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    首页 分子通 按分子结构分类 有机化合物 苯丙烷和聚酮 黄酮类化合物

    黄酮类化合物

    黄酮类化合物 定义与结构特征

    黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。

    生物来源

    黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。

    化学性质 亲水性与溶解度

    由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。

    稳定性与光敏性

    大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。

    生理活性与药用价值

    黄酮类化合物因其丰富的生理活性而备受关注，主要包括：

    • 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
    • 抗炎效应：有助于减轻炎症反应，缓解症状。
    • 心血管保护：可能通过多种机制改善心脑血管健康。
    • 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
    应用领域 食品工业

    作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。

    化妆品行业

    利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。

    药物开发

    由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— N-[(4E)-2-(4-methoxyphenyl)-4H-chromen-4-ylidene]-5-methyl-4-(4-phenoxyphenyl)-1,3-thiazol-2-amine —— C32H24N2O3S
    N-[(4E)-2-(4-methoxyphenyl)-4H-chromen-4-ylidene]-5-methyl-4-(4-phenoxyphenyl)-1,3-thiazol-2-amine
    —— Methyl 6-hydroxy-2,2-bis(4-methoxyphenyl)-8-[2-[4-[4-(4-pentylcyclohexyl)cyclohexanecarbonyl]oxyphenyl]benzoyl]oxybenzo[h]chromene-5-carboxylate —— C60H62O10
    Methyl 6-hydroxy-2,2-bis(4-methoxyphenyl)-8-[2-[4-[4-(4-pentylcyclohexyl)cyclohexanecarbonyl]oxyphenyl]benzoyl]oxybenzo[h]chromene-5-carboxylate
    —— [4-[4,22-Dimethoxy-10,10-bis(4-methoxyphenyl)-25,25-dimethyl-9-oxahexacyclo[12.11.0.02,7.08,13.015,24.016,21]pentacosa-1(14),2(7),3,5,8(13),11,15(24),16,18,20,22-undecaen-23-yl]piperazin-1-yl]-[4-[4-(4-pentylcyclohexyl)phenyl]phenyl]methanone —— C70H72N2O6
    [4-[4,22-Dimethoxy-10,10-bis(4-methoxyphenyl)-25,25-dimethyl-9-oxahexacyclo[12.11.0.02,7.08,13.015,24.016,21]pentacosa-1(14),2(7),3,5,8(13),11,15(24),16,18,20,22-undecaen-23-yl]piperazin-1-yl]-[4-[4-(4-pentylcyclohexyl)phenyl]phenyl]methanone
    —— N-[4-[5,5-bis(4-methoxyphenyl)-6,22-dioxapentacyclo[12.8.0.02,7.08,13.015,20]docosa-1(14),2(7),3,8(13),9,11,15,17,19-nonaen-11-yl]-3-(trifluoromethyl)phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide —— C65H58F3NO5
    N-[4-[5,5-bis(4-methoxyphenyl)-6,22-dioxapentacyclo[12.8.0.02,7.08,13.015,20]docosa-1(14),2(7),3,8(13),9,11,15,17,19-nonaen-11-yl]-3-(trifluoromethyl)phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide
    —— Methyl 3-(2-fluorophenyl)-6-methoxy-3-(4-methoxyphenyl)-8-[4-[[4-[4-(4-pentylcyclohexyl)phenyl]benzoyl]amino]-2-(trifluoromethyl)phenyl]naphtho[1,2-h]chromene-12-carboxylate —— C64H57F4NO6
    Methyl 3-(2-fluorophenyl)-6-methoxy-3-(4-methoxyphenyl)-8-[4-[[4-[4-(4-pentylcyclohexyl)phenyl]benzoyl]amino]-2-(trifluoromethyl)phenyl]naphtho[1,2-h]chromene-12-carboxylate
    —— N-[4-[5-(4-fluorophenyl)-18,21,21-trimethyl-5-(4-piperidin-1-ylphenyl)-10-(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15(20),16,18-nonaen-3-yl]phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide —— C71H68F4N2O2
    N-[4-[5-(4-fluorophenyl)-18,21,21-trimethyl-5-(4-piperidin-1-ylphenyl)-10-(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15(20),16,18-nonaen-3-yl]phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide
    —— (2-Methylperoxy-2-oxoethyl) 2,2-bis(4-fluorophenyl)-6-methyl-8-[4-[[4-(4-pentylcyclohexyl)phenyl]methoxycarbonyl]phenyl]benzo[h]chromene-5-carboxylate —— C55H52F2O8
