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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 4-methylsulfanyl-2-phenyl-6H-1,3-thiazin-6-one 1217055-33-8 C11H9NOS2
    4-methylsulfanyl-2-phenyl-6H-1,3-thiazin-6-one
    —— 1-[(5-Ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]propan-2-one 81555-98-8 C7H10N2O2S
    1-[(5-Ethyl-1,3,4-oxadiazol-2-yl)sulfanyl]propan-2-one
    —— 6-Methyl-uracil-sulfonsaeure-(5)-azid —— C5H5N5O4S
    6-Methyl-uracil-sulfonsaeure-(5)-azid
    —— (Z)-3-{(phenylthio)methylene}tetrahydropyran-2-one 1231177-51-7 C12H12O2S
    (Z)-3-{(phenylthio)methylene}tetrahydropyran-2-one
    —— (E)-5-hydroxy-N-phenyl-2-(phenylthiomethylene)pentanethioamide 1231177-55-1 C18H19NOS2
    (E)-5-hydroxy-N-phenyl-2-(phenylthiomethylene)pentanethioamide
    —— 7-fluoro-9,10-dihydropyrrolo[2,1-b][1,3]benzothiazepin-9-one 256950-28-4 C12H8FNOS
    7-fluoro-9,10-dihydropyrrolo[2,1-b][1,3]benzothiazepin-9-one
    —— (+/-)-7-fluoro-9,10-dihydro-9-hydroxypyrrolo[2,1-b][1,3]benzothiazepine 256950-29-5 C12H10FNOS
    (+/-)-7-fluoro-9,10-dihydro-9-hydroxypyrrolo[2,1-b][1,3]benzothiazepine
    —— (+/-)-9-bromo-9,10-dihydro-7-fluoropyrrolo[2,1-b][1,3]benzothiazepine 256950-30-8 C12H9BrFNS
    (+/-)-9-bromo-9,10-dihydro-7-fluoropyrrolo[2,1-b][1,3]benzothiazepine
    —— Methyl 4-(3-cyano-6-methylpyridin-2-yl)sulfanyl-3-oxobutanoate 625372-26-1 C12H12N2O3S
    Methyl 4-(3-cyano-6-methylpyridin-2-yl)sulfanyl-3-oxobutanoate
    —— (E)-4-hydroxy-N-phenyl-2-(phenylthiomethylene)butanethioamide 1231177-48-2 C17H17NOS2
    (E)-4-hydroxy-N-phenyl-2-(phenylthiomethylene)butanethioamide
    —— (E)-3-(phenylthiomethylene)dihydrofuran-2(3H)-one 69993-32-4 C11H10O2S
    (E)-3-(phenylthiomethylene)dihydrofuran-2(3H)-one
    —— 3-cyano-N-1,2,4-thiadiazol-5-yl-4-{[2-(trifluoromethyl)phenyl]thio}benzenesulfonamide 1354917-34-2 C16H9F3N4O2S3
    3-cyano-N-1,2,4-thiadiazol-5-yl-4-{[2-(trifluoromethyl)phenyl]thio}benzenesulfonamide
    —— N-(6-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclo-propanecarboxamide 1208247-64-6 C16H13N7OS
    N-(6-([1,2,4]triazolo[4,3-a]pyridin-3-ylthio)imidazo[1,2-b]pyridazin-2-yl)cyclo-propanecarboxamide
    —— 3-cyano-4-[(3-methoxyphenyl)thio]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide 1354917-06-8 C16H12N4O3S3
    3-cyano-4-[(3-methoxyphenyl)thio]-N-1,2,4-thiadiazol-5-ylbenzenesulfonamide
    —— 3-cyano-4-[(3,4-difluorophenyl)thio]-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide 1354917-36-4 C15H8F2N4O2S3
    3-cyano-4-[(3,4-difluorophenyl)thio]-N-1,2,4-thiadiazol-5-yl-benzenesulfonamide
    —— 1-benzyl-6-bromomethyl-5-chloro-3-(ethylsulfanyl)-2(1H)-pyrazinone 658071-59-1 C14H14BrClN2OS
    1-benzyl-6-bromomethyl-5-chloro-3-(ethylsulfanyl)-2(1H)-pyrazinone
    —— S<sup>1</sup>-{[1-benzyl-3-chloro-1,6-dihydro-5-(ethylsulfanyl)-6-oxo-2-pyrazinyl]methyl}ethanethioate 658071-60-4 C16H17ClN2O2S2
