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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— Methylglyoxal-<bis-(1,3-propylen)-dithioacetal> 53178-56-6 C9H16S4
    Methylglyoxal-<bis-(1,3-propylen)-dithioacetal>
    —— dimethyl-[[(N-methyl-C-methylsulfanylcarbonimidoyl)amino]methylidene]azanium;iodide 283168-65-0 C6H13N3S*HI
    dimethyl-[[(N-methyl-C-methylsulfanylcarbonimidoyl)amino]methylidene]azanium;iodide
    —— 4-benzyl-3-(benzylthio)-5-thien-2-yl-4H-1,2,4-triazole 139614-68-9 C20H17N3S2
    4-benzyl-3-(benzylthio)-5-thien-2-yl-4H-1,2,4-triazole
    —— 3,4-Dibromo-2-phenylsulfanyl-furan 505048-35-1 C10H6Br2OS
    3,4-Dibromo-2-phenylsulfanyl-furan
    —— (9S)-9-(tert-butyldiphenylsilyloxy)-8-(2-hydroxyethyl)-7-hydroxymethyl-1,5-dithiaspiro[5.4]dec-7-ene 769168-64-1 C27H36O3S2Si
    (9S)-9-(tert-butyldiphenylsilyloxy)-8-(2-hydroxyethyl)-7-hydroxymethyl-1,5-dithiaspiro[5.4]dec-7-ene
    —— Benzoic acid, 4-[[4-[(4,5-dihydro-1H-imidazol-2-yl)amino]phenyl]thio]- 677343-51-0 C16H15N3O2S
    Benzoic acid, 4-[[4-[(4,5-dihydro-1H-imidazol-2-yl)amino]phenyl]thio]-
    —— (+)-(4R)-4-[(1R)-2-Hydroxy-1-vinylethyl]-2,2-propanedithiocyclopentan-1-one 319906-95-1 C12H18O2S2
    (+)-(4R)-4-[(1R)-2-Hydroxy-1-vinylethyl]-2,2-propanedithiocyclopentan-1-one
    —— N<sup>4</sup>-allyl-6-(benzylsulfanyl)-2,4-diaminopyrimidine 674310-79-3 C14H16N4S
    N<sup>4</sup>-allyl-6-(benzylsulfanyl)-2,4-diaminopyrimidine
    —— Guanidine, N-[[4-[(4-chlorophenyl)thio]phenyl]methyl]-N'-ethyl- 677343-07-6 C16H18ClN3S
    Guanidine, N-[[4-[(4-chlorophenyl)thio]phenyl]methyl]-N'-ethyl-
    —— Guanidine, N,N'-diethyl-N''-[4-[(4-methoxyphenyl)thio]phenyl]- 677343-06-5 C18H23N3OS
    Guanidine, N,N'-diethyl-N''-[4-[(4-methoxyphenyl)thio]phenyl]-
    —— tert-butyl-diphenyl-[(Z)-2-pyridin-2-ylsulfanyl-2-tri(propan-2-yl)silyloxyethenoxy]silane 1000004-71-6 C32H45NO2SSi2
    tert-butyl-diphenyl-[(Z)-2-pyridin-2-ylsulfanyl-2-tri(propan-2-yl)silyloxyethenoxy]silane
    —— (1'R,2R,3R,4S,5S)-4-azido-2-(1'-hydroxy-2',2'-bis-phenylsulfanyl-ethyl)-5-methoxy-5-methyl-tetrahydro-pyran-3-ol 864941-71-9 C21H25N3O4S2
    (1'R,2R,3R,4S,5S)-4-azido-2-(1'-hydroxy-2',2'-bis-phenylsulfanyl-ethyl)-5-methoxy-5-methyl-tetrahydro-pyran-3-ol
    —— 1H-Imidazole, 4,5-dihydro-2-[4-[(4-methoxyphenyl)thio]phenyl]- 677343-16-7 C16H16N2OS
    1H-Imidazole, 4,5-dihydro-2-[4-[(4-methoxyphenyl)thio]phenyl]-
    —— 5-(2-Fluoro-phenyl)-6-methyl-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile 864370-24-1 C14H10FNO2S
    5-(2-Fluoro-phenyl)-6-methyl-4-methylsulfanyl-2-oxo-2H-pyran-3-carbonitrile
    —— (1-Difluoromethylene-butylsulfanyl)-benzene 161144-43-0 C11H12F2S
    (1-Difluoromethylene-butylsulfanyl)-benzene
    —— 6-benzenesulfanyl-2-heptyl-3,4-dihydro-2H-pyran 553670-66-9 C18H26OS
    6-benzenesulfanyl-2-heptyl-3,4-dihydro-2H-pyran
