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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-butylsulfanyl-4-N-[[(2S)-1,4-dimethylpiperazin-2-yl]methyl]pyrimidine-4,6-diamine —— C15H28N6S
    2-butylsulfanyl-4-N-[[(2S)-1,4-dimethylpiperazin-2-yl]methyl]pyrimidine-4,6-diamine
    —— N-[(4-chloro-2-phenylsulfanyl-1,3-thiazol-5-yl)methyl]-1-[(3S)-oxolan-3-yl]methanamine —— C15H17ClN2OS2
    N-[(4-chloro-2-phenylsulfanyl-1,3-thiazol-5-yl)methyl]-1-[(3S)-oxolan-3-yl]methanamine
    —— (2S)-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-2-(2-propan-2-ylimidazol-1-yl)propanamide —— C15H23N5OS2
    (2S)-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-2-(2-propan-2-ylimidazol-1-yl)propanamide
    —— (2R)-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-2-(2-propan-2-ylimidazol-1-yl)propanamide —— C15H23N5OS2
    (2R)-N-[3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propyl]-2-(2-propan-2-ylimidazol-1-yl)propanamide
    —— (1S,2S)-2-(furan-2-yl)-N-(2-phenylsulfanylphenyl)cyclopropane-1-carboxamide —— C20H17NO2S
    (1S,2S)-2-(furan-2-yl)-N-(2-phenylsulfanylphenyl)cyclopropane-1-carboxamide
    —— (1R,2R)-2-(furan-2-yl)-N-(2-phenylsulfanylphenyl)cyclopropane-1-carboxamide —— C20H17NO2S
    (1R,2R)-2-(furan-2-yl)-N-(2-phenylsulfanylphenyl)cyclopropane-1-carboxamide
    —— (1S,2R)-2-(furan-2-yl)-N-(2-phenylsulfanylphenyl)cyclopropane-1-carboxamide —— C20H17NO2S
    (1S,2R)-2-(furan-2-yl)-N-(2-phenylsulfanylphenyl)cyclopropane-1-carboxamide
    —— (3S)-1-(6-amino-2-butylsulfanylpyrimidin-4-yl)piperidine-3-carbonitrile —— C14H21N5S
    (3S)-1-(6-amino-2-butylsulfanylpyrimidin-4-yl)piperidine-3-carbonitrile
    —— (1R,2S)-2-(furan-2-yl)-N-(2-phenylsulfanylphenyl)cyclopropane-1-carboxamide —— C20H17NO2S
    (1R,2S)-2-(furan-2-yl)-N-(2-phenylsulfanylphenyl)cyclopropane-1-carboxamide
    —— Diethyl-[3-[[2-[4-(furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanylacetyl]amino]propyl]azanium —— C18H24F3N4O2S+
    Diethyl-[3-[[2-[4-(furan-2-yl)-6-(trifluoromethyl)pyrimidin-2-yl]sulfanylacetyl]amino]propyl]azanium
    —— 6-[(2R)-2-(2-aminoethyl)morpholin-4-yl]-2-butylsulfanylpyrimidin-4-amine —— C14H25N5OS
    6-[(2R)-2-(2-aminoethyl)morpholin-4-yl]-2-butylsulfanylpyrimidin-4-amine
    —— [(1S,2R)-1-[5-[(4-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]azanium —— C14H19FN3OS+
    [(1S,2R)-1-[5-[(4-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylbutyl]azanium
    —— (3R)-1-(6-amino-2-butylsulfanylpyrimidin-4-yl)piperidine-3-carbonitrile —— C14H21N5S
    (3R)-1-(6-amino-2-butylsulfanylpyrimidin-4-yl)piperidine-3-carbonitrile
    —— 6-[(2S)-2-(2-aminoethyl)morpholin-4-yl]-2-butylsulfanylpyrimidin-4-amine —— C14H25N5OS
    6-[(2S)-2-(2-aminoethyl)morpholin-4-yl]-2-butylsulfanylpyrimidin-4-amine
    —— (3R)-1-(6-amino-2-butylsulfanylpyrimidin-4-yl)-3-[(dimethylamino)methyl]piperidin-3-ol —— C16H29N5OS
    (3R)-1-(6-amino-2-butylsulfanylpyrimidin-4-yl)-3-[(dimethylamino)methyl]piperidin-3-ol
    —— (3S)-1-(6-amino-2-butylsulfanylpyrimidin-4-yl)-3-[(dimethylamino)methyl]piperidin-3-ol —— C16H29N5OS
    (3S)-1-(6-amino-2-butylsulfanylpyrimidin-4-yl)-3-[(dimethylamino)methyl]piperidin-3-ol
    —— [(1S)-1-[5-[(3-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-3-methylbutyl]azanium —— C14H19FN3OS+
