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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2,2,3-Trimethyl-1lambda~6~-thietane-1,1-dione 62501-38-6 C6H12O2S
    2,2,3-Trimethyl-1lambda~6~-thietane-1,1-dione
    —— 1-aza-8-trifluoromethyl-phenothiazine hydrochloride 158438-82-5 C12H7F3N2S*ClH
    1-aza-8-trifluoromethyl-phenothiazine hydrochloride
    —— 2,3-Diamino-3-[(4-chlorophenyl)sulfanyl]prop-2-enenitrile 116014-25-6 C9H8ClN3S
    2,3-Diamino-3-[(4-chlorophenyl)sulfanyl]prop-2-enenitrile
    —— 1-[4-(2-Phenylsulfanylphenoxy)butyl]piperidine;hydrochloride 62232-66-0 C21H28ClNOS
    1-[4-(2-Phenylsulfanylphenoxy)butyl]piperidine;hydrochloride
    —— 3-[(Prop-2-en-1-yl)sulfanyl]furan 113680-31-2 C7H8OS
    3-[(Prop-2-en-1-yl)sulfanyl]furan
    —— Sodium(10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)methane-sulfonate 203657-68-5 C11H8N3O3S2*Na
    Sodium(10H-pyrazino[2,3-b][1,4]benzothiazin-8-yl)methane-sulfonate
    —— 2-{[3-(Triethoxysilyl)propyl]sulfanyl}-1H-imidazole 805244-13-7 C12H24N2O3SSi
    2-{[3-(Triethoxysilyl)propyl]sulfanyl}-1H-imidazole
    —— Cyclopropyltrifluormethylsulfon 57964-43-9 C4H5F3O2S
    Cyclopropyltrifluormethylsulfon
    —— (1R,2R)-(-)-2-dimethylamino-1-[4-(methylthio)phenyl]-1,3-propanediol 906548-47-8 C12H19NO2S
    (1R,2R)-(-)-2-dimethylamino-1-[4-(methylthio)phenyl]-1,3-propanediol
    —— 3-{[(2H-Tetrazol-5-yl)methyl]sulfanyl}aniline 195622-62-9 C8H9N5S
    3-{[(2H-Tetrazol-5-yl)methyl]sulfanyl}aniline
    —— (3R)-3-Hydroxy-5-(phenylsulfanyl)pentanoic acid 454458-22-1 C11H14O3S
    (3R)-3-Hydroxy-5-(phenylsulfanyl)pentanoic acid
    —— 2-[3-cyano-4-(4-fluorophenylthio)phenyl]thiazolo[5,4-d]pyrimidine 918880-42-9 C18H9FN4S2
    2-[3-cyano-4-(4-fluorophenylthio)phenyl]thiazolo[5,4-d]pyrimidine
    —— 3-[2-(3-fluoro-phenylsulfanyl)-phenyl]-propan-1-ol 791642-74-5 C15H15FOS
    3-[2-(3-fluoro-phenylsulfanyl)-phenyl]-propan-1-ol
    —— 4-{[4-(2-[{(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl]thio}phenol 643093-61-2 C22H22ClNO2S
    4-{[4-(2-[{(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino}ethyl)phenyl]thio}phenol
    —— 2-allyl-4-(trifluoromethylthio)phenol 653578-28-0 C10H9F3OS
    2-allyl-4-(trifluoromethylthio)phenol
    —— 5-ethyl-3-(4-fluoro-phenylthio)-4-methyl-1-phenyl-1H-pyridine-2-one 918543-38-1 C20H18FNOS
    5-ethyl-3-(4-fluoro-phenylthio)-4-methyl-1-phenyl-1H-pyridine-2-one
    —— tert-butyl [(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][2-[4-[(4-hydroxyphenyl)thio]phenyl]ethyl]carbamate 643093-69-0 C27H30ClNO4S
    tert-butyl [(2R)-2-(3-chlorophenyl)-2-hydroxyethyl][2-[4-[(4-hydroxyphenyl)thio]phenyl]ethyl]carbamate
    —— 5-acetyl-3-(4-fluoro-phenylthio)-4-methyl-1H-pyridine-2-one 918542-62-8 C14H12FNO2S
    5-acetyl-3-(4-fluoro-phenylthio)-4-methyl-1H-pyridine-2-one
    —— 3-(4-methoxy-phenylthio)-4,5,6-trimethyl-1-phenyl-1H-pyridine-2-one 918543-42-7 C21H21NO2S
