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    首页 分子通 按分子结构分类 有机化合物 苯丙烷和聚酮 黄酮类化合物

    黄酮类化合物

    黄酮类化合物 定义与结构特征

    黄酮类化合物是一大类天然存在的有机化合物，属于酚类衍生物。它们的分子结构通常包含两个苯环（A和B环）和一个三碳环（C环），形成一个基本骨架。该骨架由多个亚结构组成，包括黄烷醇、黄酮、黄酮醇等。

    生物来源

    黄酮类化合物广泛存在于植物界中，常见于许多蔬菜、水果及中药中。例如，在大豆、柑橘、茶叶和甘草中都可以找到它们的身影。

    化学性质 亲水性与溶解度

    由于其分子结构中含有多个酚羟基，因此具有一定的亲水性和良好的溶解性，这使得黄酮类化合物在药物设计中扮演重要角色。

    稳定性与光敏性

    大多数黄酮类化合物相对稳定，在适宜条件下不易发生降解。但某些类型的黄酮对光照比较敏感，容易被氧化，导致颜色变化。

    生理活性与药用价值

    黄酮类化合物因其丰富的生理活性而备受关注，主要包括：

    • 抗氧化作用：可有效清除体内自由基，保护细胞免受损伤。
    • 抗炎效应：有助于减轻炎症反应，缓解症状。
    • 心血管保护：可能通过多种机制改善心脑血管健康。
    • 抗癌潜力：研究表明某些黄酮类物质具有抑制肿瘤生长的能力。
    应用领域 食品工业

