氯化天竺葵色素苷 | 17334-58-6

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物 - 羧酸酯及其衍生物的盐
• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 黄酮类化合物
• 中文名称: 氯化天竺葵色素苷
• 中文别名: 草酸铁钾；花葵素3,5-二葡萄糖苷氯化物；天竺葵素双葡萄糖苷
• 英文名称: pelargonin
• 英文别名: pelargonidin 3,5-O-diglucoside；pelargonin chloride；Pelargonidin 3,5-diglucoside；(2S,3R,4S,5S,6R)-2-[7-hydroxy-2-(4-hydroxyphenyl)-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxychromenylium-5-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol;chloride
• CAS: 17334-58-6
• 化学式: C₂₇H₃₁O₁₅*Cl
• 分子量: 630.987
• InChiKey: DIRROHKULXIUCB-DHJOXOLYSA-N

物化性质

• 比旋光度：
  D -291°
• 溶解度：
  溶于甲烷

计算性质

• 辛醇/水分配系数(LogP)：
  -4.85
• 重原子数：
  43
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  240
• 氢给体数：
  10
• 氢受体数：
  15

安全信息

• WGK Germany：
  3
• 海关编码：
  2915900090

反应信息

• 作为产物：
  描述：

  [4-[7-acetyloxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]chromenylium-2-yl]phenyl] acetate;chloride 生成 氯化天竺葵色素苷
  参考文献：
  名称：

  YAMAGUCHI, MASA-ATSU;TERAHARA, NORINIKO;SHIZUKUISZI, KEN-ICHI, PHYTOCHEMISTRY, 29,(1990) N, C. 1269-1270

  摘要：

  DOI：

文献信息

• INHIBITION OF THE FORMATION OF AGEs
  申请人：Abdul-Malak Nabil

  公开号：US20100316743A1

  公开（公告）日：2010-12-16

  The present invention relates to the use of an active substance that promotes the inhibition of the formation of AGEs, for preparing a composition to prevent and/or combat the reduction in elastic and plastic properties of tissues, and in particular of the skin, for inhibiting the formation of AGEs, or for preventing and/or combating glycation of proteins in the skin. The invention also relates to a method of screening such active substances.

  本发明涉及使用促进抑制AGEs形成的活性物质，用于制备一种用于预防和/或对抗组织，特别是皮肤的弹性和塑性特性降低的组合物，用于抑制AGEs的形成，或用于预防和/或对抗皮肤中蛋白质的糖基化。本发明还涉及一种筛选此类活性物质的方法。
• NOVEL GLYCOSYLTRANSFERASE, NOVEL GLYCOSYLTRANSFERASE GENE, AND NOVEL SUGAR DONOR COMPOUND
  申请人：Ozeki Yoshihiro

  公开号：US20120135469A1

  公开（公告）日：2012-05-31

  An object of the present invention is to provide a sugar donating reagent comprising a sugar donor compound other than a sugar nucleotide and an enzyme capable of catalyzing a glycosyl transfer reaction using a sugar donor compound other than a sugar nucleotide. The present invention provides the following: a sugar donating reagent containing a compound of formula (A): wherein R 1 is independently selected from hydrogen, or C 1-6 alkyl, C 2-6 alkenyl, and C 2-6 alkynyl in which each of the groups is unsubstituted or substituted with one or more groups selected from OH, F, Cl, Br, I, CN, NO 2 , and SO 2 , n is 0, 1, 2, 3, 4 or 5, m is 0 or 1, and X represents a monosaccharide bound via a β bond on its anomeric carbon; a glycosyltransferase capable of catalyzing a glycosyl transfer reaction using the sugar donor; and a glycosyltransferase gene comprising DNA encoding the glycosyltransferase.

  本发明的目的是提供一种含有糖供体化合物的糖供体试剂，该糖供体化合物不是糖核苷酸，并且包含一种能够催化使用糖供体化合物进行糖基转移反应的酶。本发明提供以下内容：一种糖供体试剂，其包含式（A）的化合物：其中R1独立地选自氢、C1-6烷基、C2-6烯基和C2-6炔基，其中每个基团未取代或取代有一种或多种从OH、F、Cl、Br、I、CN、NO2和SO2中选出的基团，n为0、1、2、3、4或5，m为0或1，X代表通过其环式异构碳上的β键结合的单糖；一种能够催化使用糖供体进行糖基转移反应的糖基转移酶；以及编码糖基转移酶的DNA的糖基转移酶基因。
• Pharmaceutical composition containing substance inhibiting HSP47 production
  申请人：Kureha Chemical Industry Co., Ltd.

