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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— Methyl 3-(3,4-dimethoxyphenyl)sulfanyl-1-benzothiophene-2-carboxylate 1213779-93-1 C18H16O4S2
    Methyl 3-(3,4-dimethoxyphenyl)sulfanyl-1-benzothiophene-2-carboxylate
    —— RP99GC2ZB2 2136295-90-2 C5H12OS
    RP99GC2ZB2
    —— 2-(4-chloro-phenylsulfanyl)-<i>N</i>-methoxy-acetamide 41402-91-9 C9H10ClNO2S
    2-(4-chloro-phenylsulfanyl)-<i>N</i>-methoxy-acetamide
    —— Ethanethiol, 2-(octylthio)- 53787-06-7 C10H22S2
    Ethanethiol, 2-(octylthio)-
    —— (ethylsulfanyl-methyl)-dimethyl-amine 117409-99-1 C5H13NS
    (ethylsulfanyl-methyl)-dimethyl-amine
    —— 4,4'-thiobis(2-tert-butyl-m-cresol) 96-69-5 C22H30O2S
    4,4'-thiobis(2-tert-butyl-m-cresol)
    —— 2-methyl-2-propyl (Z)-1'-propenyl sulfoxide 69113-51-5 C7H14OS
    2-methyl-2-propyl (Z)-1'-propenyl sulfoxide
    —— (1S)-N-methyl-1-(2-phenylsulfanylphenyl)ethanamine 1227795-24-5 C15H17NS
    (1S)-N-methyl-1-(2-phenylsulfanylphenyl)ethanamine
    —— S-phenyl N-(2-trimethylsilylphenyl)carbamothioate 1233211-56-7 C16H19NOSSi
    S-phenyl N-(2-trimethylsilylphenyl)carbamothioate
    —— 2-(methylthio)-N-phenylpyridin-3-amine 1294517-68-2 C12H12N2S
    2-(methylthio)-N-phenylpyridin-3-amine
    —— 7-cyano-8-(2-furyl)-3-phenyl-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one 951957-19-0 C17H12N4O2S
    7-cyano-8-(2-furyl)-3-phenyl-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one
    —— 1-tert-butyloxycarbonyl-2-phenylthiomethyl-2-imidazoline 272110-40-4 C15H20N2O2S
    1-tert-butyloxycarbonyl-2-phenylthiomethyl-2-imidazoline
    —— 3-(4-chlorophenyl)-7-cyano-8-(2-furyl)-3,4-dihydro-2Hpyrimido[2,1-b]-1,3,5-thiadiazin-6-one 951928-99-7 C17H11ClN4O2S
    3-(4-chlorophenyl)-7-cyano-8-(2-furyl)-3,4-dihydro-2Hpyrimido[2,1-b]-1,3,5-thiadiazin-6-one
    —— 3-(4-bromophenyl)-7-cyano-8-(2-furyl)-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thia-diazin-6-one 951958-75-1 C17H11BrN4O2S
    3-(4-bromophenyl)-7-cyano-8-(2-furyl)-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thia-diazin-6-one
    —— 3-benzyl-7-cyano-8-(2-furyl)-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one 1262508-84-8 C18H14N4O2S
    3-benzyl-7-cyano-8-(2-furyl)-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one
    —— Isopropyl isopropylthiomethyl sulfoxide 37032-08-9 C7H16OS2
    Isopropyl isopropylthiomethyl sulfoxide
    —— 3-butyl-7-cyano-8-(2-furyl)-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one 1262508-82-6 C15H16N4O2S
    3-butyl-7-cyano-8-(2-furyl)-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one
    —— 4-[Benzyl(prop-2-enyl)amino]-6-phenylsulfanylpyrimidine-5-carbaldehyde 1233706-01-8 C21H19N3OS
    4-[Benzyl(prop-2-enyl)amino]-6-phenylsulfanylpyrimidine-5-carbaldehyde