    S<sup>1</sup>-{[1-benzyl-3-chloro-1,6-dihydro-5-(ethylsulfanyl)-6-oxo-2-pyrazinyl]methyl}ethanethioate
    —— 1-benzyl-5-chloro-3-(ethylsulfanyl)-6-[(2-propynylsulfanyl)methyl]-2(1H)-pyrazinone 658071-62-6 C17H17ClN2OS2
    1-benzyl-5-chloro-3-(ethylsulfanyl)-6-[(2-propynylsulfanyl)methyl]-2(1H)-pyrazinone
    —— N-benzyl-4-(4-(3-(2,4-dichlorophenyl)thioureido)phenylthio)picolinamide 1395063-43-0 C26H20Cl2N4OS2
    N-benzyl-4-(4-(3-(2,4-dichlorophenyl)thioureido)phenylthio)picolinamide
    —— 6-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)pyridazin-3-ylamine 1208249-65-3 C10H8N6S
    6-([1,2,4]triazolo[4,3-a]pyridin-3-ylsulfanyl)pyridazin-3-ylamine
    —— 4-[4-benzyl-5-methyl-3-oxo-6-(o-tolylthio)-3,4-dihydropyrazin-2-ylamino]benzonitrile 467468-95-7 C26H22N4OS
    4-[4-benzyl-5-methyl-3-oxo-6-(o-tolylthio)-3,4-dihydropyrazin-2-ylamino]benzonitrile
    —— 2-benzylthio-4-(3-bromophenylamino)-6-methylpyrimidine hydrochloride 1162754-39-3 C18H16BrN3S*ClH
    2-benzylthio-4-(3-bromophenylamino)-6-methylpyrimidine hydrochloride
    —— 2-(benzylthio)-4-chloro-6-methylpyrimidine 121180-58-3 C12H11ClN2S
    2-(benzylthio)-4-chloro-6-methylpyrimidine
    —— 2,6-bis-(methylthio)-4-ethyl-3-methylpyridine 128736-18-5 C10H15NS2
    2,6-bis-(methylthio)-4-ethyl-3-methylpyridine
    —— 3,5-Dimethyl-2-[(4-methylphenyl)amino]-6-methylsulfanylthiopyran-4-one 99878-38-3 C15H17NOS2
    3,5-Dimethyl-2-[(4-methylphenyl)amino]-6-methylsulfanylthiopyran-4-one
    —— acetic acid 3-[6-amino-8-(7-chlorobenzothiazol-2-ylsulfanyl)-purin-9-yl]-propyl ester 908355-51-1 C17H15ClN6O2S2
    acetic acid 3-[6-amino-8-(7-chlorobenzothiazol-2-ylsulfanyl)-purin-9-yl]-propyl ester
    —— methanesulfonic acid 3-[6-amino-8-(7-chlorobenzothiazol-2-ylsulfanyl)-purin-9-yl]-propyl ester 908355-86-2 C16H15ClN6O3S3
    methanesulfonic acid 3-[6-amino-8-(7-chlorobenzothiazol-2-ylsulfanyl)-purin-9-yl]-propyl ester
    —— 4-Ethyl-3-methyl-2-methylthiothiophene 146041-18-1 C8H12S2
    4-Ethyl-3-methyl-2-methylthiothiophene
    —— acetic acid 4-[6-amino-8-(7-chlorobenzothiazol-2-ylsulfanyl)-purin-9-yl]-butyl ester 908355-52-2 C18H17ClN6O2S2
    acetic acid 4-[6-amino-8-(7-chlorobenzothiazol-2-ylsulfanyl)-purin-9-yl]-butyl ester
    —— 8-[(7-chloro-1,3-benzothiazol-2-yl)thio]-9H-purin-6-amine 940908-25-8 C12H7ClN6S2
    8-[(7-chloro-1,3-benzothiazol-2-yl)thio]-9H-purin-6-amine
    —— 3-[6-amino-8-(7-chlorobenzothiazol-2-ylsulfanyl)-purin-9-yl]-propan-1-ol 908355-57-7 C15H13ClN6OS2
    3-[6-amino-8-(7-chlorobenzothiazol-2-ylsulfanyl)-purin-9-yl]-propan-1-ol
    —— 5-amino-2-(7-chloro-benzothiazol-2-ylsulfanyl)-1-methyl-1H-imidazole-4-carboxamide 1102466-67-0 C12H10ClN5OS2
    5-amino-2-(7-chloro-benzothiazol-2-ylsulfanyl)-1-methyl-1H-imidazole-4-carboxamide
    —— 5-amino-1-butyl-2-(7-chloro-benzothiazol-2-ylsulfanyl)-1H-imidazole-4-carboxamide 1102466-64-7 C15H16ClN5OS2
    5-amino-1-butyl-2-(7-chloro-benzothiazol-2-ylsulfanyl)-1H-imidazole-4-carboxamide
