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    首页 分子通 按分子结构分类 有机化合物 有机硫化合物

    有机硫化合物

    有机硫化合物是指含有硫原子的有机化合物。这些化合物在自然界中广泛存在，在医药、农药和材料科学等领域有着重要的应用。有机硫化合物因其化学性质独特，在药物设计、合成化学以及材料制备方面扮演着重要角色。

    1. 结构与分类

    有机硫化合物可以按硫的连接方式分为饱和和不饱和类，如二硫化物、噻吩衍生物、砜等。常见的结构类型有：

    • 二硫化物：含-S-S-键的化合物。
    • 硫醚（Thiols）：含有-R-S-H或-R-S-R 基团的化合物。
    • 磺酸酯（Sulfonates）与磺酸盐（Sulfonates）：带有-SO3H基团的化合物，广泛应用于合成和制药领域。
    • 噻吩及其衍生物：具有环状结构的有机硫化物。
    2. 生物学活性

    许多有机硫化合物在生物学上有重要功能或应用潜力。例如：

    • 某些硫醚类药物被用于抗真菌、抗菌以及抗癌治疗。
    • 硫代葡萄糖苷（Glycosinolate）是十字花科植物中的一种天然存在物质，具有生物活性。
    3. 合成方法

    有机硫化合物可通过多种途径合成：

    • 亲核取代反应：使用含硫试剂与卤化物进行反应。
    • 自由基加成法：采用氧化剂引发自由基形成，通过烯烃与H2S、R-S-H等反应制备。
    • 金属催化转化：利用钯、铜等催化剂促进特定硫化过程。
    4. 应用领域

    有机硫化合物的应用广泛：

    • 医药领域：用于开发抗菌剂、抗病毒药物及抗癌药物等。
    • 农学研究：某些有机硫化合物作为生物农药的有效成分，能够抑制病害的发生。
    • 材料科学与技术：在导电聚合物和塑料添加剂中有重要应用。
    5. 环境与安全性