    [(1S)-1-[5-[(3-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-3-methylbutyl]azanium
    —— tert-butyl N-[(1S)-1-[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-3-methylbutyl]carbamate —— C19H26ClN3O3S
    tert-butyl N-[(1S)-1-[5-[(4-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-3-methylbutyl]carbamate
    —— 1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C20H23N3O3S
    1-[1-[(2R)-1-methoxypropan-2-yl]-2,5-dimethylpyrrol-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— (2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanenitrile —— C11H9N3OS
    (2S)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanenitrile
    —— (5R)-7-(6-amino-2-butylsulfanylpyrimidin-4-yl)-3-methyl-1-oxa-3,7-diazaspiro[4.4]nonan-2-one —— C15H23N5O2S
    (5R)-7-(6-amino-2-butylsulfanylpyrimidin-4-yl)-3-methyl-1-oxa-3,7-diazaspiro[4.4]nonan-2-one
    —— (5S)-7-(6-amino-2-butylsulfanylpyrimidin-4-yl)-3-methyl-1-oxa-3,7-diazaspiro[4.4]nonan-2-one —— C15H23N5O2S
    (5S)-7-(6-amino-2-butylsulfanylpyrimidin-4-yl)-3-methyl-1-oxa-3,7-diazaspiro[4.4]nonan-2-one
    —— (4R)-3-acetyl-2-methyl-4-phenyl-6-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-5-carbonitrile —— C22H20N2OS2
    (4R)-3-acetyl-2-methyl-4-phenyl-6-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-5-carbonitrile
    —— N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide —— C18H16ClN3O2S
    N-[(1R)-1-(3-chlorophenyl)ethyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]acetamide
    —— 2-Phenyl-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,3,4-oxadiazole —— C18H13N3OS2
    2-Phenyl-5-[(2-phenyl-1,3-thiazol-4-yl)methylsulfanyl]-1,3,4-oxadiazole
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-methylacetamide —— C15H21NO3S2
    2-(2,5-dimethylphenyl)sulfanyl-N-[(3S)-1,1-dioxothiolan-3-yl]-N-methylacetamide
    —— (4R)-5-acetyl-6-methyl-4-(3-methylthiophen-2-yl)-2-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-3-carbonitrile —— C21H20N2OS3
    (4R)-5-acetyl-6-methyl-4-(3-methylthiophen-2-yl)-2-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-3-carbonitrile
    —— 6-[(3R)-3-(aminomethyl)pyrrolidin-1-yl]-2-butylsulfanylpyrimidin-4-amine —— C13H23N5S
    6-[(3R)-3-(aminomethyl)pyrrolidin-1-yl]-2-butylsulfanylpyrimidin-4-amine
    —— N-(1-cyanocyclohexyl)-2-(2,4-dimethylphenyl)sulfanyl-N-methylacetamide —— C18H24N2OS
    N-(1-cyanocyclohexyl)-2-(2,4-dimethylphenyl)sulfanyl-N-methylacetamide
    —— (4S)-3-acetyl-2-methyl-4-phenyl-6-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-5-carbonitrile —— C22H20N2OS2
    (4S)-3-acetyl-2-methyl-4-phenyl-6-(phenylsulfanylmethylsulfanyl)-3,4-dihydropyridine-5-carbonitrile
    —— 2-(2,4-dimethylphenyl)sulfanyl-N-(4-methylcyclohexyl)acetamide —— C17H25NOS
    2-(2,4-dimethylphenyl)sulfanyl-N-(4-methylcyclohexyl)acetamide
    —— 2-methyl-5-[3-[4-[(3S)-piperidin-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole —— C13H20N6S2
    2-methyl-5-[3-[4-[(3S)-piperidin-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole
    —— 2-methyl-5-[3-[4-[(3R)-piperidin-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole —— C13H20N6S2
    2-methyl-5-[3-[4-[(3R)-piperidin-3-yl]triazol-1-yl]propylsulfanyl]-1,3,4-thiadiazole
