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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 5-chloro-4-(methoxymethyl)-6-methyl-2-(methylsulfanyl)pyrimidine 1374134-62-9 C8H11ClN2OS
    5-chloro-4-(methoxymethyl)-6-methyl-2-(methylsulfanyl)pyrimidine
    —— (E)-4-Amino-3-(but-2-enylthio)-5-methyl-4H-1,2,4-triazole 341520-12-5 C7H12N4S
    (E)-4-Amino-3-(but-2-enylthio)-5-methyl-4H-1,2,4-triazole
    —— 5-chloro-6-(methoxymethyl)-2-(methylsulfanyl)pyrimidin-4-yl trifluoromethanesulfonate 1374134-61-8 C8H8ClF3N2O4S2
    5-chloro-6-(methoxymethyl)-2-(methylsulfanyl)pyrimidin-4-yl trifluoromethanesulfonate
    —— 3-methyl-4,4-bis(phenylthio)-1-butene 133817-99-9 C17H18S2
    3-methyl-4,4-bis(phenylthio)-1-butene
    —— 3-(2-furyl)-4,5-dihydrothiazolo<2,3-c>triazole 72647-25-7 C8H7N3OS
    3-(2-furyl)-4,5-dihydrothiazolo<2,3-c>triazole
    —— 2-phenyl-1,3-benzodithian-4-thione 77586-88-0 C14H10S3
    2-phenyl-1,3-benzodithian-4-thione
    —— 2-(2,6-dimethyl-phenylsulfanyl)-4,5-dihydro-thiazole 55545-16-9 C11H13NS2
    2-(2,6-dimethyl-phenylsulfanyl)-4,5-dihydro-thiazole
    —— N-(dicyclopropylmethyl)N'-(β-chloroethyl) thiourea 54187-05-2 C10H17ClN2S
    N-(dicyclopropylmethyl)N'-(β-chloroethyl) thiourea
    —— N-(2-[(2,3-difluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)morpholine-4-sulfonamide 654074-09-6 C18H23F2N5O4S2
    N-(2-[(2,3-difluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)morpholine-4-sulfonamide
    —— aziridine-1-thiocarbonyl chloride 13163-21-8 C3H4ClNS
    aziridine-1-thiocarbonyl chloride
    —— methyl β-methyl-α-phenylthiocrotonate 66716-63-0 C12H14O2S
    methyl β-methyl-α-phenylthiocrotonate
    —— 1-[(4R)-4-(hydroxymethyl)-2,2-dimethyl-1,3-oxazolidin-3-yl]-2-phenylsulfanylethanone 371229-55-9 C14H19NO3S
    1-[(4R)-4-(hydroxymethyl)-2,2-dimethyl-1,3-oxazolidin-3-yl]-2-phenylsulfanylethanone
    —— (2RS,3RS)-methyl 3-hydroxy-2-(phenylthio)benzenepropanoate 66716-32-3 C16H16O3S
    (2RS,3RS)-methyl 3-hydroxy-2-(phenylthio)benzenepropanoate
    —— 1-[(4S)-4-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dimethyl-1,3-oxazolidin-3-yl]-2-phenylsulfanylethanone 371229-56-0 C20H33NO3SSi
    1-[(4S)-4-[[tert-butyl(dimethyl)silyl]oxymethyl]-2,2-dimethyl-1,3-oxazolidin-3-yl]-2-phenylsulfanylethanone
    —— Methyl (2R,3R,4S)-<5-oxo-4-(phenylthio)-2-propyltetrahydrofuran-3-yl>acetate 134829-40-6 C16H20O4S
    Methyl (2R,3R,4S)-<5-oxo-4-(phenylthio)-2-propyltetrahydrofuran-3-yl>acetate