    尽管有机硫化合物具有许多潜在益处，但其生产和使用也可能对环境造成影响。因此，在设计和合成这些化合物时需要考虑可持续性和环保性因素。

    以上是对有机硫化合物的简单介绍，包括它们的结构、生物学活性、合成方法及其应用领域等基本信息。

    下级分类

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-Methylmercapto-1-benzyl-4,7-dihydroxy-1H-imidazo<4,5-d>pyridazin 3434-22-8 C13H12N4O2S
    2-Methylmercapto-1-benzyl-4,7-dihydroxy-1H-imidazo<4,5-d>pyridazin
    —— Acetic acid (1E,3E)-4-phenylsulfanyl-buta-1,3-dienyl ester 65174-14-3 C12H12O2S
    Acetic acid (1E,3E)-4-phenylsulfanyl-buta-1,3-dienyl ester
    —— 3-(phenylsulfanyl)pent-2-enoic acid methyl ester 1093350-54-9 C12H14O2S
    3-(phenylsulfanyl)pent-2-enoic acid methyl ester
    —— 1-[1-(4-methylthio-phenyl)-ethyl]-biguanide hydrochloride 205937-74-2 C11H17N5S*ClH
    1-[1-(4-methylthio-phenyl)-ethyl]-biguanide hydrochloride
    —— 2-chloro-5-(4-bromophenylthio)-4-aminopyridine 1235873-05-8 C11H8BrClN2S
    2-chloro-5-(4-bromophenylthio)-4-aminopyridine
    —— (1'S,3'S,6'R,7'R,8'R)-3',6',8'-trimethylspiro[1,3-dithiolane-2,10'-tricyclo[5.3.1.03,8]undecane]-2'-one 922173-47-5 C16H24OS2
    (1'S,3'S,6'R,7'R,8'R)-3',6',8'-trimethylspiro[1,3-dithiolane-2,10'-tricyclo[5.3.1.03,8]undecane]-2'-one
    —— 1-(4-methylthio-phenyl)-ethylamine hydrochloride 205937-77-5 C9H13NS*ClH
    1-(4-methylthio-phenyl)-ethylamine hydrochloride
    —— 2-methyl-5-[(4-phenyl-1,2,3-selenadiazol-5-yl)sulfanyl]-1,3,4-thiadiazole 1394139-83-3 C11H8N4S2Se
    2-methyl-5-[(4-phenyl-1,2,3-selenadiazol-5-yl)sulfanyl]-1,3,4-thiadiazole
    —— n-Benzyl-1-[(4-chlorophenyl)sulfanyl]-n-{[(4-chlorophenyl)sulfanyl]methyl}methanamine 67857-75-4 C21H19Cl2NS2
    n-Benzyl-1-[(4-chlorophenyl)sulfanyl]-n-{[(4-chlorophenyl)sulfanyl]methyl}methanamine
    —— 5,6-dihydro-12H-6-oxopyrrolo<2,1-e><4,1,6>benzothiadiazonine 117954-57-1 C13H12N2OS
    5,6-dihydro-12H-6-oxopyrrolo<2,1-e><4,1,6>benzothiadiazonine
    —— 6-(3-Fluoro-phenylsulfanyl)-3,4-dihydro-2H-naphthalen-1-one 1231765-07-3 C16H13FOS
    6-(3-Fluoro-phenylsulfanyl)-3,4-dihydro-2H-naphthalen-1-one
    —— O,S-Dipropyl-thiosulfit 17796-40-6 C6H14O2S2
    O,S-Dipropyl-thiosulfit
    —— (R)-(6-phenylsulfanyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetic acid 895534-22-2 C18H18O2S
    (R)-(6-phenylsulfanyl-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetic acid
    —— bis-(4-methyl-[2]quinolyl)-sulfide 102007-55-6 C20H16N2S
    bis-(4-methyl-[2]quinolyl)-sulfide
    —— (E)-5,5-dimethyl-2-[4-(phenylthio)but-2-en-2-yl]-1,3-dioxane 1606991-69-8 C16H22O2S
    (E)-5,5-dimethyl-2-[4-(phenylthio)but-2-en-2-yl]-1,3-dioxane
    —— 4,4,5,5-Tetrafluoro-2,3-bis-phenylsulfanyl-cyclopent-2-enone 74835-71-5 C17H10F4OS2
    4,4,5,5-Tetrafluoro-2,3-bis-phenylsulfanyl-cyclopent-2-enone
