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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— tert-butyl-2-{[4-({(6-chloropyrimidm-4-yl)[(2-methyl-1,3-thiazol-4-yl)methyl]amino}methyl)-phenyl]thio}-2-methylpropanoate 881687-58-7 C24H29ClN4O2S2
    tert-butyl-2-{[4-({(6-chloropyrimidm-4-yl)[(2-methyl-1,3-thiazol-4-yl)methyl]amino}methyl)-phenyl]thio}-2-methylpropanoate
    —— tert-butyl-2-{[4-({[6-(cyclohexyloxy)pyrimidin-4-yl][(3,5-dimethylisoxazol-4-yl)methyl]amino}-methyl)phenyl]thio}-2-methylpropanoate 881687-56-5 C31H42N4O4S
    tert-butyl-2-{[4-({[6-(cyclohexyloxy)pyrimidin-4-yl][(3,5-dimethylisoxazol-4-yl)methyl]amino}-methyl)phenyl]thio}-2-methylpropanoate
    —— 4'-[(3-benzyloxy)phenylthio]-2'-chlorodihydrocinnamyl alcohol 676482-21-6 C22H21ClO2S
    4'-[(3-benzyloxy)phenylthio]-2'-chlorodihydrocinnamyl alcohol
    —— (R)-2-(3-chloro-4-cyclopropylsulfanyl-phenyl)-3-(tetrahydropyran-4-yl)-propionic acid 936362-93-5 C17H21ClO3S
    (R)-2-(3-chloro-4-cyclopropylsulfanyl-phenyl)-3-(tetrahydropyran-4-yl)-propionic acid
    —— tert-butyl N-[2-[2-amino-5-(2-oxopyridin-1-yl)phenyl]sulfanylethyl]carbamate 1039517-27-5 C18H23N3O3S
    tert-butyl N-[2-[2-amino-5-(2-oxopyridin-1-yl)phenyl]sulfanylethyl]carbamate
    —— (3aR,4S,7R,7aS)-7-[(5-amino-6-chloro-2-propylsulfanylpyrimidin-4-yl)amino]-2,2-dimethyl-3a,4,7,7a-tetrahydro-1,3-benzodioxol-4-ol 1022927-14-5 C16H23ClN4O3S
    (3aR,4S,7R,7aS)-7-[(5-amino-6-chloro-2-propylsulfanylpyrimidin-4-yl)amino]-2,2-dimethyl-3a,4,7,7a-tetrahydro-1,3-benzodioxol-4-ol
    —— {[4-(Phenylsulfanyl)phenyl]sulfanyl}acetic acid 152171-23-8 C14H12O2S2
    {[4-(Phenylsulfanyl)phenyl]sulfanyl}acetic acid
    —— 1,2-Di(ethenesulfonyl)ethan-1-ol 172650-62-3 C6H10O5S2
    1,2-Di(ethenesulfonyl)ethan-1-ol
    —— 6-methyl-4-(4-methylthio)phenyl-pyran-2-one 387866-30-0 C13H12O2S
    6-methyl-4-(4-methylthio)phenyl-pyran-2-one
    —— di(4-hydroxybut-2-ynyl)sulfone 122951-66-0 C8H10O4S
    di(4-hydroxybut-2-ynyl)sulfone
    —— 2,5-Dihydro-4-[4-(methylthio)phenyl]-2-[(trimethylsilyl)oxy]furan 179175-16-7 C14H20O2SSi
    2,5-Dihydro-4-[4-(methylthio)phenyl]-2-[(trimethylsilyl)oxy]furan
    —— Pyridazine, 6-[[(4-fluorophenyl)methyl]thio]-4-methoxy-3-methyl- 528878-34-4 C13H13FN2OS
    Pyridazine, 6-[[(4-fluorophenyl)methyl]thio]-4-methoxy-3-methyl-
    —— 1H-1,2,3-Triazole-4-methanamine, 1-[2-[(4-fluorophenyl)thio]ethyl]-N-methyl- 1481252-52-1 C12H15FN4S
    1H-1,2,3-Triazole-4-methanamine, 1-[2-[(4-fluorophenyl)thio]ethyl]-N-methyl-
    —— Propanoic acid, 2-[[1-[2-(ethylamino)ethyl]-1H-tetrazol-5-yl]thio]- 1479801-25-6 C8H15N5O2S
    Propanoic acid, 2-[[1-[2-(ethylamino)ethyl]-1H-tetrazol-5-yl]thio]-
    —— 1,2,4-Thiadiazol-5-amine, N-ethyl-3-[[(3-fluorophenyl)thio]methyl]- 1478590-05-4 C11H12FN3S2
    1,2,4-Thiadiazol-5-amine, N-ethyl-3-[[(3-fluorophenyl)thio]methyl]-
    —— Pyrimidine, 4-chloro-2-[[(2-chlorophenyl)thio]methyl]-6-cyclopropyl- 1492530-76-3 C14H12Cl2N2S
    Pyrimidine, 4-chloro-2-[[(2-chlorophenyl)thio]methyl]-6-cyclopropyl-
    —— 1-[(2-Aminoethyl)thio]-2-propanamine 23185-28-6 C5H14N2S
    1-[(2-Aminoethyl)thio]-2-propanamine
    —— Cyclohexanemethanamine, I+/--[[(4-fluorophenyl)thio]methyl]-N,4-dimethyl- 1493550-87-0 C16H24FNS