  公开号：EP0742012A2

  公开（公告）日：1996-11-13

  A pharmaceutical composition comprising a substance inhibiting HSP47 production, selected from the group consisting of a malt extract, a flavonoid compound, a protein-bound-polysaccharide obtained from a fungus belonging to Coriolus versicolor, a paeoniflorin derivative, a tocopherol derivative, and a ferulic acid derivative, and a pharmaceutically acceptable carrier is disclosed. The substance inhibiting HSP47 production can efficiently improve physiological conditions of a patient suffering from diseases exhibiting pathosis of overproduction of the extracellular matrix, and efficiently treat such diseases. Further, the substance is useful for preventing or treating various diseases accompanied with abnormal growth of the vascularization.

  本发明公开了一种药物组合物，该组合物包含一种抑制 HSP47 生成的物质，该物质选自麦芽提取物、黄酮类化合物、从属于 Coriolus versicolor 的真菌中获得的蛋白结合多糖、芍药苷衍生物、生育酚衍生物和阿魏酸衍生物组成的组，以及一种药学上可接受的载体。这种抑制 HSP47 生成的物质可以有效改善患有细胞外基质过度生成病症的患者的生理状况，并有效治疗此类疾病。此外，该物质还可用于预防或治疗伴有血管异常生长的各种疾病。
• SUCRALOSE-CONTAINING COMPOSITION AND EATABLE PRODUCT COMPRISING THE SAME
  申请人：SAN-EI GEN F.F.I., INC.

  公开号：EP1177728A1

  公开（公告）日：2002-02-06

  A composition which is obtained by causing a specific compound to be present together with sucralose. The composition provides a sucralose in a stable form, more particularly, a sucralose which is still stable and thus is significantly suppressed wiht respect to the decrease in sweetness and discoloration (browning, blackening), even when it is subjected to a heating treatment under a condition wherein temperature is high and especially water content is low and/or pH is low. The stabilized sucralose-containing composition can be used as a sweetener by itself and as a compound with a food or a drug.

  一种通过使特定化合物与蔗糖素(三氯蔗糖)一起存在而获得的组合物。该组合物提供了一种稳定形式的蔗糖素(三氯蔗糖)，更具体地说，是一种仍然稳定的蔗糖素(三氯蔗糖)，因此，即使在温度高、特别是含水量低和/或 pH 值低的条件下进行加热处理，其甜度下降和变色（褐变、变黑）的情况也会明显减少。这种稳定的含蔗糖素(三氯蔗糖)组合物既可用作甜味剂，也可用作食品或药物的复合物。
• Method of detecting viable cells
  申请人：FUJI ELECTRIC HOLDINGS CO., LTD.

  公开号：EP1624071A2

  公开（公告）日：2006-02-08

  An object of the represent invention is to provide a method of detecting viable cells that can detect and quantify viable cells in a sample quickly, readily, and accurately. The reagents used in the method are safe, stable in storage, and inexpensive. The method comprises steps (1), (2) and (3). In the step (1), the cells are fluorescently stained by adding a fluorescent dye into the sample or making the sample in contact with the fluorescent dye. In the step (2), a quenching dye is added to the sample stained with the fluorescent dye, or the sample is made in contact with the quenching dye, under a condition of a pH value that is different from the pH value in the viable cells. The quenching dye used in this step, (a) is permeable through a membrane of a viable cell, (b) hardly absorbs fluorescence of the fluorescent dye under a condition of the pH value in the viable cells, but (c) absorbs the fluorescence of the fluorescent dye under a condition different from the pH value of the fluorescent dye. In the step (3), the sample stained with the fluorescent dye and the quenching dye is illuminated by an excitation light for the fluorescent dye under a condition of a pH value different from the pH value in the viable cells and the fluorescence emitted from the sample is collected and detected.

  本发明的目的是提供一种检测有活力细胞的方法，它能快速、方便、准确地检测和定量样品中的有活力细胞。该方法中使用的试剂安全、储存稳定、价格低廉。 该方法包括步骤(1)、(2)和(3)。 在步骤(1)中，通过在样品中加入荧光染料或使样品与荧光染料接触，对细胞进行荧光染色。 在步骤(2)中，向被荧光染料染色的样品中加入淬灭染料，或使样品与淬灭染料接触，条件是 pH 值不同于存活细胞中的 pH 值。该步骤中使用的淬灭染料(a)可透过有活力细胞的膜，(b)在有活力细胞中的 pH 值条件下几乎不吸收荧光染料的荧光，但(c)在不同于荧光染料 pH 值的条件下吸收荧光染料的荧光。 在步骤(3)中，用荧光染料和淬灭染料染色的样品在与存活细胞中的 pH 值不同的条件下被荧光染料的激发光照射，收集并检测样品发出的荧光。