    —— 2-(1,3-benzothiazol-2-ylsulfanyl)-4-methylquinoline 413593-30-3 C17H12N2S2
    2-(1,3-benzothiazol-2-ylsulfanyl)-4-methylquinoline
    —— 4-methyl-2-(p-tolylthio)quinoline 64789-02-2 C17H15NS
    4-methyl-2-(p-tolylthio)quinoline
    —— 6-(6-methyl-2-phenylpyrimidin-4-ylthio)hexan-1-ol 112641-06-2 C17H22N2OS
    6-(6-methyl-2-phenylpyrimidin-4-ylthio)hexan-1-ol
    —— 2-(2-n-butyl-4-methylthiophenyl)-4,4-dimethyloxazoline 136515-51-0 C16H23NOS
    2-(2-n-butyl-4-methylthiophenyl)-4,4-dimethyloxazoline
    —— N-Cyclohexyl-4-(1-methyl-1,2,3,4-tetrazol-5-yl)thio-butyramide 80463-78-1 C12H21N5OS
    N-Cyclohexyl-4-(1-methyl-1,2,3,4-tetrazol-5-yl)thio-butyramide
    —— 2-<2-(4-Methylphenylthio)>phenylpropan-2-ol 150192-74-8 C16H18OS
    2-<2-(4-Methylphenylthio)>phenylpropan-2-ol
    —— 3-Chloro-1-isothiocyanato-2-methyl-butane 691358-93-7 C6H10ClNS
    3-Chloro-1-isothiocyanato-2-methyl-butane
    —— 2-methylsulfanylphenyl octyl sulfide 161431-84-1 C15H24S2
    2-methylsulfanylphenyl octyl sulfide
    —— 2,3-Bis-octylthio-propan-1-ol 102731-53-3 C19H40OS2
    2,3-Bis-octylthio-propan-1-ol
    —— (Z)-1-<(1,1-dimethylethyl)sulfinyl>-2-methylbut-2-ene 114652-39-0 C9H18OS
    (Z)-1-<(1,1-dimethylethyl)sulfinyl>-2-methylbut-2-ene
    —— 2-<(3-nitrophenyl)thio>indole 139461-67-9 C14H10N2O2S
    2-<(3-nitrophenyl)thio>indole
    —— N-Ethyl-4-(1-methyl-1H-tetrazol-5-ylsulfanyl)-butyramide 80463-96-3 C8H15N5OS
    N-Ethyl-4-(1-methyl-1H-tetrazol-5-ylsulfanyl)-butyramide
    —— Bis[6-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]hexyl] propanedioate 1351165-90-6 C31H36N4O6S2
    Bis[6-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]hexyl] propanedioate
    —— N-Benzyl-4-(1-methyl-1H-tetrazol-5-ylsulfanyl)-butyramide 80475-43-0 C13H17N5OS
    N-Benzyl-4-(1-methyl-1H-tetrazol-5-ylsulfanyl)-butyramide
    —— 4-isothiocyanato-3-methyl-2-butanol 691359-05-4 C6H11NOS
    4-isothiocyanato-3-methyl-2-butanol
    —— 4-(5-{[(4-Methylphenyl)methyl]sulfanyl}-1,3,4-oxadiazol-2-yl)pyridine 485334-75-6 C15H13N3OS
    4-(5-{[(4-Methylphenyl)methyl]sulfanyl}-1,3,4-oxadiazol-2-yl)pyridine
    —— 2-(4-fluorobenzylthio)-5-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3,4-oxadiazole 568561-40-0 C14H10FN3OS
    2-(4-fluorobenzylthio)-5-(4-methyl-1,2,3-thiadiazol-5-yl)-1,3,4-oxadiazole
    —— (1Z,3S)-3-tert-butyldimethylsilyloxy-1-(4'-methylphenylthio)-1-nitrobut-1-ene 160349-77-9 C17H27NO3SSi
    (1Z,3S)-3-tert-butyldimethylsilyloxy-1-(4'-methylphenylthio)-1-nitrobut-1-ene
    —— 5-Hydroxymethyl-6-methyl-2-methylsulfanyl-nicotinonitrile 113859-02-2 C9H10N2OS
    5-Hydroxymethyl-6-methyl-2-methylsulfanyl-nicotinonitrile
    —— 3-cyano-5-<(methoxymethoxy)methyl>-7-methyl-2-(methylthio)pyridine 113859-08-8 C11H14N2O2S