    —— 1H-Imidazole, 4,5-dihydro-2-[[4-[(4-methoxyphenyl)thio]phenyl]methyl]- 677343-14-5 C17H18N2OS
    1H-Imidazole, 4,5-dihydro-2-[[4-[(4-methoxyphenyl)thio]phenyl]methyl]-
    —— 19,25,31,36-Tetratert-butyl-40,41-dihydroxy-3,15-dioxa-6,8,10,12-tetrathiaheptacyclo[15.15.7.123,27.134,38.02,29.07,11.016,21]hentetraconta-1,7(11),16,18,20,23(41),24,26,29,31,34,36,38(40)-tridecaen-9-one 197228-57-2 C51H62O5S4
    19,25,31,36-Tetratert-butyl-40,41-dihydroxy-3,15-dioxa-6,8,10,12-tetrathiaheptacyclo[15.15.7.123,27.134,38.02,29.07,11.016,21]hentetraconta-1,7(11),16,18,20,23(41),24,26,29,31,34,36,38(40)-tridecaen-9-one
    —— 3-[4-(2-Dimethylcarbamoyl-phenylsulfanyl)-3-nitro-phenyl]-propionic acid methyl ester 627488-12-4 C19H20N2O5S
    3-[4-(2-Dimethylcarbamoyl-phenylsulfanyl)-3-nitro-phenyl]-propionic acid methyl ester
    —— (S)-(1-phenylethyl)-(2-phenylsulfenylcyclohex-1-enyl)amine 272787-49-2 C20H23NS
    (S)-(1-phenylethyl)-(2-phenylsulfenylcyclohex-1-enyl)amine
    —— 5-[2-(2-benzyloxyethyl)-3,5-diethyl-3H-imidazol-4-ylsulfanyl]-isophthalonitrile 868525-12-6 C24H24N4OS
    5-[2-(2-benzyloxyethyl)-3,5-diethyl-3H-imidazol-4-ylsulfanyl]-isophthalonitrile
    —— Ecg1qci7DB 757211-45-3 C20H20Cl2N4O3S
    Ecg1qci7DB
    —— 3-pentyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 86628-11-7 C15H18N4S
    3-pentyl-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— 2-Propylmercapto-ethyl-isothiocyanat 89676-98-2 C6H11NS2
    2-Propylmercapto-ethyl-isothiocyanat
    —— 2-acetyl-6,10-dithiaspiro[4,5]dec-2-ene 868764-58-3 C10H14OS2
    2-acetyl-6,10-dithiaspiro[4,5]dec-2-ene
    —— iodo(methylsulfonyl)methane 798568-07-7 C2H5IO2S
    iodo(methylsulfonyl)methane
    —— 4-phenyl-4-(phenylsulfanyl)deca-1,9-dien-5-one 878480-51-4 C22H24OS
    4-phenyl-4-(phenylsulfanyl)deca-1,9-dien-5-one
    —— intermediate 4 840537-43-1 C11H11FN4S
    intermediate 4
    —— (2R)-1-[2-[3-[tert-butyl(dimethyl)silyl]oxypropyl]-1,3-dithian-2-yl]propan-2-ol 900807-23-0 C16H34O2S2Si
    (2R)-1-[2-[3-[tert-butyl(dimethyl)silyl]oxypropyl]-1,3-dithian-2-yl]propan-2-ol
    —— Azathioprine Sodium 55774-33-9 C9H6N7NaO2S
    Azathioprine Sodium
    —— 2-(2-bromoethylthio)-1,4-difluorobenzene 426842-92-4 C8H7BrF2S
    2-(2-bromoethylthio)-1,4-difluorobenzene
    —— 2-Allylsulfanyl-propane-1,3-diol 136808-44-1 C6H12O2S
    2-Allylsulfanyl-propane-1,3-diol
    —— methyl 3-{6-[(2,4-difluorophenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}benzoate 876372-77-9 C20H13F2N3O2S
    methyl 3-{6-[(2,4-difluorophenyl)thio][1,2,4]triazolo[4,3-a]pyridin-3-yl}benzoate
    —— 2(1H)-Pyrimidinone, 1-cyclohexyl-4-(methylthio)- 92050-23-2 C11H16N2OS
    2(1H)-Pyrimidinone, 1-cyclohexyl-4-(methylthio)-
    —— 2-Propanethiol, 1,1'-thiobis[3-[(2-aminophenyl)thio]- 816445-60-0 C18H24N2S5
    2-Propanethiol, 1,1'-thiobis[3-[(2-aminophenyl)thio]-
