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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— Phenyl 1,2,2-trifluoroethyl sulfide 136370-27-9 C8H7F3S
    Phenyl 1,2,2-trifluoroethyl sulfide
    —— 4,6-dimethyl-2-(prop-2-en-1-ylsulfanyl)pyrimidine 55749-32-1 C9H12N2S
    4,6-dimethyl-2-(prop-2-en-1-ylsulfanyl)pyrimidine
    —— 5-acetyl-5,6,11,12-tetrahydro-8-bromo-2-methylthiodibenz[b,f]azocine 1446113-94-5 C18H18BrNOS
    5-acetyl-5,6,11,12-tetrahydro-8-bromo-2-methylthiodibenz[b,f]azocine
    —— 1-(3,5-dimethyl-1H-pyrazol-1-yl)-2-phenyl-1-(phenylthio)ethane 122606-08-0 C19H20N2S
    1-(3,5-dimethyl-1H-pyrazol-1-yl)-2-phenyl-1-(phenylthio)ethane
    —— 4-{[(1-methyl-1H-imidazol-5-yl)methyl]sulfanyl}aniline 497853-77-7 C11H13N3S
    4-{[(1-methyl-1H-imidazol-5-yl)methyl]sulfanyl}aniline
    —— 4-chloro-N-(3-methylsulfanylphenyl)pyrimidin-2-amine 945396-91-8 C11H10ClN3S
    4-chloro-N-(3-methylsulfanylphenyl)pyrimidin-2-amine
    —— 8-Methylthio-1-azaphenothiazin 117000-77-8 C12H10N2S2
    8-Methylthio-1-azaphenothiazin
    —— (3-methylsulfanyl-phenyl)-pyridin-2-yl-amine 106167-23-1 C12H12N2S
    (3-methylsulfanyl-phenyl)-pyridin-2-yl-amine
    —— 2-(3'-Methylthioanilinium)-5-methyl-5-nitro-1,3,2-dioxaphosphorinan 2-oxid 20926-64-1 C11H15N2O5PS
    2-(3'-Methylthioanilinium)-5-methyl-5-nitro-1,3,2-dioxaphosphorinan 2-oxid
    —— 1,1'-(5,5'-disulfanediylbis(2-chloro-5,1-phenylene))bis(3-methyl-3-(3-(methylthio)phenyl)guanidine) 1349064-27-2 C30H30Cl2N6S4
    1,1'-(5,5'-disulfanediylbis(2-chloro-5,1-phenylene))bis(3-methyl-3-(3-(methylthio)phenyl)guanidine)
    —— N-(5-benzylthio-2-chlorophenyl)-N'-(3-methylthiophenyl)-N'-methyl-guanidine hydrochloride 917894-08-7 C22H22ClN3S2*ClH
    N-(5-benzylthio-2-chlorophenyl)-N'-(3-methylthiophenyl)-N'-methyl-guanidine hydrochloride
    —— 2-benzyl-8-(4-chlorophenylthio)-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one 1262118-00-2 C25H18ClN3OS
    2-benzyl-8-(4-chlorophenylthio)-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one
    —— 2-benzyl-8-(4-chlorophenylthio)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one 1262117-95-2 C25H18ClN3O2S
    2-benzyl-8-(4-chlorophenylthio)-6-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-3(7H)-one
    —— methyl n-octanesulphonylacetate 221119-53-5 C11H22O4S
    methyl n-octanesulphonylacetate
    —— 3-(2-chloro-5-((2-(18)fluoroethyl)thio)phenyl)-1-methyl-1-(3-(methylthio)phenyl)guanidine 917894-12-3 C17H19ClFN3S2
    3-(2-chloro-5-((2-(18)fluoroethyl)thio)phenyl)-1-methyl-1-(3-(methylthio)phenyl)guanidine
