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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(1R)-1-(1-adamantyl)ethyl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide —— C16H23N3OS2
    N-[(1R)-1-(1-adamantyl)ethyl]-2-(1,3,4-thiadiazol-2-ylsulfanyl)acetamide
    —— (2S)-N-cyclopropyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C9H13N3OS2
    (2S)-N-cyclopropyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-(furan-2-ylmethyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C11H13N3O2S2
    (2S)-N-(furan-2-ylmethyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C14H16FN3OS2
    (2S)-N-[(1S)-1-(4-fluorophenyl)ethyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— (1R,6S,7S,9R)-12-imino-9-(4-methylsulfanylphenyl)-10,11-dioxatricyclo[5.3.2.01,6]dodecane-7,8,8-tricarbonitrile —— C20H18N4O2S
    (1R,6S,7S,9R)-12-imino-9-(4-methylsulfanylphenyl)-10,11-dioxatricyclo[5.3.2.01,6]dodecane-7,8,8-tricarbonitrile
    —— (2E,5S)-5-[[4-(difluoromethylsulfanyl)phenyl]methyl]-2-[(E)-furan-2-ylmethylidenehydrazinylidene]-1,3-thiazolidin-4-one —— C16H13F2N3O2S2
    (2E,5S)-5-[[4-(difluoromethylsulfanyl)phenyl]methyl]-2-[(E)-furan-2-ylmethylidenehydrazinylidene]-1,3-thiazolidin-4-one
    —— N-[(1R)-1-(2-chlorophenyl)ethyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H14ClN3OS2
    N-[(1R)-1-(2-chlorophenyl)ethyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-[(1R,2R,3S)-2,3-dimethylcyclohexyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H21N3OS2
    N-[(1R,2R,3S)-2,3-dimethylcyclohexyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H14ClN3OS2
    N-[(1S)-1-(3-chlorophenyl)ethyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— N-[(3R)-1,1-dioxo-2,3-dihydrothiophen-3-yl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine —— C14H20N4O2S2
    N-[(3R)-1,1-dioxo-2,3-dihydrothiophen-3-yl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine
    —— N-[(3S)-1,1-dioxo-2,3-dihydrothiophen-3-yl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine —— C14H20N4O2S2
    N-[(3S)-1,1-dioxo-2,3-dihydrothiophen-3-yl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine
    —— N-(1-adamantylmethyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C16H23N3OS2
    N-(1-adamantylmethyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— 2-(1,3,4-thiadiazol-2-ylsulfanyl)-N-[(1S)-1-thiophen-2-ylethyl]acetamide —— C10H11N3OS3
    2-(1,3,4-thiadiazol-2-ylsulfanyl)-N-[(1S)-1-thiophen-2-ylethyl]acetamide
    —— N-(4-methylcyclohexyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C12H19N3OS2
    N-(4-methylcyclohexyl)-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (3S)-3-[[[6-amino-2-[(2-methylphenyl)methylsulfanyl]pyrimidin-4-yl]amino]methyl]piperidin-3-ol —— C18H25N5OS
    (3S)-3-[[[6-amino-2-[(2-methylphenyl)methylsulfanyl]pyrimidin-4-yl]amino]methyl]piperidin-3-ol
    —— (2S)-N-benzyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide —— C13H15N3OS2
    (2S)-N-benzyl-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]propanamide
    —— N-[(1S,2R,3S)-2,3-dimethylcyclohexyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide —— C13H21N3OS2