    —— diethyl 2-(phenylthio)cyclopent-1-en-1-yl phosphate 1233941-23-5 C15H21O4PS
    diethyl 2-(phenylthio)cyclopent-1-en-1-yl phosphate
    —— 1-allyl-3-methyl-2-phenyl-5-phenylthio-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine 1012786-98-9 C22H22N4S
    1-allyl-3-methyl-2-phenyl-5-phenylthio-1,2,3,4-tetrahydropyrimido[4,5-d]pyrimidine
    —— 2-{[(4-Chlorophenyl)methyl]sulfanyl}-4-(furan-2-YL)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 137447-02-0 C16H10ClN3O2S
    2-{[(4-Chlorophenyl)methyl]sulfanyl}-4-(furan-2-YL)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
    —— 7-cyano-8-(2-furyl)-3-isobutyl-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one 1262508-83-7 C15H16N4O2S
    7-cyano-8-(2-furyl)-3-isobutyl-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one
    —— 6-(2-furyl)-2-(2-hydroxy-3-morpholinopropylthio)-4-morpholino-pyrimidine-5-carbonitrile 1449008-67-6 C20H25N5O4S
    6-(2-furyl)-2-(2-hydroxy-3-morpholinopropylthio)-4-morpholino-pyrimidine-5-carbonitrile
    —— 5-ethyl-2,3-dihydro-[1,4]dithiine 23230-02-6 C6H10S2
    5-ethyl-2,3-dihydro-[1,4]dithiine
    —— 6-(2-furyl)-2-methylthio-3-methyl-3,4-dihydro-4-oxopyrimidine-5-carbonitrile 137446-92-5 C11H9N3O2S
    6-(2-furyl)-2-methylthio-3-methyl-3,4-dihydro-4-oxopyrimidine-5-carbonitrile
    —— 2-ethylsulfanyl-4-(2-furyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 156176-72-6 C11H9N3O2S
    2-ethylsulfanyl-4-(2-furyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
    —— 2-benzylthio-6-(2-furyl)-4-oxo-3,4-dihydropyrimidine-5-carbonitrile 137447-01-9 C16H11N3O2S
    2-benzylthio-6-(2-furyl)-4-oxo-3,4-dihydropyrimidine-5-carbonitrile
    —— 7-cyano-8-(2-furyl)-3-(4-tolyl)-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one 1262508-85-9 C18H14N4O2S
    7-cyano-8-(2-furyl)-3-(4-tolyl)-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one
    —— 2-Amino-6-(5-brom-2-methylmercapto-pyrimidinyl-(4)-mercapto)-purin 68498-46-4 C10H8BrN7S2
    2-Amino-6-(5-brom-2-methylmercapto-pyrimidinyl-(4)-mercapto)-purin
    —— 7-cyano-3-ethyl-8-(2-furyl)-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one 1262508-81-5 C13H12N4O2S
    7-cyano-3-ethyl-8-(2-furyl)-3,4-dihydro-2H-pyrimido[2,1-b]-1,3,5-thiadiazin-6-one
    —— 2-(4'-Oxobutyl)-2-(5"-oxopentyl)-1,3-dithiane 146353-23-3 C13H22O2S2
    2-(4'-Oxobutyl)-2-(5"-oxopentyl)-1,3-dithiane
    —— 2-(3'-Oxopropyl)-2-(5"-oxopentyl)-1,3-dithiane 146353-22-2 C12H20O2S2
    2-(3'-Oxopropyl)-2-(5"-oxopentyl)-1,3-dithiane
    —— N-(2-azidoethyl)-2-(phenylthio)acetamide 1192358-12-5 C10H12N4OS
    N-(2-azidoethyl)-2-(phenylthio)acetamide
    —— 2-<3'-(1,3-Dioxolanyl)propyl>-2-<4"-(1,3-dioxolanyl)butyl>-1,3-dithiane 146353-21-1 C17H30O4S2