    作为一种天然色素和抗氧化剂，被广泛应用于食品加工中以提高其保质期及营养价值。

    化妆品行业

    利用其良好的生物相容性和抗衰老特性，在化妆品配方中应用广泛。

    药物开发

    由于黄酮类化合物展现出广泛的药理活性，已成为新药研发的重要候选目标之一。

    中文名称 英文名称 CAS号 化学式 结构式图片
    —— 2-methyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-1,3-thiazole-4-carboxamide —— C24H21N3O3S2
    2-methyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-1,3-thiazole-4-carboxamide
    —— N-[(2-methylpyrimidin-4-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide —— C25H22N4O3S
    N-[(2-methylpyrimidin-4-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide
    —— N-[(3S,4S)-4-methoxypyrrolidin-3-yl]-2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamide —— C24H25N3O4S
    N-[(3S,4S)-4-methoxypyrrolidin-3-yl]-2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamide
    —— 2-oxo-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-1H-pyridine-4-carboxamide —— C25H21N3O4S
    2-oxo-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-1H-pyridine-4-carboxamide
    —— N-[(2-chloropyridin-4-yl)methyl]-4-methyl-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide —— C26H22ClN3O3S
    N-[(2-chloropyridin-4-yl)methyl]-4-methyl-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide
    —— N-[(2S,3S)-1-hydroxy-3-methylpentan-2-yl]-2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamide —— C25H28N2O4S
    N-[(2S,3S)-1-hydroxy-3-methylpentan-2-yl]-2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamide
    —— 2-[[2-(3-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(pyridin-4-ylmethyl)-1,3-thiazole-5-carboxamide —— C25H20FN3O3S
    2-[[2-(3-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(pyridin-4-ylmethyl)-1,3-thiazole-5-carboxamide
    —— 4-methyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-2,3-dihydro-1,4-benzoxazine-7-sulfonamide —— C28H27N3O5S2
    4-methyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-2,3-dihydro-1,4-benzoxazine-7-sulfonamide
    —— ethyl (1R,2S)-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]cyclohexane-1-carboxylate —— C28H30N2O5S
    ethyl (1R,2S)-2-[[2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carbonyl]amino]cyclohexane-1-carboxylate
    —— N-[(4,6-dimethylpyrimidin-2-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide —— C26H24N4O3S
    N-[(4,6-dimethylpyrimidin-2-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide
    —— 2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(pyridin-4-ylmethyl)-1,3-thiazole-5-carboxamide —— C25H21N3O3S
    2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(pyridin-4-ylmethyl)-1,3-thiazole-5-carboxamide
    —— N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]pyridine-3-sulfonamide —— C24H21N3O4S2
    N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]pyridine-3-sulfonamide
    —— N-[2-(2-oxoimidazolidin-1-yl)ethyl]-2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-4-carboxamide —— C24H24N4O4S
    N-[2-(2-oxoimidazolidin-1-yl)ethyl]-2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-4-carboxamide
    —— 4-methyl-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-N-(pyridin-4-ylmethyl)-1,3-thiazole-5-carboxamide —— C26H23N3O3S
    4-methyl-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-N-(pyridin-4-ylmethyl)-1,3-thiazole-5-carboxamide
    —— 4-methyl-2-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-[2-(2-oxoimidazolidin-1-yl)ethyl]-1,3-thiazole-5-carboxamide —— C26H28N4O4S
    4-methyl-2-[[2-(2-methylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-[2-(2-oxoimidazolidin-1-yl)ethyl]-1,3-thiazole-5-carboxamide
    —— N-[(1S,2S)-2-aminocyclopropyl]-2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamide —— C22H21N3O3S
    N-[(1S,2S)-2-aminocyclopropyl]-2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-1,3-thiazole-5-carboxamide
    —— N-[(2-aminopyridin-4-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide —— C25H22N4O3S
    N-[(2-aminopyridin-4-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide
    —— 1-ethyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]pyrazole-3-carboxamide —— C25H24N4O3S
    1-ethyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]pyrazole-3-carboxamide
    —— 2-[[2-(3-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(1,2-oxazol-5-ylmethyl)-1,3-thiazole-5-carboxamide —— C23H18FN3O4S
    2-[[2-(3-fluorophenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(1,2-oxazol-5-ylmethyl)-1,3-thiazole-5-carboxamide
    —— N-[(2-oxo-1H-pyridin-4-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide —— C25H21N3O4S
    N-[(2-oxo-1H-pyridin-4-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide
    —— 2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-N-[(1S)-1-(1,3-thiazol-2-yl)ethyl]-1,3-thiazole-5-carboxamide —— C24H21N3O3S2
    2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-N-[(1S)-1-(1,3-thiazol-2-yl)ethyl]-1,3-thiazole-5-carboxamide