    —— (Z)-2-(5-bromo-1H-indol-yl)-3-(4-(phenylthio)pyridin-3-yl)acrylonitrile 1613334-42-1 C22H14BrN3S
    (Z)-2-(5-bromo-1H-indol-yl)-3-(4-(phenylthio)pyridin-3-yl)acrylonitrile
    —— 3-(2-chloro-5-(2-fluoroethylthio)phenyl)-N'-methyl-N'-(3-(methylthio)phenyl)guanidine 917894-11-2 C17H19ClFN3S2
    3-(2-chloro-5-(2-fluoroethylthio)phenyl)-N'-methyl-N'-(3-(methylthio)phenyl)guanidine
    —— pyridine-4-carboxaldehyde (3-methylthiophenyl)imine 165806-93-9 C13H12N2S
    pyridine-4-carboxaldehyde (3-methylthiophenyl)imine
    —— 1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-(phenylthio)ethane 122606-09-1 C13H16N2S
    1-(3,5-dimethyl-1H-pyrazol-1-yl)-1-(phenylthio)ethane
    —— 2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-(4-methylphenyl)-2-(phenylthio)ethanol 122606-12-6 C20H22N2OS
    2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-(4-methylphenyl)-2-(phenylthio)ethanol
    —— 1-Methylspiro(piperidine-4,6'-dibenz<b,e>-1,4-oxathiepin) 98796-28-2 C18H19NOS
    1-Methylspiro(piperidine-4,6'-dibenz<b,e>-1,4-oxathiepin)
    —— 2-[5-Chloro-2-(2-fluorophenyl)sulfanylphenyl]acetic acid 73129-27-8 C14H10ClFO2S
    2-[5-Chloro-2-(2-fluorophenyl)sulfanylphenyl]acetic acid
    —— (R)-N-[2-fluoro-4-(2-fluorophenylthio)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide 252016-86-7 C16H12F5NO2S
    (R)-N-[2-fluoro-4-(2-fluorophenylthio)phenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide
    —— 6-(3-Piperidinopropyl)-6H-dibenz<b,e>-1,4-oxathiepin 83193-49-1 C21H25NOS
    6-(3-Piperidinopropyl)-6H-dibenz<b,e>-1,4-oxathiepin
    —— S-Methyl-S'-(2'-bromphenyl)-3-acetamido-dithio-hydrochinon 5166-81-4 C15H14BrNOS2
    S-Methyl-S'-(2'-bromphenyl)-3-acetamido-dithio-hydrochinon
    —— 4,4'-Diisocyanato-diphenylsulfid 14353-02-7 C14H8N2O2S
    4,4'-Diisocyanato-diphenylsulfid
    —— 2-(2-Fluorophenylthio)benzaldehyde 83193-43-5 C13H9FOS
    2-(2-Fluorophenylthio)benzaldehyde
    —— 2-(2-fluorophenylthio)benzyl alcohol 87033-72-5 C13H11FOS
    2-(2-fluorophenylthio)benzyl alcohol
    —— 4-{[5-chloro-2-(2-fluoro-phenylsulfanyl)-phenyl]-thioacetyl}-morpholine 73129-23-4 C18H17ClFNOS2
    4-{[5-chloro-2-(2-fluoro-phenylsulfanyl)-phenyl]-thioacetyl}-morpholine
    —— 8-Trifluoromethyl-6-(1-methyl-4-piperidyl)-6H-dibenz<b,e>-1,4-oxathiepin 83986-18-9 C20H20F3NOS
    8-Trifluoromethyl-6-(1-methyl-4-piperidyl)-6H-dibenz<b,e>-1,4-oxathiepin
    —— α-(1-Methyl-4-piperidyl)-2-(2-fluorophenylthio)benzyl Alcohol 83193-46-8 C19H22FNOS
    α-(1-Methyl-4-piperidyl)-2-(2-fluorophenylthio)benzyl Alcohol
