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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 4-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide 1380333-95-8 C23H20ClN5O2S
    4-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide
    —— N-(4-nitrophenyl)-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine 1380334-06-4 C22H20N6O3S
    N-(4-nitrophenyl)-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine
    —— N-methyl-4-(4-(3-(4-(trifluoromethoxy)phenyl)thioureido)phenylthio)picolinamide 1417344-65-0 C21H17F3N4O2S2
    N-methyl-4-(4-(3-(4-(trifluoromethoxy)phenyl)thioureido)phenylthio)picolinamide
    —— 5-bromo-6-(methylthio)-2-(1H-pyrazol-1-yl)pyrimidin-4-amine 1337962-98-7 C8H8BrN5S
    5-bromo-6-(methylthio)-2-(1H-pyrazol-1-yl)pyrimidin-4-amine
    —— N-(4-methoxyphenyl)-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine 1380334-04-2 C23H23N5O2S
    N-(4-methoxyphenyl)-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine
    —— ethyl [[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]acetate 666752-81-4 C18H21F2N3O4S2
    ethyl [[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]acetate
    —— N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide 1380333-88-9 C23H21N5O2S
    N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide
    —— 4-methyl-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide 1380333-93-6 C24H23N5O2S
    4-methyl-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide
    —— 2-ethylsulfanyl-6-isopropyl-4H-thiopyran-4-one 935700-39-3 C10H14OS2
    2-ethylsulfanyl-6-isopropyl-4H-thiopyran-4-one
    —— N-(3-nitrophenyl)-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine 1380334-05-3 C22H20N6O3S
    N-(3-nitrophenyl)-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine
    —— 3-nitro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide 1380333-91-4 C23H20N6O4S
    3-nitro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide
    —— N-phenyl-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine 1380334-03-1 C22H21N5OS
    N-phenyl-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine
    —— 3-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide 1380333-94-7 C23H20ClN5O2S
    3-chloro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide
    —— N-benzyl-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine 1380334-09-7 C23H23N5OS
    N-benzyl-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine
    —— 4-fluoro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide 1380333-97-0 C23H20FN5O2S
    4-fluoro-N-(6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-yl)benzamide
    —— 6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-N-p-tolyl-9H-purin-8-amine 1380334-08-6 C23H23N5OS
    6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-N-p-tolyl-9H-purin-8-amine
    —— 2-[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]-N-[2-(dimethylamino)ethyl]acetamide 666752-83-6 C20H27F2N5O3S2
    2-[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]-N-[2-(dimethylamino)ethyl]acetamide
    —— N-(4-fluorophenyl)-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine 1380334-07-5 C22H20FN5OS
    N-(4-fluorophenyl)-6-(phenylthio)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-8-amine
    —— 1-[[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]acetyl]piperazine 666752-84-7 C20H25F2N5O3S2
    1-[[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]acetyl]piperazine
    —— 7-nitro-1,1-dioxo-N-phenyl-1lambda6,4,2-benzodithiazin-3-amine 379726-12-2 C13H9N3O4S2
    7-nitro-1,1-dioxo-N-phenyl-1lambda6,4,2-benzodithiazin-3-amine
    —— 2-[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]-N-methyl-acetamide 666752-82-5 C17H20F2N4O3S2
    2-[[2-[[(2,3-difluorophenyl)methyl]thio]-4-hydroxy-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-pyrimidinyl]thio]-N-methyl-acetamide
    —— 4-Chloro-N-[2,2-dichloro-1-(4-chloro-phenylsulfanyl)-ethyl]-thiobenzamide 130775-23-4 C15H11Cl4NS2
    4-Chloro-N-[2,2-dichloro-1-(4-chloro-phenylsulfanyl)-ethyl]-thiobenzamide