    N-[(1S,2R,3S)-2,3-dimethylcyclohexyl]-2-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]acetamide
    —— (3R)-3-[[[6-amino-2-[(2-methylphenyl)methylsulfanyl]pyrimidin-4-yl]amino]methyl]piperidin-3-ol —— C18H25N5OS
    (3R)-3-[[[6-amino-2-[(2-methylphenyl)methylsulfanyl]pyrimidin-4-yl]amino]methyl]piperidin-3-ol
    —— tert-butyl N-[(1S)-1-(5-ethylsulfanyl-1,3,4-oxadiazol-2-yl)-2-methylpropyl]carbamate 1173667-58-7 C13H23N3O3S
    tert-butyl N-[(1S)-1-(5-ethylsulfanyl-1,3,4-oxadiazol-2-yl)-2-methylpropyl]carbamate
    —— tert-butyl N-[(1S)-1-[5-[(2-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylpropyl]carbamate —— C18H24FN3O3S
    tert-butyl N-[(1S)-1-[5-[(2-fluorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-2-methylpropyl]carbamate
    —— 2-[2-[2-(4-Chlorophenyl)sulfanylethoxy]ethylazaniumyl]ethyl-dimethylazanium —— C14H25ClN2OS+2
    2-[2-[2-(4-Chlorophenyl)sulfanylethoxy]ethylazaniumyl]ethyl-dimethylazanium
    —— [(1S)-1-[5-[(3-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-3-methylbutyl]azanium —— C14H19ClN3OS+
    [(1S)-1-[5-[(3-chlorophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]-3-methylbutyl]azanium
    —— [(S)-1-(5-Benzylsulfanyl-[1,3,4]oxadiazol-2-yl)-3-methyl-butyl]-carbamic acid tert-butyl ester —— C19H27N3O3S
    [(S)-1-(5-Benzylsulfanyl-[1,3,4]oxadiazol-2-yl)-3-methyl-butyl]-carbamic acid tert-butyl ester
    —— VAS3947 —— C14H10N6OS
    VAS3947
    —— N-[(1S,2S)-2-methylcyclohexyl]-2-phenylsulfanylacetamide —— C15H21NOS
    N-[(1S,2S)-2-methylcyclohexyl]-2-phenylsulfanylacetamide
    —— N-benzyl-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C19H23NOS
    N-benzyl-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— N-[(2-chlorophenyl)methyl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C19H22ClNOS
    N-[(2-chlorophenyl)methyl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— N-(1-cyanocyclohexyl)-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C19H26N2OS
    N-(1-cyanocyclohexyl)-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— 1-methyl-N-[2-(2,3,5,6-tetramethylphenyl)sulfanylacetyl]pyrrole-2-carboxamide —— C18H22N2O2S
    1-methyl-N-[2-(2,3,5,6-tetramethylphenyl)sulfanylacetyl]pyrrole-2-carboxamide
    —— 1-(5-Phenyl-3,4-dihydropyrazol-2-yl)-2-(2,3,5,6-tetramethylphenyl)sulfanylethanone —— C21H24N2OS
    1-(5-Phenyl-3,4-dihydropyrazol-2-yl)-2-(2,3,5,6-tetramethylphenyl)sulfanylethanone
    —— (2R)-2-(2-propan-2-ylimidazol-1-yl)-N-[2-(2H-triazol-4-ylsulfanyl)ethyl]propanamide —— C13H20N6OS
    (2R)-2-(2-propan-2-ylimidazol-1-yl)-N-[2-(2H-triazol-4-ylsulfanyl)ethyl]propanamide
    —— 2-butylsulfanyl-4-N-[[(3R)-1-methylpyrrolidin-3-yl]methyl]pyrimidine-4,6-diamine —— C14H25N5S
    2-butylsulfanyl-4-N-[[(3R)-1-methylpyrrolidin-3-yl]methyl]pyrimidine-4,6-diamine
    —— N-[(2R)-1-imidazol-1-yl-3,3-dimethylbutan-2-yl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine —— C19H30N6S
    N-[(2R)-1-imidazol-1-yl-3,3-dimethylbutan-2-yl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine
    —— N-[(1S)-1-(3-chlorophenyl)ethyl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C20H24ClNOS