    (2-Methylperoxy-2-oxoethyl) 2,2-bis(4-fluorophenyl)-6-methyl-8-[4-[[4-(4-pentylcyclohexyl)phenyl]methoxycarbonyl]phenyl]benzo[h]chromene-5-carboxylate
    —— [10-Methoxy-5-(4-methoxyphenyl)-21,21-dimethyl-5-(4-methylphenyl)-3-[4-[[4-[4-(4-pentylcyclohexyl)phenyl]benzoyl]amino]phenyl]-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8,10,12,15,17,19-nonaen-11-yl] 2-[4-[4-(4-pentylcyclohexyl)cyclohexanecarbonyl]oxyphenyl]benzoate —— C98H103NO8
    [10-Methoxy-5-(4-methoxyphenyl)-21,21-dimethyl-5-(4-methylphenyl)-3-[4-[[4-[4-(4-pentylcyclohexyl)phenyl]benzoyl]amino]phenyl]-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8,10,12,15,17,19-nonaen-11-yl] 2-[4-[4-(4-pentylcyclohexyl)cyclohexanecarbonyl]oxyphenyl]benzoate
    —— [4-[5-(4-Butoxyphenyl)-5-(4-fluorophenyl)-21,21-dimethyl-10-(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15,17,19-nonaen-3-yl]piperazin-1-yl]-[4-[4-(4-pentylcyclohexyl)phenyl]phenyl]methanone —— C67H68F4N2O3
    [4-[5-(4-Butoxyphenyl)-5-(4-fluorophenyl)-21,21-dimethyl-10-(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15,17,19-nonaen-3-yl]piperazin-1-yl]-[4-[4-(4-pentylcyclohexyl)phenyl]phenyl]methanone
    —— N-[4-[5-(4-butoxyphenyl)-5-(4-methoxyphenyl)-21,21-dimethyl-10-(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15,17,19-nonaen-3-yl]phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide —— C70H68F3NO4
    N-[4-[5-(4-butoxyphenyl)-5-(4-methoxyphenyl)-21,21-dimethyl-10-(trifluoromethyl)-6-oxapentacyclo[12.7.0.02,7.08,13.015,20]henicosa-1(14),2(7),3,8(13),9,11,15,17,19-nonaen-3-yl]phenyl]-4-[4-(4-pentylcyclohexyl)phenyl]benzamide
    —— (2-Methoxy-2-oxoethyl) 2,2-bis(4-fluorophenyl)-6-methyl-8-[4-[[4-(4-pentylcyclohexyl)phenyl]methoxycarbonyl]phenyl]benzo[h]chromene-5-carboxylate —— C55H52F2O7
    (2-Methoxy-2-oxoethyl) 2,2-bis(4-fluorophenyl)-6-methyl-8-[4-[[4-(4-pentylcyclohexyl)phenyl]methoxycarbonyl]phenyl]benzo[h]chromene-5-carboxylate
    —— 5-[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-1,3-benzodioxole-2-thione —— C16H12O6S
    5-[(2R,3R)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-2-yl]-1,3-benzodioxole-2-thione
    —— (2R,3S)-N-benzyl-2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3,4-dihydro-2H-chromen-3-amine —— C26H29NO5
    (2R,3S)-N-benzyl-2-(3,4-dimethoxyphenyl)-5,7-dimethoxy-3,4-dihydro-2H-chromen-3-amine
    —— (2R)-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-3,5,7-triol —— C28H22O6
    (2R)-2-(2,2-diphenyl-1,3-benzodioxol-5-yl)-3,4-dihydro-2H-chromene-3,5,7-triol
    —— (2R,3R)-2-[3-hydroxy-4-(3-methylbut-2-enoxy)phenyl]-3,4-dihydro-2H-chromene-3,5,7-triol —— C20H22O6
    (2R,3R)-2-[3-hydroxy-4-(3-methylbut-2-enoxy)phenyl]-3,4-dihydro-2H-chromene-3,5,7-triol
    —— (2R,3R)-2-[3,4-bis(phenylmethoxy)phenyl]-3,7-dimethyl-5-phenylmethoxy-2,4-dihydrochromen-3-ol —— C38H36O5
    (2R,3R)-2-[3,4-bis(phenylmethoxy)phenyl]-3,7-dimethyl-5-phenylmethoxy-2,4-dihydrochromen-3-ol
    —— [4-(2-o-tolyl-chroman-6-yloxy)-cyclohexyl]-(1 ,3,5-trimethyl-1H-pyrazol-4-ylmethyl)-amine —— C29H37N3O2
    [4-(2-o-tolyl-chroman-6-yloxy)-cyclohexyl]-(1 ,3,5-trimethyl-1H-pyrazol-4-ylmethyl)-amine
    —— ({[cis-4-(2-o-Tolyl-chroman-6-yloxy)-cyclohexylmethyl]-carbamoyl}-methyl)-carbamic acid tert-butyl ester —— C30H40N2O5
    ({[cis-4-(2-o-Tolyl-chroman-6-yloxy)-cyclohexylmethyl]-carbamoyl}-methyl)-carbamic acid tert-butyl ester