    —— bis-(1-dimethylsulphamoyl-2-phenylthioimidazol-5-yl)methanol 123914-20-5 C23H26N6O5S4
    bis-(1-dimethylsulphamoyl-2-phenylthioimidazol-5-yl)methanol
    —— bis-chloroacetyl-sulfane 819-95-4 C4H4Cl2O2S
    bis-chloroacetyl-sulfane
    —— tert-butyl N-(3-phenylthio-3-butenyl)-N-(2-furyl)carbamate 226710-84-5 C19H23NO3S
    tert-butyl N-(3-phenylthio-3-butenyl)-N-(2-furyl)carbamate
    —— 2,4,6-trichloro-5-phenylthiopyrimidine 183811-00-9 C10H5Cl3N2S
    2,4,6-trichloro-5-phenylthiopyrimidine
    —— 1-[1,2-Bis[(2,3,4,5,6-pentafluorophenyl)sulfanyl]-2-phenylethenyl]sulfanyl-2,3,4,5,6-pentafluorobenzene 129537-81-1 C26H5F15S3
    1-[1,2-Bis[(2,3,4,5,6-pentafluorophenyl)sulfanyl]-2-phenylethenyl]sulfanyl-2,3,4,5,6-pentafluorobenzene
    —— 4-[2-[2-(2-Morpholin-4-ylethylsulfanyl)pyrimidin-4-yl]sulfanylethyl]morpholine 95264-03-2 C16H26N4O2S2
    4-[2-[2-(2-Morpholin-4-ylethylsulfanyl)pyrimidin-4-yl]sulfanylethyl]morpholine
    —— 1-(Benzylsulfanyl)-4-isothiocyanatobenzene 19457-05-7 C14H11NS2
    1-(Benzylsulfanyl)-4-isothiocyanatobenzene
    —— Formamide, N-[2-methyl-1-(phenylthio)propyl]- 109053-99-8 C11H15NOS
    Formamide, N-[2-methyl-1-(phenylthio)propyl]-
    —— 7-(4-methylsulfanylphenyl)-5-thiophen-2-yl-1,7-dihydrotetrazolo[1,5-a]pyrimidine —— C15H13N5S2
    7-(4-methylsulfanylphenyl)-5-thiophen-2-yl-1,7-dihydrotetrazolo[1,5-a]pyrimidine
    —— Cyclohexenyl-(1)-butylsulfon 22598-76-1 C10H18O2S
    Cyclohexenyl-(1)-butylsulfon
    —— 1-(4-methylsulfanylphenyl)-N-phenylmethanimine oxide 59699-27-3 C14H13NOS
    1-(4-methylsulfanylphenyl)-N-phenylmethanimine oxide
    —— 3-hydroxy-4-(methylamino)-1-methoxy-1-(phenylthio)butane 127915-72-4 C12H19NO2S
    3-hydroxy-4-(methylamino)-1-methoxy-1-(phenylthio)butane
    —— 3,4-dihydro-2-phenyl-2H-1,6-benzothiazocin-5(6H)-thione 89569-00-6 C16H15NS2
    3,4-dihydro-2-phenyl-2H-1,6-benzothiazocin-5(6H)-thione
    —— 3,4-dihydro-5-methylamino-2-phenyl-2H-1,6-benzothiazocine 89569-08-4 C17H18N2S
    3,4-dihydro-5-methylamino-2-phenyl-2H-1,6-benzothiazocine
    —— 1-ethyl 3-(methylthio)indeno[2,1-e][4,1,2]oxadiazine9(1H)-one 1144163-64-3 C13H12N2O2S
    1-ethyl 3-(methylthio)indeno[2,1-e][4,1,2]oxadiazine9(1H)-one
    —— 4((3-(((1,1-dimethylethyl)dimethylsilyl)oxy)-1-propenyl)thio)benzenamine 287171-45-3 C15H25NOSSi
    4((3-(((1,1-dimethylethyl)dimethylsilyl)oxy)-1-propenyl)thio)benzenamine
    —— 4-Benzylsulfanyl-5-chloro-2-methylpyridazin-3-one 25818-68-2 C12H11ClN2OS
    4-Benzylsulfanyl-5-chloro-2-methylpyridazin-3-one
    —— 2-Methyl-3-oxo-5,5a,6,7-tetrahydro-2H,8H-pyridazino<4,5-b>pyrrolo<1,2-d><1,4>thiazine 134330-83-9 C10H13N3OS
    2-Methyl-3-oxo-5,5a,6,7-tetrahydro-2H,8H-pyridazino<4,5-b>pyrrolo<1,2-d><1,4>thiazine
    —— 1-(azepan-1-yl)-3-(4-chlorophenylthio)propan-2-ol 1388758-82-4 C15H22ClNOS
    1-(azepan-1-yl)-3-(4-chlorophenylthio)propan-2-ol
    —— (2S,3S)-3-(tert-butoxycarbonylamino)-6-(tert-butyldimethylsiloxy)-1-phenylthio-2-hexanol 799559-97-0 C23H41NO4SSi
    (2S,3S)-3-(tert-butoxycarbonylamino)-6-(tert-butyldimethylsiloxy)-1-phenylthio-2-hexanol
    —— 5-methyl-2-(methylthio)pyrimidine-4,6-diol 27870-37-7 C6H8N2O2S
    5-methyl-2-(methylthio)pyrimidine-4,6-diol
    —— N-methyl-3,3-dimethyl-4-phenylthiopyrrolidine-2,5-dione 87216-32-8 C13H15NO2S
    N-methyl-3,3-dimethyl-4-phenylthiopyrrolidine-2,5-dione
    —— N-methyl-3,3-dimethyl-4,4-di(phenylthio)-pyrrolidine-2,5-dione 87216-33-9 C19H19NO2S2
    N-methyl-3,3-dimethyl-4,4-di(phenylthio)-pyrrolidine-2,5-dione
    —— 2,4-dicyano-5-methylthio-3-phenylthiothiophene 116170-88-8 C13H8N2S3
    2,4-dicyano-5-methylthio-3-phenylthiothiophene
    —— 1-(azepan-1-yl)-3-(3,5-dimethylphenylthio)propan-2-ol 1388758-84-6 C17H27NOS
    1-(azepan-1-yl)-3-(3,5-dimethylphenylthio)propan-2-ol
    —— 1-(azepan-1-yl)-3-(phenylthio)propan-2-ol 1388758-79-9 C15H23NOS
    1-(azepan-1-yl)-3-(phenylthio)propan-2-ol
    —— 1,2-Dichloro-1,2-bis(ethylsulfonyl)ethene 90429-52-0 C6H10Cl2O4S2
    1,2-Dichloro-1,2-bis(ethylsulfonyl)ethene
    —— 3-Butyryl-1-methylthio-5,6,7,8-tetrahydroisoquinoline 188251-47-0 C14H19NOS
    3-Butyryl-1-methylthio-5,6,7,8-tetrahydroisoquinoline