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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-(2-[(2,3-difluoro-4-methylbenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}azetidine-1-sulfonamide 654073-41-3 C24H37F2N5O4S2Si
    N-(2-[(2,3-difluoro-4-methylbenzyl)thio]-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}azetidine-1-sulfonamide
    —— N-(2-(benzylthio)-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}pyrrolidine-1-sulfonamide 654074-20-1 C24H39N5O4S2Si
    N-(2-(benzylthio)-6-{[(1R)-2-hydroxy-1-methylethyl]amino}pyrimidin-4-yl)-N-{[2-(trimethylsilyl)ethoxy]methyl}pyrrolidine-1-sulfonamide
    —— 2-amino-2-{2-[4-(5-phenylthionaphthalen-1-yl)phenyl]ethyl}propane-1,3-diol hydrochloride 956036-85-4 C27H27NO2S*ClH
    2-amino-2-{2-[4-(5-phenylthionaphthalen-1-yl)phenyl]ethyl}propane-1,3-diol hydrochloride
    —— 2-(Hydroxyethyl) phenyl sulfide 129524-69-2 C16H18O2S
    2-(Hydroxyethyl) phenyl sulfide
    —— 2-amino-2-(2-{4-[5-(4-methylphenylthio)naphthalen-1-yl]phenyl}ethyl)propane-1,3-diol hydrochloride 956036-86-5 C28H29NO2S*ClH
    2-amino-2-(2-{4-[5-(4-methylphenylthio)naphthalen-1-yl]phenyl}ethyl)propane-1,3-diol hydrochloride
    —— 3-(2-methylthio-6-trifluoromethylpyrimidin-4-yl)-1,2,4-oxadiazol-5-one 1256638-11-5 C8H5F3N4O2S
    3-(2-methylthio-6-trifluoromethylpyrimidin-4-yl)-1,2,4-oxadiazol-5-one
    —— 3-{6-chloro-2-methyl-1-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-4-yl]-1H-indol-3-ylsulfanyl}-benzoic acid ethyl ester 1359981-11-5 C23H19ClF3N3O2S
    3-{6-chloro-2-methyl-1-[1-(2,2,2-trifluoro-ethyl)-1H-pyrazol-4-yl]-1H-indol-3-ylsulfanyl}-benzoic acid ethyl ester
    —— 3-(1-benzyl-6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzonitrile 1359982-10-7 C23H17ClN2S
    3-(1-benzyl-6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzonitrile
    —— 3-(6-chloro-1-isothiazol-4-yl-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester 1359980-66-7 C21H17ClN2O2S2
    3-(6-chloro-1-isothiazol-4-yl-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid ethyl ester
    —— [3-(1-benzyl-6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-methanol 1359980-05-4 C23H20ClNOS
    [3-(1-benzyl-6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-methanol
    —— 3-(1-benzyl-6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester 1359979-94-4 C24H20ClNO2S
    3-(1-benzyl-6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester
    —— [3-(1-benzyl-6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetonitrile 1359982-07-2 C24H19ClN2S
    [3-(1-benzyl-6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-phenyl]-acetonitrile
    —— 2-({4-[(3-chloro-2-methylphenyl)methyl]-2-(morpholin-4-yl)-7-oxo-4H,7H-[1,3]thiazolo[4,5-d]pyrimidin-5-yl}sulfanyl)acetic acid 1256290-18-2 C19H19ClN4O4S2
    2-({4-[(3-chloro-2-methylphenyl)methyl]-2-(morpholin-4-yl)-7-oxo-4H,7H-[1,3]thiazolo[4,5-d]pyrimidin-5-yl}sulfanyl)acetic acid
    —— 3-[3-[7-(1-hydroxy-1-methyl-ethyl)-pyrido[2,3-d]pyrimidin-4-ylamino]-4-(4-hydroxy-phenylsulfanyl)-phenoxymethyl]-benzonitrile 944502-63-0 C30H25N5O3S
    3-[3-[7-(1-hydroxy-1-methyl-ethyl)-pyrido[2,3-d]pyrimidin-4-ylamino]-4-(4-hydroxy-phenylsulfanyl)-phenoxymethyl]-benzonitrile
    —— 6-{[(1R,3S,4S)-3-{[tert-butyl(dimethyl)silyl]oxy}-4-({[tert-butyl(dimethyl)silyl]oxy}-methyl)cyclopentyl]oxy}-8-[(3-methylphenyl)sulfanyl]-9H-purine 1007126-15-9 C30H48N4O3SSi2