    —— 2-[[2-(2-ethylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(1,2-oxazol-5-ylmethyl)-1,3-thiazole-5-carboxamide —— C25H23N3O4S
    2-[[2-(2-ethylphenyl)-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(1,2-oxazol-5-ylmethyl)-1,3-thiazole-5-carboxamide
    —— N-[(2-methylpyrazol-3-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide —— C24H22N4O3S
    N-[(2-methylpyrazol-3-yl)methyl]-2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazole-5-carboxamide
    —— 2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(piperidin-2-ylmethyl)-1,3-thiazole-5-carboxamide —— C25H27N3O3S
    2-[[(2S)-2-phenyl-3,4-dihydro-2H-chromen-6-yl]oxy]-N-(piperidin-2-ylmethyl)-1,3-thiazole-5-carboxamide
    —— 3,5-dimethyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-1,2-oxazole-4-carboxamide —— C25H23N3O4S
    3,5-dimethyl-N-[[2-[(2-phenyl-3,4-dihydro-2H-chromen-6-yl)oxy]-1,3-thiazol-5-yl]methyl]-1,2-oxazole-4-carboxamide
    —— Quercetin, 3,7,3',4'-tetra-TMS —— C27H42O7Si4
    Quercetin, 3,7,3',4'-tetra-TMS
    —— Pinobanksin-3-pentanoate, bis-TMS —— C26H36O6Si2
    Pinobanksin-3-pentanoate, bis-TMS
    —— Pinobanksin-3-acetate, bis-TMS —— C23H30O6Si2
    Pinobanksin-3-acetate, bis-TMS
    —— 3,7,8-trihydroxy-2-(3-hydroxy-phenyl)-chromen-4-one —— C15H10O6
    3,7,8-trihydroxy-2-(3-hydroxy-phenyl)-chromen-4-one
    —— Poncirin chalcone —— C28H34O14
    Poncirin chalcone
    —— 5-Hydroxy-7-methoxyflavanone, tert.-butyldimethylsilyl ether —— C22H28O4Si
    5-Hydroxy-7-methoxyflavanone, tert.-butyldimethylsilyl ether
    —— (+/-)-Naringenin, O,O'-bis(heptafluorobutyryl)- —— C23H10F14O7
    (+/-)-Naringenin, O,O'-bis(heptafluorobutyryl)-
    —— 3-(4-ethoxyphenyl)-3-(nitromethyl)-3H-benzo[f]chromene —— C22H19NO4
    3-(4-ethoxyphenyl)-3-(nitromethyl)-3H-benzo[f]chromene
    —— 2-(3,4-Di(trifluoroacetyl)oxyphenyl)-2,3-dihydro-5-hydroxy,7-(trifluoroacetyl)oxy-4H-1-benzopyran-4-one —— C21H9F9O9
    2-(3,4-Di(trifluoroacetyl)oxyphenyl)-2,3-dihydro-5-hydroxy,7-(trifluoroacetyl)oxy-4H-1-benzopyran-4-one
    —— 7-[(4-bromobenzyl)oxy]-5-hydroxy-2-phenyl-4H-chromen-4-one —— C22H15BrO4
    7-[(4-bromobenzyl)oxy]-5-hydroxy-2-phenyl-4H-chromen-4-one
    —— 5-Hydroxy-7-((3-methylbenzyl)oxy)-2-phenyl-4H-chromen-4-one —— C23H18O4
    5-Hydroxy-7-((3-methylbenzyl)oxy)-2-phenyl-4H-chromen-4-one
    —— 4'-Hydroxyflavanone, trimethylsilyl ether —— C18H20O3Si
    4'-Hydroxyflavanone, trimethylsilyl ether
    —— 3-[(2-methoxyphenyl)sulfamoyl]-N-[(E)-(2-phenyl-2,3-dihydrochromen-4-ylidene)amino]benzamide —— C29H25N3O5S
    3-[(2-methoxyphenyl)sulfamoyl]-N-[(E)-(2-phenyl-2,3-dihydrochromen-4-ylidene)amino]benzamide
    —— Flavanone, 3-hydroxy-3',4',5,7-tetramethoxy-, acetate, trans- —— C21H22O8
    Flavanone, 3-hydroxy-3',4',5,7-tetramethoxy-, acetate, trans-
    —— 2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(Z)-(2-phenyl-2,3-dihydrochromen-4-ylidene)amino]acetamide —— C25H23BrN2O2S
    2-(4-bromo-2,5-dimethylphenyl)sulfanyl-N-[(Z)-(2-phenyl-2,3-dihydrochromen-4-ylidene)amino]acetamide
    —— (+/-)-7,8,3',4'-Tetramethoxy-2,3-trans-flavanol-(3)-acetat 20754-55-6 C21H24O7
    (+/-)-7,8,3',4'-Tetramethoxy-2,3-trans-flavanol-(3)-acetat
    —— (+/-)-cis-Atzelechin-trimethylether —— C18H20O5
    (+/-)-cis-Atzelechin-trimethylether
    —— 2'-Hydroxyflavanone, trimethylsilyl ether —— C18H20O3Si
    2'-Hydroxyflavanone, trimethylsilyl ether
    —— 1-(7-hydroxy-2-phenyl-3,4-dihydro-2H-chromen-6-yl)-3-phenyl-2-propen-1-one —— C24H20O3
    1-(7-hydroxy-2-phenyl-3,4-dihydro-2H-chromen-6-yl)-3-phenyl-2-propen-1-one
    —— 2-(3,4-Di(isopropyl)oxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one —— C21H24O6
    2-(3,4-Di(isopropyl)oxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one
    —— (2R,3S)-2,3-trans-3-Acetoxy-5-[(2R,3S)-2,3-trans-3-acetoxy-3',4',7,8-tetramethoxyflavan-5-yl]-3',4',7,8-tetramethoxyflavan —— C42H46O14
    (2R,3S)-2,3-trans-3-Acetoxy-5-[(2R,3S)-2,3-trans-3-acetoxy-3',4',7,8-tetramethoxyflavan-5-yl]-3',4',7,8-tetramethoxyflavan
    —— 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxy-5-methoxyphenyl)-3,4-dihydro-, cis-(+/-)- —— C16H16O7
    2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxy-5-methoxyphenyl)-3,4-dihydro-, cis-(+/-)-
    —— 5-Hydroxy-7-methoxyflavanone, pentafluoropropionate —— C19H13F5O5
    5-Hydroxy-7-methoxyflavanone, pentafluoropropionate
    —— 2-(3,4-Di(n-butyl)oxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one —— C23H28O6
    2-(3,4-Di(n-butyl)oxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one
    —— (NZ)-N-[2-(6-chloro-4H-1,3-benzodioxin-8-yl)-7-methyl-2,3-dihydrochromen-4-ylidene]hydroxylamine —— C18H16ClNO4
    (NZ)-N-[2-(6-chloro-4H-1,3-benzodioxin-8-yl)-7-methyl-2,3-dihydrochromen-4-ylidene]hydroxylamine