    —— [cis-4-(2-Phenyl-chroman-6-yloxy)-cyclohexylmethyl]amine hydrochloride —— C22H28ClNO2
    [cis-4-(2-Phenyl-chroman-6-yloxy)-cyclohexylmethyl]amine hydrochloride
    —— 2-(3-Fluoro-2-methylphenyl)-6-hydroxy-2,3-dihydrochromen-4-one —— C16H13FO3
    2-(3-Fluoro-2-methylphenyl)-6-hydroxy-2,3-dihydrochromen-4-one
    —— 4-(2-o-tolyl-chroman-6-yloxy)-cyclohexanecarboxylic acid —— C23H26O4
    4-(2-o-tolyl-chroman-6-yloxy)-cyclohexanecarboxylic acid
    —— 4-[[7-methyl-2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid —— C24H28O4
    4-[[7-methyl-2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid
    —— 2-(3-Fluoro-2-methoxyphenyl)-6-hydroxy-2,3-dihydrochromen-4-one —— C16H13FO4
    2-(3-Fluoro-2-methoxyphenyl)-6-hydroxy-2,3-dihydrochromen-4-one
    —— 8-[[2-(2,6-dimethylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,4-dioxaspiro[4.5]decane —— C25H30O4
    8-[[2-(2,6-dimethylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-1,4-dioxaspiro[4.5]decane
    —— 4-[(3-methyl-2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxylic acid —— C23H26O4
    4-[(3-methyl-2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxylic acid
    —— [4-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexyl]methanamine —— C23H29NO2
    [4-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexyl]methanamine
    —— 4-[[2-(3-fluoro-2-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid —— C23H25FO5
    4-[[2-(3-fluoro-2-methoxyphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]cyclohexane-1-carboxylic acid
    —— Bis-(tetrahydrofuran-3-ylmethyl)-[trans-4-(2-o-tolyl-chroman-6-yloxy)-cyclohexyl]-amine —— C32H43NO4
    Bis-(tetrahydrofuran-3-ylmethyl)-[trans-4-(2-o-tolyl-chroman-6-yloxy)-cyclohexyl]-amine
    —— ethyl 4-[(3-methyl-2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxylate —— C25H30O4
    ethyl 4-[(3-methyl-2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]cyclohexane-1-carboxylate
    —— ethyl 2-[4-[(2R)-5,7-dimethoxy-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyphenoxy]acetate —— C21H24O7
    ethyl 2-[4-[(2R)-5,7-dimethoxy-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyphenoxy]acetate
    —— methyl 4-ethyl-3-[2-[4-[(3E)-4-methoxypenta-1,3-dien-2-yl]phenyl]-3,4-dihydro-2H-chromen-7-yl]hexanoate —— C30H38O4
    methyl 4-ethyl-3-[2-[4-[(3E)-4-methoxypenta-1,3-dien-2-yl]phenyl]-3,4-dihydro-2H-chromen-7-yl]hexanoate
    —— (3S)-3-cyclopropyl-3-[2-[4-(2-fluoro-5-methoxyphenyl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid —— C34H39FO5
    (3S)-3-cyclopropyl-3-[2-[4-(2-fluoro-5-methoxyphenyl)-3-(1-methoxy-2,2-dimethylpropyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
    —— (3R)-3-[2-[4-(5-fluoro-2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid —— C24H22FNO5
    (3R)-3-[2-[4-(5-fluoro-2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid
    —— (3S)-3-[2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid —— C28H25FO4
    (3S)-3-[2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid
    —— (3S)-3-cyclobutyl-3-[(2S)-2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid —— C29H29FO4
    (3S)-3-cyclobutyl-3-[(2S)-2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
    —— (2S,3R)-3-cyclopropyl-3-[2-[3-(1-methoxy-2,2-dimethylpropyl)-4-(2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-2-methylpropanoic acid —— C34H41NO5