    3-(4-methoxy-phenylthio)-4,5,6-trimethyl-1-phenyl-1H-pyridine-2-one
    —— 2-phenylsulfanyl-N-(trifluoromethyl)acetamide 50679-32-8 C9H8F3NOS
    2-phenylsulfanyl-N-(trifluoromethyl)acetamide
    —— 2-Hepten-3-thiol 27482-29-7 C7H14S
    2-Hepten-3-thiol
    —— 5-[2-(2-benzyloxyethyl)-5-ethyl-3H-imidazol-4-ylsulfanyl]-isophthalonitrile 868525-11-5 C22H20N4OS
    5-[2-(2-benzyloxyethyl)-5-ethyl-3H-imidazol-4-ylsulfanyl]-isophthalonitrile
    —— N-(2-chlorophenyl)-6-morpholin-4-yl-5-nitro-2-(propylthio)pyrimidin-4-amine 640285-23-0 C17H20ClN5O3S
    N-(2-chlorophenyl)-6-morpholin-4-yl-5-nitro-2-(propylthio)pyrimidin-4-amine
    —— 5-(2-benzyloxymethyl-5-ethyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile 868525-19-3 C21H18N4OS
    5-(2-benzyloxymethyl-5-ethyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile
    —— 3-[(2-benzyloxymethyl)-5-trifluoromethyl-1H-imidazol-4-ylsulfanyl]-5-chloro-benzonitrile 897626-35-6 C19H13ClF3N3OS
    3-[(2-benzyloxymethyl)-5-trifluoromethyl-1H-imidazol-4-ylsulfanyl]-5-chloro-benzonitrile
    —— 5-(2-benzyloxymethyl-5-isopropyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile 868525-46-6 C22H20N4OS
    5-(2-benzyloxymethyl-5-isopropyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile
    —— 5-[2-(2-benzyloxy-ethyl)-5-trifluoromethyl-3H-imidazol-4-ylsulfanyl]-3-chloro-benzonitrile 897626-26-5 C20H15ClF3N3OS
    5-[2-(2-benzyloxy-ethyl)-5-trifluoromethyl-3H-imidazol-4-ylsulfanyl]-3-chloro-benzonitrile
    —— 5-(2-benzyloxymethyl-3-ethyl-5-isopropyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile 868525-48-8 C24H24N4OS
    5-(2-benzyloxymethyl-3-ethyl-5-isopropyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile
    —— 5-(2-benzyloxymethyl-5-trifluoromethyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile 868525-20-6 C20H13F3N4OS
    5-(2-benzyloxymethyl-5-trifluoromethyl-3H-imidazol-4-ylsulfanyl)-isophthalonitrile
    —— 2-(6-Chlorobenzo[d][1,3]dioxol-5-ylthio)-1-(4-methoxybenzyl)-1H-imidazo[4,5-c]pyridin-4-amine 1012059-51-6 C21H17ClN4O3S
    2-(6-Chlorobenzo[d][1,3]dioxol-5-ylthio)-1-(4-methoxybenzyl)-1H-imidazo[4,5-c]pyridin-4-amine
    —— 1-(2-hexylsulfanyl-6-methyl-pyrimidin-4-yl)-ethanone 863673-02-3 C13H20N2OS
    1-(2-hexylsulfanyl-6-methyl-pyrimidin-4-yl)-ethanone
    —— {(S)-3-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-1-hydroxymethyl-propyl}-carbamic acid ter-butyl ester 848644-03-1 C18H27ClN2O3S
    {(S)-3-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-1-hydroxymethyl-propyl}-carbamic acid ter-butyl ester
    —— ethyl 2-methyl-6-(4-methylphenyl)sulfanylnicotinate 888022-72-8 C16H17NO2S
    ethyl 2-methyl-6-(4-methylphenyl)sulfanylnicotinate
    —— 4-methyl 2-[2-(phenylthio)ethyl]-2H-1,2,3-triazole-4,5-dicarboxylate 478626-23-2 C13H13N3O4S
    4-methyl 2-[2-(phenylthio)ethyl]-2H-1,2,3-triazole-4,5-dicarboxylate