    Cyclohexanemethanamine, I+/--[[(4-fluorophenyl)thio]methyl]-N,4-dimethyl-
    —— Methyl 2-[(4-chlorophenyl)sulfanyl]ethanimidate 61671-49-6 C9H10ClNOS
    Methyl 2-[(4-chlorophenyl)sulfanyl]ethanimidate
    —— Bicyclo[4.2.0]octa-1,3,5-triene-7-ethanamine, I+/--[[(2-bromophenyl)thio]methyl]- 1533077-08-5 C17H18BrNS
    Bicyclo[4.2.0]octa-1,3,5-triene-7-ethanamine, I+/--[[(2-bromophenyl)thio]methyl]-
    —— (I+/-S)-3-(Methylthio)-I+/--(trifluoromethyl)benzenemethanamine 878539-33-4 C9H10F3NS
    (I+/-S)-3-(Methylthio)-I+/--(trifluoromethyl)benzenemethanamine
    —— (R)-1-(2-Methylsulfanyl-pyrimidin-4-yl)-pyrrolidin-3-ol 1261234-25-6 C9H13N3OS
    (R)-1-(2-Methylsulfanyl-pyrimidin-4-yl)-pyrrolidin-3-ol
    —— (1S)-1-[4-[(Trifluoromethyl)thio]phenyl]-1,2-ethanediamine 1213057-21-6 C9H11F3N2S
    (1S)-1-[4-[(Trifluoromethyl)thio]phenyl]-1,2-ethanediamine
    —— 11-Methyl-5-nitro-2-thia-10,13-diazatricyclo[13.4.0.03,8]nonadeca-1(19),3(8),4,6,15,17-hexaene-9,14-dione 1393085-59-0 C17H15N3O4S
    11-Methyl-5-nitro-2-thia-10,13-diazatricyclo[13.4.0.03,8]nonadeca-1(19),3(8),4,6,15,17-hexaene-9,14-dione
    —— 1-(6-Methoxy-2-(methylthio)pyrimidin-4-yl)azetidine-3-carboxylic acid 1353977-93-1 C10H13N3O3S
    1-(6-Methoxy-2-(methylthio)pyrimidin-4-yl)azetidine-3-carboxylic acid
    —— 2-Chloro-N-ethyl-N-(4-methylsulfanyl-benzyl)-acetamide 1353983-04-6 C12H16ClNOS
    2-Chloro-N-ethyl-N-(4-methylsulfanyl-benzyl)-acetamide
    —— 2-(((4-Fluorophenyl)thio)methyl)pyrrolidine hydrochloride 1353989-69-1 C11H15ClFNS
    2-(((4-Fluorophenyl)thio)methyl)pyrrolidine hydrochloride
    —— 6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-2-N,4-N-bis(4-nitrophenyl)-1,3,5-triazine-2,4-diamine 1408322-25-7 C28H24N12O4S2
    6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-2-N,4-N-bis(4-nitrophenyl)-1,3,5-triazine-2,4-diamine
    —— 1-(6-Methoxy-2-(methylthio)pyrimidin-4-yl)piperidin-4-ol 1353979-87-9 C11H17N3O2S
    1-(6-Methoxy-2-(methylthio)pyrimidin-4-yl)piperidin-4-ol
    —— 1-(6-Ethoxy-2-(methylthio)pyrimidin-4-yl)piperidin-3-ol 1353954-83-2 C12H19N3O2S
    1-(6-Ethoxy-2-(methylthio)pyrimidin-4-yl)piperidin-3-ol
    —— 2-(((4-Chlorophenyl)thio)methyl)pyrrolidine hydrochloride 1353945-59-1 C11H15Cl2NS
    2-(((4-Chlorophenyl)thio)methyl)pyrrolidine hydrochloride
    —— (R)-1-(6-Ethoxy-2-(methylthio)pyrimidin-4-yl)pyrrolidin-3-ol 1354019-51-4 C11H17N3O2S
    (R)-1-(6-Ethoxy-2-(methylthio)pyrimidin-4-yl)pyrrolidin-3-ol
    —— 6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-2-N,4-N-bis(4-fluorophenyl)-1,3,5-triazine-2,4-diamine 1408322-22-4 C28H24F2N10S2
    6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-2-N,4-N-bis(4-fluorophenyl)-1,3,5-triazine-2,4-diamine
    —— 6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-2-N,4-N-bis(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine 1408322-24-6 C30H30N10O2S2
    6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-2-N,4-N-bis(4-methoxyphenyl)-1,3,5-triazine-2,4-diamine
    —— [1-<sup>14</sup>C]-(R)-2-(2-amino-5-((S)-1-phenylethylthio)thiazolo[4,5-d]pyrimidin-7-ylamino)-4-methylpentan-1-ol 1403762-04-8 C19H25N5OS2
    [1-<sup>14</sup>C]-(R)-2-(2-amino-5-((S)-1-phenylethylthio)thiazolo[4,5-d]pyrimidin-7-ylamino)-4-methylpentan-1-ol