    2-<3'-(1,3-Dioxolanyl)propyl>-2-<4"-(1,3-dioxolanyl)butyl>-1,3-dithiane
    —— (5R)-1-[4-(1,3-dioxolan-2-yl)butyl]-5-{[(1-tert-butyl-1H-tetrazol-5-yl)sulfanyl]methyl}pyrrolidin-2-one 1197897-14-5 C17H29N5O3S
    (5R)-1-[4-(1,3-dioxolan-2-yl)butyl]-5-{[(1-tert-butyl-1H-tetrazol-5-yl)sulfanyl]methyl}pyrrolidin-2-one
    —— 3,4-Trimethylen-1,6-dioxa-6a-thia<sup>IV</sup>-2,5-diazapentalen 70820-83-6 C6H6N2O2S
    3,4-Trimethylen-1,6-dioxa-6a-thia<sup>IV</sup>-2,5-diazapentalen
    —— 4-Chlor-2-benzylmercapto-pyrimidin 78494-41-4 C11H9ClN2S
    4-Chlor-2-benzylmercapto-pyrimidin
    —— 10H-Pyrazino[2,3-b][1,4]benzothiazine-8-carboxylic acid 203659-84-1 C11H7N3O2S
    10H-Pyrazino[2,3-b][1,4]benzothiazine-8-carboxylic acid
    —— N-(10H-Pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)-1-methylpiperidine-4-carboxamide 203657-14-1 C18H21N5OS
    N-(10H-Pyrazino[2,3-b][1,4]benzothiazin-8-ylmethyl)-1-methylpiperidine-4-carboxamide
    —— 3-(2,4-difluorophenyl)-1-methyl-7-methylsulfanyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine 691864-48-9 C13H10F2N4OS
    3-(2,4-difluorophenyl)-1-methyl-7-methylsulfanyl-1H-pyrimido[4,5-e][1,3,4]oxadiazine
    —— 1,4-Phenylenbis(benzodithioketal) 63866-46-6 C20H14S4
    1,4-Phenylenbis(benzodithioketal)
    —— 6-(4-cholorobutyl)-4-(phenylthio)-1,2,5,6-tetrahydro-2-pyridinone 871950-83-3 C15H18ClNOS
    6-(4-cholorobutyl)-4-(phenylthio)-1,2,5,6-tetrahydro-2-pyridinone
    —— 4-(4-bromophenylsulfanyl)-3,5-dimethyl-1H-pyrazole 394237-22-0 C11H11BrN2S
    4-(4-bromophenylsulfanyl)-3,5-dimethyl-1H-pyrazole
    —— 2-ethylsulfanyl-6-phenyl-4H-thiopyran-4-one 500169-87-9 C13H12OS2
    2-ethylsulfanyl-6-phenyl-4H-thiopyran-4-one
    —— 5-Methyl-4-[(4-methylsulfanylphenyl)methylidene]-2-phenylpyrazol-3-one 146795-14-4 C18H16N2OS
    5-Methyl-4-[(4-methylsulfanylphenyl)methylidene]-2-phenylpyrazol-3-one
    —— 5-methyl-2-[4,5-bis(pentylthio)-1,3-dithiole-2-yliden]-(1,3)-dithiolo[4,5-c]pyrrole 860306-27-0 C19H27NS6
    5-methyl-2-[4,5-bis(pentylthio)-1,3-dithiole-2-yliden]-(1,3)-dithiolo[4,5-c]pyrrole
    —— (S)-2-amino-4-[2-chloro-4-(2-hydroxy-5-methylphenylthio)phenyl]-2-methylbutylphosphoric acid monoester 1260512-05-7 C18H23ClNO5PS
    (S)-2-amino-4-[2-chloro-4-(2-hydroxy-5-methylphenylthio)phenyl]-2-methylbutylphosphoric acid monoester
    —— (R)-N-[1-(hydroxymethyl)-2-methylpropyl]cyclohexanethiocarboxamide 420133-83-1 C12H23NOS
    (R)-N-[1-(hydroxymethyl)-2-methylpropyl]cyclohexanethiocarboxamide
    —— (R)-2-cyclohexyl-4-isopropyl-2-thiazoline 420134-20-9 C12H21NS
    (R)-2-cyclohexyl-4-isopropyl-2-thiazoline
    —— (S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol 1260511-77-0 C25H34ClNO5S
    (S)-2-t-butoxycarbonylamino-4-[2-chloro-4-(2-methoxymethoxy-5-methylphenylthio)phenyl]-2-methylbutan-1-ol