    6-{[(1R,3S,4S)-3-{[tert-butyl(dimethyl)silyl]oxy}-4-({[tert-butyl(dimethyl)silyl]oxy}-methyl)cyclopentyl]oxy}-8-[(3-methylphenyl)sulfanyl]-9H-purine
    —— 4-[2-amino-4-(2,5-difluoro-benzyloxy)-phenylsulfanyl]-phenol 944506-29-0 C19H15F2NO2S
    4-[2-amino-4-(2,5-difluoro-benzyloxy)-phenylsulfanyl]-phenol
    —— 4-[2-amino-4-(3-fluoro-benzyloxy)-phenylsulfanyl]-phenol 943771-52-6 C19H16FNO2S
    4-[2-amino-4-(3-fluoro-benzyloxy)-phenylsulfanyl]-phenol
    —— 4-{2-amino-4-[1-(3-bromo-phenyl)-ethoxy]-phenylsulfanyl}-phenol 943774-66-1 C20H18BrNO2S
    4-{2-amino-4-[1-(3-bromo-phenyl)-ethoxy]-phenylsulfanyl}-phenol
    —— 4-[2-amino-4-(3-bromo-benzyloxy)-phenylsulfanyl]-phenol 1076223-03-4 C19H16BrNO2S
    4-[2-amino-4-(3-bromo-benzyloxy)-phenylsulfanyl]-phenol
    —— 4-[2-amino-4-(3-trifluoromethylbenzyloxy)-phenylsulfanyl]-phenol 1076223-02-3 C20H16F3NO2S
    4-[2-amino-4-(3-trifluoromethylbenzyloxy)-phenylsulfanyl]-phenol
    —— 2-{[(5-amino-2-chlorophenyl)methyl]sulfanyl}-6-methylpyrimidin-4-ol hydrochloride 1256557-51-3 C12H12ClN3OS*ClH
    2-{[(5-amino-2-chlorophenyl)methyl]sulfanyl}-6-methylpyrimidin-4-ol hydrochloride
    —— 2-{[(4-chloro-2-ethylpyridin-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol hydrochloride 1256558-70-9 C13H11ClF3N3OS*ClH
    2-{[(4-chloro-2-ethylpyridin-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol hydrochloride
    —— 2-{[(2,4-diethylpyridin-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol hydrochloride 1256558-72-1 C15H16F3N3OS*ClH
    2-{[(2,4-diethylpyridin-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol hydrochloride
    —— 2-(1,2,3-Thiadiazol-5-ylthio)acetic acid 75849-84-2 C4H4N2O2S2
    2-(1,2,3-Thiadiazol-5-ylthio)acetic acid
    —— 2-{[(4-chloro-1-methyl-1H-pyrazol-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol hydrochloride 1256558-67-4 C10H8ClF3N4OS*ClH
    2-{[(4-chloro-1-methyl-1H-pyrazol-3-yl)methyl]sulfanyl}-6-(trifluoromethyl)pyrimidin-4-ol hydrochloride
    —— 1,1-dioxo-3-methyl-3-thietanamine trifluoroacetate 943438-03-7 C2HF3O2*C4H9NO2S
    1,1-dioxo-3-methyl-3-thietanamine trifluoroacetate
    —— [1-(3,5-difluoro-benzyl)-3-(2-nitro-phenylsulfanyl)-1H-indol-6-yl]-methyl-carbamic acid tert-butyl ester 868673-03-4 C27H25F2N3O4S
    [1-(3,5-difluoro-benzyl)-3-(2-nitro-phenylsulfanyl)-1H-indol-6-yl]-methyl-carbamic acid tert-butyl ester
    —— [1-(3,5-difluoro-benzyl)-3-(2-hydroxymethyl-phenylsulfanyl)-1H-indol-6-yl]-methyl-carbamic acid tert-butyl ester 868673-44-3 C28H28F2N2O3S
    [1-(3,5-difluoro-benzyl)-3-(2-hydroxymethyl-phenylsulfanyl)-1H-indol-6-yl]-methyl-carbamic acid tert-butyl ester
    —— Ethyl 2-[(5-amino-2-thiazolyl)thio]acetate 859522-22-8 C7H10N2O2S2
    Ethyl 2-[(5-amino-2-thiazolyl)thio]acetate
    —— tert-butyl {2-[(2-methoxyethyl)sulfanyl]benzyl}carbamate 1192348-63-2 C15H23NO3S
    tert-butyl {2-[(2-methoxyethyl)sulfanyl]benzyl}carbamate
    —— 2-({[5-(chloro)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}sulfanyl)-1,3-oxazole 1191104-28-5 C9H7ClF3N3OS
    2-({[5-(chloro)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl}sulfanyl)-1,3-oxazole
    —— 2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-[2-(3-hydroxypropyl)-1,3-thiazol-4-yl]pyridine-3,5-dicarbonitrile 1187543-26-5 C23H17ClN6OS3