    —— 3-Phenyl-5-propylsulfanyl-1,2-oxazole 120803-05-6 C12H13NOS
    3-Phenyl-5-propylsulfanyl-1,2-oxazole
    —— 3-Propylthio-5-phenyl-isoxazol 69528-69-4 C12H13NOS
    3-Propylthio-5-phenyl-isoxazol
    —— methyl 3-phenylthio-1-cyclobutanecarboxylate 344444-84-4 C12H14O2S
    methyl 3-phenylthio-1-cyclobutanecarboxylate
    —— 1-(1-phenylthiovinyl)cyclohexene 158750-11-9 C14H16S
    1-(1-phenylthiovinyl)cyclohexene
    —— Ditert-butyl 2-[4-[4-[bis[(2-methylpropan-2-yl)oxycarbonylamino]methylideneamino]phenyl]sulfanylphenyl]iminoimidazolidine-1,3-dicarboxylate 1196966-14-9 C36H50N6O8S
    Ditert-butyl 2-[4-[4-[bis[(2-methylpropan-2-yl)oxycarbonylamino]methylideneamino]phenyl]sulfanylphenyl]iminoimidazolidine-1,3-dicarboxylate
    —— 3-trifluoromethylphenyl 4-methylphenyl sulfide 788-12-5 C14H11F3S
    3-trifluoromethylphenyl 4-methylphenyl sulfide
    —— 2-acetylbenzo<b>thiophen-3(2H)-one 86296-56-2 C10H8O2S
    2-acetylbenzo<b>thiophen-3(2H)-one
    —— Hexadecane, 1-(ethynylthio)- 143570-83-6 C18H34S
    Hexadecane, 1-(ethynylthio)-
    —— 1-[2-[(2-Pentyl-1,3-dithian-2-yl)methyl]-1,3-dithian-2-yl]propan-1-ol 954143-20-5 C17H32OS4
    1-[2-[(2-Pentyl-1,3-dithian-2-yl)methyl]-1,3-dithian-2-yl]propan-1-ol
    —— zinc;methylsulfanylbenzene;iodide —— C7H7ISZn
    zinc;methylsulfanylbenzene;iodide
    —— 2-(2,4-difluorophenyl)-1-(4-(3-((5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)thio)propyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol 1528792-79-1 C26H28ClF2N7O2S
    2-(2,4-difluorophenyl)-1-(4-(3-((5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)thio)propyl)piperazin-1-yl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol
    —— (+/-)-(Z)-4-(p-tolylsulfenyl)non-4-en-2-ol 479623-82-0 C16H24OS
    (+/-)-(Z)-4-(p-tolylsulfenyl)non-4-en-2-ol
    —— 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)thioureido)phenylthio)-N-ethylpicolinamide 1395063-41-8 C22H18ClF3N4OS2
    4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)thioureido)phenylthio)-N-ethylpicolinamide
    —— 2-(ethylthio)-5-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3,4-oxadiazole 1417544-27-4 C7H8N4OS2
    2-(ethylthio)-5-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3,4-oxadiazole
    —— N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridylthio)phenyl]thiourea 1246391-76-3 C21H16ClF3N4OS2
    N-[4-chloro-3-(trifluoromethyl)phenyl]-[4-(N-methylformamide)(4-pyridylthio)phenyl]thiourea
    —— 2-{[6-(4-Fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]thio}-5-[4-(trifluoromethyl)-phenyl]-1,3,4-oxadiazole 1610410-44-0 C21H10F4N4OS2
    2-{[6-(4-Fluorophenyl)thieno[3,2-d]pyrimidin-4-yl]thio}-5-[4-(trifluoromethyl)-phenyl]-1,3,4-oxadiazole
    —— ethyl 2-((5-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3,4-oxadiazol-2-yl)thio)acetate 1417544-29-6 C9H10N4O3S2
    ethyl 2-((5-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3,4-oxadiazol-2-yl)thio)acetate