    —— 1-[2,5-Dimethyl-1-(2,2,2-trifluoroethyl)pyrrol-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone —— C18H16F3N3O2S
    1-[2,5-Dimethyl-1-(2,2,2-trifluoroethyl)pyrrol-3-yl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]ethanone
    —— (2S)-N-benzyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide —— C18H17N3O2S
    (2S)-N-benzyl-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]propanamide
    —— 2-(2,5-dimethylphenyl)sulfanyl-N-[(1R)-1-thiophen-2-ylethyl]acetamide —— C16H19NOS2
    2-(2,5-dimethylphenyl)sulfanyl-N-[(1R)-1-thiophen-2-ylethyl]acetamide
    —— 2-butylsulfanyl-6-[(3S)-3-(methylsulfonylmethyl)piperidin-1-yl]pyrimidin-4-amine —— C15H26N4O2S2
    2-butylsulfanyl-6-[(3S)-3-(methylsulfonylmethyl)piperidin-1-yl]pyrimidin-4-amine
    —— N-(1-cyanocyclopentyl)-2-{[3-(thiophen-2-yl)-1H-1,2,4-triazol-5-yl]sulfanyl}acetamide —— C14H15N5OS2
    N-(1-cyanocyclopentyl)-2-{[3-(thiophen-2-yl)-1H-1,2,4-triazol-5-yl]sulfanyl}acetamide
    —— 6-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-2-butylsulfanylpyrimidin-4-amine —— C13H23N5S
    6-[(3S)-3-(aminomethyl)pyrrolidin-1-yl]-2-butylsulfanylpyrimidin-4-amine
    —— 1-thiophen-2-yl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone —— C12H9N3OS3
    1-thiophen-2-yl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]ethanone
    —— 2-butylsulfanyl-6-[(3R)-3-(methylsulfonylmethyl)piperidin-1-yl]pyrimidin-4-amine —— C15H26N4O2S2
    2-butylsulfanyl-6-[(3R)-3-(methylsulfonylmethyl)piperidin-1-yl]pyrimidin-4-amine
    —— N-cyclohexyl-N-ethyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H22N4OS2
    N-cyclohexyl-N-ethyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C16H15FN4OS2
    N-[(1R)-1-(4-fluorophenyl)ethyl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— (2S)-N-(furan-2-ylmethyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide —— C14H14N4O2S2
    (2S)-N-(furan-2-ylmethyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]propanamide
    —— N-[(2R)-3-methylbutan-2-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C13H18N4OS2
    N-[(2R)-3-methylbutan-2-yl]-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— N,N-bis(prop-2-enyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide —— C14H16N4OS2
    N,N-bis(prop-2-enyl)-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetamide
    —— ethyl (2R)-2-phenyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetate —— C16H15N3O2S2
    ethyl (2R)-2-phenyl-2-[(5-thiophen-2-yl-1H-1,2,4-triazol-3-yl)sulfanyl]acetate
    —— N-[[(3S)-1-(2-methoxyethyl)pyrrolidin-3-yl]methyl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine —— C18H31N5OS
    N-[[(3S)-1-(2-methoxyethyl)pyrrolidin-3-yl]methyl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine
    —— N-[[(3R)-1-(2-methoxyethyl)pyrrolidin-3-yl]methyl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine —— C18H31N5OS
    N-[[(3R)-1-(2-methoxyethyl)pyrrolidin-3-yl]methyl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine
    —— N-(1-cyanocyclohexyl)-2-{[5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide —— C15H17N5OS2
    N-(1-cyanocyclohexyl)-2-{[5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl}acetamide