    —— {(S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-propyl}-carbamic acid ter-butyl ester 848644-02-0 C34H45ClN2O3SSi
    {(S)-1-(tert-butyl-diphenyl-silanyloxymethyl)-3-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-propyl}-carbamic acid ter-butyl ester
    —— tert-butyl 2-methyl-6-(4-methylphenyl)sulfanylnicotinate 888022-73-9 C18H21NO2S
    tert-butyl 2-methyl-6-(4-methylphenyl)sulfanylnicotinate
    —— tert-butyl [4-(5,6-diphenylpyrazin-2-ylsulfanyl)butoxy]acetate 475085-44-0 C26H30N2O3S
    tert-butyl [4-(5,6-diphenylpyrazin-2-ylsulfanyl)butoxy]acetate
    —— (S)-2-amino-4-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-butan-1-ol 928761-52-8 C13H19ClN2OS
    (S)-2-amino-4-[3-(4-chloro-phenylsulfanyl)-azetidin-1-yl]-butan-1-ol
    —— 3-(2-Methoxyethoxy)-5-{[(3-methylphenyl)methyl]sulfanyl}-1,2,4-thiadiazole 922505-60-0 C13H16N2O2S2
    3-(2-Methoxyethoxy)-5-{[(3-methylphenyl)methyl]sulfanyl}-1,2,4-thiadiazole
    —— (5-bromo-2-methyl-phenylsulfanyl)-acetic acid 845746-14-7 C9H9BrO2S
    (5-bromo-2-methyl-phenylsulfanyl)-acetic acid
    —— (5-bromo-2-methyl-phenylsulfanyl)-acetic acid tert-butyl ester 845746-13-6 C13H17BrO2S
    (5-bromo-2-methyl-phenylsulfanyl)-acetic acid tert-butyl ester
    —— (2R)-2-{[5-(benzylthio)-2-chloro[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-3-methylbutan-1-ol 849943-26-6 C17H19ClN4OS2
    (2R)-2-{[5-(benzylthio)-2-chloro[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-3-methylbutan-1-ol
    —— (4-Amino-2-pyrimidinyl)-essigsaeure-ethylester 61445-75-8 C8H11N3O2S
    (4-Amino-2-pyrimidinyl)-essigsaeure-ethylester
    —— 3-(3-{[(5-chloro-thiophen-3-yl)methyl]thio}-5-oxo-2,5-dihydro-1,2,4-triazin-6-yl)-propionic acid ethyl ester 824983-32-6 C13H14ClN3O3S2
    3-(3-{[(5-chloro-thiophen-3-yl)methyl]thio}-5-oxo-2,5-dihydro-1,2,4-triazin-6-yl)-propionic acid ethyl ester
    —— 5-[(4-methyl-1,3-thiazol-2-yl)thio]thiophene-2-sulfonamide 900814-33-7 C8H8N2O2S4
    5-[(4-methyl-1,3-thiazol-2-yl)thio]thiophene-2-sulfonamide
    —— [[2-(phenylthio)-5-(aminooxoacetyl)-6-ethyl-7-(phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]acetic acid methyl ester 253331-89-4 C26H24N4O5S
    [[2-(phenylthio)-5-(aminooxoacetyl)-6-ethyl-7-(phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]acetic acid methyl ester
    —— 3-{[(5-chloro-thiophen-3-yl)methyl]thio}-6-ethyl-1,2,4-triazin-5(2H)-one 824983-29-1 C10H10ClN3OS2
    3-{[(5-chloro-thiophen-3-yl)methyl]thio}-6-ethyl-1,2,4-triazin-5(2H)-one
    —— 1-(6-methyl-pyridin-2-yl)-2-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone 673480-84-7 C13H13N3OS
    1-(6-methyl-pyridin-2-yl)-2-(2-methylsulfanyl-pyrimidin-4-yl)-ethanone
    —— 2-((4-chlorobenzyl)thio)-3-nitropyridine 878404-83-2 C12H9ClN2O2S
    2-((4-chlorobenzyl)thio)-3-nitropyridine
    —— 3-[(4-methyl-1,3-thiazol-2-yl)thio]thiophene-2-sulfonamide 900814-34-8 C8H8N2O2S4
    3-[(4-methyl-1,3-thiazol-2-yl)thio]thiophene-2-sulfonamide