    N-[(1S)-1-(3-chlorophenyl)ethyl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— (2S)-N-benzyl-2-(2,3,5,6-tetramethylphenyl)sulfanylpropanamide —— C20H25NOS
    (2S)-N-benzyl-2-(2,3,5,6-tetramethylphenyl)sulfanylpropanamide
    —— N-[(4-fluorophenyl)methyl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide —— C19H22FNOS
    N-[(4-fluorophenyl)methyl]-2-(2,3,5,6-tetramethylphenyl)sulfanylacetamide
    —— 1-methyl-N-[2-(2,3,4,5,6-pentafluorophenyl)sulfanylacetyl]pyrrole-2-carboxamide —— C14H9F5N2O2S
    1-methyl-N-[2-(2,3,4,5,6-pentafluorophenyl)sulfanylacetyl]pyrrole-2-carboxamide
    —— 1-[2,5-dimethyl-1-[[(2R)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-(2,3,5,6-tetramethylphenyl)sulfanylethanone —— C23H31NO2S
    1-[2,5-dimethyl-1-[[(2R)-oxolan-2-yl]methyl]pyrrol-3-yl]-2-(2,3,5,6-tetramethylphenyl)sulfanylethanone
    —— (2S)-2-(2-propan-2-ylimidazol-1-yl)-N-[2-(2H-triazol-4-ylsulfanyl)ethyl]propanamide —— C13H20N6OS
    (2S)-2-(2-propan-2-ylimidazol-1-yl)-N-[2-(2H-triazol-4-ylsulfanyl)ethyl]propanamide
    —— N-(2-phenylsulfanylphenyl)-2-[4-(trifluoromethyl)phenoxy]acetamide —— C21H16F3NO2S
    N-(2-phenylsulfanylphenyl)-2-[4-(trifluoromethyl)phenoxy]acetamide
    —— N-cycloheptyl-2-(2,3,4,5,6-pentafluorophenyl)sulfanylacetamide —— C15H16F5NOS
    N-cycloheptyl-2-(2,3,4,5,6-pentafluorophenyl)sulfanylacetamide
    —— (2S)-2-(2,3,4,5,6-pentafluorophenyl)sulfanylpropanamide —— C9H6F5NOS
    (2S)-2-(2,3,4,5,6-pentafluorophenyl)sulfanylpropanamide
    —— 2-butylsulfanyl-4-N-[[(3S)-1-methylpyrrolidin-3-yl]methyl]pyrimidine-4,6-diamine —— C14H25N5S
    2-butylsulfanyl-4-N-[[(3S)-1-methylpyrrolidin-3-yl]methyl]pyrimidine-4,6-diamine
    —— N-[(2S)-1-imidazol-1-yl-3,3-dimethylbutan-2-yl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine —— C19H30N6S
    N-[(2S)-1-imidazol-1-yl-3,3-dimethylbutan-2-yl]-1-(2-methylsulfanylpyrimidin-4-yl)piperidin-4-amine
    —— 2-[(2R)-4-(6-amino-2-butylsulfanylpyrimidin-4-yl)morpholin-2-yl]ethanol —— C14H24N4O2S
    2-[(2R)-4-(6-amino-2-butylsulfanylpyrimidin-4-yl)morpholin-2-yl]ethanol
    —— 2-[(2S)-4-(6-amino-2-butylsulfanylpyrimidin-4-yl)morpholin-2-yl]ethanol —— C14H24N4O2S
    2-[(2S)-4-(6-amino-2-butylsulfanylpyrimidin-4-yl)morpholin-2-yl]ethanol
    —— ethyl 2,5-dimethyl-4-[2-(2,3,4,5,6-pentafluorophenyl)sulfanylacetyl]-1H-pyrrole-3-carboxylate —— C17H14F5NO3S
    ethyl 2,5-dimethyl-4-[2-(2,3,4,5,6-pentafluorophenyl)sulfanylacetyl]-1H-pyrrole-3-carboxylate
    —— 4-N-[[(3S)-1,1-dioxothiolan-3-yl]methyl]-2-[(2-methylphenyl)methylsulfanyl]pyrimidine-4,6-diamine —— C17H22N4O2S2
    4-N-[[(3S)-1,1-dioxothiolan-3-yl]methyl]-2-[(2-methylphenyl)methylsulfanyl]pyrimidine-4,6-diamine
    —— 4-N-[[(3R)-1,1-dioxothiolan-3-yl]methyl]-2-[(2-methylphenyl)methylsulfanyl]pyrimidine-4,6-diamine —— C17H22N4O2S2
    4-N-[[(3R)-1,1-dioxothiolan-3-yl]methyl]-2-[(2-methylphenyl)methylsulfanyl]pyrimidine-4,6-diamine
    —— 2-butylsulfanyl-4-N-[[(2R)-1,4-dimethylpiperazin-2-yl]methyl]pyrimidine-4,6-diamine —— C15H28N6S
    2-butylsulfanyl-4-N-[[(2R)-1,4-dimethylpiperazin-2-yl]methyl]pyrimidine-4,6-diamine