    —— 3-pentyl-6-(4-bromophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 86628-13-9 C15H17BrN4S
    3-pentyl-6-(4-bromophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
    —— (4S,4aS,7R,7aR)-7-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-[2-[(2R,3S,4R)-2-(methoxymethoxy)-3-(2-methoxypropan-2-yl)-4-phenylsulfanyloxan-4-yl]-1,3-dithian-2-yl]-4,4a,7,7a-tetrahydro-3H-cyclopenta[b]pyran-2-one 897043-96-8 C36H56O7S3Si
    (4S,4aS,7R,7aR)-7-[[tert-butyl(dimethyl)silyl]oxymethyl]-4-[2-[(2R,3S,4R)-2-(methoxymethoxy)-3-(2-methoxypropan-2-yl)-4-phenylsulfanyloxan-4-yl]-1,3-dithian-2-yl]-4,4a,7,7a-tetrahydro-3H-cyclopenta[b]pyran-2-one
    —— (1S,3R,4R,8S)-8-Hydroxy-3-[(S)-hydroxy-((R)-2-phenyl-[1,3]dioxolan-4-yl)-methyl]-1-phenylsulfanyl-2-oxa-5-aza-bicyclo[2.2.2]octan-6-one 872120-64-4 C22H23NO6S
    (1S,3R,4R,8S)-8-Hydroxy-3-[(S)-hydroxy-((R)-2-phenyl-[1,3]dioxolan-4-yl)-methyl]-1-phenylsulfanyl-2-oxa-5-aza-bicyclo[2.2.2]octan-6-one
    —— N-[2-amino-6-(6-chinolinyl)-4-pyrimidinyl]-N-[3-fluoro-4-(4-pyridinylsulfanyl)phenyl] amine 637039-02-2 C24H17FN6S
    N-[2-amino-6-(6-chinolinyl)-4-pyrimidinyl]-N-[3-fluoro-4-(4-pyridinylsulfanyl)phenyl] amine
    —— 1-phenyl-1-(phenylsulfanyl)hept-6-en-2-one 878480-44-5 C19H20OS
    1-phenyl-1-(phenylsulfanyl)hept-6-en-2-one
    —— (2,2-Dimethoxy-5,5-dimethylcyclohexyl)sulfanylbenzene 905294-35-1 C16H24O2S
    (2,2-Dimethoxy-5,5-dimethylcyclohexyl)sulfanylbenzene
    —— 2-amino-6-phenylsulfanylpyridine-3,5-dicarbonitrile 141987-67-9 C13H8N4S
    2-amino-6-phenylsulfanylpyridine-3,5-dicarbonitrile
    —— 2-phenyl-2-(phenylsulfanyl)cyclohept-4-enone 878480-53-6 C19H18OS
    2-phenyl-2-(phenylsulfanyl)cyclohept-4-enone
    —— 2-(4-methylphenyl)-2-(phenylsulfanyl)cyclohept-4-enone 878480-56-9 C20H20OS
    2-(4-methylphenyl)-2-(phenylsulfanyl)cyclohept-4-enone
    —— (4R,6S)-4-(tert-butyldimethylsilyloxy)-6-methyl-6-phenylthiocyclohex-2-enone 887404-58-2 C19H28O2SSi
    (4R,6S)-4-(tert-butyldimethylsilyloxy)-6-methyl-6-phenylthiocyclohex-2-enone
    —— (4R,6R)-4-(tert-butyldimethylsilyloxy)-6-methyl-6-phenylthiocyclohex-2-enone 887404-57-1 C19H28O2SSi
    (4R,6R)-4-(tert-butyldimethylsilyloxy)-6-methyl-6-phenylthiocyclohex-2-enone
    —— 1-(o-ethylthiobenzyl)-4,5-dimethylimidazol-2(3H)-one 873193-41-0 C14H18N2OS
    1-(o-ethylthiobenzyl)-4,5-dimethylimidazol-2(3H)-one
    —— [5-(4-methylsulfanyl-phenyl)-pyrazin-2-yl]-(2-pyridin-4-yl-ethyl)-amine 821783-96-4 C18H18N4S
    [5-(4-methylsulfanyl-phenyl)-pyrazin-2-yl]-(2-pyridin-4-yl-ethyl)-amine
    —— 1,1,3,3-Propanetetrathiol 577778-15-5 C3H8S4
    1,1,3,3-Propanetetrathiol
    —— 6-[(2,4-difluorophenyl)thio]-3-isopropyl-5-methyl[1,2,4]triazolo[4,3-a]pyridine 876372-50-8 C16H15F2N3S
    6-[(2,4-difluorophenyl)thio]-3-isopropyl-5-methyl[1,2,4]triazolo[4,3-a]pyridine