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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(1R)-1-(2-chlorophenyl)ethyl]-2-(4-fluorophenyl)sulfanylacetamide —— C16H15ClFNOS
    N-[(1R)-1-(2-chlorophenyl)ethyl]-2-(4-fluorophenyl)sulfanylacetamide
    —— 1-[1-[(4-Fluorophenyl)methyl]-2,5-dimethylpyrrol-3-yl]-2-(4-fluorophenyl)sulfanylethanone —— C21H19F2NOS
    1-[1-[(4-Fluorophenyl)methyl]-2,5-dimethylpyrrol-3-yl]-2-(4-fluorophenyl)sulfanylethanone
    —— (2R)-2-(4-fluorophenyl)sulfanyl-N-(furan-2-ylmethyl)propanamide —— C14H14FNO2S
    (2R)-2-(4-fluorophenyl)sulfanyl-N-(furan-2-ylmethyl)propanamide
    —— methyl 5-[(2R)-2-(4-fluorophenyl)sulfanylpropanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate —— C17H18FNO3S
    methyl 5-[(2R)-2-(4-fluorophenyl)sulfanylpropanoyl]-2,4-dimethyl-1H-pyrrole-3-carboxylate
    —— N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(4-fluorophenyl)sulfanylacetamide —— C22H20FNOS2
    N-[4-(2,5-dimethylphenyl)sulfanylphenyl]-2-(4-fluorophenyl)sulfanylacetamide
    —— [2-[[(1R)-1-(3-chlorophenyl)ethyl]amino]-2-oxoethyl] 2-(2-methylphenyl)sulfanylacetate —— C19H20ClNO3S
    [2-[[(1R)-1-(3-chlorophenyl)ethyl]amino]-2-oxoethyl] 2-(2-methylphenyl)sulfanylacetate
    —— N,N-dimethyl-4-[(2S,5R)-5-[(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]aniline —— C19H22N5OS2+
    N,N-dimethyl-4-[(2S,5R)-5-[(5-pyridin-4-yl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-1,3-oxazolidin-3-ium-2-yl]aniline
    —— (2R,3R,4R,5R)-1,1-bis(ethylsulfanyl)hexane-2,3,4,5-tetrol —— C10H22O4S2
    (2R,3R,4R,5R)-1,1-bis(ethylsulfanyl)hexane-2,3,4,5-tetrol
    —— [2-(4-Methylanilino)-1,3-thiazol-4-yl]methyl 2-(2,4-dimethylphenyl)sulfanylacetate —— C21H22N2O2S2
    [2-(4-Methylanilino)-1,3-thiazol-4-yl]methyl 2-(2,4-dimethylphenyl)sulfanylacetate
    —— 6-[(3R)-3-[1-(2-methoxyethyl)imidazol-2-yl]piperidin-1-yl]-2-methylsulfanylpyrimidin-4-amine —— C16H24N6OS
    6-[(3R)-3-[1-(2-methoxyethyl)imidazol-2-yl]piperidin-1-yl]-2-methylsulfanylpyrimidin-4-amine
    —— 6-[(3S)-3-[1-(2-methoxyethyl)imidazol-2-yl]piperidin-1-yl]-2-methylsulfanylpyrimidin-4-amine —— C16H24N6OS
    6-[(3S)-3-[1-(2-methoxyethyl)imidazol-2-yl]piperidin-1-yl]-2-methylsulfanylpyrimidin-4-amine
    —— (4S)-4-(bromomethyl)-11-cyclohexyl-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one —— C15H22BrN4OS+
    (4S)-4-(bromomethyl)-11-cyclohexyl-5-thia-2,7,13-triaza-11-azoniatricyclo[7.4.0.02,6]trideca-1(9),6-dien-8-one
    —— 4-(4-Methyl-5-methylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-ium —— C9H17N4S+
    4-(4-Methyl-5-methylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-ium
    —— 2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(2R)-2-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]ethanone —— C15H22N6O2S
    2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(2R)-2-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]ethanone
    —— 2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(2S)-2-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]ethanone —— C15H22N6O2S
    2-[(5-ethyl-1H-1,2,4-triazol-3-yl)sulfanyl]-1-[(2S)-2-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl]ethanone
    —— 3-((4-Bromobenzyl)thio)-6-(pyridin-4-yl)pyridazine —— C16H12BrN3S