    —— 2-(3-fluoro-4-(methylthio)phenyl)acetic acid 259543-76-5 C9H9FO2S
    2-(3-fluoro-4-(methylthio)phenyl)acetic acid
    —— 2-(2-fluorophenylthio)acetaldehyde 1248249-23-1 C8H7FOS
    2-(2-fluorophenylthio)acetaldehyde
    —— 3-<2-(2-fluorophenylthio)phenyl>propionic acid 87033-77-0 C15H13FO2S
    3-<2-(2-fluorophenylthio)phenyl>propionic acid
    —— 5-(2-Fluorophenyl)sulfanyl-6-nitrospiro[1,2-dihydroindene-3,2'-1,3-dioxolane] 1026500-21-9 C17H14FNO4S
    5-(2-Fluorophenyl)sulfanyl-6-nitrospiro[1,2-dihydroindene-3,2'-1,3-dioxolane]
    —— alpha-(1-Methyl-4-piperidyl)-2-(2-fluorophenylthio)-5-trifluoromethylbenzyl alcohol 83986-19-0 C20H21F4NOS
    alpha-(1-Methyl-4-piperidyl)-2-(2-fluorophenylthio)-5-trifluoromethylbenzyl alcohol
    —— 6-(1-Methyl-4-piperidyl)-6H-dibenz<b,e>-1,4-oxathiepin 83193-56-0 C19H21NOS
    6-(1-Methyl-4-piperidyl)-6H-dibenz<b,e>-1,4-oxathiepin
    —— 6-(1-Methyl-3-piperidylmethyl)-6H-dibenz<b,e>-1,4-oxathiepin 83985-99-3 C20H23NOS
    6-(1-Methyl-3-piperidylmethyl)-6H-dibenz<b,e>-1,4-oxathiepin
    —— α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol 83193-50-4 C20H24FNOS
    α-(1-methyl-3-piperidylmethyl)-2-(2-fluorophenylthio)benzyl alcohol
    —— N-(6-(2-(2-fluorophenylthio)pyridin-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide 1162680-03-6 C19H14FN5OS
    N-(6-(2-(2-fluorophenylthio)pyridin-4-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide
    —— 4-Cyanoethylthio-6-methyl-2-phenyl-pyrimidine-5-carbonitrile 128503-06-0 C15H12N4S
    4-Cyanoethylthio-6-methyl-2-phenyl-pyrimidine-5-carbonitrile
    —— 3-(2-fluorophenylthio)quinoline 1299398-28-9 C15H10FNS
    3-(2-fluorophenylthio)quinoline
    —— 4-((2-Fluorophenyl)thio)butan-2-one 1044058-12-9 C10H11FOS
    4-((2-Fluorophenyl)thio)butan-2-one
    —— 6-(3-Dimethylaminopropyl)-6H-dibenz<b,e>-1,4-oxathiepin 83193-47-9 C18H21NOS
    6-(3-Dimethylaminopropyl)-6H-dibenz<b,e>-1,4-oxathiepin
    —— cis-1-Methoxy-2-methylthioethen 42931-47-5 C4H8OS
    cis-1-Methoxy-2-methylthioethen
    —— Methoxy-methylmercapto-ethylen 42848-05-5 C4H8OS
    Methoxy-methylmercapto-ethylen
    —— 3-(2-Fluorophenyl)sulfanyl-1-methylindole 530116-21-3 C15H12FNS
    3-(2-Fluorophenyl)sulfanyl-1-methylindole
    —— 2,4-bis(2-phenyl-1,3-benzodithiol-2-yl)pyrrole 147089-53-0 C30H21NS4
    2,4-bis(2-phenyl-1,3-benzodithiol-2-yl)pyrrole
    —— 2-(2-Fluorophenylthio)-5-trifluoromethylbenzaldehyde 83986-21-4 C14H8F4OS
    2-(2-Fluorophenylthio)-5-trifluoromethylbenzaldehyde
    —— (S)-3-(2-fluorophenylthio)cyclohexanone 1215843-23-4 C12H13FOS
    (S)-3-(2-fluorophenylthio)cyclohexanone