-(3,5-dichloropyridin-2-yl)sulfanyl-4-(3-fluorophenyl)butan-1-ol —— C15H15Cl2FN2OS
    (2S,4R)-2-amino-4-(3,5-dichloropyridin-2-yl)sulfanyl-4-(3-fluorophenyl)butan-1-ol
    —— 4-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-(difluoromethoxy)pyridine-3-carbonitrile —— C17H17F2N3O2S
    4-[(1R,3S)-3-amino-4-hydroxy-1-phenylbutyl]sulfanyl-6-(difluoromethoxy)pyridine-3-carbonitrile
    —— 2,2,3,3,3-Pentafluoropropyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate —— C12H9F5N4O2S
    2,2,3,3,3-Pentafluoropropyl 2-(4-pyrazol-1-ylpyrimidin-2-yl)sulfanylacetate
    —— 4-(5-methyl-3-pyridin-3-ylsulfanyl-1,2-oxazol-4-yl)-N-phenylpyrimidin-2-amine —— C19H15N5OS
    4-(5-methyl-3-pyridin-3-ylsulfanyl-1,2-oxazol-4-yl)-N-phenylpyrimidin-2-amine