    —— 1-[(4S)-4-benzyl-2,2-dimethyl-1,3-oxazolidin-3-yl]-2-phenylsulfanylethanone 466690-05-1 C20H23NO2S
    1-[(4S)-4-benzyl-2,2-dimethyl-1,3-oxazolidin-3-yl]-2-phenylsulfanylethanone
    —— 2-(5-bromo-1-phenylsulfanylpentyl)-4,4-dimethyl-5H-1,3-oxazole 115492-35-8 C16H22BrNOS
    2-(5-bromo-1-phenylsulfanylpentyl)-4,4-dimethyl-5H-1,3-oxazole
    —— 2,4-Dichloro-6-pyridin-2-ylsulfanyl-1,3,5-triazine 160697-97-2 C8H4Cl2N4S
    2,4-Dichloro-6-pyridin-2-ylsulfanyl-1,3,5-triazine
    —— phenylsulfanyl-acetic acid 2-morpholin-4-yl-ethyl ester 35859-05-3 C14H19NO3S
    phenylsulfanyl-acetic acid 2-morpholin-4-yl-ethyl ester
    —— (1R)-1-methyl-2-oxopropyl (phenylthio)acetate 165544-64-9 C12H14O3S
    (1R)-1-methyl-2-oxopropyl (phenylthio)acetate
    —— 3-Hydroxy-4,4-dimethyl-2-phenylsulfanylpentanoic acid 114094-14-3 C13H18O3S
    3-Hydroxy-4,4-dimethyl-2-phenylsulfanylpentanoic acid
    —— 2,6-dimethyl-4-(heptafluoro-n-propylthio)aniline 847622-74-6 C11H10F7NS
    2,6-dimethyl-4-(heptafluoro-n-propylthio)aniline
    —— (Z)-2-(4-methylbenzylidene)benzo[b]thiophen-3(2H)-one 97871-93-7 C16H12OS
    (Z)-2-(4-methylbenzylidene)benzo[b]thiophen-3(2H)-one
    —— 2-[4-(dimethylamino)benzylidene]-1-benzothiophen-3(2H)-one 101000-94-6 C17H15NOS
    2-[4-(dimethylamino)benzylidene]-1-benzothiophen-3(2H)-one
    —— (S,E)-3-(phenylthio)-3,4,7,8,9,10-hexahydroazecin-2(1H)-one 1394135-98-8 C15H19NOS
    (S,E)-3-(phenylthio)-3,4,7,8,9,10-hexahydroazecin-2(1H)-one
    —— (1R)-1-<(1S)-1,2-Dihydroxy-1-methylethyl>heptyl (phenylthio)acetate 162264-79-1 C18H28O4S
    (1R)-1-<(1S)-1,2-Dihydroxy-1-methylethyl>heptyl (phenylthio)acetate
    —— 2,6-dibromo-4-(heptafluoro-n-propylthio)aniline 847622-69-9 C9H4Br2F7NS
    2,6-dibromo-4-(heptafluoro-n-propylthio)aniline
    —— (Z)-2-(4-bromobenzylidene)benzo[b]thiophen-3(2H)-one 101000-97-9 C15H9BrOS
    (Z)-2-(4-bromobenzylidene)benzo[b]thiophen-3(2H)-one
    —— 1-nitro-1-(phenylthio)-2-propanol 67808-90-6 C9H11NO3S
    1-nitro-1-(phenylthio)-2-propanol
    —— 2-[4-(dimethylamino)benzylidene]-1-benzothiophen-3(2H)-one 942434-36-8 C17H15NOS
    2-[4-(dimethylamino)benzylidene]-1-benzothiophen-3(2H)-one
    —— deuteriomethylsulfanyl-benzene 64732-79-2 C7H8S
    deuteriomethylsulfanyl-benzene
    —— (3S,4S)-4-tert-Butyl-3-phenylsulfanyl-oxetan-2-one 114059-26-6 C13H16O2S
    (3S,4S)-4-tert-Butyl-3-phenylsulfanyl-oxetan-2-one
    —— 2-furfurylidene-benzo[<i>b</i>]thiophen-3-one 3407-14-5 C13H8O2S
    2-furfurylidene-benzo[<i>b</i>]thiophen-3-one