    3-((4-Bromobenzyl)thio)-6-(pyridin-4-yl)pyridazine
    —— 3-((3-Chlorobenzyl)thio)-6-(pyridin-4-yl)pyridazine —— C16H12ClN3S
    3-((3-Chlorobenzyl)thio)-6-(pyridin-4-yl)pyridazine
    —— 2-methyl-5-[3-[4-[(3R)-oxolan-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole —— C12H17N5OS2
    2-methyl-5-[3-[4-[(3R)-oxolan-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole
    —— 2-methyl-5-[3-[4-[(3S)-oxolan-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole —— C12H17N5OS2
    2-methyl-5-[3-[4-[(3S)-oxolan-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole
    —— (3S)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(furan-2-ylmethyl)piperidine —— C20H24N4OS
    (3S)-3-(5-benzylsulfanyl-4-methyl-1,2,4-triazol-3-yl)-1-(furan-2-ylmethyl)piperidine
    —— [amino-(4-ethylanilino)methylidene]-[6-oxo-4-(pyridin-2-ylsulfanylmethyl)-1H-pyrimidin-2-yl]azanium —— C19H21N6OS+
    [amino-(4-ethylanilino)methylidene]-[6-oxo-4-(pyridin-2-ylsulfanylmethyl)-1H-pyrimidin-2-yl]azanium
    —— (2R)-N-cyclohexyl-2-[(6-methyl-5-oxo-4H-1,2,4-triazin-3-yl)sulfanyl]propanamide —— C13H20N4O2S
    (2R)-N-cyclohexyl-2-[(6-methyl-5-oxo-4H-1,2,4-triazin-3-yl)sulfanyl]propanamide
    —— (2R)-2-(4-methylpyrimidin-2-yl)sulfanylpropanoate —— C8H9N2O2S-
    (2R)-2-(4-methylpyrimidin-2-yl)sulfanylpropanoate
    —— (2S)-2-[(5-benzyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate —— C16H17N2O3S-
    (2S)-2-[(5-benzyl-4-methyl-6-oxo-1H-pyrimidin-2-yl)sulfanyl]butanoate
    —— Ethyl 2-[1,4-dimethyl-5-[(2-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylacetate —— C18H22N2O3S
    Ethyl 2-[1,4-dimethyl-5-[(2-methylphenyl)methyl]-6-oxopyrimidin-2-yl]sulfanylacetate
    —— 4-ethyl-3-methyl-5-[2-[4-[(3S)-oxolan-3-yl]triazol-1-yl]ethylsulfanyl]-1,2,4-triazole —— C13H20N6OS
    4-ethyl-3-methyl-5-[2-[4-[(3S)-oxolan-3-yl]triazol-1-yl]ethylsulfanyl]-1,2,4-triazole
    —— 4-ethyl-3-methyl-5-[2-[4-[(3R)-oxolan-3-yl]triazol-1-yl]ethylsulfanyl]-1,2,4-triazole —— C13H20N6OS
    4-ethyl-3-methyl-5-[2-[4-[(3R)-oxolan-3-yl]triazol-1-yl]ethylsulfanyl]-1,2,4-triazole
    —— 2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide —— C15H20N4O3S
    2-[[4-methyl-5-(2-methylfuran-3-yl)-1,2,4-triazol-3-yl]sulfanyl]-N-[[(2S)-oxolan-2-yl]methyl]acetamide
    —— 2-[4-Chloro-6-(dipropylamino)pyrimidin-2-yl]sulfanyl-1-(4-ethylpiperazin-4-ium-1-yl)ethanone —— C18H31ClN5OS+
    2-[4-Chloro-6-(dipropylamino)pyrimidin-2-yl]sulfanyl-1-(4-ethylpiperazin-4-ium-1-yl)ethanone
    —— 2-((2-Chloro-6-fluorobenzyl)thio)-4,6-dimethylnicotinonitrile —— C15H12ClFN2S
    2-((2-Chloro-6-fluorobenzyl)thio)-4,6-dimethylnicotinonitrile
    —— 2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-[(1R)-1-phenylethyl]acetamide —— C14H15N3O2S
    2-[(6-oxo-1H-pyrimidin-2-yl)sulfanyl]-N-[(1R)-1-phenylethyl]acetamide
    —— 4-propyl-2-[(2,4,5-trimethylphenyl)methylsulfanyl]-1H-pyrimidin-6-one —— C17H22N2OS
    4-propyl-2-[(2,4,5-trimethylphenyl)methylsulfanyl]-1H-pyrimidin-6-one
    —— (2R)-2-[[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(methylcarbamoyl)propanamide —— C13H13BrN4O3S
    (2R)-2-[[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-(methylcarbamoyl)propanamide
    —— 2-[[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-cyclopropylacetamide —— C13H12BrN3O2S