    2-Amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-[2-(3-hydroxypropyl)-1,3-thiazol-4-yl]pyridine-3,5-dicarbonitrile
    —— (2R)-2-(4-cyclopropylsulfanylphenyl)-3-(oxan-4-yl)propanoic acid 1001327-35-0 C17H22O3S
    (2R)-2-(4-cyclopropylsulfanylphenyl)-3-(oxan-4-yl)propanoic acid
    —— 3-(4-carboxymethyl-benzylsulfanyl)-phenylboronic acid 854778-54-4 C15H15BO4S
    3-(4-carboxymethyl-benzylsulfanyl)-phenylboronic acid
    —— (R)-5,6-dihydro-6-methylthieno[2,3-b]thiopyran-4-one 894793-31-8 C8H8OS2
    (R)-5,6-dihydro-6-methylthieno[2,3-b]thiopyran-4-one
    —— (1R,2R,4S)-2-(morpholine-4-carbonyl)-4-phenylsulfanyl-cyclopentanecarboxylic acid ethyl ester 1258451-16-9 C19H25NO4S
    (1R,2R,4S)-2-(morpholine-4-carbonyl)-4-phenylsulfanyl-cyclopentanecarboxylic acid ethyl ester
    —— 4-Chloro-3-(4-isopropylphenylthio)-9H-thioxanthen-9-one 1372152-37-8 C22H17ClOS2
    4-Chloro-3-(4-isopropylphenylthio)-9H-thioxanthen-9-one
    —— 2-[4-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-ylsulfanyl)-phenyl]-propionic acid 1241507-73-2 C18H19N3O2S
    2-[4-(3-isopropyl-[1,2,4]triazolo[4,3-a]pyridin-6-ylsulfanyl)-phenyl]-propionic acid
    —— 6-{3-[3-(2-morpholin-4-yl-ethoxy)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-ylsulfanyl}-pyridin-3-ylamine 1241507-42-5 C23H24N6O2S
    6-{3-[3-(2-morpholin-4-yl-ethoxy)-phenyl]-[1,2,4]triazolo[4,3-a]pyridin-6-ylsulfanyl}-pyridin-3-ylamine
    —— 4-Chloro-3-(2,5-dimethylphenylthio)-9H-thioxanthen-9-one 1372152-28-7 C21H15ClOS2
    4-Chloro-3-(2,5-dimethylphenylthio)-9H-thioxanthen-9-one
    —— 3-(3-Methylthiophenyl)-2-oxopropylamine hydrochloride 955036-75-6 C10H13NOS*ClH
    3-(3-Methylthiophenyl)-2-oxopropylamine hydrochloride
    —— 3-[(1-methylethyl)sulfanyl]-6,7,8,9-tetrahydropyrazino[2,3-f][1,4]oxazepine hydrochloride 1258393-55-3 C10H15N3OS*ClH
    3-[(1-methylethyl)sulfanyl]-6,7,8,9-tetrahydropyrazino[2,3-f][1,4]oxazepine hydrochloride
    —— 2-(hexylthio)butyraldehyde 1137737-28-0 C10H20OS
    2-(hexylthio)butyraldehyde
    —— 2-(5-fluoro-1H-indol-3-ylsulfanyl)-benzylamine 857499-69-5 C15H13FN2S
    2-(5-fluoro-1H-indol-3-ylsulfanyl)-benzylamine
    —— 2-[(2,6-difluorobenzyl)sulfanyl]-1,3-oxazole 1191082-68-4 C10H7F2NOS
    2-[(2,6-difluorobenzyl)sulfanyl]-1,3-oxazole
    —— 2-[(2,3,6-trichlorobenzyl)sulfanyl]-1,3-oxazole 1191082-66-2 C10H6Cl3NOS
    2-[(2,3,6-trichlorobenzyl)sulfanyl]-1,3-oxazole
    —— 2-(5-bromo-4-ethoxy-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylthio)thiazole-4-carboxylic acid 1275599-15-9 C14H13BrN4O3S2
    2-(5-bromo-4-ethoxy-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylthio)thiazole-4-carboxylic acid
    —— 4-(4-aminophenyl)sulfanyl-N-[(1S)-1-naphthalen-2-ylethyl]-3-[(7-propan-2-ylpyrido[2,3-d]pyrimidin-4-yl)amino]benzamide 943779-23-5 C35H32N6OS
    4-(4-aminophenyl)sulfanyl-N-[(1S)-1-naphthalen-2-ylethyl]-3-[(7-propan-2-ylpyrido[2,3-d]pyrimidin-4-yl)amino]benzamide
    —— N-{2-[(2,3-difluorobenzyl)thio]-6-methoxypyrimidin-4-yl}-4-oxopiperidine-4-sulfonamide 878388-23-9 C17H18F2N4O4S2
    N-{2-[(2,3-difluorobenzyl)thio]-6-methoxypyrimidin-4-yl}-4-oxopiperidine-4-sulfonamide
    —— 7-(4-(3,6-diazabicyclo[3.2.0]heptan-3-yl)-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylthio)pyrido[3,2-b]pyrazine 1275603-02-5 C20H19ClN8S
    7-(4-(3,6-diazabicyclo[3.2.0]heptan-3-yl)-5-chloro-6-ethyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylthio)pyrido[3,2-b]pyrazine