    —— (2E)-2-(2-furylmethylene)-1'-benzothiophen-3(2H)-one 1006603-24-2 C13H8O2S
    (2E)-2-(2-furylmethylene)-1'-benzothiophen-3(2H)-one
    —— N-[2-(diethylamino)ethyl]-2-phenylsulfanylacetamide 35859-07-5 C14H22N2OS
    N-[2-(diethylamino)ethyl]-2-phenylsulfanylacetamide
    —— 1-(hydroxymethyl)-1-(phenylsulfenyl)cyclopentane 57557-47-8 C12H16OS
    1-(hydroxymethyl)-1-(phenylsulfenyl)cyclopentane
    —— (Phenylthio)acetic acid 2-(dimethylamino)-1-methylethyl ester 35859-03-1 C13H19NO2S
    (Phenylthio)acetic acid 2-(dimethylamino)-1-methylethyl ester
    —— 2-(Dimethylamino)ethyl 2-phenylsulfanylacetate 35859-01-9 C12H17NO2S
    2-(Dimethylamino)ethyl 2-phenylsulfanylacetate
    —— 2-(Diethylamino)ethyl 2-phenylsulfanylacetate 35859-02-0 C14H21NO2S
    2-(Diethylamino)ethyl 2-phenylsulfanylacetate
    —— 2-(2-Oxocyclohexyl)-2-phenylsulfanylacetic acid 344440-96-6 C14H16O3S
    2-(2-Oxocyclohexyl)-2-phenylsulfanylacetic acid
    —— (4R)-2,2-dimethyl-3-(2-phenylsulfanylacetyl)-1,3-oxazolidine-4-carbaldehyde 1025965-41-6 C14H17NO3S
    (4R)-2,2-dimethyl-3-(2-phenylsulfanylacetyl)-1,3-oxazolidine-4-carbaldehyde
    —— ethyl (S)-3-<(phenylthioacetyl)pyrrolidin-2-yl>propenoate 146405-66-5 C17H21NO3S
    ethyl (S)-3-<(phenylthioacetyl)pyrrolidin-2-yl>propenoate
    —— (2S)-1-(2-phenylsulfanylacetyl)pyrrolidine-2-carbaldehyde 122030-56-2 C13H15NO2S
    (2S)-1-(2-phenylsulfanylacetyl)pyrrolidine-2-carbaldehyde
    —— N-[2-(dimethylamino)ethyl]-2-phenylsulfanylacetamide 35859-06-4 C12H18N2OS
    N-[2-(dimethylamino)ethyl]-2-phenylsulfanylacetamide
    —— 2-furyl phenylthiomethyl ketone 122657-58-3 C12H10O2S
    2-furyl phenylthiomethyl ketone
    —— vinyl 2-(phenylthio)acetate 1173105-42-4 C10H10O2S
    vinyl 2-(phenylthio)acetate
    —— tert-butyl (6S,7R,7aS)-5,6,7,7a-tetrahydro-3,3-dimethyl-5-oxo-6-phenylthio-1H,3H-pyrrolo<1,2-c>oxazol-7-ylacetate 161644-50-4 C20H27NO4S
    tert-butyl (6S,7R,7aS)-5,6,7,7a-tetrahydro-3,3-dimethyl-5-oxo-6-phenylthio-1H,3H-pyrrolo<1,2-c>oxazol-7-ylacetate
    —— [(4R)-9-fluoro-1,1-dioxo-2-prop-2-enyl-3,4-dihydro-5,1lambda6,2-benzoxathiazepin-4-yl]methyl 2-phenylsulfanylacetate 1216844-77-7 C20H20FNO5S2
    [(4R)-9-fluoro-1,1-dioxo-2-prop-2-enyl-3,4-dihydro-5,1lambda6,2-benzoxathiazepin-4-yl]methyl 2-phenylsulfanylacetate
    —— 2,3-Dihydroxypropyl (phenylthio)acetate 168258-00-2 C11H14O4S
    2,3-Dihydroxypropyl (phenylthio)acetate
    —— tert-butyl-2-chloro-2-(phenylthio)acetate 135996-01-9 C12H15ClO2S
    tert-butyl-2-chloro-2-(phenylthio)acetate