    —— 2-N,4-N-bis(4-bromophenyl)-6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-1,3,5-triazine-2,4-diamine 1408322-21-3 C28H24Br2N10S2
    2-N,4-N-bis(4-bromophenyl)-6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-1,3,5-triazine-2,4-diamine
    —— 6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-2-N,4-N-bis(4-methylphenyl)-1,3,5-triazine-2,4-diamine 1408322-23-5 C30H30N10S2
    6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-2-N,4-N-bis(4-methylphenyl)-1,3,5-triazine-2,4-diamine
    —— 2-N,4-N-bis(4-chlorophenyl)-6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-1,3,5-triazine-2,4-diamine 1408322-20-2 C28H24Cl2N10S2
    2-N,4-N-bis(4-chlorophenyl)-6-[[5-[(3,5-dimethyl-2-phenyl-3,4-dihydropyrazol-4-yl)amino]-1,3,4-thiadiazol-2-yl]sulfanyl]-1,3,5-triazine-2,4-diamine
    —— 4-[3-({4-[(2E)-3-(dimethylamino)prop-2-enoyl]-2-fluorophenyl}thio)phenyl]tetrahydro-2H-pyran-4-carboxamide 1159186-46-5 C23H25FN2O3S
    4-[3-({4-[(2E)-3-(dimethylamino)prop-2-enoyl]-2-fluorophenyl}thio)phenyl]tetrahydro-2H-pyran-4-carboxamide
    —— (4-chloro-3-trifluoromethylsulfanyl-phenyl)-piperidin-4-yl-amine hydrochloride 1247029-13-5 C12H14ClF3N2S*ClH
    (4-chloro-3-trifluoromethylsulfanyl-phenyl)-piperidin-4-yl-amine hydrochloride
    —— (4-bromo-2-fluoro-5-methylphenyl)(methyl)sulfane 1011460-51-7 C8H8BrFS
    (4-bromo-2-fluoro-5-methylphenyl)(methyl)sulfane
    —— 4-[(4-hydroxyphenyl)thio]-N-methyl-N-[2-(1,2,3,6-tetrahydropyridin-4-yl)benzyl]butanamide 1229040-96-3 C23H28N2O2S
    4-[(4-hydroxyphenyl)thio]-N-methyl-N-[2-(1,2,3,6-tetrahydropyridin-4-yl)benzyl]butanamide
    —— N-(2-bromobenzyl)-4-[(4-hydroxyphenyl)thio]-N-methylbutanamide 1229041-26-2 C18H20BrNO2S
    N-(2-bromobenzyl)-4-[(4-hydroxyphenyl)thio]-N-methylbutanamide
    —— 4-[(4-hydroxyphenyl)thio]-N-methyl-N-[2-(N'-boc-1,2,3,6-tetrahydropyridin-4-yl)benzyl]butanamide 1229041-27-3 C28H36N2O4S
    4-[(4-hydroxyphenyl)thio]-N-methyl-N-[2-(N'-boc-1,2,3,6-tetrahydropyridin-4-yl)benzyl]butanamide
    —— α-Chlordicyclopropylsulfon 27531-50-6 C6H9ClO2S
    α-Chlordicyclopropylsulfon
    —— N-{6-{[(1R)-2-hydroxy-1-methylethyl]amino}-2-[(2,3,4-trifluorobenzyl)thio]pyrimidin-4-yl}-N-{[2-(trimethylsilyl)ethoxy]methyl}azetidine-1-sulfonamide 654073-39-9 C23H34F3N5O4S2Si
    N-{6-{[(1R)-2-hydroxy-1-methylethyl]amino}-2-[(2,3,4-trifluorobenzyl)thio]pyrimidin-4-yl}-N-{[2-(trimethylsilyl)ethoxy]methyl}azetidine-1-sulfonamide
    —— Tert-butyl cyclobutyl sulfone 713109-35-4 C8H16O2S
    Tert-butyl cyclobutyl sulfone
    —— N-(2-[benzylthio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}morpholine-4-sulfonamide 654074-11-0 C24H39N5O5S2Si
    N-(2-[benzylthio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}-pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}morpholine-4-sulfonamide
    —— N-(2-[(3-chloro-2-fluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}azetidine-1-sulfonamide 654073-37-7 C23H35ClFN5O4S2Si
    N-(2-[(3-chloro-2-fluorobenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}azetidine-1-sulfonamide
    —— N-(2-(benzylthio)-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}azetidine-1-sulfonamide 654073-34-4 C23H37N5O4S2Si
    N-(2-(benzylthio)-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}azetidine-1-sulfonamide