    2-[[5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl]sulfanyl]-N-cyclopropylacetamide
    —— [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 1-benzofuran-2-carboxylate —— C23H17NO4S
    [2-Oxo-2-(2-phenylsulfanylanilino)ethyl] 1-benzofuran-2-carboxylate
    —— N-(1-adamantyl)-2-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide —— C20H22F3N3OS
    N-(1-adamantyl)-2-[3-cyano-6-methyl-4-(trifluoromethyl)pyridin-2-yl]sulfanylacetamide
    —— 3-((2-Chloro-6-fluorobenzyl)thio)-6-(furan-2-yl)pyridazine —— C15H10ClFN2OS
    3-((2-Chloro-6-fluorobenzyl)thio)-6-(furan-2-yl)pyridazine
    —— 2-[(2,4-Difluorophenyl)methylsulfanyl]-6-ethyl-3-methyl-5-[(3-methylphenyl)methyl]pyrimidin-4-one —— C22H22F2N2OS
    2-[(2,4-Difluorophenyl)methylsulfanyl]-6-ethyl-3-methyl-5-[(3-methylphenyl)methyl]pyrimidin-4-one
    —— 3-[(4-Chlorophenyl)methylthio]-6-(2-furanyl)pyridazine 872701-27-4 C15H11ClN2OS
    3-[(4-Chlorophenyl)methylthio]-6-(2-furanyl)pyridazine
    —— 2-((6-(furan-2-yl)pyridazin-3-yl)thio)-N-(4-methylbenzyl)acetamide —— C18H17N3O2S
    2-((6-(furan-2-yl)pyridazin-3-yl)thio)-N-(4-methylbenzyl)acetamide
    —— N-tert-butyl-2-(7-butyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylacetamide —— C18H27N5O3S
    N-tert-butyl-2-(7-butyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanylacetamide
    —— 2-{[6,8-Dimethyl-2-(2-methylpropyl)-5,7-dioxo-5H,6H,7H,8H-[1,3]diazino[4,5-D]pyrimidin-4-YL]sulfanyl}-N-[(furan-2-YL)methyl]acetamide —— C19H23N5O4S
    2-{[6,8-Dimethyl-2-(2-methylpropyl)-5,7-dioxo-5H,6H,7H,8H-[1,3]diazino[4,5-D]pyrimidin-4-YL]sulfanyl}-N-[(furan-2-YL)methyl]acetamide
    —— (2R)-2-(7-butyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N,N-dimethyl-3-oxobutanamide —— C18H25N5O4S
    (2R)-2-(7-butyl-1,3-dimethyl-2,4-dioxopyrimido[4,5-d]pyrimidin-5-yl)sulfanyl-N,N-dimethyl-3-oxobutanamide
    —— 2-[(2S)-butan-2-yl]sulfanyl-4-(4-chlorophenyl)thiophene-3-carbonitrile —— C15H14ClNS2
    2-[(2S)-butan-2-yl]sulfanyl-4-(4-chlorophenyl)thiophene-3-carbonitrile
    —— 5-[(1R)-1-(4,6-dimethylpyrimidin-2-yl)sulfanylethyl]-3-pyridazin-3-yl-1,2,4-oxadiazole —— C14H14N6OS
    5-[(1R)-1-(4,6-dimethylpyrimidin-2-yl)sulfanylethyl]-3-pyridazin-3-yl-1,2,4-oxadiazole
    —— 5-[(1S)-1-(4,6-dimethylpyrimidin-2-yl)sulfanylethyl]-3-pyridazin-3-yl-1,2,4-oxadiazole —— C14H14N6OS
    5-[(1S)-1-(4,6-dimethylpyrimidin-2-yl)sulfanylethyl]-3-pyridazin-3-yl-1,2,4-oxadiazole
    —— 2-(4-acetamidophenoxy)-N-(2-phenylsulfanylphenyl)acetamide —— C22H20N2O3S
    2-(4-acetamidophenoxy)-N-(2-phenylsulfanylphenyl)acetamide
    —— 7-{[(2-Fluorophenyl)methyl]sulfanyl}-3-methyl-4H-[1,3,4]thiadiazolo[2,3-C][1,2,4]triazin-4-one —— C12H9FN4OS2
    7-{[(2-Fluorophenyl)methyl]sulfanyl}-3-methyl-4H-[1,3,4]thiadiazolo[2,3-C][1,2,4]triazin-4-one
    —— Ethyl 4-({3-methyl-4-oxo-4H-[1,3,4]thiadiazolo[2,3-C][1,2,4]triazin-7-YL}sulfanyl)-3-oxobutanoate —— C11H12N4O4S2
    Ethyl 4-({3-methyl-4-oxo-4H-[1,3,4]thiadiazolo[2,3-C][1,2,4]triazin-7-YL}sulfanyl)-3-oxobutanoate
    —— 7-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-3-methyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one —— C12H8ClFN4OS2
    7-[(2-Chloro-6-fluorophenyl)methylsulfanyl]-3-methyl-[1,3,4]thiadiazolo[2,3-c][1,2,4]triazin-4-one