    3-cyano-5-<(methoxymethoxy)methyl>-7-methyl-2-(methylthio)pyridine
    —— (1'S,2R,3R)-3-<1'-(tert-butoxydimethylsilyloxy)ethyl>-2-(4''-methylphenylthio)-2-nitrooxirane 160401-33-2 C17H27NO4SSi
    (1'S,2R,3R)-3-<1'-(tert-butoxydimethylsilyloxy)ethyl>-2-(4''-methylphenylthio)-2-nitrooxirane
    —— Diisopropyl-(1-isopropyl-4,4-dimethyl-2-oxo-3-p-tolylsulfanyl-2λ<sup>5</sup>-[1,2]azaphosphetidin-2-yl)-amine 122093-54-3 C20H35N2OPS
    Diisopropyl-(1-isopropyl-4,4-dimethyl-2-oxo-3-p-tolylsulfanyl-2λ<sup>5</sup>-[1,2]azaphosphetidin-2-yl)-amine
    —— mesylate of (+)-(2S,3S)-(4E)-3-[(tert-butyldimethylsilyl)oxy]-6-methyl-4-(phenylsulfenyl)hept-4-en-2-ol 304881-71-8 C21H36O4S2Si
    mesylate of (+)-(2S,3S)-(4E)-3-[(tert-butyldimethylsilyl)oxy]-6-methyl-4-(phenylsulfenyl)hept-4-en-2-ol
    —— mesylate of (2S,3S)-(4E)-2-[(tert-butyldimethylsilyl)oxy]-6-methyl-4-(phenylsulfenyl)hept-4-en-3-ol 304881-70-7 C21H36O4S2Si
    mesylate of (2S,3S)-(4E)-2-[(tert-butyldimethylsilyl)oxy]-6-methyl-4-(phenylsulfenyl)hept-4-en-3-ol
    —— 2-Carbamoylmethylmercapto-1-benzyl-4,7-dihydroxy-1H-imidazo<4,5-d>pyridazin 3434-21-7 C14H13N5O3S
    2-Carbamoylmethylmercapto-1-benzyl-4,7-dihydroxy-1H-imidazo<4,5-d>pyridazin
    —— 2-(2-Brom-benzylmercapto)-1-benzyl-4,7-dihydroxy-1H-imidazo<4,5-d>pyridazin 3494-20-0 C19H15BrN4O2S
    2-(2-Brom-benzylmercapto)-1-benzyl-4,7-dihydroxy-1H-imidazo<4,5-d>pyridazin
    —— 4-(4-chlorophenyl)-5-(hydroxymethyl)-2-(isopropylthio)thiophene-3-carbonitrile 1191249-25-8 C15H14ClNOS2
    4-(4-chlorophenyl)-5-(hydroxymethyl)-2-(isopropylthio)thiophene-3-carbonitrile
    —— 3-<4-(hexylthio)-1,2,5-thiadiazol-3-yl>pyridine 131988-10-8 C13H17N3S2
    3-<4-(hexylthio)-1,2,5-thiadiazol-3-yl>pyridine
    —— bis-(4-guanidino-phenyl)-sulfide 109045-56-9 C14H16N6S
    bis-(4-guanidino-phenyl)-sulfide
    —— 3-(tert-butyl)-5-(hexylthio)-4H-1,2,4-triazole 1353654-30-4 C12H23N3S
    3-(tert-butyl)-5-(hexylthio)-4H-1,2,4-triazole
    —— 6-chloro-2-hexylmercapto-pyrimidine-4-carbaldehyde diethyl acetal 775349-60-5 C15H25ClN2O2S
    6-chloro-2-hexylmercapto-pyrimidine-4-carbaldehyde diethyl acetal
    —— (+)-(2S,3S)-(4E)-3-[(tert-butyldimethylsilyl)oxy]-6-methyl-4-(phenylsulfenyl)hept-4-en-2-ol 304881-47-8 C20H34O2SSi
    (+)-(2S,3S)-(4E)-3-[(tert-butyldimethylsilyl)oxy]-6-methyl-4-(phenylsulfenyl)hept-4-en-2-ol
    —— (-)-(2S,3S)-(4E)-2-[(tert-butyldimethylsilyl)oxy]-6-methyl-4-(phenylsulfenyl)hept-4-en-3-ol 304881-46-7 C20H34O2SSi
    (-)-(2S,3S)-(4E)-2-[(tert-butyldimethylsilyl)oxy]-6-methyl-4-(phenylsulfenyl)hept-4-en-3-ol
    —— (E)-(3-(adamantan-1-yl)but-1-enyl)(phenyl)sulfane 1393672-45-1 C20H26S
    (E)-(3-(adamantan-1-yl)but-1-enyl)(phenyl)sulfane