    (2S,3R)-3-cyclopropyl-3-[2-[3-(1-methoxy-2,2-dimethylpropyl)-4-(2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-2-methylpropanoic acid
    —— (3R)-3-[2-[2-fluoro-4-(6-methoxypyrazin-2-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid —— C23H21FN2O5
    (3R)-3-[2-[2-fluoro-4-(6-methoxypyrazin-2-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid
    —— (3S)-3-cyclobutyl-3-[(2R)-2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid —— C29H29FO4
    (3S)-3-cyclobutyl-3-[(2R)-2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
    —— (3R)-3-hydroxy-3-[2-[4-(6-methoxypyrazin-2-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid —— C23H22N2O5
    (3R)-3-hydroxy-3-[2-[4-(6-methoxypyrazin-2-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
    —— methyl (2S,3R)-3-[2-[2-fluoro-4-(2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxy-2-methylpropanoate —— C26H26FNO5
    methyl (2S,3R)-3-[2-[2-fluoro-4-(2-methoxypyridin-4-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxy-2-methylpropanoate
    —— methyl (3S)-3-cyclobutyl-3-[(2S)-2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoate —— C30H31FO4
    methyl (3S)-3-cyclobutyl-3-[(2S)-2-[4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoate
    —— (3S)-3-cyclopropyl-3-[2-[4-(2-fluoro-5-methoxyphenyl)-3-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid —— C29H26F4O5
    (3S)-3-cyclopropyl-3-[2-[4-(2-fluoro-5-methoxyphenyl)-3-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid
    —— (2S,3R)-3-cyclopropyl-3-[2-[4-(2-fluoro-5-methoxyphenyl)-3-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-7-yl]-2-methylpropanoic acid —— C30H28F4O5
    (2S,3R)-3-cyclopropyl-3-[2-[4-(2-fluoro-5-methoxyphenyl)-3-(trifluoromethoxy)phenyl]-3,4-dihydro-2H-chromen-7-yl]-2-methylpropanoic acid
    —— 2-[(3S)-7-[2-fluoro-5-(2-methylphenyl)phenyl]-3,5,6,7-tetrahydro-2H-furo[3,2-g]chromen-3-yl]acetic acid —— C26H23FO4
    2-[(3S)-7-[2-fluoro-5-(2-methylphenyl)phenyl]-3,5,6,7-tetrahydro-2H-furo[3,2-g]chromen-3-yl]acetic acid
    —— (3S)-3-[2-[2-fluoro-5-[2-(trifluoromethyl)pyridin-3-yl]phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid —— C27H21F4NO3
    (3S)-3-[2-[2-fluoro-5-[2-(trifluoromethyl)pyridin-3-yl]phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid
    —— 3-[2-[3-(2-methylpyridin-3-yl)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid —— C27H25NO3
    3-[2-[3-(2-methylpyridin-3-yl)phenyl]-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid
    —— (3R)-3-[2-[2-fluoro-4-(4-methyl-2,3-dihydro-1,4-benzoxazin-7-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid —— C27H26FNO5
    (3R)-3-[2-[2-fluoro-4-(4-methyl-2,3-dihydro-1,4-benzoxazin-7-yl)phenyl]-3,4-dihydro-2H-chromen-7-yl]-3-hydroxypropanoic acid
    —— 3-[2-(5-bromo-2-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid —— C21H18BrFO3
    3-[2-(5-bromo-2-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]hex-4-ynoic acid
    —— (4E)-6-fluoro-N-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-imine —— C16H12FNO3
    (4E)-6-fluoro-N-hydroxy-2-(4-methoxyphenyl)-4H-chromen-4-imine
    —— 3-cyclopropyl-3-[2-[3-(5,5-dimethylcyclopenten-1-yl)-4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid —— C35H37FO4
    3-cyclopropyl-3-[2-[3-(5,5-dimethylcyclopenten-1-yl)-4-(2-fluoro-5-methoxyphenyl)phenyl]-3,4-dihydro-2H-chromen-7-yl]propanoic acid